Science Goals and Mission Objectives for the Future Exploration of Ice Giants Systems - A Horizon 2061 Perspective

2020 ◽  
Author(s):  
Michel Blanc ◽  
Kathleen Mandt ◽  
Olivier Mousis ◽  
Nicolas Andre ◽  
Alexis Bouquet ◽  
...  

<p>The comparative study of the different planetary systems accessible to our observations is a unique source of new scientific insight: it can reveal to us the diversity of these systems and of the objects within them, help us better understand their origins and how they work, find and characterize habitable worlds, and ultimately, search for alien life in our galactic neighborhood. But, in the solar system itself, two of its secondary planetary systems, the ice giant systems, as well as their two main objects, Uranus and Neptune, remain poorly explored. We will present an analysis of our current limited knowledge of these systems in the light of six key science questions about planetary systems formulated in the “Planetary Exploration, Horizon 2061” long-term foresight exercise: (Q1) What is the diversity of planetary systems objects? (Q2) What is the diversity of their architectures? (Q3) What do we know of their origins and formation scenarios? (Q4) How do they work? (Q5) Do they host potential habitats? (Q6) Where and how to search for life?</p> <p>We will show that a long-term plan for the space exploration of ice giants and their systems, complemented by the combination of Earth and space-based observations, will provide major contributions to answers to these six questions. In order to do so, we identify the measurements that must be performed in priority to address each of these questions, the destinations to choose (Uranus, Neptune, Triton or a subset of them), and the combinations of space platform(s) (orbiter, atmospheric entry probe(s), lander…) and of  flight sequences needed.</p> <p>Based on this analysis, we look at the different launch windows available until 2061, using a Jupiter fly-by, to send a mission to Uranus or Neptune and find that:</p> <p>(1) a single mission to one of the Ice giants, combining an atmospheric entry probe and an orbiter tour starting on a high-inclination, low-periapse orbit, followed by a sequence of lower- inclination orbits, at least at one of the planets, will make it possible to address a broad range of these key questions;</p> <p>(2) a combination of two well-designed missions to each of the ice giant systems, to be flown in parallel or in sequence, will make it possible to address five out of the six key questions, and to establish the prerequisites for addressing the sixth one. The 2032 Jupiter fly-by window offers a unique opportunity to achieve this goal;</p> <p>(3) if this window cannot be met, using the 2036 Jupiter fly-by window to send a mission to Uranus first, and then the 2045 window for a mission to Neptune, will achieve the same goals. As a back-up option, the feasibility of sending an orbiter + probe mission to one of the planets and using the opportunity of a mission on its way to the interstellar medium to execute a close fly-by of the other planet and deliver a probe into its atmosphere should be studied carefully;</p> <p>(4) based on the expected science return of the first two missions, a third mission focusing on the search for life at a promising moon, namely Triton based on our current knowledge, or perhaps one of the active moons of Uranus after due characterization, can be properly designed.</p> <p>By the 2061 horizon, the first two missions of this plan can be implemented and the design of a third mission focusing on the search for life can be consolidated. Given the likelihood that such a plan may be out of reach of a single national agency, international collaboration is the most promising way to implement it.</p>

2021 ◽  
pp. jnnp-2020-324005
Author(s):  
Klaus Fassbender ◽  
Fatma Merzou ◽  
Martin Lesmeister ◽  
Silke Walter ◽  
Iris Quasar Grunwald ◽  
...  

Since its first introduction in clinical practice in 2008, the concept of mobile stroke unit enabling prehospital stroke treatment has rapidly expanded worldwide. This review summarises current knowledge in this young field of stroke research, discussing topics such as benefits in reduction of delay before treatment, vascular imaging-based triage of patients with large-vessel occlusion in the field, differential blood pressure management or prehospital antagonisation of anticoagulants. However, before mobile stroke units can become routine, several questions remain to be answered. Current research, therefore, focuses on safety, long-term medical benefit, best setting and cost-efficiency as crucial determinants for the sustainability of this novel strategy of acute stroke management.


2021 ◽  
Vol 22 (3) ◽  
pp. 1201
Author(s):  
Hsuan Peng ◽  
Kazuhiro Shindo ◽  
Renée R. Donahue ◽  
Ahmed Abdel-Latif

Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.


2020 ◽  
Vol 501 (1) ◽  
pp. L12-L17
Author(s):  
Christina Schoettler ◽  
Richard J Parker

ABSTRACT Planetary systems appear to form contemporaneously around young stars within young star-forming regions. Within these environments, the chances of survival, as well as the long-term evolution of these systems, are influenced by factors such as dynamical interactions with other stars and photoevaporation from massive stars. These interactions can also cause young stars to be ejected from their birth regions and become runaways. We present examples of such runaway stars in the vicinity of the Orion Nebula Cluster (ONC) found in Gaia DR2 data that have retained their discs during the ejection process. Once set on their path, these runaways usually do not encounter any other dense regions that could endanger the survival of their discs or young planetary systems. However, we show that it is possible for star–disc systems, presumably ejected from one dense star-forming region, to encounter a second dense region, in our case the ONC. While the interactions of the ejected star–disc systems in the second region are unlikely to be the same as in their birth region, a second encounter will increase the risk to the disc or planetary system from malign external effects.


Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1575
Author(s):  
Ajda Demšar Luzar ◽  
Peter Korošec ◽  
Mitja Košnik ◽  
Mihaela Zidarn ◽  
Matija Rijavec

Hymenoptera venom allergy is one of the most severe allergic diseases, with a considerable prevalence of anaphylactic reaction, making it potentially lethal. In this review, we provide an overview of the current knowledge and recent findings in understanding induced immune mechanisms during different phases of venom immunotherapy. We focus on protection mechanisms that occur early, during the build-up phase, and on the immune tolerance, which occurs later, during and after Hymenoptera venom immunotherapy. The short-term protection seems to be established by the early desensitization of mast cells and basophils, which plays a crucial role in preventing anaphylaxis during the build-up phase of treatment. The early generation of blocking IgG antibodies seems to be one of the main reasons for the lower activation of effector cells. Long-term tolerance is reached after at least three years of venom immunotherapy. A decrease in basophil responsiveness correlates with tolerated sting challenge. Furthermore, the persistent decline in IgE levels and, by monitoring the cytokine profiles, a shift from a Th2 to Th1 immune response, can be observed. In addition, the generation of regulatory T and B cells has proven to be essential for inducing allergen tolerance. Most studies on the mechanisms and effectiveness data have been obtained during venom immunotherapy (VIT). Despite the high success rate of VIT, allergen tolerance may not persist for a prolonged time. There is not much known about immune mechanisms that assure long-term tolerance post-therapy.


Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 347
Author(s):  
Tomoyuki Fujisawa

Idiopathic inflammatory myopathies, including polymyositis (PM), dermatomyositis (DM), and clinically amyopathic DM (CADM), are a diverse group of autoimmune diseases characterized by muscular involvement and extramuscular manifestations. Interstitial lung disease (ILD) has major pulmonary involvement and is associated with increased mortality in PM/DM/CADM. The management of PM-/DM-/CADM-associated ILD (PM/DM/CADM-ILD) requires careful evaluation of the disease severity and clinical subtype, including the ILD forms (acute/subacute or chronic), because of the substantial heterogeneity of their clinical courses. Recent studies have highlighted the importance of myositis-specific autoantibodies’ status, especially anti-melanoma differentiation-associated gene 5 (MDA5) and anti-aminoacyl tRNA synthetase (ARS) antibodies, in order to evaluate the clinical phenotypes and treatment of choice for PM/DM/CADM-ILD. Because the presence of the anti-MDA5 antibody is a strong predictor of a worse prognosis, combination treatment with glucocorticoids (GCs) and calcineurin inhibitors (CNIs; tacrolimus (TAC) or cyclosporin A (CsA)) is recommended for patients with anti-MDA5 antibody-positive DM/CADM-ILD. Rapidly progressive DM/CADM-ILD with the anti-MDA5 antibody is the most intractable condition, which requires immediate combined immunosuppressive therapy with GCs, CNIs, and intravenous cyclophosphamide. Additional salvage therapies (rituximab, tofacitinib, and plasma exchange) should be considered for patients with refractory ILD. Patients with anti-ARS antibody-positive ILD respond better to GC treatment, but with frequent recurrence; thus, GCs plus immunosuppressants (TAC, CsA, azathioprine, and mycophenolate mofetil) are often needed in order to achieve favorable long-term disease control. PM/DM/CADM-ILD management is still a therapeutic challenge for clinicians, as evidence-based guidelines do not exist to help with management decisions. A few prospective clinical trials have been recently reported regarding the treatment of PM/DM/CADM-ILD. Here, the current knowledge on the pharmacologic managements of PM/DM/CADM-ILD was mainly reviewed.


2021 ◽  
Vol 11 (6) ◽  
pp. 483
Author(s):  
Marwa Saadaoui ◽  
Manoj Kumar ◽  
Souhaila Al Khodor

The COVID-19 pandemic is a worldwide, critical public health challenge and is considered one of the most communicable diseases that the world had faced so far. Response and symptoms associated with COVID-19 vary between the different cases recorded, but it is amply described that symptoms become more aggressive in subjects with a weaker immune system. This includes older subjects, patients with chronic diseases, patients with immunosuppression treatment, and pregnant women. Pregnant women are receiving more attention not only because of their altered physiological and immunological function but also for the potential risk of viral vertical transmission to the fetus or infant. However, very limited data about the impact of maternal infection during pregnancy, such as the possibility of vertical transmission in utero, during birth, or via breastfeeding, is available. Moreover, the impact of infection on the newborn in the short and long term remains poorly understood. Therefore, it is vital to collect and analyze data from pregnant women infected with COVID-19 to understand the viral pathophysiology during pregnancy and its effects on the offspring. In this article, we review the current knowledge about pre-and post-natal COVID-19 infection, and we discuss whether vertical transmission takes place in pregnant women infected with the virus and what are the current recommendations that pregnant women should follow in order to be protected from the virus.


