Management of a patient with viral conjunctivitis on an outpatient basis: a case of acute viral conjunctivitis in a patient with hay fever

2021 ◽  
Author(s):  
А.В. Захарова
Keyword(s):  
High Efficiency ◽  
Age Groups ◽  
Anterior Segment ◽  
Clinical Manifestations ◽  
Local Therapy ◽  
Eye Diseases ◽  
Outpatient Basis ◽  
Differential Analysis ◽  
Bacterial Conjunctivitis ◽  
Wide Range

На долю конъюнктивита приходится 33% всех случаев заболеваний глаз. Конъюнктивит, или воспаление конъюнктивы, относится к ее наиболее частым заболеваниям. Независимо от этиологии клинические проявления примерно одинаковые. На прием в поликлинику приходят пациенты с жалобами на светобоязнь, ощущение инородного тела, покраснение склер, зуд, боль, слезотечение, отек век. Первой целью офтальмолога является дифференциация между вирусным и бактериальным конъюнктивитом. Вторым этапом необходимо провести детальный дифференциальный анализ между нозологиями. Для решения этих задач врачу необходимо провести детальный сбор жалоб и анамнеза, а также биомикроскопию переднего отрезка глаза. Вирусные заболевания глаз представляют собой серьезную медико-социальную проблему. Вирусы – одна из наиболее частых причин инфекционного поражения наружных структур глаза с широким спектром возможных проявлений – от легкого преходящего конъюнктивита до более серьезных состояний, при которых поражение конъюнктивы и роговицы может приводить к рубцеванию, что в некоторых случаях ведет к слепоте. Такие возбудители, как аденовирус, пикорнавирус, вирусы простого герпеса и герпеса зостер, могут вызывать изолированный конъюнктивит, однако нередко они поражают также роговицу и веки. В последние годы отмечается рост распространенности аденовирусных конъюнктивитов. Заболевание отличается высокой частотой встречаемости и поражает все возрастные группы. Рост заболеваемости приходится на осенне-весенний период, когда вирусная контагиозность повышена. В клинической практике для местной терапии таких заболеваний, как вирусные (аденовирусные и герпетические) конъюнктивиты, кератиты, кератоконъюнктивиты, увеиты, с высокой эффективностью используются препараты интерферона. Conjunctivitis accounts for 33% of all eye diseases. Conjunctivitis, or inflammation of the conjunctiva, is one of its most common diseases. Regardless of the etiology, the clinical manifestations are approximately the same. Patients come to the clinics with complaints of photophobia, a feeling of a foreign body, red eye, itching, pain, lacrimation, hyperemia and swelling of the eyelids. The first goal of an ophthalmologist is to differentiate between viral and bacterial conjunctivitis. The second stage is to conduct a detailed differential analysis between nosologies. To solve these problems, the doctor needs to conduct a detailed collection of complaints and anamnesis, conducting a detailed biomicroscopy of the anterior segment of the eye. Viral eye diseases are a serious medical and social problem. Viruses are one of the most common causes of infection of the outer structures of the eye with a wide range of possible manifestations - from mild transient conjunctivitis to more serious conditions in which damage to the conjunctiva and cornea can lead to scarring, which in some cases leads to blindness. Pathogens such as adenovirus, picornavirus, herpes simplex virus and herpes zoster can cause isolated conjunctivitis, but they often also affect the cornea and eyelids. In recent years, there has been an increase in the prevalence of adenoviral conjunctivitis. The disease has a high frequency of occurrence and affects all age groups The increase in morbidity occurs in the autumn-spring period, when viral contagiousness is increased. In clinical practice, for local therapy of diseases such as viral (adenoviral and herpetic) conjunctivitis, keratitis, keratoconjunctivitis, uveitis, interferon preparations are used with high efficiency.

