scholarly journals Comparison of hematological parameters in mild and severe COVID-19 infected patients: A retrospective observational study

Biomedicine ◽  
2021 ◽  
Vol 41 (4) ◽  
pp. 799-804
Author(s):  
Tania Eltrida Pinto ◽  
Rithesh Joseph D'Cunha ◽  
Shannon Fernandes ◽  
. Nireeksha ◽  
Gurumurthy T.
Keyword(s):  
Medical Records ◽  
Leukocyte Count ◽  
Hematological Parameters ◽  
Demographic Data ◽  
Severe Disease ◽  
Disease Group ◽  
Differential Leukocyte Count ◽  
Mild Disease ◽  
Significant Difference ◽  
D Dimer

Introduction and Aim: With the coronavirus disease 2019 (COVID-19) pandemic raging on, there is a need to identify clinical and laboratory predictors which predict progression towards severe and fatal forms of this illness. Our study aims to evaluate the ability of hematologic and biochemical biomarkers to discriminate between patients with and without severe or fatal forms of COVID-19.   Materials and Methods: A retrospective study was conducted on 200 Covid positive patients;100 with mild disease and 100 with severe disease. Medical records were reviewed to collect demographic data and results of the following blood investigations were noted at admission: Hb, Platelet count, Total and Differential leukocyte count, CRP, AST, ALT, LDH, Ferritin and D-Dimer. Comparative analysis was performed between the 2 groups.   Results: A significant difference in the basophil count (mean 2.35 and 5.92) among those with mild and severe disease respectively was noted as also with the eosinophil count (mean 6.88 and 1.79). The levels of CRP were higher in those with severe disease as compared to the mild disease group (mean 276.29 and 65.23). Ferritin levels were markedly increased severe disease patients (mean 1275.66 and 533.94). D-dimer was markedly increased in COVID-19 patients with severe disease (mean 3813.91 ng/ml) compared to those with mild disease group (mean 521.78 ng/ml).   Conclusion: Hematological and biochemical markers positively correlate to the severity of covid infection, thus highlighting their role in the early diagnosis of the disease and can act as independent markers in predicting severity and prognosis of disease.

scholarly journals Evaluation of Effect of Melatonin on Hematological Parameters in Patients of Periodontitis

2019 ◽  
pp. 46-49
Author(s):  
Anagha Marawar ◽  
Pramod Marawar ◽  
Nandal D H ◽  
Rahul Kunkulol ◽  
Sandeep Narwane
Keyword(s):  
Leukocyte Count ◽  
Hematological Parameters ◽  
Total Leukocyte Count ◽  
Differential Leukocyte Count ◽  
Erythrocyte Sedimentation ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Root Planning ◽  
Scaling And Root Planning

Introduction: Considering the immunity enhancing property of melatonin, a study on the evaluation of the effect of melatonin on the hematological parameters in patients suffering from Periodontitis.  Methods: This study was conducted in the Department of Periodontics, Rural Dental College, Loni. Patients of chronic Periodontitis, of age between 18 to 65 years of either gender ready to give informed consent to participate in the study were included. Postoperative patients, patients having night duties, drivers and those using heavy machinery, pregnant women, lactating mothers, patients with any clinically significant systemic disease and patients on any other drugs were excluded from the study. Patients were divided into two Groups. Group B received scaling and root planning (SRP) and melatonin 3 mg per day were compared to Group A which received SRP only. The Total Leukocyte count, Differential Leukocyte count and Erythrocyte sedimentation rate of each patient was studied at a baseline, 1st (30 days) visit, 2nd (60 days) visit and 3rd (90 days) visit. Results: Both the groups consisted of 80 subjects each. Group A consisted of 71.25% male and 28.75% female patients. There were 56.25% male and 43.75% female patients in Group B. With respect to visit 3, the TLC was statistically lower in Group B. The neutrophil count of Group B was significantly lower during visit 3 as compared to Group A. The lymphocyte count of Group B was significantly lower than that of Group A during the visit 1, and also significantly higher during visit 3 on comparison with Group A. There was no statistically significant difference in the groups with respect to eosinophil and basophil count. The Monocyte count of Group B was statistically lower when compared to that of Group A. There was no statistically significant difference between ESR of Group A & Group B.  Conclusions: It can be concluded that melatonin has a positive effect on TLC and differential count of patients of periodontitis, conferring a new facet to the management of periodontitis and an attempt to impede the disease progression. Keywords: Melatonin; Hematological parameters; Periodontitis; Total Leukocyte count; Differential Leukocyte count; Erythrocyte sedimentation rate; Scaling and Root Planning.

