scholarly journals Results of Frequency Analysis Distribution of A1188c Rs3212227 Polymorphism in the IL12b Gene among Patients with Chronic Polypoid Rhinosinusit

2021 ◽  
pp. 6-10
Author(s):  
Khasanov Ulugbek Saidakramovich ◽  
◽  
Djuraev Jamolbek Abdukhakhorovich ◽  
Keyword(s):  
Clinical Stage ◽  
Study Groups ◽  
Promoter Regions ◽  
Medical Academy ◽  
Homozygous Genotype ◽  
Multidisciplinary Clinic ◽  
Opposite Situation ◽  
Il12b Gene ◽  
Genotype A ◽  
Group 1

Our data confirm the complexity of the genetic mechanism for the development of polyposis processes in patients with CPRS and indicate the necessity and importance of understanding complex gene interactions in the analysis of the development and clinical stage of the studied pathology. Material and methods. In accordance with the purpose of the study and to fulfill the assigned tasks, clinical studies were carried out in 140 patients with CPRS and with chronic rhinosinusitis, who were examined and treated at the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy in 2017-2019. To study the diallelic polymorphism of the promoter regions of the genes of the studied interleukins, 50 healthy (no CPRS) donors, men and women, were examined. The average age of the examined donors was 51.3 ± 1.44 years. Conclusion. Analyzing the prevalence of genotypic variants of this polymorphism, we revealed a direct association of the C / C monogenotype of the A1188C rs3212227 polymorphism in the IL12B gene with the development of polyposis processes. The study of the distribution of genotypes showed that the homozygous genotype A / A was insignificant, almost 1.2 times more often found in group 1 (80.64%), while the frequency of detection of the heterozygous genotype A / C was insignificantly 1.1 times higher among patients with HRC 2 groups. The opposite situation could be observed in the study of the homozygous C / C genotype, which was not identified among all study groups.

scholarly journals Results of Frequency Analysis Distribution of A1188c Rs3212227 Polymorphism in the IL12b Gene among Patients with Chronic Polypoid Rhinosinusitis

2021 ◽  
Vol 1 (2) ◽  
pp. 6-10
Author(s):  
Khasanov Ulugbek Saidakramovich ◽  
◽  
Djuraev Jamolbek Abdukhakhorovich* ◽  
Keyword(s):  
Clinical Stage ◽  
Study Groups ◽  
Promoter Regions ◽  
Medical Academy ◽  
Homozygous Genotype ◽  
Multidisciplinary Clinic ◽  
Opposite Situation ◽  
Il12b Gene ◽  
Genotype A ◽  
Group 1

Our data confirm the complexity of the genetic mechanism for the development of polyposis processes in patients with CPRS and indicate the necessity and importance of understanding complex gene interactions in the analysis of the development and clinical stage of the studied pathology. Material and methods. In accordance with the purpose of the study and to fulfill the assigned tasks, clinical studies were carried out in 140 patients with CPRS and with chronic rhinosinusitis, who were examined and treated at the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy in 2017-2019. To study the diallelic polymorphism of the promoter regions of the genes of the studied interleukins, 50 healthy (no CPRS) donors, men and women, were examined. The average age of the examined donors was 51.3 ± 1.44 years. Conclusion. Analyzing the prevalence of genotypic variants of this polymorphism, we revealed a direct association of the C / C monogenotype of the A1188C rs3212227 polymorphism in the IL12B gene with the development of polyposis processes. The study of the distribution of genotypes showed that the homozygous genotype A / A was insignificant, almost 1.2 times more often found in group 1 (80.64%), while the frequency of detection of the heterozygous genotype A / C was insignificantly 1.1 times higher among patients with HRC 2 groups. The opposite situation could be observed in the study of the homozygous C / C genotype, which was not identified among all study groups.

