Efficacy of casein phosphopeptide varnish reducing dental hypersensitivity: A randomized clinical trial

Introduction: Dentin hypersensitivity (DH) is the most common concern faced by most dentists in their day-to-day clinical practice. It is characterized by short-term, acute pain of variable intensity, which occurs in response to thermal, tactile, osmotic or chemical stimuli that cannot be attributed to any other type of defect or dental decay. Casein phosphopeptide varnish is a newer material used to treat dentinal hypersensitivity as it reduces demineralization and promotes remineralization. The aim of this study is to evaluate the efficacy of casein phosphopeptide based varnish (MI Varnish®) vs sodium fluoride-based varnish (Fluoritop SR® varnish) in treating dentinal hypersensitivity. Materials and methods: 40 subjects with a chief complaint of DH were divided into two equal groups, Group A (MI varnish®) and Group B (Fluoritop SR® varnish). Scaling and root planing was done and sensitivity was assessed using Visual analog scale (VAS) at baseline. On the 14th day, sensitivity was reassessed using VAS. The data obtained were subjected to statistical analysis using students‘t’ test. Results: On intragroup comparison, VAS scale showed a statistically significant difference for both the groups. On intergroup comparison, no statistical difference was found between both groups. (p = 0.139) Conclusions: From the above results, it can be concluded that MI varnish® and Fluoritop SR® varnish are equally efficacious in reducing dentinal hypersensitivity.

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Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee Osteoarthritis

Journal of Bahria University Medical and Dental College ◽

10.51985/jbumdc2019096 ◽

2019 ◽

Vol 09 (04) ◽

pp. 308-311

Author(s):

Mehtab Munir ◽

Shahid Mustafa Memon ◽

Sajid Abbas Jaffri ◽

Khalid Mustafa Memon

Keyword(s):

Knee Osteoarthritis ◽

P Value ◽

Womac Pain ◽

Test Results ◽

Knee Oa ◽

Significant Difference ◽

Group A ◽

Insignificant Difference ◽

Group B ◽

Pain At Rest

Objective: To compare clinical efficacy of diacerein-ginger with diacerein alone in treating knee osteoarthritis. Duration and place of study: It was a randomized clinical trial conducted from 21st September 2018 to 31stMarch 2019, in medical OPD of a private hospital in Karachi. Methodology: 60 diagnosed patients of knee osteoarthritis were included in this study. Male and female patients 50 years of age, fulfilling the inclusion criteria and after written informed consent experienced a wash-out period of 72 hours. These patients were systematically randomized into 2 groups each having 30 members. Group A received capsule Diacerein 50mg + capsule Ginger 550 mg twice daily and group B received capsule Diacerein 50mg twice daily, for 12 weeks. Parameters checked at 0, 6 and 12 weeks were: Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, pain at rest and movement (Visual Analogue Scale). Comparison of the two groups was done by independent t-test. Results: Among 60 patients; 20 (33.33 %) were males and 40 (66.66%) were females. 4 patients in group A and 4 in B, dropped out during the study. Comparison of group A with group B in WOMAC and pain (at rest and movement) scores showed insignificant difference at day 0 before prescription of the drugs. However comparison showed highly significant difference (P-value < 0.001) between the two groups in WOMAC, pain at rest and movement scores at the end of 6th and 12th weeks of intervention. Conclusion: Diacerein-Ginger is clinically more efficacious for management of knee OA than Diacerein alone

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Application Value of Coagulation Function Test in Prognosis of Patients with Cardiovascular and Cerebrovascular Diseases

Advanced Emergency Medicine ◽

10.18686/aem.v9i4.181 ◽

2021 ◽

Vol 9 (4) ◽

pp. 89

Author(s):

Jing Luo

Keyword(s):

