Phytochemical and Pharmacological Evaluation of Annona reticulate

2021 ◽  
pp. 4881-4886
Author(s):  
Veena Kadasala ◽  
Niladry Sekhar Ghosh ◽  
Santhosh Kumar Chinnaiyan ◽  
Arunabha Mallik ◽  
Manjunath S.Y. ◽  
...  
Keyword(s):  
Castor Oil ◽  
Gastric Content ◽  
Gastric Volume ◽  
Antiulcer Activity ◽  
Total Acidity ◽  
Aqueous Extracts ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
Tropical Areas ◽  
Dose Dependent

Annona reticulate (AR) is indigenous to the tropical areas of India and worldwide. The use of plant as remedy for diarrhea and ulcer is well documented in Ayurvedic system of medicine. However, pharmacological evidence does not exist to substantiate its therapeutic efficacy for the same. The aim was to investigate the antiulcer and anti-diarrheal activity of methanolic (ME) and aqueous extracts (AE) of A. reticulate in animal model. The antiulcer activity of extracts was investigated using ethanol and pylorus ligation-induced ulcer. The anti-diarrheal activity of MEAR and AEAR extracts was evaluated by castor oil induced diarrhea and gastro intestinal motility using parameters such as onset of diarrhea, number of wet stools, total number of stool and weight of total number of stools. The antiulcer activity of the extracts was confirmed by a reduction in ulcer index along with the decrease in gastric volume, total acidity, and an increase in pH of gastric content in both the models. A. reticulate extracts were more efficacious in reducing number of total stools in both the models of diarrhea and showed a dose-dependent antidiarrheal effect. The obtained results have established a pharmacological evidence for the folkloric use of the A. reticulate as antiulcer and antidiarrhoeal agent.

scholarly journals Antiulcerogenic effect of Methanolic Root Extract of Berberis lycium Linn by Pylorus ligation and Ethanol induced Ulceration

2021 ◽  
Vol 11 (4-S) ◽  
pp. 9-14
Author(s):  
Priyanka Namdeo ◽  
Madhuri Pandole ◽  
Priti Singh
Keyword(s):  
Gastric Volume ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Root Extract ◽  
Total Acidity ◽  
Free Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
Pylorus Ligation ◽  
Berberis Lycium

Background: Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. The present study was carried out to evaluate the antiulcer activity of the methanolic root extract of Berberis lycium in albino rats. Method: The methanolic root extract of Berberis lycium was prepared by hot extraction method. Anti-ulcer activity was evaluated and method employed was pylorus ligation and ethanol induced in albino rats. Preliminary methanolic extract of Berberis lycium was subjected to the acute oral toxicity study according to the OECD guideline no. 425. Animals were divided into four groups of six animals each. The animals of Group I served as normal control (vehicle) which received distilled water. Group II and III received 250 mg/kg and 500 mg/kg of methanolic root extract, respectively. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for ethanol induced ulcer model. Group IV received Ranitidine at 50 mg/kg was used as the standard drug. Pretreatment of methanol root extract of Berberis lycium showed significant (P˂0.05) decrease in the gastric volume, total acidity and free acidity. However, pH of the gastric juice was significantly increased only at higher dose 500 mg/kg. It showed also significant (P˂0.05) decrease in number of ulcers and ulcer score index in pylorus ligation and ethanol induced ulceration models. Results: The methanol root extract of Berberis lycium showed a significant reduction in the total acidity, free acidity and acid volume. The efficacy of plant extract at high dose was comparable with the standard drug Ranitidine. Conclusion: Our study results support the ethnomedical use of root of Berberis lycium. Keywords: Antiulcer activity, Berberis lycium, Pylorus ligation, Ranitidine, Ulcer Index.

