Comparison of Antihyperlipidemic Activity Temu Mangga’s Rhizomes and Ketepeng Cina’s Leaves Infusion

Statins are first line therapy of antihyperlipidemia. It reduced LDL levels more than 50%. However, a serious side effects such as rhabdomyolisis which can lead to kidney failure. On other side, people often consumed boiled water of Temu Mangga’s Rhizome and/or Ketepeng Cina’s Leeaves as antihyperlipidemic. Both of them has a potential as adjuvant therapy. Purpose: To compare antihyperlipidemic activity of Temu Mangga’s Rhizome and Ketepeng Cina’s Leaves as alternative treatment. Method : Test animals were induced with High Fat Diet Food (HFDF) for the first 15 days, and with Temu Mangga’s Rhizome and Ketepeng Cina’s Leaves for the next 15 days. Study group: Simvastatin (positive control), Na CMC 0.5% (negative control), 450 mg/Kg BW; 900 mg/Kg BW; 1.800 mg/Kg BW of Temu Mangga’s Rhizome and 225 mg/Kg BW; 450 mg/Kg BW; and 900 mg/Kg BW Ketepeng Cina’s Leaves. Results: Temu Mangga 360 mg/200 gram BW was not significantly different from positive control in reducing total cholesterol, triglycerides, LDL and increasing HDL. Ketepeng Cina’s Leaves 180 mg/200 gram BW had the best effect, but it was not comparable to the positive control. Conclusion: 1.800 mg/Kg BW Temu Mangga’s Rhizome showed better antiyperlipidemic activity than 900 mg/Kg BW Ketepeng Cina’s Leaves.

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The Comparison of Bay Leaf and Celery Leaf Infusion Effect on Decreasing LDL Level in Dyslipidemic Wistar Rats Model

Journal of Agromedicine and Medical Sciences ◽

10.19184/ams.v1i1.1700 ◽

1970 ◽

Vol 1 (1) ◽

pp. 21

Author(s):

Anjani Putri Retnaninggalih ◽

Erfan Efendi ◽

Hairrudin Hairrudin

Keyword(s):

Cholesterol Level ◽

High Fat Diet ◽

Wistar Rats ◽

Ldl Cholesterol ◽

Wistar Rat ◽

Positive Control ◽

Negative Control ◽

High Fat ◽

Leaf P ◽

One Way Anova

Coronary heart disease (CHD) is the cause of 7,3 million death globally in 2008. The main pathophysiology process that leads to CHD is atherosclerosis which is caused by high LDL cholesterol level. The aim of this study was to explore bay leaf and celery leaf infusion effect on reducing LDL cholesterol level in dyslipidemic rat model. The type of this study was true experimental research using wistar rat (Rattus novergicus) as the sample. The rats were induced by high fat diet and PTU for two weeks then each of the group were given either bay leaf infusion, celery leaf infusion, simvastatin (positive control), or aquadest (negative control) for a week. The measurement of LDL level used Friedewald formulation. Data was analyzed using paired sample t test and one way ANOVA. As the result there was a significance reduction on LDL level after treatment with bay leaf (p=0,013) and celery leaf infusion (p=0,035) but there was no significance difference between groups (p=0,293). It was concluded that bay leaf and celery leaf infusion could reduce the LDL level in dyslipidemic wistar rat but there was no difference on the capability of the two different leafs on reducing LDL level. Keywords: dyslipidemia, LDL, bay leaf, celery leaf, wistar rats

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PENGARUH PEMBERIAN JUS BUAH BELIMBING WULUH (AVERRHOA BILIMBI L.) TERHADAP KADAR KOLESTEROL LDL DARAH TIKUS PUTIH (RATTUS NORVEGICUS) JANTAN GALUR WISTAR DENGAN DIET TINGGI LEMAK

Jurnal Ilmiah Kedokteran Wijaya Kusuma ◽

10.30742/jikw.v8i2.572 ◽

2019 ◽

Vol 8 (2) ◽

pp. 35-41

Author(s):

Kartika Dwi Rahminiwati ◽

◽

IGM Antara Hambarsika ◽

Fitri Handajani ◽

◽

...

