scholarly journals Clinical and laboratory features of COVID-19 in young people

2021 ◽  
Author(s):  
А.Х. Hурпейсова ◽  
Л.К. Алимова ◽  
Ж.Б. Понежева ◽  
И.В. Маннанова ◽  
К.Н. Попова ◽  
...  
Keyword(s):  
Age Groups ◽  
Young Patients ◽  
Viral Pneumonia ◽  
Lung Damage ◽  
Laboratory Parameters ◽  
Hospitalization Period ◽  
Depth Study ◽  
Coronavirus Infection ◽  
Ct Data ◽  
Loss Of Appetite

Оценены клинико-лабораторные показатели у больных молодого возраста, госпитализированных в инфекционный стационар с диагнозом COVID-19. В исследование было включено 89 больных с диагнозом «коронавирусная инфекция COVID-19» в возрасте от 18 до 44 лет, средний возраст – 35,8 ± 1,6 года: 59 (66,3%) мужчин и 30 (33,7%) женщин. Клиническая картина заболевания у большинства пациентов характеризовалась наличием двусторонней вирусной пневмонии в 97% случаев. Сопутствующие заболевания имели место у 32 больных (36%), чаще всего в группе от 35 до 40 лет, при этом доля сердечно-сосудистых заболеваний и ожирения составила 51%. Легкая степень тяжести регистрировалась у 3 (3,4%) больных, средняя – у 86 (96,6%) пациентов. У мужчин по сравнению с женщинами чаще наблюдались симптомы интоксикации (50,6% против 28,2%) и одышка (28,2% против 10,1%), сухой кашель, дисгевзия и потеря аппетита. У 73% больных регистрировали разной степени дыхательную недостаточность (ДН), у четверти (26%) не было признаков ДН. По данным КТ в момент госпитализации повреждение легочной ткани различной степени наблюдалось у 88% больных. В динамике у большинства пациентов отмечалось снижение степени повреждения легких, но в 30% случаев отсутствовал регресс поражения легких на момент окончания периода госпитализации. Установлено, что COVID-19 у пациентов молодого возраста протекает с высокой вероятностью развития осложнений в виде пневмонии, течение которой имеет доброкачественный характер. Отсутствие регресса вирусной пневмонии у более трети пациентов требует диспансерного наблюдения всех переболевших и мониторирования лабораторных параметров в динамике для выявления и оценки последствий перенесенной коронавирусной инфекции, а также необходимость дальнейшего углубленного изучения клинико-иммунологических особенностей течения COVID-19 в различных возрастных группах. Clinical and laboratory parameters in young patients hospitalized in an infectious hospital with a diagnosis of COVID-19 were evaluated. The study included 89 patients with a diagnosis of «covid-19 Coronavirus infection» aged 18 to 44 years, the average age was 35,8 ± 1,6 years (59 (66,3%) men and 30 (33,7%) women). The clinical picture of the disease in most patients was characterized by the presence of bilateral viral pneumonia in 97% of cases. Concomitant diseases occurred in 32 patients (36%), most often in the group from 35 to 40 years, while the share of cardiovascular diseases and obesity was 51%. Mild severity was registered in 3 (3,4%) patients, average-in 86 (96,6%) patients. Men compared to women were more likely to have symptoms of intoxication (50,6% vs. 28,2%) and shortness of breath (28,2% vs. 10,1%), dry cough, dysgeusia and loss of appetite. In 73% of patients, respiratory failure (DN) was registered to varying degrees, and a quarter (26%) had no signs of DN. According to CT data, at the time of hospitalization, lung tissue damage of varying degrees was observed in 88% of patients. In dynamics, most patients showed a decrease in the degree of lung damage, but in 30% of cases there was no regression of lung damage at the end of the hospitalization period. COVID-19 in young patients is highly likely to develop complications in the form of pneumonia, the course of which is benign. The lack of regression of viral pneumonia more than one third of patients require follow-up all survivors and monitoring the laboratory parameters in dynamics for the identification and evaluation of consequences coronavirus infection and the need for further in-depth study of clinical and immunological characteristics of the course COVID-19 in different age groups.