Evaluation of the Antiulcer Activity of Ethanolic Leave Extracts of Saraca indica against Ethanol, Pylorus Ligature and Indomethacin Induced Ulcer in Albino Rats

2020 ◽  
Vol 16 (8) ◽  
pp. 1191-1196
Author(s):  
Pritt Verma ◽  
Shravan K. Paswan ◽  
Vishal K. Vishwakarma ◽  
Priyanshi Saxena ◽  
Chandana V. Rao ◽  
...  
Keyword(s):  
Mucosal Injury ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Cellulose Solution ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
High Doses

Background: To evaluate the antiulcer activity of ethanolic leaves extract of Saraca indica against ethanol, pylorus ligature and indomethacin in albino rats. Materials and Methods: Ulcer was produced by ethanol, pylorus ligature and indomethacin in albino rats. Five groups (n=6) of rats were orally pre-treated with carboxymethyl cellulose solution, and ranitidine (80 mg/kg) respectively. In ethanol induced ulcer, the animals were treated with 200 and 400 mg/kg b.w. ethanolic leave extracts of Saraca indica in 0.3% CMC solution, 60 minutes before oral administration of absolute ethanol to produce gastric mucosal injury. In indomethacin induced ulcer, the drug was administered orally at the dose of 30 mg/kg b.w. After 7-9 hours of administration of indomethacin (30 mg/kg); the animals were sacrificed with high doses of anesthesia. In the pylorus ligature method, volume of free acidity, gastric secretion, pH and total acidity were estimated. In all three models, the ulcer index and % protection were estimated. Results: The anti ulcer activity of ethanolic leave extracts of Saraca indica in ethanol, indomethacin and pylorus ligature models is evident from the significant (P<0.001) reduction in ulcer index. In pylorus ligature model, significant (P<0.001) reduction in total acidity gastric volume and increase in pH were observed when compared with the standard drug. Conclusion: Ethanolic leave extracts of Saraca indica were found to be significantly protective against ethanol, indomethacin and pylorus ligature induced gastric ulcers in the experimental albino rats. The result obtained suggest that ethanolic leave extracts of Saraca indica possesses significant anti-ulcer activity.

scholarly journals Evaluation of anti-ulcer activity of 4-hydrooxy benzalydehide against NSAIDs induced ulcers in rats

2021 ◽  
Vol 9 (5) ◽  
pp. 1412
Author(s):  
Rupali V. Jadhav ◽  
V. K. Redasani ◽  
Shankar B. Kalbhare ◽  
Karishma Yadav ◽  
Aryan Langeh ◽  
...  
Keyword(s):  
Low Dose ◽  
Positive Control ◽  
Gastric Volume ◽  
Control Group ◽  
High Dose ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
The Impact ◽  
Intermediate Dose

Background: The aim of this study was to evaluate antiulcer activity of 4-hydroxybenzaldehyde against NSAIDs induced ulcer in rats based differences in its morphology, distance with other external landmarks and also to sigmoid and transverse sinuses.Methods: The antiulcer activity of 4-HBD was evaluated using pylorus ligation-aspirin induced ulcer method. Animals of this models were treated with 4-HBD (50mg/kg, 100mg/kg and 150mg/kg).Results: It has been observed that 4-HBD at low dose (50mg/kg), intermediate dose (100mg/kg) and high dose (150mg/kg) showed significant increase in pH, significant decrease in gastric volume, significant decrease in ulcer index and significant decrease in total acidity.Conclusions: The impact of 4-HBD therapy with intermediate (100mg/kg, p.o.) dose was observed to be similar with the positive control group.  