scholarly journals SAT0541 THE SEVERITY OF FMF MAY BE ASSOCIATED WITH CO-MORBIDITIES

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1227.3-1228
Author(s):  
M. E. Tezcan ◽  
N. Şen ◽  
M. Yilmaz ◽  
Ö. Volkan ◽  
E. Tükel ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Scoring System ◽  
Disease Duration ◽  
Severe Disease ◽  
Smoking History ◽  
Disease Group ◽  
Severity Scoring ◽  
Mild Disease ◽  
Co Morbidity ◽  
Mediterranean Fever

Background:Familial Mediterranean fever (FMF) is an auto inflammatory disease with recurrent attacks of serositis. Frequent attacks and disease related sequels may be associated with co-morbidities in FMF patients.Objectives:One of the tools for evaluating the FMF severity is the international severity scoring system for FMF (ISSF)1. This score includes disease related sequels, acute phase measurements, attack features and exertional leg pain. Therefore, more severe disease may be link with subclinical inflammation, amyloidosis and frequent, prolonged and widespread attacks. All these components may augment the frequency of non-disease related co-morbidities.Methods:We enrolled 158 FMF patients who fulfilled modifiedTel-HashomerDiagnosisCriteria2. The patients dichotomized based upon disease severity (mild disease or severe disease). Patients with ISSF scores lower or equal to 2 were accepted to have mild disease. Then, we compared frequency of non-disease related co-morbidities between the groups. These co-morbidities arehypertension, hypothyroidism, hyperthyroidism cardiovascular diseases, coronary artery diseases, cerebrovascular diseases, chronic renal disease (non-FMF related), chronic obstructive pulmonary diseases, and diabetes mellitus. This study was approved by the Local Research Ethics Committee and carried out in compliance with the Helsinki Declaration. All the patients gave written informed consent. P-value lower than 0.05 was considered as statistically significant.Results:Demographic features, disease duration, smoking history and body mass index (BMI) were similar between the groups. Frequency of co-morbidity in severe disease group was statistically higher than mild disease group (p=0.02). Most frequent co-morbidity was hypertension in both groups.Table.Features of mild and severe FMF groupsMild (n=135)Severe (n=23)pGender (M/F)47/8811/120.23Age36.4±11.336.5±14.30.68Smoking (%)38 (28.1)5 (21.7)0.52BMI (kg/m2)24.3±9.224.0±8.90.34Disease duration (year)7.7±11.38.6±14.30.09Amyloidosis (%)2 (1.4)3 (13.0)0.02Exon 10 homozygote (%)35 (25.9)9 (39.1)0.19Colchicine dosage (mg/day)1.2±0.41.4±0.50.02ISSF scores0.7 ±0.73.4±0.5<0.001Co-morbidity (%)25 (18.5)9 (39.1)0.02Conclusion:In our FMF patient cohort, we found that severity of the disease may be associated with higher frequency of co-morbidities. Therefore, clinicians should be aware of the high possibility of co-morbidities in patients with more severe FMF and addressed these co-morbidities timely and properly.References:[1]Demirkaya E, et al. Development and initial validation of international severity scoring system for familial Mediterranean fever (ISSF). Ann Rheum Dis 2016;75:1051-6.[2]Berkun Y, et al. Diagnostic criteria of familial Mediterranean fever. Autoimmun Rev 2014;13:388-90.Acknowledgments:NoneDisclosure of Interests:None declared

scholarly journals Effects of Imidacloprid-Contaminated Feed Exposure on Hematological Parameters in Adult Rabbits (Oryctolagus Cuniculus)

