scholarly journals Frequency of Vitamin D deficiency in liver cirrhosis and its correlation with Child Pugh Score

2021 ◽  
Vol 15 (9) ◽  
pp. 2480-2482
Author(s):  
M. Akif Dilshad ◽  
Shafqat Rasool ◽  
Amir Latif ◽  
Asif Gul ◽  
Israr ul Haque ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Cirrhosis ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
P Value ◽  
Vitamin D Levels ◽  
Pugh Class ◽  
Cirrhosis Of Liver ◽  
Ctp Score ◽  
Relationship Of

Objective: To determine the frequency of vitamin D deficiency in patients with liver cirrhosis and the relationship of vitamin D deficiency with Child Pugh Class in patients with cirrhosis. Materials and Methods: Vitamin D and calcium levels were checked in patients with cirrhosis of liver aged 18 to 80 years admitted in Gastroenterology department of Lahore General Hospital. Investigations were also done to calculate Child Pugh (CTP) score and Child Class was assigned on the basis of score. Quantitative variables were expressed in terms of mean and standard deviation. Frequency and percentage were used for qualitative measures. The p-value was calculated by the contingency coefficient to find a relationship of vitamin D levels to CTP scores of liver cirrhosis. Data was analyzed using SPSS 24 Study Duration: The study was carried out from December 2019 to October 2020 Results: A total of 170 patients with mean age of 43.82 ± 9.72 (19-61) years were evaluated of which 144 (84.7%) were males, 26 (15.3%) were females. Vitamin D3 deficiency was found in 144/170 (84.7%) patients while insufficiency was found in 14/170(8.2 %). It was more common in male patients (86.1%) compared to female patients (76.9%). Mean vitamin D3 levels was 14.4 ± 9.4 ng/ ml. Patients with Child A cirrhosis 6/10 (60%) had deficiency, with child B 66/82 (80.5%) while with Child C 72/78 (92.3%) had deficiency of Vitamin D3. Conclusion: Vitamin D deficiency is common in patients with cirrhosis and level has decreased stepwise with higher Child Pugh Class. Keywords: Cirrhosis, Vitamin D, Child Pugh score

scholarly journals Frequency of Vitamin D Deficiency with Non-Specific Musculoskeletal Symptoms in Female Patients

2021 ◽  
Vol 2 (1) ◽  
pp. 4
Author(s):  
Abdul Latif Khattak ◽  
Abdul Moueed Tariq ◽  
Syed Karamat Hussain Shah Bukhari ◽  
Shahzeb Ahmad Satti ◽  
Raffi ud Din ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Vitamin B12 Deficiency ◽  
Musculoskeletal Symptoms ◽  
Military Hospital ◽  
P Value ◽  
Chi Square ◽  
Female Patients ◽  
Vitamin D Levels

Objective: To determine frequency of vitamin D deficiency in female patients presenting with non-specific musculoskeletal symptoms.Study Design: Descriptive cross sectional.Place and Duration of Study: The study was conducted in Medical Outpatient Department (OPD), Combined Military Hospital (CMH) Quetta from 30th November 2018 to 30th May 2019.Materials and Methods: A total of 150 female patients with nonspecific musculoskeletal symptoms were included. Patients on vitamin D supplements, osteopenia, osteoporosis, chronic kidney disease, neuropathies, cancers, diabetes mellitus, iron and Vitamin B12 deficiency were excluded. Data including gender, age and presence of bone pain, muscle aches, bone tenderness and fracture was collected. SPSS v 17 was used for data analysis. Chi-square test was applied to test for associations,  p value less than 0.05 was taken as significant.Results: The mean age was 37.20 + 13.30 years. Mean Vitamin D levels were 14.89 + 7.76 ng/ml with range from 3.10 to 35.67ng/ml. Participants with vitamin D3 < 10 ng/ml were 24% (n=36), < 20 ng/ml were 54% (n= 81), <30 ng/ml were 12 % (n=18) and only 10 % (n= 15) had optimal Vitamin D3 levels. Among the study population 82% (n=123) had bone pains, 88.6% (n=33) had muscle aches and weakness, 72.66% (n=109) had bone tenderness while only 4% (n=6) had fractures. There was a statistically significant association between symptoms and vitamin D3 deficiency with p value <0.001.Conclusion: This study showed that vitamin D deficiency is prevalent in our female populationand it presents with nonspecific musculoskeletal symptoms.