Pharmacological Evaluation of Saccharum Officinarum Linn. as Anti-ulcer Agent

2018 ◽  
Vol 4 (1-2) ◽  
Author(s):  
Preksha Dwivedi ◽  
Vikas Mishra ◽  
Vipul Agarwal ◽  
Talha Jawaid
Keyword(s):  
Gastric Ulcer ◽  
Gastric Content ◽  
Index Volume ◽  
Saccharum Officinarum ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Significant Protection ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
Plant Stem

The purpose of the study was to elucidate the antiulcer activity of stem of Saccharum Officinarum (Poaceae) in albino rats against aspirin induced gastric ulcer, ethanol induced gastric ulcer and pylorus ligation induced gastric ulcer models. Groups of rats were fasted overnight, received ranitidine (20 mg/kg) as a standard and plant stem juice extract at dose of 0.75 mL/100 gm and 1.5 mL/100 gm as a treatment against aspirin induced gastric ulcer, ethanol induced gastric ulcer and pylorus ligation induced gastric ulcer. The treatment produced significant protection of ulcer induced by aspirin, ethanol and pylorus ligation induced ulcer. The extract also reduced ulcer index, volume of gastric content, free and total acidity, suggesting that extract possesses significant anti-ulcer activity.

Assessment of Hepatoprotective and Antiulcer Activity of Launaea aspleniifolia Hook in Laboratory Animals

2020 ◽  
Vol 16 (5) ◽  
pp. 703-712
Author(s):  
Sadik Ali ◽  
AnupMaiti ◽  
Vishal Kumar Vishwakarma ◽  
Kumar Ajay
Keyword(s):  
Gastric Volume ◽  
Direct Bilirubin ◽  
Laboratory Animals ◽  
High Density Lipoproteins ◽  
Antiulcer Activity ◽  
Dependent Manner ◽  
Total Acidity ◽  
Protective Effects ◽  
Free Acidity ◽  
Dose Dependent

Background: Launaea aspleniifolia Hook (Family Asteraceae) is used traditionally in medicine in Indian system for the treatment of leucoderma. This study was conducted to evaluate the hepatoprotective and antiulcer effects using the methanolic extract of Launaea aspleniifolia Hook (MELA). Methods: The MELA in the dose of 200 and 400 mg/kg body weight (b.w.) was administered orally, daily for 7 days to prevent the acetaminophen-induced hepatotoxicity and peptic ulcer. In order to determine the antioxidant enzymes activity, various enzymatic parameters including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBL), direct bilirubin (DBL), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), high density lipoproteins (HDL), random glucose test (RBS), serum creatinine levels (SCL) and direct bilirubin (DBL) were determined. Further, the histopathology of tissue and various gastric secretion parameters like free acidity, total acidity ulcer score, % ulcer inhibition, gastric volume, pH, Na+ and K+ and histopathology were determined in PLinduced ulcer model. Results: MELA showed dose-dependent hepatoprotective and ulcer protective effect in acetaminopheninduced hepatotoxicity and antiulcer activity. Furthermore, tissue antioxidant parameter such as reduced Malondialdehyde (MDA), histopathology was also investigated. MELA was more potent in controlling all the serological parameter of liver like ALT, AST, TBL, DBL, ALP, HDL, RBS, SCL, TP and ALB in a dose-dependent manner (P<0.05) induced by Acetaminophen. Apart from this, antiulcer activity MELA was confirmed by the low level of ulcer index along with the reduction of free acidity, total acidity ulcer score, % ulcer inhibition, gastric volume, Na+ and an increase K+, pH of gastric content in a dose-dependent manner (P<0.05) induced PL model. Conclusion: The results indicated a significant dose-dependent effect of MELA from injuries induced in liver and stomach. These protective effects of MELA can be examined in various other toxicities as alone and in combinations.

scholarly journals Comparative evaluation of antiulcer activity of combination of extracts of Embilica officinalis Gaertn and Musa sapientum Linn in rats

2019 ◽  
Vol 10 (2) ◽  
pp. 1535-1539
Author(s):  
Keserla Bhavani ◽  
Gnanavel V ◽  
Ratna B ◽  
Jayakar B ◽  
Aanandan ◽  
...  
Keyword(s):  
Gastric Juice ◽  
Methanolic Extract ◽  
Gastric Volume ◽  
Antiulcer Activity ◽  
Total Acidity ◽  
Emblica Officinalis ◽  
Free Acidity ◽  
Ulcer Index ◽  
Musa Sapientum ◽  
Unripe Fruits