Features of mahagment of a patient with a new coronaviral infection in the observator on the basis of student’s dormitory

2020 ◽  
Vol 24 (2) ◽  
pp. 45-51
Author(s):  
Olga Yu. Kuznetsova ◽  
Alexandr V. Meltser ◽  
Anna V. Lubimova ◽  
Zhanna V. Pleshanova ◽  
Olga S. Zamyatina ◽  
...  
Keyword(s):  
Young Patients ◽  
Clinical Manifestations ◽  
Hypochromic Anemia ◽  
Lung Damage ◽  
Outpatient Basis ◽  
History Of ◽  
Complicated Course ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome ◽  
Severe Weakness

The article is devoted to the peculiarities of clinical manifestations and the severity of a new coronary virus infection in a university student transferred to an observatory organized in a hotel-type hostel to prevent the spread of COVID-19 among students living in hostels. The data on the epidemiological history of the patient, the results of clinical observation and examination are provided. The tactics of managing a patient with a suspected of COVID-19 on an outpatient basis, symptoms that determine the indications for hospitalization, the results of examination and treatment in a hospital, and further observation at the observatory are considered. A new coronavirus infection can lead to a rapid deterioration in the condition of young patients, which does not correlate with indicators indicating lung damage on the 5th day of the disease. Persistent hyperthermia and severe weakness with anorexia can be indicators of the complicated course of the disease, including the development of hyperactive inflammatory syndrome. Hypochromic anemia can be another disease, which is an unfavorable background for the development of COVID-19. The course of the new coronavirus infection in young patients requires careful attention and further study.

scholarly journals Peculiarities of clinical manifestations of the new COVID-19 coronavirus infection in patients hospitalized during the epidemic depending on their age

2021 ◽  
Vol 17 (7) ◽  
pp. 32-36
Author(s):  
V.I. Trykhlib ◽  
N.R. Tsiurak ◽  
K.P. Beliaeva ◽  
T.I. Lysenko ◽  
A.O. Yeroshenko ◽  
...  
Keyword(s):  
Chest Pain ◽  
Age Groups ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Productive Cough ◽  
Thoracic Pain ◽  
Average Temperature ◽  
General Weakness ◽  
Significant Difference ◽  
Coronavirus Infection

This article presents a review of the literature and data from a personal study concerning the clinical manifestations of new coronavirus infection in patients hospitalized during the COVID-19 epidemic depending on their age. It was found that most patients complained about dry or low-productive cough, moderate general weakness. The patients aged 18–30 years old more frequently experienced no cough. The patients aged 31–40 years old significantly more frequently complained about dry cough (p < 0.05). Low-productive cough was less frequent but typical in all age groups and more frequent in patients aged 51–60 years. Moist cough was more frequent in patients over 60 years. Chest pain was registered in patients over 60 years (p < 0.05). The frequency of dyspnea was found to increase with age. More often dyspnea was registered in patients older than 60 years old. No dyspnea was noted in young patients aged 18–30 years. Half of the patients aged 18–30 years had no fever. At hospitalization, the average temperature was within normal or subfebrile, which predominated in patients aged 41–50 years (p < 0.05). The frequency of febrile fever increased in patients with age. There was no significant difference in the frequency of pyretic temperature among all age groups. The patients aged over 30 years complained more about moderate weakness, and patients aged over 40 years complained more about severe weakness. Younger patients more often complained about a sore throat, while older patients had practically no symptoms (p > 0.05). Thoracic pain was significantly more frequently registered in patients older than 60 years old. Young patients aged 18–30 years and 31–40 years had no chest pain.

scholarly journals Retrospective Evaluation of Elderly and Young Patients with Acute Pancreatitis

2020 ◽  
Vol 7 (01) ◽  
pp. 4691-4694
Author(s):  
Hatice Beyazal Polat ◽  
Teslime Ayaz ◽  
Hüseyin Duru ◽  
Adnan Remzi Akdoğan ◽  
Mehmet Beyazal ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Disease Severity ◽  
Age Groups ◽  
Young Patients ◽  
Scoring Systems ◽  
Demographic Characteristics ◽  
Morbidity And Mortality ◽  
Additional Risk Factor ◽  
Laboratory Findings ◽  
Hospitalization Period

Background/aim: Acute pancreatitis (AP) is a clinical situation that should be included in the differential diagnosis of patients presenting with complaints of abdominal pain, nausea, and vomiting. The aim of this study is to investigate the in-hospital morbidity and mortality of patients with acute pancreatitis at our clinic. Materials and Methods: In total, 159 patients with acute pancreatitis were included in the study and analyzed retrospectively. Patients were divided into two groups: those over 65 years old and those younger than 65 years. The demographic characteristics, severity, treatment, patient prognoses,and hospitalization duration were recorded. The relationship between APseverity, etiological factors, age, gender, length of stay, and prognosis was investigated for both groups. Results: Acute biliary pancreatitis was detected in 99 (62.3) of the 159 patients. Biliary causes were significantly higher among the elderly group. There was no relationship between disease severity and demographic characteristics or clinical and laboratory findings. When the hospitalization period was compared between age groups, the hospitalization period for the group over 65 years was found to be significantly longer than that of the other group. The mortality rate was 0% in the group younger than 65 years and 3.2% in the group older than 65 years (three patients). This rate was not statistically significant due to the low incidence of death. Conclusion: Gallstonesis a leading cause in the etiology of AP. Prognostic scoring systems should be used to determine the disease severity and age should be considered an additional risk factor in the increased morbidity and mortality of AP.

