scholarly journals Evaluation of anti ulcer activity of ethanolic root extract of Beta vulgaris in rats

2017 ◽  
Vol 6 (2) ◽  
pp. 359 ◽  
Author(s):  
K. Samyuktha ◽  
Krishna Mohan Chinnala ◽  
G. Prathiba ◽  
D. Rajendhar ◽  
P. Smana Reddy
Keyword(s):  
Beta Vulgaris ◽  
Maximum Dose ◽  
Antiulcer Activity ◽  
Root Extract ◽  
Alcoholic Extract ◽  
Free Acidity ◽  
Phytochemical Screening ◽  
Ulcer Index ◽  
Medicinal Uses ◽  
Pylorus Ligation

Background: Beta vulgaris (chenopodiacea) is a plant reported for its variety of ethnic medicinal uses. Hence we have planned to screen anti ulcer activity of root of the plant with the alcoholic extract. Root powders successively extracted with alcohol and were subjected for phytochemical screening to identify different phytoconstituents.Methods: Anti ulcer activity was evaluated in various animal models like pylorus ligation and ethanol induced ulcer models in rats.Results: Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, carbohydrates, saponins, polyphenols. No mortality was observed with root extract up to maximum dose level of 4g/kg. Further alcoholic extract of 200 and 400mg/ kg / p.o significantly (p˂0.01) reduced the ulcer score, ulcer number, ulcer index, free acidity and total acidity in pylorus ligation and ethanol induced ulcer models in rats.Conclusions: The present study revealed that the root extract of Beta vulgaris has antiulcer activity.

scholarly journals Antiulcerogenic effect of Methanolic Root Extract of Berberis lycium Linn by Pylorus ligation and Ethanol induced Ulceration

2021 ◽  
Vol 11 (4-S) ◽  
pp. 9-14
Author(s):  
Priyanka Namdeo ◽  
Madhuri Pandole ◽  
Priti Singh
Keyword(s):  
Gastric Volume ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Root Extract ◽  
Total Acidity ◽  
Free Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
Pylorus Ligation ◽  
Berberis Lycium

Background: Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. The present study was carried out to evaluate the antiulcer activity of the methanolic root extract of Berberis lycium in albino rats. Method: The methanolic root extract of Berberis lycium was prepared by hot extraction method. Anti-ulcer activity was evaluated and method employed was pylorus ligation and ethanol induced in albino rats. Preliminary methanolic extract of Berberis lycium was subjected to the acute oral toxicity study according to the OECD guideline no. 425. Animals were divided into four groups of six animals each. The animals of Group I served as normal control (vehicle) which received distilled water. Group II and III received 250 mg/kg and 500 mg/kg of methanolic root extract, respectively. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for ethanol induced ulcer model. Group IV received Ranitidine at 50 mg/kg was used as the standard drug. Pretreatment of methanol root extract of Berberis lycium showed significant (P˂0.05) decrease in the gastric volume, total acidity and free acidity. However, pH of the gastric juice was significantly increased only at higher dose 500 mg/kg. It showed also significant (P˂0.05) decrease in number of ulcers and ulcer score index in pylorus ligation and ethanol induced ulceration models. Results: The methanol root extract of Berberis lycium showed a significant reduction in the total acidity, free acidity and acid volume. The efficacy of plant extract at high dose was comparable with the standard drug Ranitidine. Conclusion: Our study results support the ethnomedical use of root of Berberis lycium. Keywords: Antiulcer activity, Berberis lycium, Pylorus ligation, Ranitidine, Ulcer Index.

ANTIULCER AND ANTI-INFLAMMATORY ACTIVITIES OF HYDROALCOHOLIC EXTRACTS OF STEM BARK AND LEAF OF ANOGEISSUS PENDULA EDGEW

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (01) ◽  
pp. 41-46
Author(s):  
Deeksha Singh ◽  
◽  
Amit Nayak ◽  
Rakesh Yadav ◽  
Uttam Singh Baghel ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Stem Bark ◽  
Inflammatory Activity ◽  
Antiulcer Activity ◽  
Paw Edema ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
Anti Inflammatory ◽  
Anogeissus Pendula

Anogeissus pendula Edgew has been reported to be used in gastric disorder even though no attempt has been made to evaluate the same. The present study was designed to evaluate the hydroalcoholic extracts of stem bark and leaves for in vivo acute antiulcer and anti-inflammatory activities. Antiulcer activity was studied by pylorus ligation induced ulcers while anti-inflammatory activities was studied by carrageenan induced paw edema. The extract of stem bark at 200 and 400 mg/kg b. w., significantly (P<0.05) reduced ulcer index whereas extracts of both stem bark and leaves significantly (P<0.001) reduced paw diameter at the fifth hour. The hydroalcholic extract of stem bark of A. pendula possesses more significant antiulcer and anti-inflammatory activity than the hydroalcholic extract of leaves may be due to the presence of higher amount of phenolic compounds.