The present study is to evaluate the anti-ulcer activity of methanolic extract of unripe fruits of Musa Sapientum Linn. and the fresh juice of the fruits of Emblica Officinalis Gaertn in Wistar rats. The methanolic extract unripened fruits of Musa Sapientum Linn.  and the fresh juice of the fruits of Emblica Officinalis Gaertn were combined and evaluated for the gastroprotective activity by ethanol-induced model and indomethacin-induced model in rats at a dose of 25mg/kg (p.o) and 50mg/kg (p.o) respectively. Biochemical parameters like ulcer index, the volume of gastric juice, pH of gastric juice, free acidity and total acidity were studied. The unripe fruits of Musa and the fresh juice of Embilica will contain flavonoids, flavones, abscisic acid which shows a significant reduction in gastric volume, pH, free acidity, total acidity and ulcer index at the doses of 25mg/kg (p.o) and 50mg/kg (p.o). The results show that the unripe fruits 0f Musa Sapientum Linn. and fresh juice from the fruits of Emblica Officinalis Gaertn will combinedly possess greater antiulcer activity than that of the individual drugs.

scholarly journals Gastroprotective effect of leaves of Breyniavitis-Idaea

2020 ◽  
Vol 11 (2) ◽  
pp. 2519-2524
Author(s):  
Poojitha M ◽  
Saravanakumar A S ◽  
Satyanarayana S V
Keyword(s):  
Side Effects ◽  
Chemical Constituents ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Standard Drug ◽  
Synthetic Drugs ◽  
Pylorus Ligation ◽  
Dose Dependent ◽  
Ligation Method

Due to the lure backs of synthetic drugs that are being used medical field has turned over to the traditional medicine which are devoid of side effects and major adverse effects. So that Herbal drugs were seen as probable replacements for the handling of PUD without showing side effects and equaling the treatment efficacy. The literature review on investigations of antiulcer activity of various plant drug, the present investigation was carried out to investigate the antiulcer potential, chemical constituents present in the methanol extract of traditional plant Breyniavitis-idaea. Gastric ulcers in experimental animals were brought by four different models like  Ethanol(Alcohol)  induced, NSIDS (Indomethacin) induced, Pylorus ligation method and Cold resistant stress induced method by comparing with the standard drug namely omeprazole (20mg/kg) which exhibited the dose dependent capacity of the extract (125mg/kg,250mg/kg, 500mg/kg) and also the biochemical parameters like ALP, GSH, pH and Gastric volume contents were estimated in all the selected groups (Design of Experiment). The results obtained from the study has helped to identify that 500mg/kg of plant extract has gastro protective effect in all the chosen models in comparison to the omeprazole (20mg/kg) standard drug. Owing to the prevalence of different phytoconstituents like poly phenols and flavonoids shown the dose dependent potent gastroprotective activity.

ANTIULCER AND ANTI-INFLAMMATORY ACTIVITIES OF HYDROALCOHOLIC EXTRACTS OF STEM BARK AND LEAF OF ANOGEISSUS PENDULA EDGEW

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (01) ◽  
pp. 41-46
Author(s):  
Deeksha Singh ◽  
◽  
Amit Nayak ◽  
Rakesh Yadav ◽  
Uttam Singh Baghel ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Stem Bark ◽  
Inflammatory Activity ◽  
Antiulcer Activity ◽  
Paw Edema ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
Anti Inflammatory ◽  
Anogeissus Pendula

Anogeissus pendula Edgew has been reported to be used in gastric disorder even though no attempt has been made to evaluate the same. The present study was designed to evaluate the hydroalcoholic extracts of stem bark and leaves for in vivo acute antiulcer and anti-inflammatory activities. Antiulcer activity was studied by pylorus ligation induced ulcers while anti-inflammatory activities was studied by carrageenan induced paw edema. The extract of stem bark at 200 and 400 mg/kg b. w., significantly (P<0.05) reduced ulcer index whereas extracts of both stem bark and leaves significantly (P<0.001) reduced paw diameter at the fifth hour. The hydroalcholic extract of stem bark of A. pendula possesses more significant antiulcer and anti-inflammatory activity than the hydroalcholic extract of leaves may be due to the presence of higher amount of phenolic compounds.