2020 ◽  
Vol 7 (3) ◽  
pp. 439-444
Author(s):  
Md Alamgir Kobir ◽  
Latifa Akther ◽  
Imam Hasan ◽  
Md Ahosanul Haque Shahid ◽  
Ziaul Haque ◽  
...  
Keyword(s):  
Leukocyte Count ◽  
Hematological Parameters ◽  
Blood Parameters ◽  
The Body ◽  
Standard Diet ◽  
Cell Analysis ◽  
Differential Leukocyte Count ◽  
Once Daily ◽  
Important Index ◽  
Fresh Vegetables

Blood parameters are an important index to assess the body homeostasis in mammals. Here, the effect of pesticide (imidacloprid) contaminated feed exposure on the haematological parameters of adult rabbits (n=15) was studied. Pesticides (Imidacloprid, Bildor® 0.5ml (100mg)/L water spray on vegetables and green grass) exposed feed fed to rabbits with wash (washed feed rabbit) or without a wash (not washed feed rabbit) in the once-daily morning for every alternative day up to 15 days. Control rabbits have received a standard diet (fresh vegetables and green grass). The blood cell analysis showed that the total erythrocyte count, packed cell volume, and haemoglobin values were not changed significantly in pesticide exposed rabbit. For differential leukocyte count, the percentage of neutrophil and eosinophil was significantly decreased in the pesticide-exposed rabbit as compared to the control rabbit. The lymphocyte percentage was increased significantly in pesticide-exposed rabbits compared to control rabbits. Interestingly, the number of lymphocytes was significantly increased in not washed feed rabbits compared to wash feed rabbits. The results of the present study suggest that residue of agriculturally used pesticides may affect the body homeostasis of animals. Res. Agric., Livest. Fish.7(3): 439-444,  December 2020

scholarly journals Valores hematológicos do gavião carijó Buteo magnirostris (GMELIN, 1788) (AVE, FALCONIFORME)

2017 ◽  
Vol 2 (1) ◽  
pp. 43-54
Author(s):  
Antenor A. Santos ◽  
Adriana A. Joper ◽  
Mizue I. Egami
Keyword(s):  
Blood Cells ◽  
Leukocyte Count ◽  
Hematological Parameters ◽  
Total Count ◽  
Morphological Description ◽  
Differential Leukocyte Count ◽  
Blood Samples ◽  
Green Area ◽  
Blood Smears ◽  
Spherical Core

RESUMO: Os animais utilizados neste trabalho foram fornecidos pelo Departamento de Parque de Área Verde (SP). As amostras de sangue foram colhidas entre agosto de 1999 a novembro de 2001 e determinados os seguintes parâmetros hematológicos: contagem total de eritrócitos (Er), hematócrito (Ht), taxa de hemoglobina (Hb), contagem total e diferencial de leucócitos, índices hematimétricos absolutos VCM e CHCM. Foi realizada também a descrição morfológica das células sanguíneas em extensões sanguíneas após aplicação do método de Leishman. Os valores referentes à série eritrocítica apresentaram as seguintes médias: Er= 2,62 ± 0.48 x 106/µL; Ht=43,16 ± 11,19%; Hb= 14,59 ± 3,38g/dl; VCM=166,33 fL; CHCM= 33,84 ± 2,55g/dl e àqueles referentes a contagem de leucócitos apresentaram média: Lc= 3,95 ± 2,06 x 103/µL; Ht=45,33 ± 9,48%; Eo=17,66 ± 10,40%; B=7,3 ± 3,05%; L= 27,33 ± 11,53% e M= 2 ± 2,30%. Foram observados eritrócitos elípticos, com núcleo heterocromático alongado e citoplasma acidófilo; trombócitos elípticos com núcleo basófilo, cromatina condensada e citoplasma hialino; heterófilos esféricos, com núcleo lobulado e presença de grânulos acidófilos fusiformes; eosinófilos esféricos com núcleo lobulado apresentando grânulos eosinófilos esféricos; basófilos com núcleo volumoso e grânulos basófilos; linfócitos de aspecto irregular, com núcleo esférico e grânulos azurófilos; monócitos esféricos, com núcleo reniforme, cromatina frouxa, nucléolo visível e grânulos azurófilos finos.Palavras-chave: Gavião Carijó; Buteo magnirostris; Hematologia. ABSTRACT: The animals used in this study were provided by the Green Area Park Department (SP). Blood samples were collected from August 1999 to November 2001 and determined the following hematological parameters: total count of erythrocytes (Er), hematocrit (Ht), hemoglobin (Hb), total count and differential leukocyte count, erythrocyte indices absolute MCV and MCHC. It also performed the morphological description of the blood cells in blood smears after application of Leishman method. The figures for the erythrocyte series presented the following averages: Er = 2.62 ± 0:48 x 106 / µL; Ht = 43.16 ± 11.19%; Hb = 14.59 ± 3,38g / dl; VCM = 166.33 fL; MCHC = 33.84 ± 2.55g / dl and those related to leukocyte count showed average: Lc = 3.95 ± 2.06 x 103 / µL; Ht = 45.33 ± 9.48%; And = 17.66 ± 10.40%; B = 7.3 ± 3.05%; L = 27.33 ± 11.53% and M = 2 ± 2.30%. erythrocytes were observed elliptical, with elongated heterochromatic nucleus and cytoplasm acidophilus; thrombocytes Elliptical with basophil nucleus, condensed chromatin and hyaline cytoplasm; Spherical heterophile with lobed nucleus and presence of acidophilic spindle granules; eosinophil-lobed spherical core having eosinophils spherical granules; basophils with large nuclei and basophil granules; irregular aspect of lymphocytes, with spherical core and azurophilic granules; Spherical monocyte, a kidney-shaped core, loose chromatin and nucleoli visible fine azurophilic granules.Keywords: Sparrowhawk Carijó; Buteo magnirostris; Hematology.