Local antibiotic therapy of bacterial infectious and inflammatory diseases of the anterior segment of the eye (literature review)

2021 ◽  
pp. 89-93
Author(s):  
A.E. Babushkin ◽  
Keyword(s):  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
High Efficiency ◽  
Inflammatory Diseases ◽  
Anterior Segment ◽  
Eye Diseases ◽  
Good Tolerability ◽  
Wide Range ◽  
Local Antibiotic ◽  
Topical Antimicrobial

Inflammatory eye diseases are one of the most important problems of ophthalmology. They can be caused by various pathogens of the infection, which is still more often bacterial. Therapy of bacterial inflammatory diseases of the eye involves the use of antibacterial drugs (sulfonamides, antiseptics, nitrofurans, etc.), among which antibiotics are of primary importance. Of this group of drugs, in this review article, special attention is paid to quinolones, mainly synthetic fluoroquinolones, which are distinguished by a wide range of bactericidal action, fairly high efficiency, low level of resistance of microorganisms to it and the frequency of side effects, as well as good tolerability by patients, i.e. they best meet the requirements for modern topical antimicrobial agents. In certain clinical situations and indications, it is advisable to use ophthalmic antiseptics and combined preparations containing several antibiotics of different effects at once, or an antibiotic and a corticosteroid. Key words: infectious and inflammatory eye diseases, antibacterial agents, antibiotics, combined preparations, antiseptics.

scholarly journals Martorell’s ulcer: a literature review and own clinical observation

2021 ◽  
Vol 18 (1) ◽  
pp. 55-70
Author(s):  
B. V. Boldin ◽  
P. Yu. Golosnitskiy ◽  
V. Yu. Bogachev ◽  
S. V. Rodionov ◽  
I. M. Dizengof
Keyword(s):  
Clinical Observation ◽  
Treatment Options ◽  
Local Treatment ◽  
Local Therapy ◽  
Pain Syndrome ◽  
Definitive Treatment ◽  
Outpatient Basis ◽  
Narcotic Analgesics ◽  
Wide Range ◽  
The Right

Introduction. Martorell’s ulcer is a rather rare pathology that occurs exclusively in patients with long-term and poorly controlled arterial hypertension and continues to be one of the poorly studied areas of modern surgery. There are few reports on the occurrence of this pathology in the medical literature and, as a rule, describe extremely rare clinical cases. The issues of etiology, pathogenesis and differential diagnosis of this disease continue to cause debate. The article provides a review of the literature on this rare surgical pathology, presents its own clinical observation, discusses the issues of diagnosis and treatment options for this disease.Clinical case. A 56-year-old patient was admitted with complaints of a non-healing trophic ulcer on the lateral surface in the lower third of the right leg since one year ago with severe pain syndrome not adequately controlled with non-narcotic analgesics. he received treatment in an outpatient department and in the hospital, underwent courses of rheological therapy to the ulcer region as a local therapy, used a wide range of dressings of domestic and foreign origin. No positive effect was reported on the top of already administered combination therapy, the ulcer continued to increase in size. A Martorell’s ulcer was diagnosed, and a decision was made to provide a course of presurgical conservative rheological therapy with PGE1 (VAP 20 mg), antibiotic therapy, and local therapy aimed at maximal ulcer necrotic tissue clearance before the forthcoming planned surgical treatment. The patient underwent the surgery – autodermatoplasty of the trophic ulcer of the right leg with a mesh graft, continued local treatment of the ulcer using dressings with peruvian balsam and other medications on an outpatient basis without chemical and biological components from the antiseptics and healing stimulants group. Two months after the surgery, the patient had no complaints, the pain syndrome in the ulcer region completely regressed, no edema occurred in the lower operated leg, the right let ulcer completely healed with the formation of a permanent scar.Conclusion. Surgical management is the final and definitive treatment for Martorell’s chronic hypertensive ulcer and should be carried out promptly to minimize the spread of the ulcer and minimize a pain syndrome.

scholarly journals MANAGEMENT OF YOUNG PATIENTS WITH MARFAN SYNDROME

2019 ◽  
Vol 22 (6) ◽  
pp. 395-400
Author(s):  
Ekaterina B. Luneva ◽  
E. G. Malev
Keyword(s):  
Marfan Syndrome ◽  
Beta Blockers ◽  
Angiotensin Receptor Blockers ◽  
Relevant Literature ◽  
Age Groups ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Wide Range ◽  
Receptor Blockers ◽  
Musculoskeletal Systems