Cerebrovascular Diseases ◽

Good Prognosis ◽

Control Group ◽

Study Group ◽

Test Results ◽

Coagulation Function ◽

Significant Difference ◽

Function Test ◽

Group A ◽

Group B

<p><span lang="EN-US">Objective: to explore the application value of coagulation function test in the prognosis of patients with cardiovascular and cerebrovascular diseases. Methods: from December 2018 to December 2019, 100 patients with cardiovascular and cerebrovascular diseases were randomly selected as the study group. According to the follow-up results of patients, they were divided into study group A (good prognosis, n = 64) and study group B (disability or death, n = 36) 100 subjects served as the control group. The test results of coagulation function of the two groups were analyzed retrospectively. The test results of the study group before and after treatment were compared with those of the control group, and the test results of the study group A and study group B after treatment were compared. Results: the coagulation function of the study group after treatment was significantly improved compared with that before treatment (P < 0.05), and there was a significant difference between the two groups before treatment (P < 0.05), and there was no difference after treatment (P > 0.05); after treatment, the coagulation function of study group A and study B was significantly different (P < 0.05). Conclusion: coagulation function test has a certain application value for the prognosis of patients with cardiovascular and cerebrovascular diseases, and can be used as an index to judge the patient’s condition and treatment effect, which has good application value in clinical practice.</span></p>

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Efficacy of Locally Administered 1.2% Rosuvastatin Gel in Patients with Periodontitis: A Randomized Placebo Controlled Clinical Trial

European Journal of Dentistry ◽

10.1055/s-0039-1688522 ◽

2019 ◽

Vol 13 (01) ◽

pp. 029-035 ◽

Cited By ~ 1

Author(s):

Debopriya Chatterjee ◽

Anjali Kapoor ◽

Sharmistha Vijay ◽

Geetika Sobti ◽

Dheeraj Kara ◽

...

Keyword(s):

Clinical Trial ◽

Phase 1 ◽

Colony Count ◽

Controlled Clinical Trial ◽

Clinical Parameters ◽

Pharmacological Agents ◽

Intergroup Comparison ◽

Significant Difference ◽

Group A ◽

Group B

Abstract Objective Periodontitis initiation and progression are a result of host immune inflammatory response to oral pathogens. Several pharmacological agents are being delivered locally, to improve periodontal health. Hence, the present randomized placebo controlled clinical trial is designed to check the clinical and antimicrobial efficacy of locally delivered 1.2% rosuvastatin (RSV) in intrabony defects (IBD) in periodontitis patients. Materials and Methods One-hundred patients were randomly allotted into two treatment groups: group A received 1. 2% RSV gel, scaling and root debridement and group B received placebo gel, scaling and root debridement. Clinical parameters, including modified sulcus bleeding index (mSBI), probing depth (PD), clinical attachment level (CAL), and plaque index (PI), were recorded at baseline before phase 1 and after 6 months. Radiographic assessment of IBD was done by cone beam computed tomography at baseline and after 6 months. Anaerobic colony count was done at baseline and after 180 days. Results On intragroup comparison, there is a significant improvement in periodontal parameters in both the groups. On intergroup comparison, there is significant gain in CAL in group A than group B (p = 0.04). There is significant decrease in PD in group A, compared to group B. There is significant bone fill in group A (p = 0.034), compared to group B. With respect to mSBI, PI, and anaerobic colony count, there is no significant difference between the two groups after 6 months. No adverse effect was noticed in any subjects. Conclusion The author concludes that 1.2% RSV gel when delivered locally into IBD improved periodontal clinical parameters such as PD and CAL and showed significant bone fill.