Hematological indicators for lung damage caused by COVID-19 infection

2020 ◽  
Vol 65 (11) ◽  
pp. 676-682
Author(s):  
E. A. Borodulina ◽  
Zh. P. Vasneva ◽  
B. E. Borodulin ◽  
E. S. Vdoushkina ◽  
L. V. Povalyaeva ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Blood Analysis ◽  
Lung Damage ◽  
Pcr Analysis ◽  
Coronavirus Infection ◽  
Ct Data ◽  
Group 2 ◽  
Hematological Indicators ◽  
Lung Tissue Damage ◽  
Damage Characteristic

During the pandemic of a new coronavirus infection one of the most serious complications is pneumonia. When entering a specialized pulmonology Department, the presence of pneumonia is confirmed by computed tomography (CT), the etiology is confirmed by the detection of SARS-CoV-2 RNA by PCR, the article analyzes the indicators of blood analysis when patients are admitted to the hospital. All admitted patients were divided into 2 groups. Group 1 of the study - with a new coronavirus infection Covid-19, confirmed by the detection of PCR-RNA SARS-CoV-2 (n=27). Group 2 consisted of 65 patients (70.7%) with lung tissue damage characteristic of Covid-19 according to CT, who had a negative analysis of PCR-RNA SARS-CoV-2. Statistically significant deviations were shown in a decrease in the percentage and absolute content of lymphocytes, monocytes and platelets, and an increase in neutrophils. The comparative analysis in the groups with positive and negative PCR analysis for the detection of SARS-CoV-2 RNA showed no statistically significant differences. It can be assumed that with the similarity of clinical manifestations and CT-data, a negative result of PCR-RNA SARS-CoV-2 can be diagnosed as «lung damage caused by COVID-19 infection».

Treating patients with a new coronavirus infection in the clinic of Izmerov Research Institute of Occupational Health

2021 ◽  
Vol 61 (1) ◽  
pp. 27-33
Author(s):  
Igor V. Bukhtiyarov ◽  
Lyudmila P. Kuzmina ◽  
Viktor F. Pfaf ◽  
Elvira S. Tsidilkovskaya
Keyword(s):  
Occupational Health ◽  
Lung Tissue ◽  
Ambient Air ◽  
Immune Defense ◽  
Viral Pneumonia ◽  
Laboratory Parameters ◽  
Continue Treatment ◽  
Coronavirus Infection ◽  
D Dimer ◽  
Research Institute

Introduction. To comply with the order of the Government of the Russian Federation and the Ministry of Education and Science, the clinic of Izmerov Research Institute of Occupational Health received the necessary conditions for the provision of medical care to patients with a new coronavirus infection. The study aims to identify possible criteria for the positive dynamics of pneumonia caused by the SARS-CoV-2 virus and to describe the general characteristics of patients hospitalized in the COVID center of Izmerov Research Institute of Occupational Health. Materials and methods. The article describes the clinical, laboratory, and instrumental data of 68 patients with pneumonia caused by the SARS-CoV-2 virus hospitalized to continue treatment. Statistical analysis included descriptive statistics. The significance level was less than 0.05. Results. The COVID-center received patients with complaints of shortness of breath on exertion, an unproductive cough, general weakness, myalgias, headaches, and an impaired sense of smell and taste. The condition of the patients was moderate. O2 saturation in ambient air was 93% and higher. Computed tomography of the chest revealed lesions of the lung tissue (numerous peripheral seals of the "frosted glass" type of various shapes and lengths with areas of consolidation), mainly corresponding to bilateral polysegmental viral pneumonia CT 1-2 degrees. The most frequent changes in laboratory parameters in patients were increased values of ESR (51.16% of cases), D-dimer (50% of cases), CRP (22.06% of cases), relative values of monocytes (58.14% of cases), as well as low hemoglobin concentrations (23% of cases). Conclusions. In patients with a new coronavirus infection hospitalized to continue treatment in the COVID center of Izmerov Research Institute of Occupational Health, lung tissue lesions were detected, mainly corresponding to the moderate-severe form of bilateral polysegmental viral pneumonia (CT of the 1-2 degree). The most frequent changes in laboratory parameters in patients with COVID-19 were increased ESR values, D-dimer, CRP, relative values of monocytes, and low hemoglobin concentrations. Monocytes, being one of the indicators of activation of the immune defense, are a laboratory criterion for the positive dynamics of the course of new coronavirus infection.