scholarly journals The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss

2020 ◽  
Vol 15 (1) ◽  
pp. 884-889
Author(s):  
İbrahim Özcan ◽  
İbrahim Hira ◽  
Altan Kaya ◽  
Mehmet Yaşar ◽  
Murat Doğan ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Predictive Value ◽  
Study Groups ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Microvascular Damage ◽  
Distribution Width ◽  
Group 1

AbstractBackgroundWe aimed to evaluate the association between mean platelet volume, platelet distribution width (PDW), platelet count (PC) and plateletcrit (PCT), and the presence of sudden sensorineural hearing loss (SSNHL) and treatment response. In the literature, there is no study that investigates the platelet functions in diabetic patients with SSNHL.MethodsThe patients were retrospectively assigned into Group 1 (68 diabetic patients with SSNHL), Group 2 (63 nondiabetic patients with SSNHL) and Group 3 (64 healthy controls).ResultsPC was not significantly different between the groups (p > 0.05). MPV, PDW and PCT values were significantly higher in Group 1 as compared to Groups 2 and 3 (p < 0.05). Platelet parameters were not significantly different between the patients who were responsive and nonresponsive to the treatment. Therefore, the platelet parameters did not affect prognosis significantly in this study samples (p > 0.05).ConclusionsThis study showed that platelet parameters did not have a significant effect as a prognostic and predictive value in diabetic and nondiabetic patients with SSNHL. Further studies with more homogenous and larger study groups investigating the platelet parameters are needed to demonstrate microvascular damage and vascular alterations induced by diabetes mellitus.

scholarly journals Evaluation of Gingival Microleakage in Class II Composite Restorations with Different Lining Techniques: An In Vitro Study

Scientifica ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Vedavathi Bore Gowda ◽  
B. V. Sreenivasa Murthy ◽  
Swaroop Hegde ◽  
Swapna Devarasanahalli Venkataramanaswamy ◽  
Veena Suresh Pai ◽  
...  
Keyword(s):  
Study Groups ◽  
Class Ii ◽  
Composite Liner ◽  
Flowable Composite ◽  
Composite Restorations ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim. To compare the microleakage in class II composite restorations without a liner/with resin modified glass ionomer and flowable composite liner.Method. Forty standardized MO cavities were prepared on human permanent mandibular molars extracted for periodontal reasons and then divided into 4 groups of ten specimens. The cavity preparations were etched, rinsed, blot dried, and light cured and Adper Single Bond 2 is applied. Group 1 is restored with Filtek P60 packable composite in 2 mm oblique increments. Group 2 is precure group where 1 mm Filtek Z350 flowable liner is applied and light cured for 20 sec. Group 3 is the same as Group 2, but the liner was cocured with packable composite. In Group 4, 1 mm RMGIC, Fuji Lining LC is applied and cured for 20 sec. All the teeth were restored as in Group 1. The specimens were coated with nail varnish leaving 1 mm around the restoration, subjected to thermocycling, basic fuchsin dye penetration, sectioned mesiodistally, and observed under a stereomicroscope.Results. The mean leakage scores of the individual study groups were Group 1 (33.40), Group 2 (7.85), Group 3 (16.40), and Group 4 (24.35). Group 1 without a liner showed maximum leakage. Flowable composite liner precured was the best.

scholarly journals Characterization of Enamel After the Use of Oral Hygiene Auxiliaries with Whiteners

2019 ◽  
pp. 227-236
Author(s):  
Norma Verónica Zavala-Alonso DDS, MSc, PhD ◽  
Jorge Humberto Ramírez-González DDS, MSc ◽  
Mariana Ramírez-Vergara DDS ◽  
José Gilberto Roque-Márquez DDS, MSc ◽  
Flores Daniel Silva-Herzog DDS, MSc, PhD
Keyword(s):  
Oral Hygiene ◽  
Dental Enamel ◽  
Hardness Test ◽  
Study Groups ◽  
Micro Hardness ◽  
Sem Images ◽  
Group 4 ◽  
Group 2 ◽  
Mouth Wash ◽  
Group 1