scholarly journals Fingerprints: A simple method for Screening Hemophilic Patients

2015 ◽  
Vol 40 (2) ◽  
pp. 85-88
Author(s):  
M Jamalian ◽  
M Mesri ◽  
HRK Vishteh ◽  
H Solhi ◽  
R Salehpour
Keyword(s):  
Severe Disease ◽  
Healthy People ◽  
Control Group ◽  
Case Group ◽  
Factor Level ◽  
Simple Method ◽  
Mild Disease ◽  
Normal People ◽  
Significant Difference ◽  
New Occurrences

Background: The present study aims to compare hemophilic patients’ fingerprint types with the normal people to help diagnose the disease, particularly new occurrences of the disease. Method: This casecontrol study was conducted in 2012. Sixty two patients with hemophilia type A and 62 normal healthy people were selected. The type of fingerprint was determined by a forensic specialist who was kept unaware of the participants’ group. Using advanced Henry method, the main types of fingerprints were classified as arch, loop, whorl, as well as other types. Results: In the control group, loop type (65%) and in the case group the whorl type (34%) were the most frequent fingerprint type (p<0.001) and there was a significant difference of fingerprint in each finger between two groups. In addition, the average number of whorl type in the patients with mild disease was significantly higher and the average number of arch and other types of fingerprints was significantly lower than patients with moderate or severe disease. Conclusion: The findings of the present study indicated that not only are the fingerprints of normal and hemophilic people different, but also a difference was observed between hemophilic patients with the mild factor level and patients with moderate or severe one.Bangladesh Med Res Counc Bull 2014; 40 (2): 85-88

scholarly journals The Importance Of A Consultation Liaison Psychiatry Service In General Hospitals: A Brazilian 6-Years Experience

2021 ◽  
Author(s):  
Yoichi Takaki Konno ◽  
Fernanda Menezes de Faria ◽  
Gisele Zocoller Seno ◽  
Vinicius dos Santos Sguerri ◽  
Ana Carolina Gonçalves Olmos ◽  
...  
Keyword(s):  
Medical Records ◽  
Treatment Plan ◽  
Demographic Data ◽  
Liaison Psychiatry ◽  
Chi Square ◽  
General Hospitals ◽  
Significant Difference ◽  
Chi Square Test ◽  
Consultation Liaison Psychiatry ◽  
Level Of Significance