2021 ◽  
Vol 10 (11) ◽  
pp. 2501
Author(s):  
Angelo Cignarelli ◽  
Valentina Annamaria Genchi ◽  
Rossella D’Oria ◽  
Fiorella Giordano ◽  
Irene Caruso ◽  
...  

Erectile dysfunction (ED) is a long-term complication of type 2 diabetes (T2D) widely known to affect the quality of life. Several aspects of altered metabolism in individuals with T2D may help to compromise the penile vasculature structure and functions, thus exacerbating the imbalance between smooth muscle contractility and relaxation. Among these, advanced glycation end-products and reactive oxygen species derived from a hyperglycaemic state are known to accelerate endothelial dysfunction by lowering nitric oxide bioavailability, the essential stimulus of relaxation. Although several studies have explained the pathogenetic mechanisms involved in the generation of erectile failure, few studies to date have described the efficacy of glucose-lowering medications in the restoration of normal sexual activity. Herein, we will present current knowledge about the main starters of the pathophysiology of diabetic ED and explore the role of different anti-diabetes therapies in the potential remission of ED, highlighting specific pathways whose activation or inhibition could be fundamental for sexual care in a diabetes setting.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Evan Miles ◽  
Michael McCarthy ◽  
Amaury Dehecq ◽  
Marin Kneib ◽  
Stefan Fugger ◽  
...  

AbstractGlaciers in High Mountain Asia generate meltwater that supports the water needs of 250 million people, but current knowledge of annual accumulation and ablation is limited to sparse field measurements biased in location and glacier size. Here, we present altitudinally-resolved specific mass balances (surface, internal, and basal combined) for 5527 glaciers in High Mountain Asia for 2000–2016, derived by correcting observed glacier thinning patterns for mass redistribution due to ice flow. We find that 41% of glaciers accumulated mass over less than 20% of their area, and only 60% ± 10% of regional annual ablation was compensated by accumulation. Even without 21st century warming, 21% ± 1% of ice volume will be lost by 2100 due to current climatic-geometric imbalance, representing a reduction in glacier ablation into rivers of 28% ± 1%. The ablation of glaciers in the Himalayas and Tien Shan was mostly unsustainable and ice volume in these regions will reduce by at least 30% by 2100. The most important and vulnerable glacier-fed river basins (Amu Darya, Indus, Syr Darya, Tarim Interior) were supplied with >50% sustainable glacier ablation but will see long-term reductions in ice mass and glacier meltwater supply regardless of the Karakoram Anomaly.


2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Christopher C. M. Kyba ◽  
Kai Pong Tong ◽  
Jonathan Bennie ◽  
Ignacio Birriel ◽  
Jennifer J. Birriel ◽  
...  

Abstract Despite constituting a widespread and significant environmental change, understanding of artificial nighttime skyglow is extremely limited. Until now, published monitoring studies have been local or regional in scope and typically of short duration. In this first major international compilation of monitoring data we answer several key questions about skyglow properties. Skyglow is observed to vary over four orders of magnitude, a range hundreds of times larger than was the case before artificial light. Nearly all of the study sites were polluted by artificial light. A non-linear relationship is observed between the sky brightness on clear and overcast nights, with a change in behavior near the rural to urban landuse transition. Overcast skies ranged from a third darker to almost 18 times brighter than clear. Clear sky radiances estimated by the World Atlas of Artificial Night Sky Brightness were found to be overestimated by ~25%; our dataset will play an important role in the calibration and ground truthing of future skyglow models. Most of the brightly lit sites darkened as the night progressed, typically by ~5% per hour. The great variation in skyglow radiance observed from site-to-site and with changing meteorological conditions underlines the need for a long-term international monitoring program.


Author(s):  
A. L. Cunningham ◽  
J. W. Stephens ◽  
D. A. Harris

AbstractObesity and type 2 diabetes mellitus (T2DM) are common, chronic metabolic disorders with associated significant long-term health problems at global epidemic levels. It is recognised that gut microbiota play a central role in maintaining host homeostasis and through technological advances in both animal and human models it is becoming clear that gut microbiota are heavily involved in key pathophysiological roles in the aetiology and progression of both conditions. This review will focus on current knowledge regarding microbiota interactions with short chain fatty acids, the host inflammatory response, signaling pathways, integrity of the intestinal barrier, the interaction of the gut-brain axis and the subsequent impact on the metabolic health of the host.


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