Rate of HCV Seroconversion And Its Associated Factors In Hemodialysis Patients

2021 ◽  
Vol 15 (7) ◽  
pp. 1653-1656
Author(s):  
Muhammad Usman Javaid ◽  
Azhar Ali Khan ◽  
Mateen Akram ◽  
Muhammad Asif ◽  
Nasir Iqbal ◽  
...  

Background: CKD is a worldwide public health problem. HCV is the most frequent complication of patients on hemodialysis, it is very important to screen patients for HCV seropositivity, asit may lead to severe liver disease, complications in renal transplant and death. Aim: To find the incidence of HCV seropositivity and identify factors associated with hemodialysis patients at the Dialysis Center. Methodology: A Retrospective Cohort study conducted at Hemodialysis Unit, Sheikh Zayed Hospital, Lahore from January 2015 to December 2015. Secondary data was collected from all the record files of all the patients included in the study available at Sheikh Zayed hospital. Data was also collected by a questionnaire from patient to determine different variables. Data for age, gender, HCV seroconversion, number of transfusions, emergency dialysis at any other hemodialysis center, surgeries, previous history of HCV, dialyzer reuse and dental procedure etc. was collected and patients were divided in two groups according to HCV status at the end of study. Data for seroconversion was studied for relation with given risk factors using Chi-square test and odds ratios with 95% confidence interval. Binary logistic regression was used to see the adjusted odds ratio of various risk factors for seroconversion. P-value ≤0.05 was considered significant. Results: The mean age of the patients was 43.40±16.37 years. The frequency of previous transfusions was 120(48%) The frequency of emergency dialysis outside Shaikh Zayed Hospital was 76(30.4%). The frequency of surgeries was 126(50.4%). The frequency of dental procedures was 102(40.8%). The mean duration of dialysis was 17.6±5.73. The incidence of HCV seroconversion in hemodialysis patients was 124(49.6%). Conclusion: We concluded that the incidence of HCV seroconversion in hemodialysis patients was 8.2% per year and over a period of six years nearly 49.6% who were undergoing dialysis in our dialysis center. Keywords: HCV seroconversion, hemodialysis patients

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Federica Urciuolo ◽  
Nicola Panocchia ◽  
Alessandro Naticchia ◽  
Viola D'Ambrosio ◽  
Silvia Barbarini ◽  
...  

Abstract Background and aim COVID-19 (COronaVIrus Disease 19) is an acute respiratory disease caused by SARS CoV 2 virus. The correlation between SARS-CoV2 infection and comorbidities is complex; patients with multiple comorbidities present often with the most severe symptoms that could potentially lead to death. Patients undergoing hemodialysis are generally frail and immunodeficient. This leads to a greater risk of contracting infectious diseases. In the literature, the estimated incidence of SARS-CoV2 infection is 3.24% in chronic hemodialysis patients. Method Fondazione Policlinico A. Gemelli is a COVID hospital. During the pandemic patients from several dialysis centers converged in our hospital. FPG has two dialysis centers, one for outpatients and one for inpatients. Patients admitted for COVID-19 infection have been treated in three different settings: 1. isolation room within the dialysis center; 2. Bedside; 3. In a COVID-19 dialysis center. We retrospectively collected data of patients treated from March 2020 to January 2021 and analyzed the SARS-CoV2 incidence in our center’s chronic hemodialysis patients. Results 66 hemodialysis patients affected by COVID-19 have been treated in our hospital from March 2020 to January 2021, 60 patients undergoing chronic dialysis and 6 patients diagnosed with acute kidney injury (AKI) stage III non-intensive care unit. Among chronic patients, 64 underwent chronic hemodialysis and 2 patients underwent peritoneal dialysis. Median age was 68.19 (46 males, 20 females), all patients had multiple comorbidities: 37.8% of patients had diabetes mellitus; 72.7% cardiovascular diseases and 16.6% a positive clinical history for cancer. Among the 6 AKI cases, 3 patients regained total kidney function; the other 3 had to continue renal replacement therapy. The mean hospital stay length was 18.5 days with a mean time of COVID-19 infection of 21.23 days. The overall mean Charlson Comorbidty Index was 6.21. Among the 66 treated patients, 43 were diagnosed with COVID-19-related pneumonia, 14 had the infection, no pulmonary involvement, but presented with other complications, and 5 patients resulted positive although asymptomatic. Among the 116 hemodialysis outpatients, only 4 presented with SARS-CoV2 infection, 3 were contacts of a positive family member and 1 resulted positive during a hospital stay for Clostridium Difficile infection. All patients required hospitalization. 14 (21%) patients died. Among the deceased patients, the mean age was 76.90 years (9 males, 3 females), mean Charlson Comorbidity Index was 7.3, mean hospital stay length was 9 days. Among patients who survived the disease the mean age was 76.92 years (34 males, 14 females), mean Charlson Comorbidty Index was 5.87 and mean hospital stay length was 19.47 days. Statistical significance was reached for age (p value 0.005) and Charlson Comorbidty Index (p value 0.39), but not for mean hospital stay length (p value 0.13). All COVID-19 patients were treated with bicarbonate hemodialysis and a Theranova 400 Baxter® filter. This filter was chosen for its efficiency on medium-size molecules removal (between 25 kDa and 60 kDa) that may be associated with inflammation. Bedside treatments were performed using the Genius© Fresenius system. Each treatment lasted 180 minutes, in order to reduce the time of exposure to COVID-19 of medical staff and the risk of virus spread on one hand, but still ensuring an optimal and complication-free treatment to patients. Conclusion Our experience seems to confirm the national data collected so far, both in terms of patients’ outcomes and mortality rate. Our study confirms that age is a risk factor for mortality. How to properly manage chronic hemodialysis patients affected by COVID-19 remains a challenging and burdensome question. However, there is the need of new flexible solutions that guarantee the patients and the medical staff’s safety on one hand and a personalized management on the other.