Abstract Background: The importance of consultation-liaison psychiatry (CLP) services have been progressively growing in all general hospitals.Methods: Data were collected from medical records of patients treated by the CLP service, from 2014 to 2020, including clinical-demographic data, characteristics of hospitalization, reason for request, treatment plan, and clinical outcome. For these analyses, the chi-square test, z-test, and Kruskal-Wallis test were used. The level of significance was set at 5%.Results: A total of 2,742 consultation requests were evaluated by the psychiatry team. The number of requests made grew by 109.64% over the years. In 58.21% of cases, the patient was in the ward, and 33% were requested by Internal Medicine. There was a statistically significant difference (p <0.001) in the distribution of reasons for request according to patients' characterization variables.Conclusions: This study sought to analyze the functioning and growth of CLP in a tertiary Brazilian general hospital. The present findings reinforce the importance of this service and the need to implement and develop CLP in general hospitals.

scholarly journals Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil

2020 ◽  
Vol 9 (11) ◽  
pp. e2559119873
Author(s):  
Ana Paula Biadola ◽  
André Aparecido dos Santos Correa ◽  
Amanda Aparecida Silva de Aguiar ◽  
Ualter Guilherme Cipriano Rosa ◽  
Paulo José Mascarenhas Mazaro ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Medical Records ◽  
Leukocyte Count ◽  
Hematological Parameters ◽  
Total Leukocyte Count ◽  
Clinical Prognosis ◽  
Tuberculosis Patients ◽  
Antituberculosis Treatment ◽  
Single Center Study ◽  
Using Data

Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis.

Optical coherence tomography analyses based segmentation and relative intensity evaluation of outer retinal layers in patients affected with X-linked juvenile retinoschisis

2021 ◽  
pp. 112067212199511
Author(s):  
Panayiotis D Christodoulou
Keyword(s):  
Optical Coherence Tomography ◽  
Relative Intensity ◽  
Severe Disease ◽  
High Dispersion ◽  
Optical Coherence ◽  
External Limiting Membrane ◽  
Ellipsoid Zone ◽  
Mild Disease ◽  
Juvenile Retinoschisis ◽  
Significant Difference

Purpose: We aim to provide a description of the optical coherence tomography findings in the outer macula hyperreflective bands of our patients with X-linked juvenile retinoschisis. Also to categorize these changes and to quantitatively and qualitatively correlate their reflectivity levels with visual function. Methods: We manually segmented the borders, and depicted relative intensity of the inner segment ellipsoid band, and quantified the volume of edema. Results: The average relative intensity of the ellipsoid zone, ISe band, for the control subject was 14.864, our patient’s, with the mild disease was, 28.238 and 34.943 in OD and OS, respectively, and for the patient with severe disease was, 44.442 and 40.154 for OD and OS respectively. Thresholding showed a significant difference in edema volume between mild disease (~20%), and severe form (~50%). Relative intensity analyses are indicative of homogeneity variability. High standard deviation value illustrates the high dispersion of data values and is a safe marker of ellipsoid zone homogeneity. Conclusion: Data suggested that both anatomic and functional characteristic of outer macula hyperreflective bands were notably associated with the pathogenesis cascade in the photoreceptor cells. External limiting membrane line disruption is initiated by the volume of macular edema and followed by disorganization of the three lines in a stepwise pattern, first at the ellipsoid zone, followed by the cone outer segment tips zone and finally at the External limiting membrane.

scholarly journals THE RELIABILITY OF CLINICAL PROBABILITY SCORE IN (WELLS SCORE) THE DIAGNOSIS OF PULMONARY EMBOLISM (PE) IN COVID-19 PATIENTS

2021 ◽  
Vol 9 (09) ◽  
pp. 345-349
Author(s):  
Saleh Alkhubaizi ◽  
◽  
Ahmad Al. ALalwi ◽  
Mamdoh Mahboob ◽  
Mohammed Al. Thubity ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Medical Records ◽  
Healthcare Professionals ◽  
Medical Center ◽  
Pulmonary Angiography ◽  
Clinical Probability ◽  
Study Results ◽  
Significant Difference ◽  
Wells Score ◽  
D Dimer

