scholarly journals Antitrypanosoma effect of methanol fruit pod extract of Acacia nilotica (Linn) in acute Trypanosoma brucei infection in wistar rats

2020 ◽  
Vol 44 (5) ◽  
pp. 29-33
Author(s):  
I. D. Jatau ◽  
V. V. Tsok-Nwok
Keyword(s):  
Trypanosoma Brucei ◽  
Post Infection ◽  
Wistar Rats ◽  
Methanol Extract ◽  
Acacia Nilotica ◽  
Diminazene Aceturate ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Chemotherapy of trypanosomosis has been adversely affected by widespread drug resistance and toxicity. Attention has now been shifted towards the search for ethnobothanical means of controlling the disease. The aimof this study was to determine the effect of methanol extract of the fruit pod of Acacia nilotica on experimental Trypanosoma brucei infection inWistar rats. TwentyWistar rats were randomly alloted into four groups of 5 rats each. Rats in groups I to III were experimentally infected with an isolate of T. brucei while group V served as uninfected control. At day 2 post infection (PI), rats in groups I were orally treated with extract of fruit pod of A nilotica at a dose of 500 mg/kg for 5 days while rats in group II were treated with diminazene aceturate at 3.5mg/kg subcutaneously once. Rats in group III served as infected untreated control. Parasitaemia, PCV and survival rates were monitored during the course of the study. Parasitaemia begins 3 days PI and progressively increased in groups I and III but was not observed in group II. There was decrease in PCV of rats in groups I and III compared to that of groups II and IV. The differences observed in parasitaemia and PCV between the groups compared were not statistically significant (P>0.05).Mortalitywas observed in group I from day 8PIwith 2 rats (40%) surviving up to day 10 PI. All rats in group III died within 7 days post infection while mortalities were not recorded in groups II and IV. It was concluded that the methanol extract of the fruit pod of A. nilotica had no In vivo trypanocidal effect at the dose of 500mg/kg, but demonstrated some ameliorative effect on the severity of the infection in Wistar rats.

scholarly journals GAMBARAN MIKROSKOPIK GINJAL TIKUS WISTAR (RATTUS NORVEGICUS) SETELAH DIINDUKSI DENGAN GENTAMISIN

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Poppy M Lintong ◽  
Carla F Kairupan ◽  
Priska L N Sondakh
Keyword(s):  
Body Weight ◽  
Epithelial Cells ◽  
Wistar Rats ◽  
Periodic Acid ◽  
Basal Membrane ◽  
Tubular Epithelial Cells ◽  
Periodic Acid Schiff ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Abstract: Gentamycin, a frequently used aminoglycoside antibiotics, has a nephrotoxic effect to human beings and animals. The purpose of this research was to find out the microscopic changes of wistar rat kidneys after gentamycin induction. This was an experimental study, using five adult wistar rats, divided into three groups. Group I was the control group; group II consisted of two rats, injected with gentamycin 0,3 ml/day (dose of 60 mg/kg body weight/day) intraperitoneally for seven days; and group III consisted of two rats, injected with gentamycin 0,3 ml/day intraperitoneally for 10 days. Group I and II were terminated at day-8, and group III at day-11. Their kidneys were processed for microscopic slides, stained with hematoxylin eosin and Periodic Acid Schiff. In microscopic evaluation, group II and III showed oedema, necrosis, apoptosis, and basal membrane destruction of tubular epithelial cells. Group III also showed fat vacuoles in these epithelial cells (macrovesicular fatty changes). Conclusion: wistar rats injected with gentamycin 60 mg/kg body weight/day for 7 and 10 days showed oedema, necrosis, apoptosis, and basal membrane destruction of tubular epithelial cells; and macrovesicular fatty changes after 10 days of gentamycin.Key words: gentamycin, necrosis tubular epithelial cells, fatty changesAbstrak: Gentamisin termasuk antibiotik golongan aminoglikosida berspektrum luas yang bersifat nefrotoksik terhadap manusia dan hewan. Tujuan penelitian ini untuk melihat perubahan mikroskopik struktur ginjal tikus Wistar setelah diberikan gentamisin. Metode penelitian eksperimental dengan menggunakan lima ekor tikus Wistar dewasa yang dibagi atas tiga kelompok. Kelompok I tanpa perlakuan; kelompok II terdiri dari dua ekor tikus perlakuan yang diinjeksi dengan gentamisin 0,3 ml/hari (dosis 60 mg/kgBB/hari) secara intraperitonial selama tujuh hari; dan kelompok III terdiri dari dua ekor tikus perlakuan yang diinjeksi dengan gentamisin 0,3 ml/hari secara intraperitonial selama 10 hari. Tikus Wistar kelompok I dan II diteminasi hari ke-8, sedangkan kelompok III diterminasi hari ke-11. Ginjal tikus kelompok I -III kemudian dibuat preparat histopatologik dengan pengecatan rutin hematoksilin eosin dan Periodic Acid Schiff (PAS). Hasil penelitian menunjukkan tikus Wistar perlakuan yang diberikan gentamisin 0,3 ml/hari selama 7 sampai 10 hari secara mikroskopik memperlihatkan pembengkakan, nekrosis, apoptosis, dan destruksi membrana basalis sel epitel tubulus; dan pada hari ke-10 terlihat vakuol-vakuol lemak pada sel epitel sehingga inti terdesak ke tepi (perlemakan makrovesikuler). Simpulan: pemberian gentamisin pada tikus Wistar dengan dosis 60 mg/kg BB/hari selama 7-10 hari menunjukkan pembengkakan, nekrosis, apoptosis sel epitel tubulus, dan membrana basalis tubulus rusak; dan setelah hari ke-10 juga terlihat perlemakan makrovesikuler.Kata kunci: gentamisin, nekrosis sel epitel tubulus, perlemakan makrovesikuler