Marfan syndrome is a hereditary, autosomal disease with a relatively high prevalence in the general population. Numerous manifestations of Marfan syndrome are expressed in a wide range of disorders involving cardiovascular, ocular and musculoskeletal systems. The article describes the principles of management of the syndrome in children and adolescents. Clinical manifestations of the disease are evaluated in young patients of different age groups. There are presented data on the main medicines used in the therapy of Marfan syndrome, such as beta-blockers, angiotensin receptor blockers, statins. Relevant literature was searched using the databases PubMed, MedLine, Scopus, Web of Science. The article will be interesting to a wide range of specialists: pediatricians, cardiologists, general practitioners and other specialties

Modern understanding of bacterial vaginosis

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (1) ◽  
pp. 37-42
Author(s):  
Aleksey A. Khryanin ◽  
German Yu. Knorring
Keyword(s):  
Bacterial Vaginosis ◽  
High Efficiency ◽  
Sexual Transmission ◽  
Clinical Manifestations ◽  
Local Therapy ◽  
Bacterial Biofilm ◽  
Gardnerella Vaginalis ◽  
Laboratory Diagnostics ◽  
Combination Drug ◽  
Main Component

Bacterial vaginosis is an infectious non-inflammatory syndrome characterized by the replacement of the usual microflora by the polymicrobial associations of anaerobes and Gardnerella vaginalis. The review is devoted to current issues of this disease, including pathogenesis, clinical manifestations and approaches to laboratory diagnostics. Discussion issues of this disease related to the possibility of sexual transmission are discussed. Particular attention is paid to the factors causing the development of bacterial vaginosis. The classical concepts of diagnostic criteria for diagnosis are presented. Bacterial vaginosis is not characterized by the presence of a specific microorganism, but is the result of the formation of a bacterial biofilm on the epithelium of the vagina or foreskin. The main component of this biofilm is G. vaginalis. Bacterial vaginosis is caused by polymicrobial gardnerella biofilm, which can only be transferred as a whole (for example, with the help of key cells) only during sexual intercourse. Along with this, the authors discuss modern aspects related to the problem of microbial biofilm formation. In this regard, the authors propose to use a new term biofilm vaginosis, which more accurately reflects the essence of this problem. The modern possibilities of treating bacterial vaginosis are presented. The use of combined local therapy of nonspecific inflammatory processes of the vulvovaginal zone is becoming especially relevant at the present stage. The use of a local combination drug (Gainomax) with the widest possible spectrum of action allows doctors to achieve rapid relief of symptoms and high efficiency of therapy.

scholarly journals CORRECTION OF IODINE DEFICIENCY STATES AND DYNAMIC MODELING OF POSITIVE DYNAMICS OF INDICATORS OF THYROID FUNCTIONS BY SUPPLEMENTATION

2018 ◽  
Vol 2 ◽  
pp. 17-23
Author(s):  
Olesya Horlenko ◽  
Lubov Pushkash ◽  
Oleg Devinyak ◽  
Ivan Pushkash
Keyword(s):  
Thyroid Gland ◽  
Iodine Deficiency ◽  
Preventive Measures ◽  
Initial Level ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Detailed Examination ◽  
Wide Range ◽  
Deficiency Diseases ◽  
Marked Tendency

The problem of iodine deficiency diseases (IDD) is recognized as relevant due to the significant prevalence of iodine deficiency among the population of many countries of the world, an increase in the incidence of diseases with a wide range of clinical manifestations and a marked tendency to increase the frequency and severity of IDD among children of all age groups We carried out a clinical-anamnestic examination of the child's contingent (187 persons) aged 13–17 years living in an ecologically dependent biogeochemical endemic zone of iodine deficiency, the mountain region of the Zakarpattya region during the period from 2014 to 2015. To identify the pathology of the thyroid gland, a palpatory method of examination was used according to the methodology of the WHO / MRKIDZ, 2001. According to our data 80 pupils (42.8 %) had increased thyroid gland of 1 degree, they were allocated for further and detailed examination and identification of environmentally caused somatic effects. Preventive measures included taking the dietary supplement Yosen, the manufacturer of TOV “OmniFarm”, TU U 10.8-35758392-004: 2014 for 6 months. A statistical model for forecasting the dynamics of TSH with supplements with iodine and selenium has been developed. According to our data, the degree of positive changes (decrease of TSH, increase of T4) with supplements with iodine and selenium depends on the starting content of the microelement of iodine in plasma and / or urine: the lower is the initial level of iodine - the more pronounced is the effect of supplements.