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The effect of glycerin on the surface hardness and roughness of nanofill composite

Conservative Dentistry Journal ◽

10.20473/cdj.v8i2.2018.104-111 ◽

2019 ◽

Vol 8 (2) ◽

pp. 104

Author(s):

Diana Zakiyah ◽

Ruslan Effendy ◽

Edhie Arif Prasetyo

Keyword(s):

Surface Roughness ◽

Composite Resin ◽

Surface Hardness ◽

Test Results ◽

Inhibition Layer ◽

Chain Reaction ◽

Oxygen Inhibition ◽

Significant Difference ◽

Group A ◽

Group B

Background: Present research studied the surface hardness and roughness dependence on polymerization. Polymerization of composites occurs through chain reaction that is induced by free radicals. Oxygen in the air decreases the excitability of the photo initiator, causing polymerization interference. Oxygen inhibition layer (OIL) is formed on the surface. OIL can be reduced by curing the composite through by application of glycerin to the surface. Purpose: To determine the effect of glycerin on the surface hardness and roughness of nanofill composite. Material and Methods: 64 specimens of composite (Z350 XT, 3M) were prepared using a disc-shaped acrylic. The groups were divided into group A surface hardness (N=32) and group B surface roughness (N=32). Group A1, the specimen was coated with glycerin and light cured for 20 s and group A2, the specimen was exposed to air and light cured for 20 s. Group B1 was coated with glycerin and light cured for 20 s and Group B2 was exposed to air and light cured for 20 s. The specimens were stored in distilled water for 24 h at 370. Measuring with Vickers and surface roughness tester and. Data were statistically analyzed using Mean-whitney U Test. Results: There were statiscally significant difference between the surface hardness and roughness of nanofill composite coated with glycerin and without glycerin (p<0,05) Conclusion: The surface hardness of nanofill composite resin coated with glycerin is higher than composite without glycerin and the surface roughness of nanofill composite resin coated with glycerin is lower than composite without glycerin

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Comparative Evaluation of Triphala and Ela Decoction With 0.2% Chlorhexidine as Mouthwash in the Treatment of Plaque-Induced Gingivitis and Halitosis: A Randomized Controlled Clinical Trial

Journal of Evidence-Based Complementary & Alternative Medicine ◽

10.1177/2156587216679532 ◽

2016 ◽

Vol 22 (3) ◽

pp. 468-472 ◽

Cited By ~ 6

Author(s):

Pratibha Mamgain ◽

Abhishek Kandwal ◽

Ravindra K. Mamgain

Keyword(s):

Group Analysis ◽

T Test ◽

Plaque Index ◽

Controlled Clinical Trial ◽

Base Line ◽

Time Intervals ◽

Intergroup Comparison ◽

Significant Difference ◽

Group A ◽

Group B

Present study evaluates efficacy of Trifala and Ela as plaque controlling agent and compares it with chlorhexidine. Aim. To evaluate Antigingivitis, Antiplaque and Antihalitosis effect of Triphala and Ela decoction. A randomized sample of 60 patients with plaque induced gingivitis was enrolled and equally divided into two groups group A and group B. Group A was given Trifala and Ela decoction and Group B Chlorehexidine mouthwash for 21 days twice daily. Gingival inflammation index, plaque index and Organoleptic scoring scale was recorded at baseline, 14th day and 21st day. Comparing the plaque index for Group A with group B the reduction in from baseline to 14 day was 42.59 % and 38.62% respectively while from baseline to 21 day was 56.20% and 68.57% respectively. On comparing Gingival index for group A with group B the reduction from baseline to 14 day was 31.95% and 38.62 % respectively while from baseline to 21 day was 69.95 % and 68.57% respectively. Halitosis Percentage reduction at 14th day from base line was 33.33% and 38.18%; at 21 day from baseline 66.66% and 72.72% respectively for group A and group B. No statistical significant difference for intergroup comparison was found using paired t test. Intra group analysis using unpaired t test was significant for all the indices at different time intervals. Triphala and Ela decoction is organic, easy to prepare economical and equally effective as compared to chlorhexidine mouthwash.