scholarly journals Relationship between vitamin D deficiency and serum ferritin level in healthy women

2019 ◽  
Vol 10 (3) ◽  
pp. 2095-2098
Author(s):  
Mohanad Adel Mohammed ◽  
Mushtaq Talib Abed ◽  
Muhannad Shweash ◽  
Hayder Adnan Fawzi ◽  
Muntaha Qasim Hendi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Ferritin Level ◽  
P Value ◽  
Cross Sectional ◽  
Healthy Women ◽  
Group I ◽  
Vitamin D Levels ◽  
Group Ii

Vitamin D is an essential vitamin that regulates many biological processes and involved in the ‎activity of many organs like the skin, bone, kidney, etc. ferritin is an essential marker for ‎assessment of anemic status. The current study aimed to assess the relationship between ferritin ‎and vitamin D3 in healthy women at various age groups. A cross-sectional study carried out in ‎Ramadi city and involved 92 healthy women aged from ‎20-50 years‎, the participants divided into two groups according to age: group I with age ‏‎20 – 35 years and group II with age 36 – 50 years. In the present study mean vitamin D3 in group II ‎11.8 ‎±‎ 3.5‎ ‎ng/dL was ‎significantly lower than group I (35.3 ‎±‎ 12.2‎ ng/dL) p-value < 0.001, a similar ‎finding observed for ferritin (‎19.6 ‎±‎ 13.9‎ ‎vs ‎66.7 ‎±‎ 52.1‎, p-value <0.001). There was a direct relationship between ferritin with vitamin D. However, this relationship was ‎only significant in group II (p-value <0.05), while in group I it was statistically significant. In conclusion, low vitamin D levels associated with low ferritin, indicating that vitamin D ‎deficiency is associated with anemia.

Association between vitamin D deficiency and prostate cancer: Prospective case-control study

2021 ◽  
pp. 205141582199360
Author(s):  
Ghanshyam Kumawat ◽  
Vijay Chaudhary ◽  
Anurag Garg ◽  
Nishkarsh Mehta ◽  
Gagan Talwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

Abstract 121: Vitamin D Deficiency Study in Postural Orthostatic Tachycardia Syndrome

2015 ◽  
Vol 8 (suppl_2) ◽  
Author(s):  
Chandralekha Ashangari ◽  
Amer Suleman
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Electronic Medical Records ◽  
Vitamin D3 ◽  
Medical Records ◽  
Postural Orthostatic Tachycardia Syndrome ◽  
Vitamin D Levels ◽  
The World ◽  
25 Oh Vitamin D ◽  
Vitamin D3 Deficiency

Objectives The aim of this study is to assess vitamin D levels, including the prevalence of vitamin D deficiency/insufficiency in Postural Orthostatic Tachycardia Syndrome (POTS) patients. Background : The Postural Orthostatic Tachycardia Syndrome (POTS) affects primarily young women. POTS is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. We frequently find vitamin D deficiency in patients who present with POTS Methods: 180 patients were selected randomly from our clinic with POTS. Patients Vitamin D levels charts were reviewed from electronic medical records, 25-OH vitamin D (Vitamin D3 ) status was defined as Normal (>30 ng/mL), Insufficient (20.0-29.9 ng/mL), and deficient (<20 ng/mL). Results: Out of 180 patients, 170 patients are female (94%, n=170, age 31.88±10.36), 10 patients are male (6% ,age 25.83±6.19). 79 patients had vitamin D3 level >30 ng/ml, 10 patients had vitamin D3 level range >20.0 to 29.9 ng/mL, 91 patients had vitamin D3 level < 20ng/mL. Conclusion: Our research results demonstrated that Postural Orthostatic Tachycardia Syndrome (POTS) patients have a higher rate of vitamin D3 deficiency (51% have Vitamin D3 less than 20 ng/mL). Vitamin D3 levels are low in more than half of POTS patients (56% had less than 30 ng/mL )