Background: The risk of developing pulmonary embolism (PE) is high in patients infected with COVID-19, and its diagnosis is a severe challenge for healthcare professionals duringthe COVID-19 pandemic. Physicians are frequently usingcomputed tomography pulmonary angiography(CTPA), d-dimer, and well score for the diagnosis of PE. Methods: A retrospective study was used in which we investigated the reliability of clinical well scores by collecting data, such as medical records in registered form (serum D-dimer level and Wells scores) of every patient for whom physicians have requested whose CTPA with suspicion of PE at King Faisal Medical Center (KFMC) from the period from 1st of April to the 1st of October. Results: The study results showed significantly higher values of d-dimer in patients with positive PEcompared to those with negative values. In addition wells score is not a reliable preclinical score in diagnosis PE in COVID 19 patient. Conclusions: As per the results of the well score, there is no significant difference between vulnerable people with PE +ve and -ve.

scholarly journals COVID-19 Disease Severity and Determinants among Ethiopian Patients: A study of the Millennium COVID-19 Care Center

2020 ◽  
Author(s):  
Tigist W. Leulseged ◽  
Kindalem G. Abebe ◽  
Ishmael S. Hassen ◽  
Endalkachew H. Maru ◽  
Wuletaw C. Zewde ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Disease Severity ◽  
Multinomial Logistic Regression ◽  
Care Center ◽  
Severe Disease ◽  
P Value ◽  
Age Group ◽  
Disease Category ◽  
Mild Disease ◽  
Significant Difference

ABSTRACTBackgroundUnderstanding determinants of developing severe COVID-19 disease is important as studies show that severe disease is associated with worse outcomes.ObjectiveThe study aimed to assess the determinants of COVID-19 disease severity among COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia.MethodsA cross-sectional study was conducted from June to August 2020 among randomly selected 686 patients. Chi-square test was used to detect the presence of a statistically significant difference in the characteristics of the patients based on disease severity (Mild Vs Moderate Vs Severe), where p-value of <0.05 was considered as having a statistically significant difference. A Multivariable multinomial logistic regression model was used to assess the presence of a significant association between the independent variables and COVID-19 disease severity where Adjusted Odds ratio (AOR), 95% CIs for AOR and P-values were used for testing significance and interpretation of results.ResultsHaving moderate as compared with mild disease was significantly associated with having hypertension (AOR= 2.302, 95% CI= 1.266, 4.184, p-value=0.006), diabetes mellitus (AOR=2.607, 95% CI= 1.307, 5.198, p-value=0.007 for diabetes mellitus), fever (AOR= 6.115, 95% CI= 2.941, 12.716, p-value=0.0001) and headache (AOR= 2.695, 95% CI= 1.392, 5.215, p-value=0.003). Similarly, having severe disease as compared with mild disease was associated with age group (AOR= 4.428, 95% CI= 2.497, 7.853, p-value=0.0001 for 40-59 years and AOR=18.070, 95% CI=9.292, 35.140, p-value=0.0001 for ≥ 60 years), sex (AOR=1.842, 95% CI=1.121, 3.027, p-value=0.016), hypertension (AOR= 1.966, 95% CI= 1.076, 3.593, p-value=0.028), diabetes mellitus (AOR= 3.926, 95% CI= 1.964, 7.847, p-value=0.0001), fever (AOR= 13.218, 95% CI= 6.109, 28.601, p-value=0.0001) and headache (AOR= 4.816, 95% CI= 2.324, 9.979, p-value=0.0001). In addition, determinants of severe disease as compared with moderate disease were found to be age group (AOR= 4.871, 95% CI= 2.854, 8.315, p-value=0.0001 for 40-59 years and AOR= 18.906, 95% CI= 9.838, 36.334, p-value=0.0001 for ≥ 60 years), fever (AOR= 2.161, 95% CI= 1.286, 3.634, p-value=0.004) and headache (AOR= 1.787, 95% CI= 1.028, 3.107, p-value=0.039).ConclusionsBeing old, male sex, hypertension, diabetes mellitus, and having symptoms of fever and headache were found to be determinants of developing a more severe COVID-19 disease category. We recommend a better preventive practice to be set in place so that these groups of patients can be protected from acquiring the disease. And for those who are already infected, a more careful follow-up and management should be given so that complication and death can be prevented. Furthermore, considering the above non respiratory symptoms as disease severity indicator could be important.

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