scholarly journals Evaluation of anti ulcer activity of ethanolic root extract of Beta vulgaris in rats

2017 ◽  
Vol 6 (2) ◽  
pp. 359 ◽  
Author(s):  
K. Samyuktha ◽  
Krishna Mohan Chinnala ◽  
G. Prathiba ◽  
D. Rajendhar ◽  
P. Smana Reddy
Keyword(s):  
Beta Vulgaris ◽  
Maximum Dose ◽  
Antiulcer Activity ◽  
Root Extract ◽  
Alcoholic Extract ◽  
Free Acidity ◽  
Phytochemical Screening ◽  
Ulcer Index ◽  
Medicinal Uses ◽  
Pylorus Ligation

Background: Beta vulgaris (chenopodiacea) is a plant reported for its variety of ethnic medicinal uses. Hence we have planned to screen anti ulcer activity of root of the plant with the alcoholic extract. Root powders successively extracted with alcohol and were subjected for phytochemical screening to identify different phytoconstituents.Methods: Anti ulcer activity was evaluated in various animal models like pylorus ligation and ethanol induced ulcer models in rats.Results: Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, carbohydrates, saponins, polyphenols. No mortality was observed with root extract up to maximum dose level of 4g/kg. Further alcoholic extract of 200 and 400mg/ kg / p.o significantly (p˂0.01) reduced the ulcer score, ulcer number, ulcer index, free acidity and total acidity in pylorus ligation and ethanol induced ulcer models in rats.Conclusions: The present study revealed that the root extract of Beta vulgaris has antiulcer activity.

GASTRO-PROTECTIVE POTENTIAL OF FLOWERS OF HIBISCUS ROSA-SINENSIS (L.) IN MUCOSAL LESION ON RATS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (03) ◽  
pp. 25-31
Author(s):  
K. K Agrawal ◽  
A. Verma ◽  
K Singh ◽  
Keyword(s):  
Wistar Rats ◽  
Gastric Volume ◽  
Control Group ◽  
Phytochemical Screening ◽  
Protective Activity ◽  
Ulcer Index ◽  
Hibiscus Rosa Sinensis ◽  
Pylorus Ligation ◽  
Ethanolic Extracts ◽  
Ulcer Model

study was conducted to evaluate the gastro-protective activity of aqueous (HAE) and ethanolic (HEE) extracts of Hibiscus rosa-sinensis Linn. (Malvaceae) flowers in experimental animals. Aqueous and ethanolic extracts were investigated for pylorus ligation and indomethacin induced ulcer models in albino wistar rats. The pH, gastric volume, ulcer index, ulcer score and free and total acidity were determined by pylorus ligation induced ulcer model and ulcer score, ulcer index and percentage protection were determined by Indomethacin induced ulcer model. Phytochemical screening of aqueous and ethanolic extracts were conducted for and it showed that extracts have alkaloids, glycosides, tannins, flavonoids and mucilage. Both the extracts at dose of 200 and 400mg/kg showed significant (P<0.05) reduction in gastric volume (1.20±0.17, 0.83±0.20, 0.90±0.12, 0.96±0.17) and ulcer index (1.50±0.19, 1.33±0.11, 2.16±0.03, 0.75±0.17, 0.92±0.22, 0.31±0.04, 0.42±0.06, 0.19±0.04) as compared to the control group (1.47±0.15, 3.00±0.21, 1.64±0.13) in both of the models. It can be concluded that both the extracts possess gastro-protective activity that might be due the presence of flavanoids, tannins and/or mucilage.

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