scholarly journals WORK EXPERIENCE BUREAU OF FORENSIC MEDICINE OF MOSCOW REGION IN THE CONTEXT OF A PANDEMIC CAUSED BY A NEW CORONAVIRUS INFECTION

2020 ◽  
Author(s):  
A. Maksimov
Keyword(s):  
Work Experience ◽  
Diffuse Alveolar Damage ◽  
Age Groups ◽  
The Body ◽  
Lung Damage ◽  
Internal Organs ◽  
Forensic Research ◽  
Qualitative Variables ◽  
Coronavirus Infection ◽  
Common Sign

The article presents the results of studying cases of deaths of individuals from a new coronavirus infection according to forensic research. Aim. Based on the study of the results of forensic research of corpses to generalize and identify patterns of damage to internal organs and body systems in cases of death from COVID-19 without medical assistance. Material and methods. We studied 198 cases of fatal outcomes from a new coronavirus infection. We determined the frequency of fatal outcomes in various age groups. The leading morphological manifestations of internal organ lesions were established. Absolute (abs) and relative (%) frequencies were calculated for qualitative variables. Conclusion. In the structure of mortality from COVID-19 outside medical organizations, the proportion of deaths of elderly (60-80 years) and senile (over 80 years) age was 74.2%. Among the internal organs, the lungs are the most susceptible to changes. in 77.8% of cases, pathological changes corresponded to the acute phase of diffuse alveolar damage. In addition to lung damage, the most common sign was the depletion of spleen parenchyma by lymphocytes, indicating an immune inflammatory response of the body. The identified characteristic morphological signs of alveolar lung damage in OT CAVID-19 can be used as a differential diagnosis of lung damage from shocks of other etiology

scholarly journals Features of glucocorticoides using for treatment of a patient with a new coronaviral infection in the conditions of the observator on the basis of students’ dormitory. Clinical case

2020 ◽  
Vol 24 (3) ◽  
pp. 27-32
Author(s):  
Olga Yu. Kuznetsova ◽  
Anna V. Lubimova ◽  
Zhanna V. Pleshanova ◽  
Olga S. Zamyatina ◽  
Nikita V. Donetskov ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Treatment Regimen ◽  
Severe Disease ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Early Period ◽  
Lung Damage ◽  
Medical Monitoring ◽  
Number Of Patients ◽  
Coronavirus Infection

The article is devoted to the peculiarities of providing medical care for coronavirus infection in a university student who has been moved to an observatory organized in a hotel-type hostel of the university to prevent the spread of COVID-19 among students living in hostels. The article provides data on the positive experience of using dexamethasone in the treatment regimen for moderately severe disease, follow-up and examination data. The article considers the tactics of managing a patient with suspected COVID-19 in the presence of data for pneumonia according to computed tomography and clinical manifestations characteristic of a new coronavirus infection, which was later confirmed in the study of antibodies to SARS-CoV-2. The importance of round-the-clock medical monitoring of persons placed in the observatory, finding out the details of the epidemiological history from them, as well as determining the tactics of their treatment with limited hospitalization opportunities in a growing number of patients with severe manifestations of COVID-19 requiring inpatient treatment is emphasized. A new coronavirus infection can lead to a rapid deterioration of the condition in young patients, which is not always manifested by severe lung damage according to computed tomography data, but is characterized by persistent fever that cannot be stopped by antipyretics, as well as severe muscle pain, severe asthenia, which can be considered as clinical indicators of the development of hyperactive inflammatory syndrome. The use in the treatment regimen of intravenous dexamethasone at a dose of 0.1 mg / kg of body weight twice led to a rapid normalization of temperature, relief of all clinical symptoms and was not accompanied by any complications both in the early period of convalescence and 2 months after discharge from the observatory.

scholarly journals COMPLEX ASSESSMENT OF COMPUTED TOMOGRAPHY OF THE LUNGS AND CLINICAL DATA IN COVID-19 PATIENTS, HOSPITALIZED IN THE CLINIC IN NUR-SULTAN

