scholarly journals Rare tumor of the spleen - case report

2016 ◽  
Vol 3 (4) ◽  
pp. 37
Author(s):  
Rita Meireles ◽  
Joana Cordeiro Cunha ◽  
Violeta Iglesias ◽  
Paula Baptista
Keyword(s):  
Immunohistochemical Staining ◽  
Clinical Case ◽  
Incidental Finding ◽  
Benign Lesion ◽  
Abdominal Ultrasound ◽  
Clinical Impact ◽  
Definitive Treatment ◽  
Rare Tumor ◽  
Sclerosing Angiomatoid Nodular Transformation ◽  
Histological Appearance

Sclerosing angiomatoid nodular transformation was first described as a solitary angioma-like disease of the spleen by Martel et al. in 2004. It is a relatively new rare benign lesion. The authors present a clinical case of an asymptomatic, 48-year-old female. SANT has been an incidental finding in an abdominal ultrasound. Histological appearance and the immunohistochemical staining after spleen biopsy confirmed the diagnosis. As suggested in previously published articles, a splenectomy was performed for definitive treatment. This case contributes to the differential diagnosis of splenic tumors, its treatment and clinical impact.

scholarly journals Clinical Impact of Revised Ciprofloxacin Breakpoint in Patients with Urinary Tract Infections by Enterobacteriaceae

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 469
Author(s):  
Ga-Eun Park ◽  
Jae-Hoon Ko ◽  
Sun-Young Cho ◽  
Hee-Jae Huh ◽  
Jin-Yang Baek ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Clinical Outcomes ◽  
Urinary Tract Infections ◽  
Inhibitory Concentration ◽  
Clinical Impact ◽  
Definitive Treatment ◽  
Primary Endpoints ◽  
Tract Infections ◽  
Susceptible Group ◽  
Selection Of

In 2018, the Clinical and Laboratory Standards Institute (CLSI) revised ciprofloxacin (CIP)-susceptible breakpoint for Enterobacteriaceae from ≤1 μg/mL to ≤0.25 μg/mL, based on pharmacokinetic-pharmacodynamic (PK-PD) analysis. However, clinical data supporting the lowered CIP breakpoint are insufficient. This retrospective cohort study evaluated the clinical outcomes of patients with bacteremic urinary tract infections (UTIs) caused by Enterobacteriaceae, which were previously CIP-susceptible and changed to non-susceptible. Bacteremic UTIs caused by Enterobacteriaceae with CIP minimal inhibitory concentration (MIC) ≤ 1 μg/mL were screened, and then patients treated with CIP as a definitive treatment were finally included. Patients in CIP-non-susceptible group (MIC = 0.5 or 1 μg/mL) were compared with patients in CIP-susceptible group (MIC ≤ 0.25 μg/mL). Primary endpoints were recurrence of UTIs within 4 weeks and 90 days. A total of 334 patients were evaluated, including 282 of CIP-susceptible and 52 of CIP-non-susceptible. There were no significant differences in clinical outcomes between two groups. In multivariate analysis, CIP non-susceptibility was not associated with recurrence of UTIs. CIP non-susceptibility based on a revised CIP breakpoint, which was formerly susceptible, was not associated with poor clinical outcomes in bacteremic UTI patients were treated with CIP, similar to those of the susceptible group. Further evaluation is needed to guide the selection of definitive antibiotics for UTIs.

scholarly journals Verruciform xanthoma: case report

2016 ◽  
Vol 64 (1) ◽  
pp. 79-82
Author(s):  
Maria Carolina de Lima Jacy MONTEIRO ◽  
Cristiane FURUSE ◽  
Larissa Cunha CÊ ◽  
Alexandre Freitas SANTANA ◽  
Vera Cavalcanti de ARAÚJO
Keyword(s):  
Case Report ◽  
Clinical Case ◽  
Benign Lesion ◽  
Viral Origin ◽  
Pathogenic Mechanisms ◽  
Verruciform Xanthoma ◽  
Local Trauma

ABSTRACT Verruciform xanthoma is a rare, benign lesion, with a papillary aspect, asymptomatic, sessile, white colored, and well-demarcated, that occurs in the gingiva and alveolar mucosa. The histopathological aspect is characterized by the presence of macrophages with foam cytoplasm (xanthoma cells) confined to the soft papillary tissue. The etiology and pathogenic mechanisms are unknown, although some hypothesis, such as local trauma or viral origin have been suggested. The aim of this article was report a clinical case of verruciform xanthoma located in the gingiva showing the clinical and histopathological aspects.