The purpose of this study was to evaluate the effect of the use of the combined auxiliaries of oral hygiene with whitening agents on the micro-hardness and micro-morphology of dental enamel. Materials and Methods. 40 human incisors were used and sectioned to obtain 4x4mm samples and divided into four study groups. Group 1: Electric brushing with Toothpaste (BTP); Group 2: Electric brushing with Toothpaste+mouthwash (BTP+MW); Group 3: Electric brushing with Toothpaste+whitening pen (BTP+WP); Group 4: Electric brushing with Toothpaste+mouth wash+whitening pen (BTP+MW+WP). Samples were submitted toVickers micro-hardness test and visualized using scanning electron microscopy (SEM). Results. All groups, with the exception of group 1, showed a decrease in micro-hardness values after applying the treatments (p<0.05). Likewise, when comparing the values after the treatments between the groups, significant statistical differences were found in all of comparisons except for those of groups 2 and 4. SEM images showed changes in the morphology in all the study groups with the exception of group 1. Conclusion. Significant changes such as decrease in micro-hardness as well as in the topography of the enamel surface such as elevations, craters, porosities and etching patterns were founded after the use of the combination of auxiliaries of oral hygiene with whitening agents.  

scholarly journals Evaluation of DNA Methylation Changes and Micronuclei in Workers Exposed to a Construction Environment

2019 ◽  
Vol 16 (6) ◽  
pp. 902 ◽  
Author(s):  
Isana Silva ◽  
Manoela Ramos ◽  
Lídia Arantes ◽  
André Lengert ◽  
Marco Oliveira ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Particulate Matter ◽  
Repetitive Sequences ◽  
Promoter Regions ◽  
Exposed Workers ◽  
Polycyclic Aromatic ◽  
Group 2 ◽  
Environmental Air ◽  
The Relationship ◽  
Group 1

Methylation levels in tumor-suppressor genes and repetitive sequences have previously been used to study the relationship between environmental air pollution and epigenetic changes related to cancer. In this study, we measured the methylation profiles of the promoter regions CDKN2A, MLH1 and APC and the repetitive sequence LINE-1 in 59 workers exposed to the construction environment and in 49 unexposed workers. We also evaluated the micronuclei frequency and levels of trace elements in the blood of all workers. We evaluated of levels of particulate matter and polycyclic aromatic hydrocarbons (PAHs) at the construction site to characterize the environmental exposure. Our findings demonstrated that exposed workers exhibited significantly higher average levels of promoter methylation of CDKN2A, APC, and MLH1 genes and increased hypomethylation of the LINE-1 in comparison to unexposed workers (all p < 0.05). A higher frequency of micronuclei was observed in the exposed group (2 ± 2) compared to the unexposed group (1 ± 1) with p < 0.001. High levels of particulate matter (51–841 μg/m3) and some PAHs were found in samples from the construction environment. In summary, we provide evidence of increased DNA damage and altered DNA methylation of exposed workers, suggesting that genomic approaches to biomonitoring may be an effective way of estimating future cancer risk for construction workers.

Pharmacogenetic Profiling and Clinical Outcome of Patients With Advanced Gastric Cancer Treated With Palliative Chemotherapy

2006 ◽  
Vol 24 (12) ◽  
pp. 1883-1891 ◽  
Author(s):  
Annamaria Ruzzo ◽  
Francesco Graziano ◽  
Kazuyuki Kawakami ◽  
Go Watanabe ◽  
Daniele Santini ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Clinical Outcomes ◽  
Palliative Chemotherapy ◽  
Progression Free Survival ◽  
Free Survival ◽  
Innovative Strategy ◽  
Homozygous Genotype ◽  
Group 2 ◽  
Group 1