A Cross Sectional Survey of Chicken Astroviruses Antibody in Broiler and Sonali (Cross-Bred) Chickens in Selected Areas in Bangladesh

2020 ◽  
Vol 43 (1) ◽  
pp. 75-80
Author(s):  
Md Zulfekar Ali ◽  
Mohammad Moktader Moula ◽  
Zafar Ahmed Bhuiyan ◽  
Muhammad Tariq Javed
Keyword(s):  
Age Groups ◽  
Winter Season ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Blood Samples ◽  
Elisa Kit ◽  
Published Report ◽  
Poultry Birds ◽  
Wide Range ◽  
Group B

AbstractChicken astroviruses (CAstV) are enteric viruses of poultry causing gastroenteritis, malabsorption, gout and white chick disease commonly known as runting-stunting syndrome (RSS). It can affect the wide range of poultry birds, especially chicken, turkey and duck worldwide. To our best knowledge there is no published report on presence of antibodies against CAstV in Bangladesh. Therefore, the study aimed to detect the presence of CAstV antibodies in broilers and sonali chickens (a cross-bread) in Bangladesh through a cross-sectional survey. A total of 454 blood samples from 66 flocks of broiler (n=343) and sonali chickens (n=111) of different ages were obtained during 2017 from four districts. The birds were healthy but were not vaccinated against CAstV. The samples were tested for specific antibodies against CAstV Group B by using commercially available ELISA kit. Overall, 16.74% (76/454) samples and 34.84% (23/66) flocks were positive for CAstV antibodies. The seroprevalence of CAstV was significantly (p=0.001) higher in sonali chickens (36.96%) than broiler (10.20%), while it was significantly higher (p=0.001) in birds of Bogura district (36.94%) than the other three districts. Regarding the age groups, seroprevalence was insignificantly (p=0.192) higher in sonali chicken before laying age (45%) than during laying age (27.45%). Regarding the seasons, CAstV infection was prevalent significantly (p=0.001) higher in winter season. Thus, the present study indicated the presence of CAstV in poultry in Bangladesh, so further studies are required to find out the magnitude of the problem in the country.

Search for mutations of the interferon-induced transmembrane protein 5 (IFITM5) gene in patients with osteogenesis imperfecta

2019 ◽  
pp. 21-29
Author(s):  
А.Р. Зарипова ◽  
Л.Р. Нургалиева ◽  
А.В. Тюрин ◽  
И.Р. Минниахметов ◽  
Р.И. Хусаинова
Keyword(s):  
Osteogenesis Imperfecta ◽  
De Novo ◽  
Transmembrane Protein ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Heterozygous Mutation ◽  
Type I ◽  
New Genes ◽  
Wide Range ◽  
Type V