Keyword(s):

Cholesterol Level ◽

High Fat Diet ◽

Ldl Cholesterol ◽

Positive Control ◽

Negative Control ◽

Positive Control Group ◽

Control Group ◽

High Fat ◽

Cholesterol Levels ◽

The Mean

A high-fat diet can increase lipoprotein levels, total cholesterol, (Low Density Lipoprotein) LDL, and triglycerides. Starfruit has saponin and flavonoid compounds which are expected to reducing LDL cholesterol levels. The aim of the study was to determine the effect of starfruit juice on lowering the blood cholesterol LDL of Wistar rats fed with high-fat diet. Experimental study with post-test only control group design. As many as 24 male white rats from the Wistar strain were divided into 3 groups: negative control groups (K-) that were given standard feed for 28 days; positive control group (K+) who were given a high-fat diet for 28 days; the treatment group (KP) was given a high-fat diet for 28 days and on the 15th day 28th they were given a starfruit juice with a dose of 4ml / 200grBB / day. Day 29 measured LDL cholesterol. The statistic test showed a significant increase in LDL cholesterol levels (p=0.001) in the positive control group (x=12.125±2.642 mg/dL) compared to the negative control group (x=7.625±1.506 mg/dL). There was no significant different the mean cholesterol level of the treatment group (x=11±1.927) compared to the mean LDL cholesterol level of the positive control group (x=12.125±2.642). A high-fat diet significantly increases the mean LDL cholesterol level. Starfruit juice did not significantly reduce LDL cholesterol level.

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Effect of Kepok Banana Peel Extract (Musa spp.) on the Number of Pituitary Basophil Cells in Rats (Rattus norvegicus) with High-Fat Diet

E3S Web of Conferences ◽

10.1051/e3sconf/202015101063 ◽

2020 ◽

Vol 151 ◽

pp. 01063

Author(s):

Nora Usrina ◽

Muslim Akmal ◽

Rinidar Rinidar ◽

Mustafa Sabri ◽

Gholib Gholib

Keyword(s):

Rattus Norvegicus ◽

High Fat Diet ◽

Household Consumption ◽

Positive Control ◽

Negative Control ◽

Male Rats ◽

Banana Peel ◽

High Fat ◽

Group 3 ◽

Peel Extract

Banana peels are the outer envelopes of banana fruits as the by-product of household consumption and banana processing. Kepok banana peel contains bioactive compounds that function as antioxidants which reduce the effects of free radicals. This research was conducted to determine the effect of giving Kepok banana peel extract on the number of basophilic cells in rats with a high-fat diet. The study used 25 male rats aged 2.5-3 months old, which alloted into 5 groups with 5 rats each. The first group was fed on standard feed (K1, positive control), while the second group given high-fat diet (K2, negative control). The rats in group 3, 4, and 5 were given high-fat diet + vitamin C (K3), high-fat diet + 100 mg/kg BW banana peel extract (K4), and high-fat diet + 200 mg/ kg BW banana peel extract (K5), respectively. A sample of the pituitary gland was collected after 60 days of the treatment. The data were analyzed using one way analysis of variance (ANOVA) followed by the Duncan test. The results of this study indicated that the administration of Kepok banana peel extract at a dose of 100 mg/kg BW can maintain the number of basophilic cells, whereas at dose of 200 mg/kg BB has the potential to reduce the number of basophilic cells in rats fed high-fat feed.

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Pengaruh Pemberian Ekstrak Buah Naga Merah (Hylocereus polyrhizus) Terhadap Gambaran Spermatogenesis Tikus Putih (Rattus norvegicus) Galur Wistar yang Diinduksi Pakan Tinggi Lemak

Jurnal Profesi Medika Jurnal Kedokteran dan Kesehatan ◽

10.33533/jpm.v13i2.780 ◽

2019 ◽

Vol 13 (2) ◽

Author(s):

Yara Cantika ◽

Cut Fauziah ◽

Yuni Setyaningsih

Keyword(s):