Purpose To investigate whether polymorphisms with putative influence on fluorouracil/cisplatin activity are associated with clinical outcomes of patients with advanced gastric cancer (AGC). Patients and Methods Peripheral blood samples from 175 prospectively enrolled AGC patients treated with fluorouracil/cisplatin palliative chemotherapy were used for genotyping 13 polymorphisms in nine genes (TS, MTHFR, XPD, ERCC1, XRCC1, XRCC3, GSTPI, GSTTI, GSTMI). Genotypes were correlated to response and survival. Results The overall response rate was 41%, the median progression-free survival (PFS) was 24 weeks (range, 4 to 50 weeks), and the median overall survival (OS) was 39 weeks (range, 8 to 72+ weeks). Chemoresistance and poor survival were significantly associated with TS 5′-UTR 3G-genotype (2R/3G, 3C/3G, 3G/3G) and GSTP1 105 A/A homozygous genotype. Sixty-one patients (35%) did not show any of these risk genotypes (group 0), 57 patients (32.5%) showed one of the two risk genotypes (group 1), and 57 patients (32.5%) showed both risk genotypes (group 2). Median PFS and OS in group 0 patients were 32 weeks (range, 8 to 50 weeks) and 49 weeks (range, 18 to 72+ weeks), respectively. Group 1 and group 2 patients showed significantly worse PFS (median, 26 weeks [range, 6 to 44 weeks] and 14 weeks [range, 4 to 38 weeks], respectively) and worse OS (median, 39 weeks [range, 10 to 58 weeks] and 28 weeks [range, 8 to 56 weeks]), respectively, than group 0 patients. This adverse effect was retained in multivariate analysis. Conclusion Specific polymorphisms may influence clinical outcomes of AGC patients. Selecting palliative chemotherapy on the basis of pretreatment genotyping may represent an innovative strategy that warrants prospective studies.

A numerical analysis of major groupings in Medicago employing traditionally used characters

1981 ◽  
Vol 59 (9) ◽  
pp. 1553-1577 ◽  
Author(s):  
Ernest Small
Keyword(s):  
Numerical Analysis ◽  
Study Groups ◽  
Species Group ◽  
Annual Species ◽  
Agglomerative Clustering ◽  
Medicago Arborea ◽  
Group 3 ◽  
Group 2 ◽  
Numerical Examination ◽  
Group 1

Numerical taxonomic analyses (particularly agglomerative clustering and ordination) were conducted on 55 species of Medicago, using 75 mostly vegetative and fruiting characters. The material studied represents all conservatively accepted species of the genus, as well as 14 "problematical" species of which many are often considered to belong to the genus Trigonella, rather than to Medicago. Although the characters employed are substantially the same as those used by recent monographers who evaluated the genus by traditional subjective procedures, the present numerical examination suggests many relationships not previously appreciated.As a result of the analyses, it was judged appropriate to recognize 12 groupings. These are group 1: M. sativa (alfalfa) and 11 allied species; group 2: M. lupulina and M. secundiflora; group 3: eight problematical species which have troubled taxonomists with respect to whether they should be placed in Medicago or Trigonella; groups 4–8: each made up of a single divergent species, respectively: M. carstiensis, M. radiata, M. orbicularis, M. heyniana, and M. arborea; groups 9–12 four subgroupings of a larger group of 28 annual species. In the main, the composition of the seven polytypic groups is similar to those of taxa accepted by recent monographers, although some realignments of particular species are suggested by the present study. Groups 1 and 2 are much more similar to each other than indicated in recent treatments. Medicago arborea was discovered to be much more dissimilar to all other species examined than thought previously. Medicago hybrida of group 1 was found to be a "master link" between species traditionally placed in Medicago, and many placed in Trigonella (group 3).The 12 groupings in turn fall into three assemblages that could be recognized as subgenera, or even as genera. These are A: groups 1, 2, 9, 10, 11, and 12; B: groups 3–7, inclusive; and C: M. arborea. Further research is suggested before formal categorization is undertaken.

scholarly journals The usage of personalized scheme of fentanyl administration during coronary artery stenting