scholarly journals Correlation of psoriasis and serum vitamin D

2021 ◽  
Vol 7 (4) ◽  
pp. 320-323
Author(s):  
Ritika Gujrati ◽  
Krishnendra Varma ◽  
Ujjwal Kumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Psoriasis Vulgaris ◽  
Systemic Disease ◽  
Serum Vitamin ◽  
Psoriatic Skin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Psoriasis is an immuno-mediated chronic systemic disease involving cytokines of helper Th1 pathway. Vitamin D has an effect on keratinocyte proliferation, differentiation and immune modulation of immune system especially Th1 pathway, which is altered in psoriatic skin suggesting that Vitamin D may have a role in pathogenesis of psoriasis. To study correlation between psoriasis vulgaris and serum vitamin D. To evaluate serum vitamin D level in psoriasis cases and in control group and correlating vitamin D level with severity and duration of the psoriasis. 57 cases (&#62;15years of age) with psoriasis and 57 healthy subjects were recruited. Psoriasis was clinically diagnosed and severity evaluated by PASI scale. Vitamin D was analysed by enhanced chemilumine scence on vitrus Eci autoanalyzer of Orth clinical diagnostic. Vitamin D deficiency defined as &#60;20ng/ml, insufficiency 20-30ng/ml and sufficient 30-100ng/ml. Vitamin D deficiency in the study was 22.8% in patients and 14% in control group. Vitamin D insufficiency was found in 42.1% of cases and 19.3% of control. According to chi-square the p-value is 0.003 showing significant association. There was a tendency towards decrease in vitamin D level with increase in disease duration. There was negative correlation between vitamin D and PASI score. The study found a significant relationship between vitamin D and psoriasis. Further metanalysis involving larger study population will be required to establish whether vitamin D levels benefits patient with psoriasis vulgaris.

scholarly journals A clinical study to determine the relationship between serum vitamin D levels and severity of asthma

2017 ◽  
Vol 4 (4) ◽  
pp. 1397
Author(s):  
Pragalatha Kumar ◽  
Aruna Gowdra ◽  
Arathi Arathi ◽  
Ananya Sampath
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Asthma Severity ◽  
Severe Form ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Children With Asthma ◽  
Age And Sex

Background: Vitamin D deficiency has been rediscovered as a public health problem worldwide. Few studies have shown that vitamin D deficiency is associated with asthma severity. The objective of present work was to study the serum vitamin D levels and its relationship with asthma severity in children.Methods: A prospective cohort study of 100 children with asthma between the age group of 5 to 15 years and age and sex matched 40 healthy controls who had come to Indira Gandhi Institute of Child Health, Bengaluru was done. These children’s serum vitamin D levels were estimated and correlated with asthma severity.Results: A total of 100 children with asthma and 40 healthy age and sex matched controls were evaluated. The study group had lower vitamin D (34.95 ng/ml) levels as compared to the control group (57.94 ng/ml) which was statistically significant (p<0.05). 68.4% children had significantly low vitamin D levels and severe form of asthma (p value <0.001). There was also a marked rise in absolute eosinophil count in those who had low vitamin D levels (56.6%) (p-value <0.0001).Conclusions: Vitamin D deficiency is an important risk factor for asthma severity. It modifies the immune system and reduces the inflammation. In the present study, low serum vitamin D levels were significantly correlated with severe form of asthma. There was a significant rise in the absolute eosinophil count in those who exhibited deficiency of vitamin D.  

scholarly journals Relation of serum 25(OH) D with variables of thyroid and lipid profile in perimenopausal women

2017 ◽  
Vol 6 (3) ◽  
pp. 1087
Author(s):  
Poonam Rani ◽  
Seema Gupta ◽  
Gaurav Gupta
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Lipid Profile ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
The Body ◽  
P Value ◽  
Thyroid Disorder ◽  
Vitamin D Levels ◽  
Perimenopausal Women