GASTRO-PROTECTIVE POTENTIAL OF FLOWERS OF HIBISCUS ROSA-SINENSIS (L.) IN MUCOSAL LESION ON RATS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (03) ◽  
pp. 25-31
Author(s):  
K. K Agrawal ◽  
A. Verma ◽  
K Singh ◽  
Keyword(s):  
Wistar Rats ◽  
Gastric Volume ◽  
Control Group ◽  
Phytochemical Screening ◽  
Protective Activity ◽  
Ulcer Index ◽  
Hibiscus Rosa Sinensis ◽  
Pylorus Ligation ◽  
Ethanolic Extracts ◽  
Ulcer Model

study was conducted to evaluate the gastro-protective activity of aqueous (HAE) and ethanolic (HEE) extracts of Hibiscus rosa-sinensis Linn. (Malvaceae) flowers in experimental animals. Aqueous and ethanolic extracts were investigated for pylorus ligation and indomethacin induced ulcer models in albino wistar rats. The pH, gastric volume, ulcer index, ulcer score and free and total acidity were determined by pylorus ligation induced ulcer model and ulcer score, ulcer index and percentage protection were determined by Indomethacin induced ulcer model. Phytochemical screening of aqueous and ethanolic extracts were conducted for and it showed that extracts have alkaloids, glycosides, tannins, flavonoids and mucilage. Both the extracts at dose of 200 and 400mg/kg showed significant (P<0.05) reduction in gastric volume (1.20±0.17, 0.83±0.20, 0.90±0.12, 0.96±0.17) and ulcer index (1.50±0.19, 1.33±0.11, 2.16±0.03, 0.75±0.17, 0.92±0.22, 0.31±0.04, 0.42±0.06, 0.19±0.04) as compared to the control group (1.47±0.15, 3.00±0.21, 1.64±0.13) in both of the models. It can be concluded that both the extracts possess gastro-protective activity that might be due the presence of flavanoids, tannins and/or mucilage.

scholarly journals Evaluation of anti-ulcer activity of 4-hydrooxy benzalydehide against NSAIDs induced ulcers in rats

2021 ◽  
Vol 9 (5) ◽  
pp. 1412
Author(s):  
Rupali V. Jadhav ◽  
V. K. Redasani ◽  
Shankar B. Kalbhare ◽  
Karishma Yadav ◽  
Aryan Langeh ◽  
...  
Keyword(s):  
Low Dose ◽  
Positive Control ◽  
Gastric Volume ◽  
Control Group ◽  
High Dose ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
The Impact ◽  
Intermediate Dose

Background: The aim of this study was to evaluate antiulcer activity of 4-hydroxybenzaldehyde against NSAIDs induced ulcer in rats based differences in its morphology, distance with other external landmarks and also to sigmoid and transverse sinuses.Methods: The antiulcer activity of 4-HBD was evaluated using pylorus ligation-aspirin induced ulcer method. Animals of this models were treated with 4-HBD (50mg/kg, 100mg/kg and 150mg/kg).Results: It has been observed that 4-HBD at low dose (50mg/kg), intermediate dose (100mg/kg) and high dose (150mg/kg) showed significant increase in pH, significant decrease in gastric volume, significant decrease in ulcer index and significant decrease in total acidity.Conclusions: The impact of 4-HBD therapy with intermediate (100mg/kg, p.o.) dose was observed to be similar with the positive control group.  

scholarly journals Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat

2019 ◽  
Vol 7 (2) ◽  
pp. 59-61
Author(s):  
R. K. Gupta ◽  
Ravi Vishwakarma ◽  
Yashwant Giri ◽  
Varinder Singh
Keyword(s):  
Gastric Ulcer ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Gastric Volume ◽  
Gastric Ulceration ◽  
Antiulcer Activity ◽  
Free Acidity ◽  
Ulcer Index ◽  
Whole Plant ◽  
Symplocos Racemosa

Peptic ulcer is a condition which results from an imbalance between offensive and defensive factors of gastrointestinal system. The investigation was designed to evaluate the antiulcer activity of Symplocos racemosa whole plant methanol extract (MESR) in rat model of indomethacininduced gastric ulceration. The total acidity, gastric volume, pH and free acidity were measured to determine the anti-ulcer activity of MESR. Pretreatment with MESR (125-500 mg/kg) markedly reduced the indomethacin-induced increase in gastric ulcer index and score. These results revealed that antisecretory effects MESR were responsible for antiulcer activity of MESR.