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Effect of Erbium:Yttrium-Aluminum-Garnet Laser Combined with Mineralizing Agents on Microhardness of Demineralized Dentin

European Journal of Dentistry ◽

10.1055/s-0039-1688730 ◽

2019 ◽

Vol 13 (01) ◽

pp. 011-016

Author(s):

Hila Hajizadeh ◽

Atefeh Nemati-Karimooy ◽

Peiman Babaee-Rishkhori

Keyword(s):

Er:Yag Laser ◽

Additional Treatment ◽

Treatment Modalities ◽

Control Group ◽

Significant Difference ◽

Group A ◽

Casein Phosphopeptide ◽

Group B ◽

Post Hoc ◽

Demineralized Dentin

Abstract Objective The aim of this study was to assess the combined effect of erbium:yttrium-aluminum-garnet (Er:YAG) laser and mineralizing agents including casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride in improving the resistance of demineralized dentin at new demineralization process. Materials and Methods One hundred and twenty healthy dentin surfaces were prepared and demineralized using acidic solutions. Primary microhardness was measured (h1), and samples were randomly divided into six groups. Each group received a different protocol as follows: Group A (control group): no additional treatment, Group B: applying a fluoridated gel, Group C: applying a CPP-ACP-containing cream, Group D: irradiation of Er:YAG laser, Group E: irradiation of Er:YAG laser combined with the application of a fluoridated agent, and Group F: irradiation of Er:YAG laser combined with the application of CPP-ACP-containing cream. Microhardness values were measured afterward (h2). Then, all the groups were re-exposed to acidic solution, and microhardness was measured for the third time (h3). The microhardness data were analyzed using analysis of variance and Scheffe's post hoc test. Results Although application of mineralizing agents increased the microhardness of demineralized dentin in comparison with the control group, no significant difference was observed using two agents. Comparison of laser groups showed an increase in microhardness only after the irradiation of Er:YAG laser combined with the application of a fluoridated agent. Demineralizing process reduced the microhardness values in all the groups, but the application of a CPP-ACP agent caused the least reduction among the laser irradiated groups. Comparison of hardness changes at the beginning and end of the experiment did not show any significant differences between the groups. Conclusion Comparison of treatment modalities used in this study exhibited that fluoride had the greatest impact on dentin resistance. Laser irradiation on demineralized dentin did not increase the hardness or resistance to acidic attacks.

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A Pilot Study to Evaluate HEMA based Desensitising Agent and 980 nm Diode Laser in Dentinal Hypersensitivity

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2020/45814.14277 ◽

2020 ◽

Author(s):

Anupama Ahirwar ◽

Anuj Bhargava ◽

Sanjesh Kumar Meena

Keyword(s):