Author(s):  
I. Gusti Ayu Putu Putri Ulandari ◽  
Putu Dyah Widyaningsih

Background: Coronavirus disease-2019 (COVID-19) is a novel coronavirus type infection disease that was first reported at Wuhan city, Hubei province, China in December 2019. Cases of COVID-19 in Indonesia were increasing, reaching up to 287,008 confirmed cases on 30th September 2020. Sanjiwani general hospital Gianyar, Bali, one of the COVID-19 referral hospital at Gianyar, Bali, has treated as many as 149 confirmed COVID-19 cases from August to October 2020. The most significant laboratory parameter associated with COVID-19 severity was C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR).Methods: This study is a descriptive cross-sectional study. Data were gathered through secondary data from the medical records using the total sampling method. Descriptive analyses were performed to describe the samples characteristics and to calculate the mean CRP level. Meanwhile, the chi-square test was done to investigate the association between CRP level and the severity level of COVID-19. The result is considered statistically significant if the p value is <0.05Results: Most of the samples are >60 years old (24.4%), female (56.6%), and have diabetes mellitus as their comorbid (46,7%). The mean CRP level is 8.9 mg/L. CRP level >8.9 mg/l significantly affects COVID-19 patients’ severity with the p value of 0.000 (p<0.005). The higher the initial CRP level of COVID-19 patients, the higher the severity level will be.Conclusions: There is an association between the increased CRP level at the beginning of hospital admission and the severity of COVID-19 patients.


2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Marsanto Adi Nurcahyo ◽  
Aditya Subur Purwana

ABSTRACT:Anti-dumping on tinplate products aim to protect domestic industries. Still, some industries want tinplate products not to be subject to anti-dumping because domestic production is not sufficient. This research examines the application of anti-dumping import duties on tinplate products from China, Taiwan, and Korea from 2014 to 2018, to know whether there are differences in the value of imports before and during the anti-dumping import duty. Use secondary data sourced from UN-Comtrade. Samples are selected by countries that have continuously sent tinplate products to Indonesia from 2010 to 2018, namely China, Taiwan, Korea, Japan, Germany, India, and Malaysia. Using the Mean Equality Test, it is known that there are differences in the import value before and during the anti-dumping import duty, with a p-value of 0.0114 less than α (0.05), so it is concluded that there is a difference in the import value of the tinplate product before and during anti-dumping duty. Descriptive analysis results illustrate imports from China and Taiwan tend to decrease. In contrast, imports from Korea tend to increase despite being subjected to anti-dumping duties because they can compete by using preferential tariffs based on free trade schemes.Keywords: Antidumping, Import duty, TinplateABSTRAK:Anti-dumping terhadap produk tinplate bertujuan melindungi industri dalam negeri, akan tetapi terdapat ìndustri yang menginginkan produk tinplate tidak dikenakan anti-dumping karena produksi dalam negeri belum mencukupi. Penelitian ini menguji penerapan bea masuk anti-dumping terhadap produk tinplate dari China, Taiwan dan Korea selama tahun 2014 s.d. 2018, dengan tujuan mengetahui apakah ada perbedaan nilai importasi sebelum dan selama dikenakan bea masuk anti-dumping. Menggunakan data sekunder yang bersumber dari UNComtrade. Sampel dipilih negara yang secara kontinyu mengirim produk tinplate ke Indonesia sejak 2010 s.d. 2018, yaitu China, Taiwan, Korea, Jepang, Jerman, India dan Malaysia. Menggunakan Mean Equality Test, diketahui terdapat perbedaan nilai importasi sebelum dengan selama dikenakan bea masuk anti-dumping. Hasil penelitian menunjukkan bahwa nilai-P (p-value) adalah 0,0114 lebih kecil dari alpha (α=0,05), sehingga disimpulkan terdapat perbedaan pada nilai importasi produk tinplate sebelum dengan selama dikenakan bea masuk anti-dumping. Hasil analisis deskriptif menggambarkan importasi dari China dan Taiwan cenderung menurun sedangkan importasi dari Korea cenderung naik walaupun dikenakan bea masuk anti-dumping karena mampu bersaing dengan menggunakan tarif preferensi berdasarkan skema perdagangan bebas.Kata Kunci: Anti-dumping, Bea Masuk, tinplate