2020 ◽  
pp. 11-19
Author(s):  
D.О. Dziuba ◽  
Keyword(s):  
Coronary Artery ◽  
Coronary Arteries ◽  
Comparison Group ◽  
Study Groups ◽  
Stress Markers ◽  
Coronary Artery Stenting ◽  
Group 2 ◽  
Personalized Approach ◽  
Fentanyl Administration ◽  
Group 1

The aim – to develop a personalized scheme of fentanyl administrationfor coronary artery stenting. Materials and methods. Ninety patients with ischemic heart disease who underwent planned stenting of the coronary arteries were studied. The patients who underwent surgery were evenly divided into three study groups, depending on mode of the intraoperative analgesic sedation and the approaches to anesthesia. The first comparison group consisted of patients who received slow intravenous administration of diazepam and fentanyl solutions. The second comparison group consisted of patients with balanced administration of fentanyl and propofol solutions to provide analgesic sedation at the level of conscious anesthesia. The study group consisted of patients with a personalized approach to the administration of opiates, namely, we used the original fentanyl test described in the article. Analgesic sedation at the level of conscious anesthesia (ІІІ by Ramsey) was maintained by propofol infusion. Results. The usage of a personalized scheme of fentanyl administration for stenting of the coronary arteries, compared to the standard sedation using combination of diazepam and fentanyl, was accompanied by better indicators of intraoperative blood saturation with oxygen and carbon dioxide (respectively (103.67 ± 22.05) and (39.64 ± 6.85) mm Hg in group 1, (105.70 ± 31.64) and (37.68 ± 7.11) in group 2 and (109.42 ± 34.36) and (36.25 ± 6.52) mm Hg in patients of the 3rd group), lower blood pressure after surgery ((127.85 ± 9.87)/(79.64 ± 8.62) mm Hg in patients of group 1, (129.48 ± 8.73)/(81.05 ± 7.92) mm Hg in group 2 and (131.15 ± 10.64)/(82.68 ± 9.72) mm Hg in group 3), lower level of stress markers (blood cortisol during surgery in patients of the 1st group (8.83 ± 4.58) mmol/L, in patients of the 2nd group – (7.73 ± 2.79) mmol/L, in patients of the 3rd group – (7.55 ± 4.35) mmol/L), as well as lower frequency of detecting episodes of perioperative pain of various origins. Conclusions. A method of personalized anesthesia was elaborated, based on individual scheme of fentanyl administration («fentanyl test») during coronary artery stenting. Its usage is safe (due to the optimal parameters of gas exchange and hemodynamics and fewer side effects, such as nausea and residual sedation) and effective (due to the lower level of stress markers and less frequent complaints of pain of various origins) than when the routine technique was used. Key words: analgesic sedation, individual sensitivity, fentanyl, diazepam, propofol.

scholarly journals Immersion in Water During Active Labor Decreases Postpartum Hematocrit Fall Following Vaginal Delivery

2018 ◽  
pp. 1
Author(s):  
Gul Nihal Buyuk ◽  
Serkan Kahyaoglu ◽  
Ezgi Turgut ◽  
Omer Hamid Yumuşak ◽  
Caner Kose ◽  
...  
Keyword(s):  
Vaginal Delivery ◽  
Postpartum Hemorrhage ◽  
Study Groups ◽  
Normal Vaginal Delivery ◽  
Control Group ◽  
The Mean ◽  
Group 2 ◽  
Water Birth ◽  
Control Group Group ◽  
Group 1