scholarly journals Determination of Maxillary Incisal Edge Position using Canine Visibility as a Guide – An In vivo Study

2021 ◽  
pp. 165-171
Author(s):  
Ankita Piplani ◽  
G. Ganadhipathi ◽  
M. C. Suresh Sajjan
Keyword(s):  
Age Groups ◽  
Adhesive Tape ◽  
Central Incisor ◽  
Upper Lip ◽  
Maxillary Central Incisor ◽  
Group Iii ◽  
Incisal Edge ◽  
Group I ◽  
Group Ii

Purpose:  To evaluate the reliability of the visibility of the central incisor & the canine for the cervico incisal positioning of anterior maxillary teeth related to age & sex while the upper lip was in repose in dentate patients & the development of rehabilitation recommendations for edentulous individuals with regard to the location of the maxillary incisal edge Methodology: 308 subjects [152 Males & 156 Females] belonging to the age of 30 to 59 years were selected using a simple stratified random technique. There were three age and sex groups: Group I was 30 to 39 years old, Group II was 40 to 49 years old, and Group III was 50 to 59 years old. The vertical distances (in mm) between the lower border of the upper lip and the right maxillary central incisal edge and canine tip were measured and recorded using adhesive tape marked with millimetres. A single examiner recorded all the measurements and the values were tabulated and subjected to statistical analysis. Results: Men in Groups I and II had maxillary central incisor exposure ranging from +6 to -1mm, whereas males in Group III had exposure ranging from +5 to -2mm. There was an exposure range of +6 to -2 mm in females in Group I, +7 to -2 mm in Group II, and +5 to -2 mm in Group III for the central incisors. While the canine exposure in Group I and II and Group III ranged from +2 to -4mm in females, the exposure ranged from +3 to -3mm in men of all ages. In all groups, females had statistically significant (P0.05) more central incisor and canine exposure than men. Conclusions: The canine visibility was less variable in all the age groups and in both males and females in comparison to the central incisor. When restoring edentulous individuals, the average canine exposure dimension can be employed for cervico-incisal location of the anterior maxillary teeth.

scholarly journals Biochemical Effects of Matured Stem Extract of Opuntia Dillenii in Male Wistar Rats

2018 ◽  
Vol 11 (1) ◽  
pp. 49-58
Author(s):  
Uche C. Njoku ◽  
Benjamin A. Amadi ◽  
Peter U. Amadi ◽  
Onyebuchi E. Ezendiokwere ◽  
Idongesit E. Archibong
Keyword(s):  
Wistar Rats ◽  
Density Lipoprotein ◽  
Control Group ◽  
Group Iii ◽  
Therapeutic Benefits ◽  
Group I ◽  
Male Wistar Rats ◽  
Stem Extract ◽  
Group Ii ◽  
Opuntia Dillenii