Sclerosing Angiomatoid Nodular Transformation of the Spleen

2013 ◽  
Vol 137 (9) ◽  
pp. 1309-1312 ◽  
Author(s):  
Dinesh Pradhan ◽  
Sambit K. Mohanty
Keyword(s):  
Current Knowledge ◽  
Benign Lesion ◽  
Good Prognosis ◽  
Unknown Etiology ◽  
Age Group ◽  
Imaging Findings ◽  
Effective Technique ◽  
Sclerosing Angiomatoid Nodular Transformation ◽  
Malignant Lesions ◽  
Mitotic Figures

Sclerosing Angiomatoid Nodular Transformation (SANT) of the spleen is a rare benign lesion of the spleen with unknown etiology. SANT is classically considered to be a female-predominant disease, with most of the patients in the 30- to 60-year age group. Most lesions are found incidentally on imaging. Although SANT has specific imaging findings, the differential diagnosis from other splenic tumors or malignant lesions is very difficult. Histopathologically, these tumors reveal multiple confluent angiomatoid nodules; these nodules are surrounded by concentric collagen fibers exhibiting an inflammatory and myofibroblastic response and are accompanied by numerous erythrocytes and siderophages. The nodules are populated by endothelial cells, phenotypically recapitulating normal splenic vasculature, such as sinusoids, capillaries, and small veins. Nuclear atypia is minimal, mitotic figures are extremely rare, and necrosis is consistently absent. This lesion has a unique immunohistochemical profile characterized by CD34−CD31+CD8+ sinusoids, CD34+CD31+CD8− capillaries, and CD34−CD31+CD8− small veins. CD68 is positive in macrophages. Splenectomy is a useful and effective technique for the management of SANT. SANT patients have a good prognosis, with no recurrence after splenectomy. In this review, we discuss the current knowledge of SANT of the spleen and its clinical relevance.

Bouveret syndrome: a rare form of gallstone ileus

2021 ◽  
Vol 14 (2) ◽  
pp. e238126
Author(s):  
Don Haering ◽  
Mattie Murphy ◽  
John Craig ◽  
Gavin A Falk
Keyword(s):  
Clinical Evidence ◽  
Incidental Finding ◽  
Gallstone Ileus ◽  
Definitive Treatment ◽  
Abdominal Radiograph ◽  
Quadrant Pain ◽  
Abdominal Ct Scan ◽  
History Of ◽  
Bouveret Syndrome ◽  
High Index Of Suspicion

A 57-year-old woman presented with a 5-day history of worsening right upper quadrant pain, bilious emesis and approximately 20 pounds of weight loss. The patient was afebrile, without jaundice and had mild tenderness in her right upper quadrant. She noted an incidental finding of asymptomatic cholelithiasis on imaging 4 years earlier. An abdominal radiograph revealed pneumobilia and a large ectopic calculus. An abdominal CT scan confirmed pneumobilia, a large concretion completely obstructing the third portion of the duodenum and a soft tissue communication between the gallbladder and proximal duodenum. She was brought to the operating room for definitive treatment and had the obstructing gallstone removed via a transverse duodenotomy. Bouveret syndrome is a rare cause of small bowel obstruction that requires a high index of suspicion for diagnosis. It should be considered in older patients with clinical evidence of gastric or duodenal obstruction, particularly with a history of cholelithiasis.

Unusual Case of Sclerosing Angiomatoid Nodular Transformation of the Spleen in an Adolescent Patient: Case Report and Literature Review

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Abboud B ◽  
◽  
Honein K ◽  
Aidibi A ◽  
Yared F ◽  
...  
Keyword(s):  
Rare Case ◽  
Unusual Case ◽  
Benign Lesion ◽  
Relevant Literature ◽  
Clinical Suspicion ◽  
Radiographic Examination ◽  
Patient Case ◽  
Sclerosing Angiomatoid Nodular Transformation ◽  
High Clinical Suspicion ◽  
Red Pulp

Sclerosing Angiomatoid Nodular Transformation (SANT) is a rare and benign lesion arising from the red pulp of the spleen, with an unknown etiopathogenesis. These tumors are usually asymptomatic and are found incidentally on radiographic examination. Therefore, high clinical suspicion is of great importance for the diagnosis. Splenectomy provides complete cure, and no recurrence and/or malignant transformation was reported to date. In this study, a rare case of SANT was reported in aadolescent male, and was discussed with the relevant literature.