Проведено исследование гена интерферон индуцированного трансмембранного белка 5 (IFITM5) у 99 пациентов с несовершенным остеогенезом (НО) из 86 неродственных семей. НО - клинически и генетически гетерогенное наследственное заболевание соединительной ткани, основное клиническое проявление которого - множественные переломы, начиная с неонатального периода жизни, зачастую приводящие к инвалидизации с детского возраста. К основным клиническим признакам НО относятся голубые склеры, потеря слуха, аномалия дентина, повышенная ломкость костей, нарушения роста и осанки с развитием характерных инвалидизирующих деформаций костей и сопутствующих проблем, включающих дыхательные, неврологические, сердечные, почечные нарушения. НО встречается как у мужчин, так и у женщин. До сих пор не определена степень генетической гетерогенности заболевания. На сегодняшний день известно 20 генов, вовлеченных в патогенез НО, и исследователи разных стран продолжают искать новые гены. В последнее десятилетие стало известно, что аутосомно-рецессивные, аутосомно-доминантные и Х-сцепленные мутации в широком спектре генов, кодирующих белки, которые участвуют в синтезе коллагена I типа, его процессинге, секреции и посттрансляционной модификации, а также в белках, которые регулируют дифференцировку и активность костеобразующих клеток, вызывают НО. Мутации в гене IFITM5, также называемом BRIL (bone-restricted IFITM-like protein), участвующем в формировании остеобластов, приводят к развитию НО типа V. До 5% пациентов имеют НО типа V, который характеризуется образованием гиперпластического каллуса после переломов, кальцификацией межкостной мембраны предплечья и сетчатым рисунком ламелирования, наблюдаемого при гистологическом исследовании кости. В 2012 г. гетерозиготная мутация (c.-14C> T) в 5’-нетранслируемой области (UTR) гена IFITM5 была идентифицирована как основная причина НО V типа. В представленной работе проведен анализ гена IFITM5 и идентифицирована мутация c.-14C>T, возникшая de novo, у одного пациента с НО, которому впоследствии был установлен V тип заболевания. Также выявлены три известных полиморфных варианта: rs57285449; c.80G>C (p.Gly27Ala) и rs2293745; c.187-45C>T и rs755971385 c.279G>A (p.Thr93=) и один ранее не описанный вариант: c.128G>A (p.Ser43Asn) AGC>AAC (S/D), которые не являются патогенными. В статье уделяется внимание особенностям клинических проявлений НО V типа и рекомендуется определение мутации c.-14C>T в гене IFITM5 при подозрении на данную форму заболевания. A study was made of interferon-induced transmembrane protein 5 gene (IFITM5) in 99 patients with osteogenesis imperfecta (OI) from 86 unrelated families and a search for pathogenic gene variants involved in the formation of the disease phenotype. OI is a clinically and genetically heterogeneous hereditary disease of the connective tissue, the main clinical manifestation of which is multiple fractures, starting from the natal period of life, often leading to disability from childhood. The main clinical signs of OI include blue sclera, hearing loss, anomaly of dentin, increased fragility of bones, impaired growth and posture, with the development of characteristic disabling bone deformities and associated problems, including respiratory, neurological, cardiac, and renal disorders. OI occurs in both men and women. The degree of genetic heterogeneity of the disease has not yet been determined. To date, 20 genes are known to be involved in the pathogenesis of OI, and researchers from different countries continue to search for new genes. In the last decade, it has become known that autosomal recessive, autosomal dominant and X-linked mutations in a wide range of genes encoding proteins that are involved in the synthesis of type I collagen, its processing, secretion and post-translational modification, as well as in proteins that regulate the differentiation and activity of bone-forming cells cause OI. Mutations in the IFITM5 gene, also called BRIL (bone-restricted IFITM-like protein), involved in the formation of osteoblasts, lead to the development of OI type V. Up to 5% of patients have OI type V, which is characterized by the formation of a hyperplastic callus after fractures, calcification of the interosseous membrane of the forearm, and a mesh lamellar pattern observed during histological examination of the bone. In 2012, a heterozygous mutation (c.-14C> T) in the 5’-untranslated region (UTR) of the IFITM5 gene was identified as the main cause of OI type V. In the present work, the IFITM5 gene was analyzed and the de novo c.-14C> T mutation was identified in one patient with OI who was subsequently diagnosed with type V of the disease. Three known polymorphic variants were also identified: rs57285449; c.80G> C (p.Gly27Ala) and rs2293745; c.187-45C> T and rs755971385 c.279G> A (p.Thr93 =) and one previously undescribed variant: c.128G> A (p.Ser43Asn) AGC> AAC (S / D), which were not pathogenic. The article focuses on the features of the clinical manifestations of OI type V, and it is recommended to determine the c.-14C> T mutation in the IFITM5 gene if this form of the disease is suspected.

Synthesis of Elaborate Benzofuran-2-Carboxamide Derivatives Through a Combination of 8-Aminoquinoline Directed C–H Arylations and Transamidations

2019 ◽  
Author(s):  
Michael Oschmann ◽  
Linus Johansson Holm ◽  
Oscar Verho
Keyword(s):  
Small Molecule ◽  
High Efficiency ◽  
Synthetic Strategy ◽  
Small Molecule Screening ◽  
Physiological Properties ◽  
Wide Range ◽  
Directing Group ◽  
Synthetic Sequence

Benzofurans are everywhere in nature and they have been extensively studied by medicinal chemists over the years because of their chemotherapeutic and physiological properties. Herein, we describe a strategy that can be used to access elaborate benzo-2-carboxamide derivatives, which involves a synthetic sequence of 8-aminoquinoline directed C–H arylations followed by transamidations. For the directed C–H arylations, Pd catalysis was used to install a wide range of aryl and heteroaryl substituents at the C3 position of the benzofuran scaffold in high efficiency. Directing group cleavage and further diversification of the C3-arylated benzofuran products were then achieved in a single synthetic operation through the utilization of a two-step transamidation protocol. By bocylating the 8-aminoquinoline amide moiety of these products, it proved possible to activate them towards aminolysis with different amine nucleophiles. Interestingly, this aminolysis reaction was found to proceed efficiently without the need of any additional catalyst or additive. Given the high efficiency and modularity of this synthetic strategy, it constitute a very attractive approach for generating structurally-diverse collections of benzofuran derivatives for small molecule screening.