Summary The effect of aqueous matured stem extract of Opuntia dillenii on selected biochemical parameters in Male Wistar rats was explored. Standard analytical methods were applied. Forty Wistar rats (80-100g) were used in the animal studies, separated into four groups. The control group was solely administered normal feed and saline, group I was administered 100mgkg−1 of the extract, group II received 300mgkg−1 of the extract and group III received 500 mg/kg−1 of the extract. A significant increase (p<0.05) in the activities of alanine aminotransferase (ALT) and alkaline phosphatase was observed in group II and III rats, as compared with the controls. A significant decrease in urea and creatinine concentrations was found only in group III rats against the controls. Also, a significant (p<0.05) decrease in triglyceride, total cholesterol, and low density lipoprotein (LDL)-cholesterol was seen in group II and group III rats when compared with the control. The hematological evaluation revealed a significant (p<0.05) decrease in red blood cell and hemoglobin levels in group III rats when compared with the control. The findings showed both beneficial and toxicological effects of the plant. Hence, for optimal therapeutic benefits, a further toxicological survey could still be carried out perhaps at higher doses.

scholarly journals GAMBARAN HISTOPATOLOGI HATI TIKUS WISTAR YANG DIBERIKAN JUS TOMAT (Solanum Lycopersicum) PASCA KERUSAKAN HATI WISTAR YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4)

2013 ◽  
Vol 1 (3) ◽  
Author(s):  
Eka Sari Tappi ◽  
Poppy Lintong ◽  
Lily Loho
Keyword(s):  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Liver Cells ◽  
The Body ◽  
Tomato Juice ◽  
Control Group ◽  
Histopathological Changes ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Abstract: Liver is the largest organ in the abdominal cavity. As the center of metabolism in the body, liver is potentially damaged by exposure of toxic substances, inter alia carbon tetrachloride (CCl4). Metabolism of carbon tetrachloride (CCl4) produces CCl3 free radicals that can damage the liver. In Indonesia, there are a lot of natural ingredients that have antioxidant properties, such as tomato. Lycopene in tomatoes contains antioxidant compounds that can prevent damages due to free radical. This study aimed to obtain liver histopathological changes of wistar rats fed with tomato juice after being induced of carbon tetrachloride (CCl4). This was an experimental study, using 10 wistar rats which were divided into 4 groups. Group I was the negative control; group II was induced with CCl4 0,05 cc/day and was terminated on day 6; group III was induced with CCl4 0,05 cc/day and was given tomato juice 3 ml/day, and terminated on day 13; group IV was induced by CCl4 0,05 cc/day, given regular pellets, and terminated on day 13. The results showed that group II had histopathological changes of the liver indicating fatty liver, meanwhile group III showed regeneration of nearly all liver cells. Conclusion: Administration of tomato juice after the induction of 3 ml carbon tetrachloride (CCl4) for 7 day showed regeneration of almost all liver cells. Keywords: histopathological changes of the liver, carbon tetrachloride, tomato juice.   Abstrak: Hati merupakan organ terbesar dalam rongga abdomen, dan pusat metabolisme tubuh dengan fungsi yang sangat kompleks dan sangat berpotensi mengalami kerusakan akibat terpapar oleh bahan-bahan toksik, salah satunya yaitu karbon tertraklorida (CCL4). Metabolisme CCl4 menghasilkan radikal bebas CCl3 yang dapat merusak hati. Di Indonesia terdapat  banyak sekali bahan-bahan alami yang mempunyai kandungan antioksidan, salah satunya yaitu tomat. Tomat mengandung senyawa likopen sebagai antioksidan yang dapat mencegah kerusakan jaringan akibat radikal bebas. Penelitian ini bertujuan untuk mendapatkan gambaran histopatologi hati tikus wistar yang diberi jus tomat pasca induksi karbon tetraklorida (CCl4). Metode penelitian ialah eksperimental. Sampel sebanyak 10 ekor tikus wistar yang dibagi dalam 4 kelompok. Kelompok I sebagai kontrol negatif; kelompok II diinduksi CCl4 0,05cc/perhari dan diterminasi hari ke-6; kelompok III diinduksi CCl4 0,05 cc/hari kemudian diberikan jus tomat 3ml/hari;  dan kelompok IV diinduksi CCl4 0,05 cc/hari kemudian diberikan pelet biasa dan diterminasi hari ke-13. Hasil penelitian menunjukkan pada pemberian CCl4 pada tikus wistar selama 5 hari terdapat gambaran morfologik perlemakan sel hati. Pemberian jus tomat dosis 3 ml pasca induksi karbon tetraklorida (CCl4) menunjukkan terjadinya regenerasi pada hampir seluruh sel-sel hati. Simpulan: Pemberian jus tomat dosis 3 ml pasca induksi karbon tetraklorida (CCl4) selama 7 hari menunjukkan regenerasi pada hampir seluruh sel-sel hati. Kata kunci: gambaran histopatologi hati, karbon tetraklorida, jus tomat.