Atypical aspects in testicular tumors and differential diagnosis with benign lesion: Clinical case

1992 ◽  
Vol 59 (2) ◽  
pp. 77-79
Author(s):  
G. Ferro
Keyword(s):  
Differential Diagnosis ◽  
Clinical Case ◽  
Benign Lesion ◽  
Benign Lesions ◽  
Testicular Tumors

The author uses a clinical case to draw attention to some clinical and ultrasonographic aspects of testicular tumors, and in particular typical seminoma in stages I and II. Necrosis is prevalent in seminomas, which makes them difficult to differentiate from benign lesions.

scholarly journals Sclerosing angiomatoid nodular transformation of the spleen

2019 ◽  
Vol 12 (9) ◽  
pp. e229757
Author(s):  
Jiaying Liao ◽  
Aya Musbahi ◽  
Kaushik Dasgupta ◽  
Herwig Thibaut ◽  
Bussa Gopinath
Keyword(s):  
Weight Loss ◽  
Laparoscopic Splenectomy ◽  
Abdominal Ultrasound ◽  
Laboratory Analysis ◽  
High Likelihood ◽  
Unintentional Weight Loss ◽  
Histopathological Findings ◽  
Central Necrosis ◽  
Sclerosing Angiomatoid Nodular Transformation ◽  
Splenic Mass

The authors described a case of sclerosing angiomatoid nodular transformation of the spleen (SANT) in a 50-year-old woman presented with persistent neutrophilia and unintentional weight loss. An incidental splenic mass was initially found on abdominal ultrasound. It was found to be progressive in size and with high likelihood of central necrosis on further CT of abdomen and pelvis. The patient subsequently underwent an uneventful laparoscopic splenectomy. The splenic specimens were sent for laboratory analysis and the histopathological findings were highly suggestive of SANT. The patient then had routine surgical follow-ups and was eventually discharged with no further clinical concern.

scholarly journals A Rare Case of Myeloid Sarcoma Presenting as an Anorectal Ulcer

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Laxmi Parsa ◽  
Priti Bijpuria ◽  
Daniel Ringold ◽  
David Stein
Keyword(s):  
Immunohistochemical Staining ◽  
Myeloid Leukemia ◽  
Rare Case ◽  
Soft Tissues ◽  
Histochemical Staining ◽  
Myeloid Sarcoma ◽  
Atypical Presentation ◽  
Rare Tumor ◽  
Gastrointestinal Complaint ◽  
Acute Myeloid

Myeloid Sarcoma is a rare tumor composed of myeloblasts occurring at an extramedullary site like bones, or various soft tissues. Myeloid sarcoma may involve the gastrointestinal tract very rarely either solitarily, or occurring simultaneously with acute myeloid leukemia. Its diagnosis is challenging and needs biopsy and immunohistochemical staining. We are describing a case of myeloid sarcoma which presented as a painful anal ulcer mimicking an atypical fissure. Its appearance resembled crohn’s disease on sigmoidoscopy. A biopsy of the ulcer along with histochemical staining led to the diagnosis of myeloid sarcoma. Our case demonstrates the need for aggressive evaluation of any common gastrointestinal complaint with an atypical presentation.

scholarly journals Angiomyolipoma with Epithelial Cysts Masquerading as a Cystic Renal Cell Carcinoma

2015 ◽  
Vol 9 (4) ◽  
pp. 209-211
Author(s):  
Andrew Wood ◽  
Fiona Young ◽  
Marie O'Donnell
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Immunohistochemical Staining ◽  
Rare Case ◽  
Renal Tumor ◽  
Staining Pattern ◽  
Cystic Renal Cell Carcinoma ◽  
Epithelial Cysts ◽  
Histological Appearance

Angiomyolipoma with epithelial cysts (AMLEC) is a very uncommon renal tumor. AMLEC has a characteristic histological appearance and immunohistochemical staining pattern, knowledge of which should preclude misdiagnosis by pathologists. We present a rare case of an AMLEC which was suspected to be a cystic renal cell carcinoma radiologically. We describe the characteristic immunological staining pattern and ultrastructural features of this lesion and discuss the potential differential diagnoses.

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