High Fat Diet ◽

Positive Control ◽

Negative Control ◽

Diet Group ◽

P Value ◽

Standard Diet ◽

High Fat ◽

Long Term Treatment ◽

Group 5 ◽

Hylocereus Polyrhizus

Spermatogenesis can be affected by oxidative stress produced by the increasing of pro-inflammatory adipokines because of high fat diet.The spermatogenesis cells damaged can be prevented with natural substance such as red pitaya (Hylocereus polyrhizus). This study aims to analyze effect of Hylocereus polyrhizus extract on rat’s spermatogenesis cells number that induced by high fat diet. This study had used true-experiment design. 30 rats were divided into 5 groups. Groups 1 to 4 had done treatment for 52 days and group 5 treatment for 104 days. Group 1 Negative control (K1) administered with standard diet, group 2 Positive control (K2) had administered quail egg 10ml/KgBW, group 3 Experiment 1 (P1) had administered quail egg polyrhyzus 10ml/Kg BW and with simvastatin 0,72mg/day, group 4 Experiment 2 (P2) had administered quail egg 10ml/KgBW and wth Hylocereus polyrhizus extract 60mg/day in 52 days, and group 5 Experiment 3 (P3) had administered quail egg 10ml/KgBW and with Hylocereus polyrhizus extract 60mg/day in 104 days. Data were analyzed by One Way ANOVA and continued with Post Hoc Tukey’s HSD (P-Value=0,05) for 52 day groups. Group P1 and P2 showed repairing effect and increasing spermatocytes and spermatids (p.000<0,05) compared to group K2. Group P2 had more spermatids and spermatocytes than group P1 (p.000<0,05). Group P2 52 days’ spermatid cells equalled to group P3 104 days (p.469>0,05). Hylocereus polyrhizus extract not only had mechanism like simvastatin but also contained antioxidant, and a long-term treatment had not proven bad effect to spermatogenesis cells. Conclusion. Hylocereus polyrhizus extract 60mg/day can repair and increase spermatogenesis cells induced with high fat diet.

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Protective effect of ethanolic Feronia elephantum Correa fruit extract on high-fat diet induced steatohepatitis in rats

Zinc supplementation improves heme biosynthesis in rats exposed to lead ◽

10.18051/univmed.2021.v40.36-44 ◽

2021 ◽

Vol 40 (1) ◽

pp. 36

Author(s):

Maruni Wiwin Diarti ◽

Khoviya Yuwina Selinada Harmi ◽

Dwi Nur Ahsani

Keyword(s):

High Fat Diet ◽

Histopathological Examination ◽

Morphological Changes ◽

Positive Control ◽

Negative Control ◽

High Fat ◽

Fruit Extract ◽

Serum Glutamic Oxaloacetic Transaminase ◽

Male Wistar Rats ◽

Feronia Elephantum

BACKGROUND A high-fat diet can lead to hyperlipidemia which will end up as liver damage (steatohepatitis). Ethanolic Feronia elephantum Correa fruit extract (EFEC) has an antioxidant activity which is expected to overcome hyperlipidemia in the liver. The objective of this study was to determine the effects of EFEC on liver function and morphological changes in rats. METHODS This was an experimental study with a post-test only group design. A total of 20 male Wistar rats aged 2-4 months were randomized into 5 groups, A= negative control, B= positive control (high fat diet + 10 mg/kgBW simvastatin), C = high fat diet + 500 mg/kgBW EFEC fruit extract, D = high fat diet + 600 mg/kgBW EFEC, and E = high fat diet + 700 mg/kgBW EFEC). High-fat diet was given for 4 weeks (quail egg yolks, 10ml/200gBW). EFEC was administered for 4 weeks after induction of hypercholesterolemia. Examination of liver serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) was performed on rat blood serum and histopathological examination was carried out using steatohepatitis grading. One way ANOVA test and Post-Hoc Tamhane’s test were used to analyze the data. RESULTS Administration of EFEC at 700 mg/kgBW improved the liver enzymes (p=0.00 for SGPT and SGOT) and steatohepatitis grading in high-fat diet induced rats (mild condition, E = 75% vs A = 100% mild) CONCLUSION Ethanolic Feronia elephantum Correa fruit extract at 700 mg/kgBW was able to improve steatohepatitis in high-fat diet induced rats.

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Kidney stone treatment

10.1093/med/9780199659579.003.0022 ◽

2017 ◽

Author(s):

Andreas Neisius ◽

Michael E. Lipkin ◽

Glenn M. Preminger

Keyword(s):

Percutaneous Nephrolithotomy ◽

High Volume ◽

Renal Calculi ◽

Treatment Method ◽

First Line ◽

First Line Therapy ◽

Preventative Measures ◽

Line Therapy ◽

Stone Treatment ◽

Current Guidelines

Following the first large cohort of percutaneous nephrolithotomy (PCNL) reported by Alken in 1981, PCNL has subsequently become the preferred treatment method for large and/or complex renal and large proximal ureteral calculi. Current guidelines recommend PCNL as first-line therapy for all renal calculi ≥20 mm and for lower pole stones ≥15 mm. In this chapter we review the current indications, techniques, and outcomes of PCNL. Nowadays stone-free rates of approximately 70% overall can be achieved with PCNL, while at experienced high-volume centres, stone-free rates can approach 100%. While generally percutaneous nephrolithotomy has low morbidity, nonetheless significant complications can occur and the diagnosis, treatment, and preventative measures of these complications are presented in this chapter.