scholarly journals The Hepatoprotector Effect of Uncaria gambir Roxb Extract in Wistar Rats Induced by Paracetamol

2020 ◽  
Vol 10 (6-s) ◽  
pp. 61-66
Author(s):  
, Suparni ◽  
, Musthari ◽  
Liza Mutia ◽  
Mangoloi Sinurat ◽  
Siti Syarifah ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Chronic Administration ◽  
Liver Cells ◽  
Group Iv ◽  
Drug Induced ◽  
Significant Differentiation ◽  
Group Iii ◽  
Hepatoprotector Activity ◽  
Group I ◽  
Group Ii

Background: Drug induced liver injury (DILI) is known as the damage of liver cells due to chronic administrations of drug. The chronic administration of paracetamol could be trigger the damage of liver cells.The hepatoprotector agents are still limited worldwide.  Gambier(Uncaria gambir Roxb) is an Indonesia’traditional medicine which have many benefits as antioxidant, antiseptic, antidiarrhoea, etc  that commonly used in society.  Method: The present study was conducted to investigate the hepatoprotector effect ofgambier in wistar rats induced by paracetamol.  The wistar rats were divided into seven groups and received the treatment orally for 12 days. Group I (aquadest), II(curcuma,400 mg/kgBW),III (gambier,26 mg/200gr), IV(gambier, 53 mg/200gr), V(gambier,106 mg/200gr),VI(gambier,212 mg/200gr) and VII(gambier,424mg/200gr). Termination, blood and liver organ collection were done after all group induced by paracetamol for two days. Histopatology changes of liver were examined using Hematoxycilline (HE) staining. AST and ALT levels were analyzed. Results: There were significant differentiation of AST levels among the groups, especially between group I and group IV and between group II and group IV. The ALT levels were statistically significant between group II and group V using Mann-Whitney test (p<0,05). In histopatology examination, there were significant differentiation between group I with another group, not only group II but also group III-VII (p<0,05). In the treatment group, group III and IV had been showed the improvement of liver cells damage than group I by using One-way Annova, post hoc Bonferroni (p<0,05). Conclusion: Uncaria gambir Roxb has hepatoprotector activity start at dose 53 mg/200grBWin rats.  The hepatoprotector activity was not superior than curcuma.  Keywords: hepatoprotector, Uncaria gambir Roxb, AST,ALT,histopatology

scholarly journals In vitro and in vivo anti-trypanosomal potentials of Afrormosia laxiflora and Khaya senegalensis against Trypanosoma brucei brucei

2018 ◽  
Vol 39 (3) ◽  
pp. 269-284
Author(s):  
G.D. Chechet ◽  
J Yahaya ◽  
A.J. Nok
Keyword(s):  
Body Weight ◽  
Trypanosoma Brucei ◽  
Post Infection ◽  
Methanol Extract ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Trypanosoma Brucei Brucei ◽  
Khaya Senegalensis

Animal African trypanosomiasis (AAT) also known as Nagana is a resurgent disease in Africa. Medicinal plants are being used in less developed countries for the treatment of various diseases including trypanosomiasis, due to the high cost of currently available drugs. Most of these plants have been useful sources of treatment of various diseases based on information obtained from folk medicine but have not been scientifically certified. Here, we investigated the in vitro and in vivo anti-trypanosomal potentials of the methanol extract of Aformorsia laxiflora and Khaya senegalensis against T. b. brucei. Phytochemical screening as well as LD50 of the plant extracts was carried out following standard procedures. Parasitemia was monitored daily while Packed Cell Volume was determined at three time points (days 1, 4 and 7) during the course of the infection. The phytochemical analysis showed the presence of saponins, alkaloids, flavonoids, antraquinones, resins and tanins. However, steriods/terpenoids were absent in K. senegalensis but present in A. laxiflora. The toxicity of methanol extract of both A. laxiflora and K. senegalensis was above 5000mg/kg body weight. Methanol extracts of A. laxiflora (leaves) and K. senegalensis (stem bark) showed promising trypanocidal potential in vitro against T. b. brucei at concentrations of 10, 15, 25mg/ml and 40 and 20mg/ml respectively. At these concentrations, both extracts immobilized the parasites within 55mins post-incubation. In general, A. laxiflora leaf extract demonstrated prophylactic activity against T. b. brucei in vivo at a dose of 500mg/Kg body weight particularly in group C animals where a delayed pre-patent period (6 days post-infection), extended survival (14 days post-infection) and significant (P<0.05) reduction in the parasite burden confirmed by an absence of anemia (PCV 47.00±0.8 %) was observed when compared to the infected untreated control group. K. senegalensis extract on the other hand did not show anti-trypanosomal activity in the treated groups (1, 2, and 3). Based on these observations, it was therefore deduced that the methanol extract of leaves of A. laxiflora possessed the ability to ameliorate the burden of the disease and could be a plausible candidate for drug development against the disease.Keywords: Trypanosoma brucei brucei, Afromosia laxiflora, Khaya senegalensis, anti-trypanosomal, in vitro, in vivo