REPORTS ◽  
2020 ◽  
Vol 5 (333) ◽  
pp. 94-102
Author(s):  
R.I. Rakhimzhanova ◽  
◽  
D. Pavalkis ◽  
V.V. Benberin ◽  
T.B. Dautov ◽  
...  
Keyword(s):  
Ct Scan ◽  
Clinical Signs ◽  
Diagnostic Errors ◽  
Lung Damage ◽  
Ct Scans ◽  
Lesion Volume ◽  
Coronavirus Infection ◽  
Ct Data ◽  
Clinical Cases

The ambiguity of the X-ray picture and clinic in patients with coronavirus infection (CVI) was the reason for this analysis in order to avoid diagnostic errors and to achieve the effect of the treatment. Conducted a comparative description of three clinical cases of patients with coronavirus infection COVID-19. All three patients differed in different parameters of SARS Co-2 PCR. In the first two patients who underwent CT on the 7th and 10th days from the onset of the disease on control CT after treatment, a regressive positive dynamics was observed; in the third patient, after an early CT scan on the second day of illness and on the next CT scan performed on the 10th day after the appearance of the clinic and a positive PCR test, progression of signs of viral pneumonia was observed with an increase in the affected area. Thus, the earlier CT was performed, the less pronounced the changes in the CT picture (the lesion volume is up to 5% or no changes are detected). When performing CT scan, patients with a long-term clinic (7-10 days from the onset of the disease) showed a characteristic picture of lung damage - up to 25-30%. The analysis of CT scans performed in the described clinical cases at different times from the onset of the disease, regardless of the results of PCR, confirms the need for CT scans 5-7 days after the first clinical signs appear. Also, as a result of our work, we once again received confirmation from numerous studies conducted in the world on the absence of a correlation between SARS Co-2 PCR and CT data.

Projected future risk of leukemia and brain tumors from unnecessary brain CT scans: a multi-center study in Iran

2020 ◽  
Author(s):  
A. Asgari ◽  
A.A. Parach ◽  
F. Bouzarjomehri ◽  
F. Shirani-Takabi ◽  
A.H. Mehrparvar ◽  
...  
Keyword(s):  
Brain Cancer ◽  
Age Groups ◽  
Young Patients ◽  
Ct Scans ◽  
Brain Ct ◽  
Males And Females ◽  
And Gender ◽  
Multi Center Study ◽  
Gender Groups ◽  
Probability Of Cancer

Introduction: Computer Tomography (CT) scans can deliver a relatively high radiation dose to the patient, therefore radiation protection for this modality is paramount. The present study determined the frequency of no abnormality detected (NAD) brain CT scans and probability of cancer induction in different age groups and genders. Methods: In this study, brain CT reports were used to identify any findings as abnormality detected (AD) and others as NAD. Then probability of future leukemia and brain cancer was estimated for different age and gender groups. Results: On average, in 65% of the cases the results were NAD (56% and 76% among males and females, respectively). Among children, 79% of the reports were NAD. The total number of projected brain cancers was 1.8 and 1.3 for males and females, respectively. The number of projected leukemia cases was 0.75 and 0.7 for males and females, respectively. For pediatric patients, brain CT scans can lead to leukemia cases about 4.5 times more often than adults. Conclusion: Brain CT scans can lead to additional cases of brain cancer and leukemia. A significant fraction of brain CTs were NAD (non-pathologic) and could practically be replaced by other radiation-free imaging modalities, especially in pediatric and young patients.

Clinical case of lung lesions in patient with newly diagnosed systemic lupus erythematosus

2019 ◽  
Vol 1 (9) ◽  
pp. 53-57
Author(s):  
T. N. Gavva ◽  
L. V. Kuzmenkova ◽  
Yu. N. Fedulaev ◽  
T. V. Pinchuk ◽  
D. D. Kaminer ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Lung Damage ◽  
Newly Diagnosed ◽  
Systemic Lupus ◽  
Lung Lesions ◽  
Laboratory Parameters ◽  
Clinical Interest

A case of lung damage in systemic lupus erythematosus (SLE) in a 33-year-old woman is described. This case is of clinical interest due to the complexity of diagnosis due to the fact that SLE is a disease with diverse clinical manifestations involving many organs and systems, which often makes it difficult to timely recognize the onset of the disease. SLE still remains a challenge and requires special attention to the patient s history, clinical and laboratory parameters of the patient, as well as specific immunological examinations.

Sign in / Sign up

Export Citation Format

Share Document