scholarly journals Regular Exercise, Thombocyte, Collagen and Breast Cancer

2021 ◽  
Vol 15 (7) ◽  
pp. 2172-2174
Author(s):  
Tonguç Vardar ◽  
, İbrahim Kubilay Türkay
Keyword(s):  
Breast Cancer ◽  
Type I Collagen ◽  
Malignant Tumors ◽  
Brca2 Gene ◽  
Building Blocks ◽  
Cartilage Tissue ◽  
Regular Exercise ◽  
Type I ◽  
Scientific Review ◽  
Quiet Eye

Platelets, which play a very important role in the continuation of vital activities, play an important role in blood coagulation. Various chronic diseases can reduce the platelets produced by our body below the standard level or increase them in a dangerous way. Diseases related to malignancy, that is, malignant tumors, come at the beginning of the diseases that disrupt the platelet balance. One of them is breast cancer. Breast cancer is a type of cancer that occurs as a result of mutations in the BRCA1 (17q21) and P53 (17p13) genes located on the 17th chromosome and the BRCA2 gene located on the 13th chromosome. It is known that the amount of bone mass due to estrogen hormone is closely related to the formation of breast cancer. Collagen is the protein that forms bones, cartilage fibers and joints, which are the building blocks of our motor (movement) system. The main protein that forms the main structure of the bone is Type I collagen and about 30 types of collagen have been defined. It acts as a support for bone and cartilage tissue. Regular exercise, on the other hand, is a type of regular, systematic and programmed physical activity done with the aim of improving the physical and mental state of the person. There are many studies that found that exercise increases the tendency of platelet aggregation (aggregation, aggregation, aggregation). In addition, there are scientific studies that show that regular exercise and regularly used collagen stop the progression of breast cancer. The aim of this scientific review is to describe the relationship between platelet, collagen, breast cancer and regular exercise. Keywords: Quiet eye, Platelet, Collagen, Breast Cancer, Regular exercise

scholarly journals Collagen molecular phenotypic switch between non-neoplastic and neoplastic canine mammary tissues

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masahiko Terajima ◽  
Yuki Taga ◽  
Becky K. Brisson ◽  
Amy C. Durham ◽  
Kotaro Sato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Mammary Carcinoma ◽  
Cancer Biology ◽  
Type I Collagen ◽  
Critical Role ◽  
Premature Death ◽  
Mammary Tissue ◽  
Type I ◽  
Cross Links

AbstractIn spite of major advances over the past several decades in diagnosis and treatment, breast cancer remains a global cause of morbidity and premature death for both human and veterinary patients. Due to multiple shared clinicopathological features, dogs provide an excellent model of human breast cancer, thus, a comparative oncology approach may advance our understanding of breast cancer biology and improve patient outcomes. Despite an increasing awareness of the critical role of fibrillar collagens in breast cancer biology, tumor-permissive collagen features are still ill-defined. Here, we characterize the molecular and morphological phenotypes of type I collagen in canine mammary gland tumors. Canine mammary carcinoma samples contained longer collagen fibers as well as a greater population of wider fibers compared to non-neoplastic and adenoma samples. Furthermore, the total number of collagen cross-links enriched in the stable hydroxylysine-aldehyde derived cross-links was significantly increased in neoplastic mammary gland samples compared to non-neoplastic mammary gland tissue. The mass spectrometric analyses of type I collagen revealed that in malignant mammary tumor samples, lysine residues, in particular those in the telopeptides, were markedly over-hydroxylated in comparison to non-neoplastic mammary tissue. The extent of glycosylation of hydroxylysine residues was comparable among the groups. Consistent with these data, expression levels of genes encoding lysyl hydroxylase 2 (LH2) and its molecular chaperone FK506-binding protein 65 were both significantly increased in neoplastic samples. These alterations likely lead to an increase in the LH2-mediated stable collagen cross-links in mammary carcinoma that may promote tumor cell metastasis in these patients.

scholarly journals Migration of breast cancer cells into reconstituted type I collagen gels assessed via a combination of frozen sectioning and azan staining

2014 ◽  
Vol 8 (4) ◽  
pp. 212-216 ◽  
Author(s):  
Kyohei Fukuda ◽  
Yo Kamoshida ◽  
Taisuke Kurokawa ◽  
Mioto Yoshida ◽  
Yoko Fujita-Yamaguchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Type I Collagen ◽  
Type I ◽  
Collagen Gels

scholarly journals ΕGFR/ERβ-Mediated Cell Morphology and Invasion Capacity Are Associated with Matrix Culture Substrates in Breast Cancer

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2256
Author(s):  
Konstantina Kyriakopoulou ◽  
Eirini Riti ◽  
Zoi Piperigkou ◽  
Konstantina Koutroumanou Sarri ◽  
Heba Bassiony ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Morphology ◽  
Breast Cancer Cells ◽  
Type I Collagen ◽  
Morphological Characteristics ◽  
Migration And Invasion ◽  
Type I ◽  
Egfr Inhibition ◽  
The Impact