2021 ◽  
Vol 33 (2) ◽  
pp. 83-99
Author(s):  
K.A. Durowade ◽  
O.E. Elegbede ◽  
G.B. Pius-Imue ◽  
A. Omeiza ◽  
M. Bello ◽  
...  

Background: Substance use is a global public health problem with increasing burden among university students. This study assessed the prevalence, pattern and risk factors of substance use among undergraduate students of Afe Babalola University, Ado-Ekiti, Nigeria.Methods: This was a cross-sectional study of undergraduate students of Afe Babalola University, Ado-Ekiti. A multi-stage sampling technique was used to select respondents. Data collection tool was a structured self-administered questionnaire. Data analysis was done using Statistical Package for the Social Sciences (SPSS) version 23. Statistical significance was set at p value <0.05Results: The respondents’ mean age was 19.5 ± 2.0 years and all 416 (100.0%) were aware of substance abuse. The prevalence of substance use was 299 (71.9%). Alcohol 133 (32.0%) and over-the-counter drugs (29.9%) were the two most commonly used substance. Being male (p=0.017) and in 400 level (p=0.047) were associated with substance use while curiosity 112 (37.5%), peer pressure 95 (31.8%) and school stress 85 (28.4%) were reasons given. Predictors of substance use were being a female (aOR: 2.54; 95% CI=1.89-3.66; p=0.011), civil servant mother (aOR: 5.75; 95% CI=1.90-17.4; p=0.002) and mother with secondary education (aOR: 5.27; 95% CI= 2.20- 12.65; p<0.001).Conclusion: There was high prevalence of substance use with curiosity, peer pressure and school stress being influencers of substance use among the study population. Predictors of substance use were being a female, civil servant mother and mother with secondary education. The University authority should institute measures to prevent access to alcohol and other substances by the students.


2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Yeshi Metaferia ◽  
Abdurahaman Seid ◽  
Genet Mola Fenta ◽  
Daniel Gebretsadik

Background.Tuberculosis is a major public health problem and extrapulmonary tuberculosis (EPTB) accounts for a significant proportion of tuberculosis cases worldwide.Objective.To determine the magnitude of EPTB, associated risk factors, and agreement of diagnostic techniques at Dessie Referral Hospital.Methods.A cross-sectional study was conducted on consecutive presumptive EPTB cases from March 1 to June 30, 2017. Sociodemographic characteristics and other variables were collected using a structured questionnaire. Clinical specimens were collected and processed using fluorescent microscopy and Gene Xpert assay. Data was analyzed using SPSS version 20. Chi-square test and logistic regression were done and a P value of ≤0.05 was taken as statistically significant.Results.From a total of 353 presumptive EPTB cases the overall prevalence of Gene Xpert assay and smear confirmed patients was 8.8% and 2.5%, respectively. Tuberculosis lymphadenitis was the predominant (33.3%) type followed by pleural (11.9%) and peritoneal (6.7%) tuberculosis. Previous history of pulmonary tuberculosis was significantly associated with extrapulmonary infection (AOR:2.8; 95%CI: 1.05-7.54; p=0.04); however, other variables such as age, residence, sex, marital status, occupation, level of education, and monthly income did not show any association.Conclusion.High proportions (71%) of Gene Xpert assay confirmed EPTB patients were smear-negative. Sensitivity of microscopy should be enhanced in resource limited countries like Ethiopia where Gene Xpert machine is not easily accessible.


QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M M H Hassabelnabi ◽  
N Y Assaf ◽  
H F Zidan ◽  
G M M Abushanab

Abstract Background rheumatoid arthritis is currently regarded as independent cardiovascular risk factor. Accelerated atherosclerosis considered as an extra-articular manifestation of RA that occurs as a result of interaction between traditional CV risk factors and inflammatory activity of joint disease. Both atherosclerosis and RA have in common inflammatory mediators. Objectives the presented study aimed to find the relation between cardiovascular affection and erosive articular changes in RA. Subjects and Methods The presented study included 40 patients’ men and premenopausal women that were diagnosed with rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria for rheumatoid arthritis recruited from the physical Medicine, Rheumatology, and Rehabilitation outpatient clinics of Ain Shams University, patients underwent laboratory investigation, carotid duplex, musculoskeletal ultrasound and echocardiography. Results Among 40 RA patients, 16 (40%) had erosions in both hands and 24 (60%) without erosion with no statistically significance difference between both sides of hand and feet, only 3 patients (7.5%) had active erosion exhibited by power Doppler. The presence of erosion positively correlated with the mean CIMT (p-value &lt; 0.001) with mean 0.827±0.149, The presence of carotid plaques as a marker of advanced atherosclerosis showed statistically significant value with erosions (p = 0.001). There was positive relation between erosions with disease duration (p-value &lt; 0.001), and negatively with DAS-28 (p = 0.083). Out of 33 patients with positive RF, 16 patients had erosions with statistically significant value (p = 0.017). Conclusion Since the presence of bone erosions was highly associated with higher mean CIMT, consequently, we recommend that when finding bone erosions in rheumatoid arthritis patient, good monitoring should be given to cardiovascular risk factors with early and proper treatment to limit the progression of erosions and protect against atherosclerosis and its complications.


Author(s):  
Heera Shenoy T. ◽  
Sonia X. James ◽  
Sheela Shenoy T.

Background: Fetal Growth Restriction (FGR) is the single largest contributing factor to perinatal morbidity in non-anomalous foetuses. Synonymous with Intrauterine Growth Restriction (IUGR), it is defined as an estimated fetal weight less than the10th percentile. Obstetric Doppler has helped in early detection and timely intervention in babies with FGR with significant improvements in perinatal outcomes.  Hence, authors evaluated the maternal risk factors and diagnosis-delivery intervals and perinatal outcomes in FGR using Doppler.Methods: This research conducted in a tertiary care hospital in South Kerala included 82 pregnant women who gave birth to neonates with birth weight less than the 10th percentile over a period of1 year (Jan 1, 2017-Dec 31, 2017). Socio-demographic, maternal risk, Diagnosis- delivery interval in FGR and neonatal morbidities were studied.Results: Mean GA at diagnosis in weeks was 34.29 and 35.19 respectively for abnormal and normal Doppler respectively (p value-0.032). The mean birthweight in Doppler abnormal FGR was 272.34 g lesser than in Doppler normal group (p value-0.001). Growth restricted low birth weight neonates had Doppler   pattern abnormalities (p value-0.0009). FGR <3rd percentile and AFI <5 had abnormal Doppler (OR:6.7). Abnormal biophysical profile (OR:14) and Non-Reactive NST (OR:3.5) correlated with abnormal Doppler. Growth restricted with normal Doppler had shorter NICU stays than with abnormalities (p value-0.003). Term FGR went home early than early preterm. (p value-0.001).Conclusions: Abnormal Doppler velocimetry is significantly associated with earlier FGR detection, shorter decision- delivery interval, reduction in the mean birthweight and longer NICU stay. Hence, Umbilical artery Doppler and Cerebroplacental index is an integral part of in-utero fetal surveillance to identify impending fetal hypoxia, appropriate management, optimising the timing of delivery and improve perinatal health in FGR.


Author(s):  
Hadi Fiouji ◽  
Seyedeh Mahdieh Namayandeh ◽  
Sara jam Barsang ◽  
Marjan Erfani