Pharmacological Evaluation of Anti-ulcer Activity of Caesalpinia crista in Rats

2017 ◽  
Vol 10 (4) ◽  
pp. 3772-3779
Author(s):  
Kintu Patel ◽  
Bhagyabhumi Patel ◽  
Alkesh Patel ◽  
Samir Shah
Keyword(s):  
Inflammatory Cells ◽  
Control Group ◽  
Antiulcer Activity ◽  
Standard Group ◽  
Free Acidity ◽  
Rat Stomach ◽  
Ulcer Index ◽  
Standard Drug ◽  
Group Iii ◽  
Group I

In present study, we evaluated the antiulcer activity of the herbal preparation of Caesalpinia crista in rat models.  Experimental animals were divided into four groups. Rats of group I (disease control) treated with normal saline only, group II (standard group) treated with Omeprazole (2 mg/ kg; p.o.), group III and IV served as test groups and were treated with Caesalpinia crista extract (CE) in the dose of 250 mg/ kg and 500 mg/ kg orally respectively. Peptic ulcer was induced by ligating the pyloric portion of rat stomach and was done 45 min after the respective treatment. After 4 hour of pylorus ligation, rats were sacrificed. Parameters like ulcer index, percent ulcer protection, total and free acidity were estimated for evaluation of anti-ulcer activity. Histopathological evaluation was also performed. The aqueous extract of Caesalpinia crista seeds reduced the volume of gastric juice, free acidity, total acidity and ulcer index. It increased the pH of the gastric acid. Histopathology of the rat stomach revealed the presence of lesions and infiltration of inflammatory cells in control group. Moreover, animals treated with test drug and standard drug did not reveal any microscopic lesions. These findings suggest that Caesalpinia crista seeds may have anti-secretory and anti-ulcer activity and may be helpful for ulcer therapy. 

Pharmacological Evaluation of Saccharum Officinarum Linn. as Anti-ulcer Agent

2018 ◽  
Vol 4 (1-2) ◽  
Author(s):  
Preksha Dwivedi ◽  
Vikas Mishra ◽  
Vipul Agarwal ◽  
Talha Jawaid
Keyword(s):  
Gastric Ulcer ◽  
Gastric Content ◽  
Index Volume ◽  
Saccharum Officinarum ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Significant Protection ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
Plant Stem

The purpose of the study was to elucidate the antiulcer activity of stem of Saccharum Officinarum (Poaceae) in albino rats against aspirin induced gastric ulcer, ethanol induced gastric ulcer and pylorus ligation induced gastric ulcer models. Groups of rats were fasted overnight, received ranitidine (20 mg/kg) as a standard and plant stem juice extract at dose of 0.75 mL/100 gm and 1.5 mL/100 gm as a treatment against aspirin induced gastric ulcer, ethanol induced gastric ulcer and pylorus ligation induced gastric ulcer. The treatment produced significant protection of ulcer induced by aspirin, ethanol and pylorus ligation induced ulcer. The extract also reduced ulcer index, volume of gastric content, free and total acidity, suggesting that extract possesses significant anti-ulcer activity.

scholarly journals Antiulcer Activity of Methanolic Extract of Roots of Beta vulgaris, Chenopodiaceae

2018 ◽  
Vol 10 (6) ◽  
Author(s):  
Manoj Jagannath Jagtap ◽  
Amol Bhalchandra Deore
Keyword(s):  
Beta Vulgaris ◽  
Restraint Stress ◽  
Methanolic Extract ◽  
Gastric Lesion ◽  
Abnormal Behavior ◽  
Antiulcer Activity ◽  
Phytochemical Screening ◽  
Cold Restraint Stress ◽  
Pyloric Ligation ◽  
Cold Restraint