Breast cancer accounts for almost one in four cancer diagnoses in women. Studies in breast cancer patients have identified several molecular markers, indicators of aggressiveness, which help toward more individual therapeutic approaches. In triple-negative breast cancer (TNBC), epidermal growth factor receptor (EGFR) overexpression is associated with increased metastatic potential and worst survival rates. Specifically, abnormal EGFR activation leads to altered matrix metalloproteinases’ (MMPs) expression and, hence, extracellular matrix (ECM) degradation, resulting in induced migration and invasion. The use of matrix substrates for cell culture gives the opportunity to mimic the natural growth conditions of the cells and their microenvironment, as well as cell–cell and cell–matrix interactions. The aim of this study was to evaluate the impact of EGFR inhibition, estrogen receptor beta (ERβ) and different matrix substrates [type I collagen and fibronectin (FN)] on the functional properties, expression of MMPs and cell morphology of ERβ-positive TNBC cells and shERβ ones. Our results highlight EGFR as a crucial regulator of the expression and activity levels of MMPs, while ERβ emerges as a mediator of MMP7 and MT1-MMP expression. In addition, the EGFR/ERβ axis impacts the adhesion and invasion potential of breast cancer cells on collagen type I. Images obtained by scanning electron microscope (SEM) from cultures on the different matrix substrates revealed novel observations regarding various structures of breast cancer cells (filopodia, extravesicles, tunneling nanotubes, etc.). Moreover, the significant contribution of EGFR and ERβ in the morphological characteristics of these cells is also demonstrated, hence highlighting the possibility of dual pharmacological targeting.

scholarly journals Role of secreted type I collagen derived from stromal cells in two breast cancer cell lines

2014 ◽  
Vol 8 (2) ◽  
pp. 507-512 ◽  
Author(s):  
SUNG HOON KIM ◽  
HYE YOON LEE ◽  
SEUNG PIL JUNG ◽  
SANGMIN KIM ◽  
JEONG EON LEE ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Stromal Cells ◽  
Type I Collagen ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Type I

scholarly journals High type I collagen density fails to increase breast cancer stem cell phenotype

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9153
Author(s):  
Iuri C. Valadão ◽  
Ana Carolina L. Ralph ◽  
François Bordeleau ◽  
Luciana M. Dzik ◽  
Karen S.C. Borbely ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Type I Collagen ◽  
Dynamic Structure ◽  
Metastatic Potential ◽  
Breast Cancer Stem Cell ◽  
Cell Phenotype ◽  
Type I ◽  
Mcf 7

Breast cancer is a highly frequent and lethal malignancy which metastasis and relapse frequently associates with the existence of breast cancer stem cells (CSCs). CSCs are undifferentiated, aggressive and highly resistant to therapy, with traits modulated by microenvironmental cells and the extracellular matrix (ECM), a biologically complex and dynamic structure composed mainly by type I collagen (Col-I). Col-I enrichment in the tumor-associated ECM leads to microenvironment stiffness and higher tumor aggressiveness and metastatic potential. While Col-I is also known to induce tumor stemness, it is unknown if such effect is dependent of Col-I density. To answer this question, we evaluated the stemness phenotype of MDA-MB-231 and MCF-7 human breast cancer cells cultured within gels of varying Col-I densities. High Col-I density increased CD44+CD24− breast cancer stem cell (BCSC) immunophenotype but failed to potentiate Col-I fiber alignment, cell self-renewal and clonogenicity in MDA-MB-231 cells. In MCF-7 cells, high Col-I density decreased total levels of variant CD44 (CD44v). Common to both cell types, high Col-I density induced neither markers related to CSC nor those related with mechanically-induced cell response. We conclude that high Col-I density per se is not sufficient to fully develop the BCSC phenotype.

scholarly journals Effect of adjuvant chemotherapy on carboxytelopeptide of cross-linked type I collagen of egyptian women with non-metastatic breast cancer

2014 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Ehab I Mohamed ◽  
Samir M Abdel-Mageed ◽  
Gihane I Khalil ◽  
Ahmed A Emara ◽  
Heba S Ramadan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Type I Collagen ◽  
Metastatic Breast ◽  
Type I ◽  
Egyptian Women

Cross-linked type I collagen C- and N-telopeptides in women with bone metastases from breast cancer

2001 ◽  
Vol 264 (4) ◽  
pp. 186-190 ◽  
Author(s):  
U. Ulrich ◽  
K. Rhiem ◽  
J. Schmolling ◽  
C. Flaskamp ◽  
I. Paffenholz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Metastases ◽  
Type I Collagen ◽  
Type I ◽  
C And N
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