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Pemberian Ekstrak Buah Pare dan Diet Tinggi Lemak pada Penurunan Berat Badan Tikus Putih Jantan

Hang Tuah Medical journal ◽

10.30649/htmj.v17i1.185 ◽

2019 ◽

Vol 17 (1) ◽

pp. 60

Author(s):

I MADE SUBHAWA HARSA

Keyword(s):

Rattus Norvegicus ◽

High Fat Diet ◽

Negative Control Group ◽

Positive Control ◽

Negative Control ◽

Momordica Charantia ◽

Control Group ◽

Bitter Melon ◽

High Fat ◽

White Rats

<div class="Section1">AbstractBackground : Obesity is an energy balance disorder, ketogenic diet can reduce body weight. Bitter melon (Momordica charantia L.) is a type of vegetable material that is often used as an antioxidant, hypocholesterolemia and hypotriglyceridemia drug. Cucurbitasin is a substance produced by bitter melon (Momordica charantia L.) with a bitter taste which causes in decreasing appetite, resulting in a decrease in triglycerides. This is caused by the bioactivity of bitter melon (Momordica charantia L.) which can increase lipid oxidation, which causes the accumulation of decreased fat tissue which can reduce weight.Methods: This research using pre and post test randomized controlled group design with sample size of 30 male white rats (Rattus norvegicus) wistar lines divided into 3 groups, group 1 as negative control group given standard feed, group 2 as positive control group given high-fat diet with a dose of 2.5 ml and group 3 as a treatment group given a high-fat feed with dose of 2.5 ml and extract of bitter melon (Momordica charantia L.) at dose of 37.5 mg / 150 gBB by feeding tube every morning for 28 days. Data were analyzed by T-paired tests.Result: The T-paired test in each group found a significantly different result of p = 0,000.Conclusion: given bitter melon (Momordica charantia L.) extract and high-fat diet can reduce weight in male white rats (Rattus norvegicus). Keywords:Bitter molon extract, high fat feed, weight loss. </div>

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Ekstrak Kulit Pisang Kepok (Musa paradisiaca) Menurunkan Kadar AST pada Tikus Putih yang Diinduksi Diet Tinggi Lemak

Hang Tuah Medical journal ◽

10.30649/htmj.v18i2.513 ◽

2021 ◽

Vol 18 (2) ◽

pp. 172

Author(s):

STEFANUS DJONI HUSODO ◽

INDRI NGESTI RAHAYU ◽

ASAMI RIETTA KUMALA

Keyword(s):

High Fat Diet ◽

Negative Control Group ◽

Positive Control ◽

Negative Control ◽

Banana Peel ◽

Control Group ◽

High Fat ◽

Musa Paradisiaca ◽

Peel Extract ◽

K2 Group

Background. Non-alcoholic fatty liver disease (NAFLD) causes many health problems in overweight person. There is an increase in the incidence of NAFLD with the increased incidence of metabolic syndrome. NAFLD is closely related to the incidence of obesity and dyslipidemia. Increased levels of AST and ALT are the most frequently performed liver function tests that can be used as a benchmark for suspicion of NAFLD. Banana peels contain flavonoids and phenolics which are antioxidants that can function as hepatoprotectors.Aim. Proving the effect of Kepok banana peel extract (Musa paradisiaca formatypica) on AST and ALT of Wistar rats induced high fat diet.Method. A laboratory experimental study with a post-test only control group design, with four treatment groups. There is one negative control group only given four weeks standard diet, one positive control group only given four weeks high-fat diet, and two treatment group where the rats were given two weeks high-fat diet then were given two weeks high-fat diet plus Kepok banana peel extract at a dose of 200 mg/kg BW and 400 mg/kg BW.Result. Based on the results of descriptive analysis, the highest mean AST levels were in the negative control group and the lowest was the K2 group. Meanwhile, the highest mean of ALT was in the positive control group and the lowest was the K2 group. Based on the Kruskal Wallis test, the significance of the AST variable was not different (p>0.05), but the ALT variable was significantly different (p<0.05). Significant differences from the Mann Whitney-U test (p<0.05) were obtained between the negative control group and the positive control, the negative control group with K2 and the positive control group with the K2 group).Conclusion. The administration of Kepok banana peel extract (Musa paradisiaca formatypica) showed a significant decrease in ALT levels in Wistar strain white rats induced by a high-fat diet, but it was not significant for AST levels.

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