scholarly journals Methyl Gallate Attenuates Doxorubicin-Induced Cardiotoxicity in Rats by Suppressing Oxidative Stress

Scientifica ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Akheruz Zaman Ahmed ◽  
Shakta Mani Satyam ◽  
Prakashchandra Shetty ◽  
Melanie Rose D’Souza
Keyword(s):  
Oxidative Stress ◽  
Normal Control ◽  
Wistar Rats ◽  
Group Iv ◽  
Control Group ◽  
Methyl Gallate ◽  
Group Iii ◽  
Group I ◽  
Female Wistar Rats ◽  
Group Ii

Doxorubicin-induced cardiotoxicity is the leading cause of morbidity and mortality among cancer survivors. The present study was aimed to investigate the cardioprotective potential of methyl gallate; an active polyphenolic nutraceutical, against doxorubicin-induced cardiotoxicity in Wistar rats. Twenty-four female Wistar rats (150–200 g) were divided into four groups (n = 6) which consist of normal control (group I), doxorubicin control (group II), test-A (group III), and test-B (group IV). Group III and group IV animals were prophylactically treated with methyl gallate 150 mg/kg/day and 300 mg/kg/day orally, respectively, for seven days. Doxorubicin (25 mg/kg; single dose) was administered through an intraperitoneal route to group II, III, and IV animals on the seventh day to induce acute cardiotoxicity. On the 8th day, besides ECG analysis, serum CK, CK-MB, LDH, AST, MDA, and GSH were assayed. Following gross examination of isolated hearts, histopathological evaluation was performed by light microscopy. A significant ( p  < 0.05) cardiac injury, as well as oxidative stress, was observed in doxorubicin control rats in comparison to normal control rats. Methyl gallate at both the doses significantly ( p  < 0.05) reduced doxorubicin-induced ECG changes, dyslipidaemia, and elevation of CK, CK-MB, LDH, AST, MDA and increased GSH level. Methyl gallate reversed the doxorubicin-induced histopathological changes in the heart. The present study revealed that methyl gallate exerts cardioprotection against doxorubicin-induced cardiotoxicity in female Wistar rats by suppressing oxidative stress. Our study opens the perspective to clinical studies for consideration of methyl gallate as a potential chemoprotectant nutraceutical in the combination chemotherapy with doxorubicin to limit its cardiotoxicity.

scholarly journals PRENATAL AND POSTNATAL EFFECT OF LEAD ACETATE ON THE HISTOLOGY OF FRONTAL CORTEX AND MOTOR ACTIVITY IN WISTAR RATS

2021 ◽  
pp. 10-12
Author(s):  
SALEH NUHU ◽  
HAUWA IDRIS AHMAD ◽  
AISHA MUHAMMAD GARBA ◽  
TASIU ABDULLAHI SULAIMAN
Keyword(s):  
Drinking Water ◽  
Motor Activity ◽  
Frontal Cortex ◽  
Wistar Rats ◽  
Histological Study ◽  
Group Iv ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Objectives: The objective of this study was to find the histologic and motor activity effect of lead on prenatally and postnatally exposed Wistar rats. Methods: In this study, twelve Wistar Rats were used and grouped into four groups of two females and one male. Group I rats served as the control and allowed feed and water freely. The rats in Group II were administered 500ppm of Pb through drinking water from gestation day 8 (GD8) to parturition (GD21). While Group III rats were given 500ppm of Pb in drinking water from postnatal day 1 (PND1) to PND21. The rats in the fourth group (Group IV) were given 500ppm of Pb from GD8 to PND21. Palmer grasp reflex was conducted to assess the motor activity of the rat pups. The animals were then humanely sacrificed and the frontal cortices were isolated for routine histological processing. Results: The histological study has shown normal neurons in the control group while degenerating cells exhibiting karyolysis, pyknosis, karyorrhexis, vacuolation were seen in the lead-treated groups. Group II and Group IV showed considerate deficit in their motor activity while Group III showed mild effect. Conclusion: From this study, lead exposure of Wistar rats at both prenatal and postnatal period of development has effect on the histology of the frontal cortex as well as on their motor activity.