Background: Deficiency of vitamin D is quite prevalent among elderly population or postmenopausal women worldwide and may affect various function of the body. The status of its deficiency with their relation with other variables are not well explored in perimenopausal women.Methods: 100 perimenopausal women from the department of obstetrics and gynaecology were selected without having known risk of thyroid disorder and cardiovascular disease. The age group criteria for these women were 40 to 50 years. Thyroid profile including TSH, T3, and T4 were estimated by using enzyme linked immunesorbent assay. Serum levels of 25(OH) D3 was estimated by using spectrophotometric method. Lipid profile including TC, TG and HDL-C were estimated CHOD-POD method, GPO-PAP method, and CHOD-POD/Phosphotungustate method. LDL-C was calculated by friedewald formula.Results: There 58 women were presented with insufficient amount of vitamin D. They were characterised with increased BMI, elevated thyrotropin alongwith lower concentrations of T3 and T4. Increased levels of TC, TG and LDL-cholesterol alongwith lower concentration of HDL-C were also observed in women with vitamin d deficiency. Women having vitamin D deficiency were presented with overweight (OR-18.0, p-value=<0.001) and dyslipidemia (OR-12.13, p-value≤0.001). Vitamin D was negatively correlated with variable i.e. BMI, TSH, TC, TG and LDL-C. This negative association was significant (<0.001) while HDL-C and T4 were positively correlated with vitamin D levels in this study population.Conclusions: Vitamin D deficiency frequently occurs in middle aged perimenopausal women. Negative correlation of it with BMI, TSH and lipid variables may suggest the development of cardiovascular disease and hypothyroidism in coming years. Vitamin D supplements or vitamin D containing diet and regular exposure to sun is highly recommended to perimenopausal women.

scholarly journals Vitamin D Levels among Hospitalized and Non-Hospitalized COVID-19 Patients in Dr. M. Djamil General Hospital Padang

2021 ◽  
Vol 3 (6) ◽  
pp. 78-81
Author(s):  
Harika Putra ◽  
Efrida ◽  
Rismawati Yaswir
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Study Groups ◽  
P Value ◽  
Chi Square ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Chemiluminescent Microparticle Immunoassay

Coronavirus Disease 2019 (COVID-19) causes immune system dysregulation and an exaggerated systemic inflammatory response. Vitamin D acts as an immunomodulator that enhances the immunity defense. Low levels of vitamin D affect the severity of COVID-19 infection. This study aims to determine vitamin D levels in hospitalized and non-hospitalized COVID-19 patients. A case-control study was conducted involving 62 COVID-19 patients, equally divided into hospitalized and non-hospitalized groups at RSUP dr. M. Djamil, Padang from February to September 2020. Serum vitamin D levels were measured using the Chemiluminescent Microparticle Immunoassay. Vitamin D deficiency was defined as a level less than 20 ng/mL. The hospitalized group consisted of moderate to critical COVID-19 patients, whereas the non-hospitalized group consisted of the asymptomatic and mild COVID-19 patients according to the Indonesian Ministry of Health Guidelines. All data were analyzed using a T-test and Chi-square with a significant p-value of 0.05. The results showed that most subjects were women between 21–60 years. The mean level of vitamin D (ng/mL) in the hospitalized group was lower than in the non-hospitalized group (15.5 ± 7.72 vs. 19.2 ± 14.30; 95% CI -9.509–2.167; p=0.213). Vitamin D deficiency affected hospitalized group more than the non-hospitalized group, but not statistically significant (71% vs. 64.5%, p=0.566). It indicated the role of vitamin D in preventing immune system hyperactivation causing COVID-19 cytokine storm. This study concluded no difference in vitamin D levels among the study groups. Nevertheless, further research on vitamin D is needed to determine its role and benefits against COVID-19 infection.

scholarly journals Vitamin D Deficiency and Associated Factors in Adult Females of Chattogram