Beta vulgaris (chenopodiacea) is a medicinal plant reported for its variety of ethnic medicinal uses. Beta vulgaris showed antioxidant, anticancer, hepatoprotective, nephroprotective, wound healing, and anti-inflammatory activities. Hence we have planned to screen antiulcer activity of root of the plant with the methanolic extract. Root powders successively extracted with methyl alcohol and were subjected for phytochemical screening to identify different phytoconstituents. The methanolic extracts of roots of Beta vulgaris were investigated for ulcer protective activity against pyloric-ligation, ethanol induced gastric lesion and cold restraint stress induced ulcers. Preliminary phytochemical screening revealed the presence of flavonoids, saponins, sterols, and alkaloids. The extract was tested for their lethal effect up to the dose level of 2000 mg/kg. None of them have produced abnormal behavior or mortality in rats. Further methanolic extract of 200 and 400 mg/kg/p.o significantly (p˂0.01) reduced the ulcer score, ulcer number, ulcer index, free acidity and total acidity in pyloric-ligation, ethanol induced gastric lesion and cold restraint stress induced ulcer models in rats. The present study revealed that the root extract of Beta vulgaris has antiulcer activity.

scholarly journals Comparative evaluation of antiulcer activity of combination of extracts of Embilica officinalis Gaertn and Musa sapientum Linn in rats

2019 ◽  
Vol 10 (2) ◽  
pp. 1535-1539
Author(s):  
Keserla Bhavani ◽  
Gnanavel V ◽  
Ratna B ◽  
Jayakar B ◽  
Aanandan ◽  
...  
Keyword(s):  
Gastric Juice ◽  
Methanolic Extract ◽  
Gastric Volume ◽  
Antiulcer Activity ◽  
Total Acidity ◽  
Emblica Officinalis ◽  
Free Acidity ◽  
Ulcer Index ◽  
Musa Sapientum ◽  
Unripe Fruits

The present study is to evaluate the anti-ulcer activity of methanolic extract of unripe fruits of Musa Sapientum Linn. and the fresh juice of the fruits of Emblica Officinalis Gaertn in Wistar rats. The methanolic extract unripened fruits of Musa Sapientum Linn.  and the fresh juice of the fruits of Emblica Officinalis Gaertn were combined and evaluated for the gastroprotective activity by ethanol-induced model and indomethacin-induced model in rats at a dose of 25mg/kg (p.o) and 50mg/kg (p.o) respectively. Biochemical parameters like ulcer index, the volume of gastric juice, pH of gastric juice, free acidity and total acidity were studied. The unripe fruits of Musa and the fresh juice of Embilica will contain flavonoids, flavones, abscisic acid which shows a significant reduction in gastric volume, pH, free acidity, total acidity and ulcer index at the doses of 25mg/kg (p.o) and 50mg/kg (p.o). The results show that the unripe fruits 0f Musa Sapientum Linn. and fresh juice from the fruits of Emblica Officinalis Gaertn will combinedly possess greater antiulcer activity than that of the individual drugs.

scholarly journals Essential Oils Derived from Momordica charantia Seeds Exhibited Antiulcer Activity against Hydrogen Chloride/Ethanol and Indomethacin

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Nurul 'Ain Abu Bakar ◽  
Muhammad Nazrul Hakim Abdullah ◽  
Vuanghao Lim ◽  
Yoke Keong Yong
Keyword(s):  
Essential Oil ◽  
Scientific Basis ◽  
Momordica Charantia ◽  
Antiulcer Activity ◽  
Ulcer Formation ◽  
Medicinal Uses ◽  
Pylorus Ligation ◽  
Etoh Solution ◽  
Epithelial Disruption

Momordica charantia (MC) is popular for its medicinal uses especially for treating diabetic-related complications. However, the antiulcer activity of essential oil derived from the seeds has not been systematically studied. This study aims to evaluate the gastroprotective activities of essential oil derived from the seed of MC induced by hydrochloride acid/ethanol (HCl/EtOH) and indomethacin and pylorus-ligation model. Gastric ulceration was induced by oral administration of HCl/EtOH solution or indomethacin on day 7 after animals have been pretreated with testing compounds. The first group received just distilled water and the second group received ranitidine (100 mg/kg). Groups 3, 4, and 5 received 10, 50, and 100 mg/kg of essential oil based on their body weight (10 mL/kg), respectively. Macroscopically, pretreatment of essential oil extracted from MC significantly decreased ulceration induced by HCl/EtOH and indomethacin in vivo. Microscopically, essential oil also significantly suppressed the formation of edema, epithelial disruption, and mucosa erosions. Moreover, essential oil significantly elevated the pH without decreasing the total acidity of the gastric juice and was able to increase the amount of adherent mucus compared to control. Current results provide scientific basis to the ethno-pharmacological usage of the MC in preventing ulcer formation induced by HCl/EtOH and indomethacin.

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