Diode Laser ◽

Repeated Measures ◽

Repeated Measure ◽

Treatment Modalities ◽

Dentinal Tubule ◽

Significant Difference ◽

Group A ◽

Group B ◽

High Cervical ◽

Dentinal Hypersensitivity

Introduction: Dentinal Hypersensitivity (DH) presents as a short, intense pain emanating from exposed dentinal tubules. Many studies have concluded that mechanical, chemical or both factors increase the frequency of DH. Sealing of exposed dentinal tubule can be achieved with the use of Dental adhesives, restorations, Desensitising Agents (DA) and Lasers, each having their own mechanism of action. Aim: This clinical study was done to evaluate the efficacy of Hydroxy Methacrylate (HEMA) based DA and 980 nm diode laser in the treatment of DH. Materials and Methods: This two-arm parallel design split-mouth study was conducted on 30 adult patients attending the Dental Outpatient Clinic of Gandhi Medical College, Bhopal during the year December 2018 to January 2020 with clinically diagnosed high cervical DH (Charlie=3) occurring bilaterally in maxillary canine teeth. Scoring of baseline and postoperative DH was done utilising using Modified U.S. Public Health Service Criteria for DH Assessment. After recording the pretreatment baseline scores, mouth of each sample subject was divided bilaterally using split-mouth technique into Group A and Group B. The left side of patient’s mouth was designated as Group A in which a 10 W Diode Laser (980 nm) was used and right side of the patient’s mouth was classified as Group B, in which Shield Active (HEMA based) DA was used. The sensitivity score for both the groups was assessed immediately after application, after 24 hours, after seven days and after 21 days. Statistical Analysis was done by using Statistical Package for Social Sciences(SPSS) software version 22.0. Student’s t-test and repeated measures of ANOVA Test were applied. The p-value of less than 0.05 was considered statistically significant. Results: There was a statistically highly significant difference in sensitivity scores between both groups immediately after treatment p=0.038, after 24 hours, seven days and after 21 days. (p<0.001) depicting high efficacy of Diode lasers over DA. Repeated Measure of ANOVA was applied to find difference in mean score from baseline to 21 days. Immediately after application the results in Group A compared to baseline were statistically highly significant (p<0.001) and statistically significant in Group B (p<0.05). However, overall difference after 21 days compared to baseline were not significant in any group (p>0.05) depicting that the effect of both the desensitising therapies were not significant beyond 21 days in both the groups. Conclusion: Within the limits of this study, it can be concluded that both HEMA based DA and 980 nm diode laser were effective desensitisation treatment modalities for achieving immediate reduction of high cervical dentin hypersensitivity from baseline. Further, 980 nm Diode laser was found to be more efficacious and effective treatment option than HEMA based DA for treatment of DH.

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Effects of Mime Therapy With Sensory Exercises on Facial Symmetry, Strength, Functional Abilities, and the Recovery Rate in Bell's Palsy Patients

Function and Disability Journal ◽

10.32598/fdj.4.35 ◽

2021 ◽

Vol 4 (1) ◽

pp. 35-35

Author(s):

Siddharth S Mishra ◽

◽

Mahvish Sayed ◽

Keyword(s):

Electrical Stimulation ◽

Functional Abilities ◽

Facial Symmetry ◽

Intergroup Comparison ◽

Significant Difference ◽

Group A ◽

Group B ◽

Bell Palsy ◽

Facial Synkinesis ◽

Facial Function

Background and Objectives: Bell palsy is the sudden lower motor neuron paralysis of the facial nerve, characterized by acute unilateral peripheral facial muscle weakness. Physiotherapy has been proven to be beneficial in the rehabilitation of patients with Bell palsy and is important to prevent permanent contractures of the paralyzed facial muscles. A physiotherapy technique includes electrical stimulation and mime therapy to help in restoring lost muscle functions. Also, sensory exercises include varied normality solutions administered. This study aimed to find the effects of mime therapy with sensory exercises on facial symmetry and functional abilities among Bell palsy patients. Methods: A total number of 30 participants were recruited for an interventional study and conveniently assigned into three groups (n=10), where group A received electrical stimulation with facial exercises, group B received electrical stimulation with mime therapy, and group C received a combination of electrical stimulation, mime therapy, and sensory exercises. Each group received 18 sessions; each session was for 60 minutes per day, six days per week, for three weeks. Then, all the participants were assessed using the Sunnybrook facial grading system and the facial disability index. Results: Intragroup analysis showed a significant difference within all three groups (P<0.05). Besides, the intergroup comparison showed maximum recovery in group C followed by groups B and A. Conclusion: A combination of mime therapy and electrical stimulation along with sensory exercises provides the most beneficial intervention to improve facial function and reduce facial synkinesis in Bell palsy individuals. Hence, sensory exercises are recommended as an adjunct to electrical stimulation and mime therapy for the line of treatment for individuals with Bell palsy.