2021 ◽  
Vol 20 (2) ◽  
pp. 74-78
Author(s):  
Shaheda Ahmed ◽  
Mohammed Jalal Uddin ◽  
Nayeema Tasnim
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Associated Factors ◽  
Sun Exposure ◽  
P Value ◽  
Large Sample Size ◽  
Uvb Radiation ◽  
Female Population ◽  
Adult Females ◽  
Vitamin D Levels

Background : Vitamin D is an essential nutrient and deficiency of it leads to devastating disorders. This study aimed to find out the associated factors with selected variables of low vitamin D among adult females of Chattogram. Materials and methods : Cross-sectional observational study was conducted from September 2019 to February 2020 at a diagnostic complex of Chattogram. Participants were adult females of Chattogram. All participants gave oral informed consent and answered a questionnaire that included 16 questions covering demographic information, monthly income, educational status, occupation, body weight, duration of sun exposure, dress pattern (Using hijab or burkha, regular dress-up) drug and disease history. Blood samples were collected by cautious aseptic procedure. Serum vitamin D levels were measured by using immunoassay method. Adult females of Chattogram with no religious restrictions, n= 150,aged 31 to 70 years. Results: Overall, 88% had low vitamin D levels with deficient 60.66% and insufficient 27.34%. Sufficient level of vitamin D was found only among 12%. The prevalence of vitamin D deficiency was much higher in females with house-wife status 73.33% (p value of 0.0001) wearing hijab 46.66% (p value of 0.001). It could be due to interference with UVB radiation into skin, short duration of sun exposure, use of sunblock cream or less supplementary intake. Conclusion : Vitamin D deficiency is an emerging but neglected health issue in modern time, particularly more vulnerable are female population. Ironically, abundant sunlight of Bangladesh seems failed to protect the self-imposed concrete prisoner, classically known as home-makers, and practitioner of indoor life style that leads to avoidance of sun light. However, large sample size is mandatory to boost-up the findings of current study. Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 74-78

Role of Vitamin D in the Management of COVID-19 Patients Regarding Morbidity and Mortality

2021 ◽  
Vol 15 (6) ◽  
pp. 1231-1233
Author(s):  
A. W. Khan ◽  
H. T. Hussain ◽  
Z.U. Mustafa ◽  
M. A. Qamar ◽  
M. A. Qamar ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
Morbidity And Mortality ◽  
P Value ◽  
Mortality And Morbidity ◽  
Severe Vitamin ◽  
Vitamin D Levels

Aim: To determine the role of vitamin D in the management of COVID-19 patients regarding morbidity and mortality. Study Design: Prospective/Observational Place and Duration: Departments of Medicine & Pulmonology, Allama Iqbal Memorial Teaching Hospital, Sialkot and Department of Medicine, Sughra Shafi Medical Complex Narowal from 1st November 2020 to 30th April 2020. Methodology: One hundred and sixty patients of both genders diagnosed to have COVID-19, were enrolled. Patient’s ages were ranging from 17 to 70 years. The detailed demographics such as age, sex, and body mass index were recorded. 5 ml blood samples were taken from all the patients to check their vitamin D levels. Severe Vitamin D deficiency was defined as 25(OH)D <25 nmol/L (10 ng/dl). Association between mortality and morbidity was examined. Results: Ninety (56.25%) were males while 70 (43.75%) were females with mean age 40.15±17.37 years. Mean body mass index of patients was 24.16±7.26 kg/m2. Severe vitamin D deficiency was observed in 80 (50%) patients. Mortality found in 30 (18.75%) patients. Frequency of morbidity was among 66 (41.25%) patients. Patients with severe vitamin D deficiency had high rate of mortality 20 (25%) and morbidity 50 (62.5%) as compared to patients with no vitamin D deficiency had 10 (8%) mortality and 16 (20%) morbidity. A significant association was observed between severe vitamin D deficiency regarding morbidity and mortality among patients with covid-19 disease with p-value <0.05. Conclusion: The vitamin-D has strongest relationship among patients with covid-19 disease to reduce mortality and morbidity. Keywords: Morbidity, COVID-19, Vitamin D, Mortality

Sign in / Sign up

Export Citation Format

Share Document