<p><strong>OBJECTIVE:</strong> The objective of the study was to investigate the effect of immersion in water strategy during labor on postpartum bleeding by calculating the postpartum reduction rates of the hematocrit values of the patients.</p><p><strong>STUDY DESIGN:</strong> The study groups consisted of 84 women undergoing vaginal delivery with immersion in water during labor (group 1) and the control group (group 2) of 84 women undergoing normal vaginal delivery. Patients who have received additional medical and surgical interventions for alleviation of postpartum hemorrhage, patients who have undergone an episiotomy and/or perineal trauma were not included in the study. All data were taken from patients who have delivered with spontaneous vaginal delivery. Postpartum hematocrit fall rates of the groups have been compared and the effect of immersion in water on postpartum hemorrhage has been evaluated.</p><p><strong>RESULTS:</strong> The study groups consisted of 84 women undergoing vaginal delivery with immersion in water during labor (Group 1) and the control group (Group 2) of 84 women undergoing vaginal delivery at the hospital. The women in the two groups were matched with respect to age, parity, birth weight and gestational age. The mean age of the women was 29.8±4.8 and 30.5±4.9 respectively. The mean hematocrit difference in the first group was 2.08 ± 1.88 and in the second group was 3.81 ± 1.55. The mean percentage of hematocrit reduction in the first group was 5.71% and in the second group 10.23%.</p><p><strong>CONCLUSION:</strong> Our data showed that mean hematocrit level decreases among women following vaginal delivery more than women who give birth vaginally within immersion in water during labor. The percentage of hematocrit reduction in the water birth group was lower than in the control group. Water birth seems to facilitate uterine contractions more efficiently following vaginal delivery.</p>

scholarly journals Changes in the Levels of Biochemical Markers Following Coronavirus Infection in Patients with Liver Disease, Renal Disease and Diabetes Mellitus as Compared to Control Participants: A Cross Sectional Study

2021 ◽  
pp. 141-148
Author(s):  
Osama J. Ahmed ◽  
Estabraq A. Al-Wasiti ◽  
Dina Jamil ◽  
Hayder A. Al-Aubaidy
Keyword(s):  
Liver Disease ◽  
Blood Glucose ◽  
Renal Disease ◽  
Liver Enzymes ◽  
Fasting Blood Glucose ◽  
Serum Levels ◽  
Study Groups ◽  
Control Group ◽  
Group 3 ◽  
Group 1

Background & Aim of the Study: Increased levels of many biomarkers, including liver enzymes, blood urea and serum creatinine as well as glycemic markers have been reported following coronavirus (COVID-19) infection, leading to the development of acute disease. This study aims to measure and follow-up the following biomarkers (fasting blood glucose, blood urea, serum creatinine, total serum bilirubin, as well as the liver enzymes AST, ALT, and ALP) in otherwise healthy participants and patients with liver disease, renal disease and diabetes following COVID-19 infection. Materials and Methods: This is cross section study, included 144 participants who were infected with COVID-19 and admitted to the Sheikh Zayed Hospital, Baghdad, Iraq. Participants were divided into 4 study groups, Group 1: 46 participants with no pre-existing medical condition (Control), Group 2: 30 patients with existing liver disease. Group 3: 28 patients with existing renal disease and Group 4: 40 patients with diabetes mellitus. Participants were followed up for 14 days following COVID-19 infection to monitor the progression of the biochemical markers. Results: There were significant changes in serum levels of all the markers of this study between the four study groups (p<0.001). Serum ALP levels were not significantly changed within any of the four study groups. However, both ALT and AST levels were significantly changed within all the four study groups (p<0.001). The levels of TSB changes significantly within the renal group (Group 3), (p=0.017). The levels of S. Creatinine showed significant changes in all the study groups except the renal group (Group 3). The levels change significantly within all the study groups except the control group (Group 1), while fasting blood glucose levels changes significantly in the control group only (Group 1), (p=0.004). Conclusions: Following COVID-19 infection, there were significant changes in the levels of ALT, AST, S. Creatinine and B.Urea after 14 days of the disease progression. While in patients with existing renal disease, there were significant changes in the levels of TSB, AST, ALT and B. Urea following COVID-19 infection. In diabetic patients, there were significant increase in the level of   fasting blood glucose after 14 days of COVID-19 infection. there were no significant changes in serum levels of ALP and FBG in patients with chronic illnesses (liver disease, renal disease, and diabetes) when compared to control group.

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