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Changes in boar semen with a high and low level of morphologically abnormal spermatozoa

Czech Journal of Animal Science ◽

10.17221/4170-cjas ◽

2011 ◽

Vol 50 (No. 7) ◽

pp. 289-299 ◽

Cited By ~ 1

Author(s):

J. Čeřovský ◽

S. Frydrychová ◽

A. Lustyková ◽

M. Rozkot

Keyword(s):

Performance Test ◽

Sperm Quality ◽

Sperm Concentration ◽

Test Results ◽

Semen Volume ◽

Significant Difference ◽

Group A ◽

Boar Semen ◽

Group B ◽

Selection Of

The aim of the paper was to find out the level of changes in the sperm quality in two groups of boars in the insemination (A and B) with diametrically different contents of morphologically abnormal spermatozoa (AS) with an interval of 25 weeks between semen collection I and collection II. In the group A there were 22 boars with the AS content up to 10%, in the group B 16 of boars with the AS content above 40% in collection I. Both groups were comparable concerning the parameters of the performance test results and in quantitative parameters of the semen from collection I. They differed significantly in the AS content (P < 0.01) and in the age (P < 0.05). In collection II in both groups the semen volume increased significantly (A – P < 0.01; B – P < 0.05), in the group A the number of spermatozoa per ejaculate and per day also increased (P < 0.01). In the group B there was an insignificant clear decrease in the sperm concentration (P > 0.05). In comparison with the group B the group A can be characterized as a group with significantly higher dynamics in the sperm production per ejaculate. An opposite trend was noted in the total AS content. In the group A there was a significant increase (P < 0.001) and in the group B a significant decrease (P < 0.001) in collection II. In the group A there was a deterioration of the AS content in 7 boars (31.8%), in the group B an improvement in 7 boars (43.7%). Particular monitored AS forms are given. A significant difference in the total AS content between both groups was in favour of the group A (P< 0.001). While no boars from the group A exceeded the limit in the AS content for the applicability of semen for insemination (in theCzech   Republic25%), in the group B they remained above this limit without applicability possibility. The detected variations and prevailing stability in the AS occurrence in boars kept in the same conditions lead us to a consideration of hereditary characteristics of the spermatogenesis factor, of considerable persistence of the level of monitored characteristics and to a consideration of applicability of the phenotype AS presentation to selection of boars for artificial insemination.    

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Efficacy of the Rotary Instrument XP-Endo Finisher in the Removal of Calcium Hydroxide Intracanal Medicament in Combination with Different Irrigation Techniques: A Microtomographic Study

Materials ◽

10.3390/ma13102222 ◽

2020 ◽

Vol 13 (10) ◽

pp. 2222

Author(s):

Jameela Denna ◽

Lubna A Shafie ◽

Loai Alsofi ◽

Mey Al-Habib ◽

Emad AlShwaimi

Keyword(s):

Test Results ◽

Human Teeth ◽

Passive Ultrasonic Irrigation ◽

Root Canals ◽

Significant Difference ◽

Group A ◽

Ultrasonic Irrigation ◽

Group B ◽

Post Hoc ◽

Rotary Instrument

Objectives: This study aims to evaluate the efficacy of the rotary instrument XP-endo Finisher for the removal of Ca(OH)2 aided by different irrigation regimens. Methods: Sixteen double-rooted upper premolar human teeth were selected for the study. Thirty-two canals were prepared using a ProTaper Next rotary system up to X3. Then, the canals were filled with Ca(OH)2. The volume of Ca(OH)2 inside the canals was measured by microcomputed tomography (micro-CT). After that, the teeth were randomly allocated into two experimental groups, i.e., A and B (n = 16 canals). In group A, Ca(OH)2 was removed using the master apical file (X3). In group B, Ca(OH)2 was removed using a XP-endo finisher. In half of both groups (n = 8), syringe irrigation (SI) was used, while passive ultrasonic irrigation (PUI) was used for the other half. After removal, the remaining volume of Ca(OH)2 was measured. All data were statistically analyzed using two-way ANOVA with Tukey’s post hoc test. Results: The percentages of remaining Ca(OH)2 in the apical thirds of all canals were significantly higher as compared with the middle and coronal thirds in all groups (p < 0.05). There was no significant difference between different files and techniques (p > 0.05). Clinical Significance: This study presents a new method for the removal of Ca(OH)2 from root canals.

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