DIAGNOSTIC VALUE OF SPECIFIC ANTIBODY SYNTHESIS IN BRAIN OF PATIENTS WITH NEUROINFECTIONS

2019 ◽  
Vol 72 (8) ◽  
pp. 1437-1441
Author(s):  
Pavel Dyachenko ◽  
Igor Filchakov ◽  
Anatoly Dyachenko ◽  
Victoria Kurhanskaya
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Manifestations ◽  
Diagnostic Value ◽  
Diagnostic Challenge ◽  
Specific Antibodies ◽  
Intrathecal Synthesis ◽  
Varicella Zoster ◽  
Mrz Reaction ◽  
Wide Range

Introduction: Viral encephalitis accounts for 40-70% of all cases worldwide, central nervous system infections pose a diagnostic challenge because clinical manifestations are not typically pathognomonic for specific pathogens, and a wide range of agents can be causative. The aim: To assess the diagnostic value of intrathecal synthesis of specific antibodies in patients with inflammatory lesions of the central nervous system. Materials and methods: Within the framework of the study, two groups of 90 people in each were formed from the patients with neuroinfections admitted to our Center. Intrathecal synthesis (ITS) of total (unspecific) IgG in members of one of group (group of compare) was determined. Brain synthesis of specific antibodies (Ab) to some neurotropic pathogens (herpes simplex virus 1/2, cytomegalovirus, Epstein-Barr virus, varicella zoster virus, rubella virus, Borrelies) was studied in the second group of patients (group of interest). There were no statistically significant differences between groups by gender and age. Encephalitis and encephalomyelitis prevailed among patients of both groups Results: ITS of total IgG was established in 30 (33.3 ± 6.1 %) patients of the first group with IgG index more than 0.6 indicating on inflammatory process in CNS and no marked changes of CSF. ITS of specific Ab was determined in 23 of 90 (25.6 ± 4.6 %) patients included into group of interest. In more than half of cases Ab to several infectious agents were detected simultaneously. ITS of various specificity, in particular, to measles and rubella viruses, and VZV, known as MRZ-reaction, is characteristic of some autoimmune lesions of CNS, multiple sclerosis first of all. In fact, further research of 5 patients with MRZ-reaction confirmed their autoimmune failure of CNS. Detection of ITS in the CSF samples didn’t depend on concentration of specific Ab in serum and CSF and wasn’t followed by HEB dysfunctions which were observed with the same frequency in patients with or without ITS (13.0 % and 13.6 % respectively). Conclusion: Specific Ab synthesis to several neurotropic pathogens in the CSF of significant part of examined patients was established. Thus, diagnostic value of ITS of specific immunoglobulins seems to be limited to cases in which autoimmune damage of the CNS is suspected.

To the 70th anniversary of World Meteorological Organization. Scientific and technical cooperation of Hydrometeorological Center of the USSR/Russia in the Programs of World Meteorological Organization

2020 ◽  
pp. 117-138
Author(s):  
S.V. Borshch ◽  
◽  
R.M. Vil’fand ◽  
D.B. Kiktev ◽  
V.M. Khan ◽  
...  
Keyword(s):  
Environmental Monitoring ◽  
High Efficiency ◽  
World Meteorological Organization ◽  
70Th Anniversary ◽  
Technical Level ◽  
Technical Cooperation ◽  
Wide Range

The paper presents the summary and results of long-term and multi-faceted experience of international scientific and technical cooperation of Hydrometeorological Center of Russia in the field of hydrometeorology and environmental monitoring within the framework of WMO programs, which indicates its high efficiency in performing a wide range of works at a high scientific and technical level. Keywords: World Meteorological Organization, major WMO programs, representatives of Hydrometeorological Center of Russia in WMO

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