scholarly journals TOXICOLOGICAL EFFECT OF INHALED MOSQUITO INCENSE STICKS SMOKE ON THE HISTOLOGY AND BIOCHEMICAL RESPONSES IN EXPERIMENTAL RATS

2020 ◽  
Vol 4 (2) ◽  
pp. 260-268 ◽  
Author(s):  
Shafiu Nafiu Abdullahi ◽  
M. M. Dahiru ◽  
D. H. Rabiu ◽  
J. M. Mohammed
Keyword(s):  
Wistar Rats ◽  
Negative Control ◽  
Continuous Exposure ◽  
Toxicological Effect ◽  
Group Iii ◽  
Toxicological Effects ◽  
Group I ◽  
Laboratory Investigations ◽  
Group Ii ◽  
Epithelial Wall

This study was carried out to investigate the toxicological effects of four brands of mosquito incense stick smoke (DR insecticide stick (AS-1987), Incense upgraded formula (BM-102), Fragrance (B3-254) and Citronella (A7-435) on selected biochemical and histological profile of male albino wistar rats.  Fifteen (15) wistar rats with mean weight (174.6 ±0.91g) were randomly divided into five (5) groups. Group I were considered as negative control while group II, III, IV and V were challenged with the brands of mosquito incense stick smoke for 8 hours daily by inhalation for 21 days. Laboratory investigations were carried out using standard protocols. It was observed that the activities of the liver enzymes (Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and Alkaline Phosphatase (ALP) increased significantly (p<0.05) in all the experimental rats when compared with the control. The histopathological alterations examined in the liver tissues of the experimental rats during the study period include mild necrosis, mild degeneration of hepatocytes and cellular infiltration from group III, IV and V respectively. Lung tissues of the challenged rats of group II, III and V revealed mild cellular infilterations around alveolar septa, hyperplasia and bronchiolar epithelial wall degeneration   respectively. Kidney tissues revealed glomeruli distortion, mild haemorrhage and renal damage from group III and IV respectively. The alterations examined in the liver, kidney and lung tissues of the experiment rats were period dependent but independent of mosquito sticks brands which inferred that continuous exposure to mosquito stick 

scholarly journals Comparison of health supplement on strength, stamina and growth of rats

2019 ◽  
Vol 8 (4) ◽  
pp. 806
Author(s):  
Swanand S. Pathak ◽  
Nikhil S. Yadav
Keyword(s):  
Wistar Rats ◽  
Tail Length ◽  
Maximum Growth ◽  
Group Iv ◽  
Control Group ◽  
Natural Health ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Health Supplements

Background: Children require more nutrition as organs grow fast in this age group. Due to abundance of various commercial health supplements in market, parents are often confused about selection of health supplements. Traditional foods are rich source of various nutrients required by growing children. We conducted a study to compare strength, stamina and growth enhancing ability of commercial health supplement and natural health supplement on wistar rats.Methods: Total of 24 wistar rats were included. Animals were divided in four groups. Each group of rats except control group were receiving health supplements. Group I, group II, group III and group IV were receiving health supplement I, health supplement II, natural health supplement and no health supplement (control group) for 60 days. Strength and stamina of wistar rats in each group were analysed using grip strength meter and swim stress test, growth of rats in each group were analysed by measuring body length, tail length and body weight. Group of rat showing maximum growth (body length, tail length and body weight), strength and stamina were analysed.Results: Group II rats showed greater strength and stamina followed by group I, group III and group IV respectively. Group I rats showed maximum growth followed by group II, group III and group IV respectively.Conclusions: In the current study we found that strength and stamina were greater in group II rats followed by group I, group III and group IV respectively also group I rats showed maximum growth  followed by group II, group III and group IV respectively.

Sign in / Sign up

Export Citation Format

Share Document