Introduction: Stroke is the third most common cause of death in developed countries and is the most common neurological disabling disease. Today, several risk factors are known for stroke including lifestyle and risk factors such as hypertension and diabetes which differ in cultures and countries. The aim of this study was to determine the frequency of ischemic stroke in patients admitted to the brain department of Ghaem Hospital in 1395. Methods: In this observational cohort study, 201 cases of ischemic stroke who confirmed by neurologists as well as imaging techniques for diagnosis patients hospitalized to the neurology section of Ghaem Hospital, Mashhad, Iran During 1395.  The Patients' information such as age, sex, and The place of living and also the type of stroke and its main risk factors, including history of stroke in the past, hypertension, diabetes mellitus, high blood sugar cigar and high blood lipids were extracted from their records and completed in the checklist. 1 year follow up performed by telephone calling. Data were analyzed and examined by SPSS 21 and statistical tests. Results: According to the analysis, except for the cigarette variable (P-value = 0.003) HDL and TG (P-value = 0.001), no significant relationship was found between the other risk factors of disease risk and sex. In this study, 201 patients with ischemic stroke were studied. The mean age of the participants in the study was 50.92 years. In this study, the prevalence of stroke in men were higher than that of women, 104 (51.7%) for males and 97 (48.3%) for women. In the study of the most important clinical risk factors for stroke, the results showed that the highest prevalence was hypertension in women with 68 (70.1%) and the least of them was smoking with 16 (16.5%). The mean annual death rate in this study was 15.9%, which did not have a significant relationship with sex groups. Conclusion: In this study, hypertension, having diabetes and high blood glucose levels were the most important risk factors for stroke in patients, these results are in accordance with the previous finding studies. Regarding the results, it seems that the control of blood pressure and diabetes is not effectively considered, which requires further investigation.


2019 ◽  
Author(s):  
Amandine Duclau ◽  
Fanny Abad ◽  
Antoine Adenis ◽  
Malika Leneuve-Dorilas ◽  
Mathieu Nacher

Abstract Background Involved in physical and brain development, immune system functioning and various metabolic processes, micronutrients have profound health effects. The nutritional status of the pregnant woman is a major determinant of fetal health. French Guiana has the highest annual population growth rate. Social inequalities, cultural practices and parasitoses in French Guiana could affect the prevalence of these deficiencies. The main objective was to estimate the prevalence of micronutrient deficiency among pregnant women in French Guiana. The secondary objective was to identify socio-demographic, dietary, obstetric and neonatal risk factors associated with deficiencies.Methods Pregnant woman over 22 weeks of pregnancy hospitalized for delivery at the Obstetrical Emergency Department of the Hospital Center in Cayenne from May 2018 to March 2019. A socio-demographic and food questionnaire was administered. Medical data were collected from the medical records. Blood and urine samples were taken. The descriptive analysis used the Student and Chi2 tests. Prevalence ratios were obtained a Poisson regression.Results A total of 341 women were included. The majority were born in Haiti (39%) and French Guiana (34%). At least one micronutrient deficiency was documented in 81% of women. Women receiving State Medical Aid had a 35% greater risk of deficiency during pregnancy compared to those with both normal and complementary health insurance. (PR=1.35 95% CI (1.12;1.63) p-value=0. 002)Conclusions Micronutrient deficiencies in pregnant women in French Guiana are a real public health problem, a fact that was previously overlooked in a context of rising obesity. A varied and balanced diet remains the most effective solution to prevent these deficiencies. In French Guiana, a region where precariousness and obesity are widespread, nutritional care seems urgent.


2020 ◽  
Author(s):  
Nida Fatima ◽  
Maher Saqqur ◽  
Ashfaq Shauib

Abstract Introduction: Corona virus disease 2019 (COVID-19) pandemic has become a globally challenging issue after its emergence in December 2019 from Wuhan, China. Despite its common presentation as respiratory distress, patients with COVID-19 have also shown neurological manifestation especially stroke. Therefore, the authors sought to determine the etiology, underlying risk factors, and outcomes among patients with COVID-19 presenting with stroke. Methods: We conducted a systematic review of the electronic database (PubMed, Google Scholar, Scopus, Medline, EMBASE, and Cochrane library) using different MeSH terms from January 2000 to June 2020. Results: A total of 39 patients with stroke from 6 studies were included. The mean age of our included patients was 61.4±14.2 years. Majority of the patients (92.3%) with COVID-19 had ischemic stroke, 5.1% had hemorrhagic stroke, and 2.6% had cerebral venous thrombosis at the time of initial clinical presentation. Almost all of the patients presented had underlying risk factors predisposing to stroke which included, diabetes mellitus, hyperlipidemia, hypertension, and previous history of cerebrovascular disease. 51.2% of the included patients infected with COVID-19 with stroke died, while remaining patients were either discharged home or transferred to a rehabilitation unit. Conclusion: Exploring the neurological manifestation in terms of stroke among patients with COVID-19 is a step towards better understanding of the virus, preventing further spread, and treating the patients affected by this pandemic.


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