Correction of Fatty Acids Metabolism as Treatment Strategy of Autism

Exposure of tumor cells to ionizing radiation (IR) alters the microenvironment, particularly the fatty acid (FA) profile and activity. Moreover, abnormal FA metabolism, either catabolism or anabolism, is essential for synthesizing biological membranes and delivering molecular signals to induce ferroptotic cell death. The current review focuses on the bistable regulation characteristics of FA metabolism and explains how FA catabolism and anabolism pathway crosstalk harmonize different ionizing radiation-regulated ferroptosis responses, resulting in pivotal cell fate decisions. In summary, targeting key molecules involved in lipid metabolism and ferroptosis may amplify the tumor response to IR.

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Changes in Adult Rats’ Testis structure Induced by Hypothyroidism and Alleviating Role of L-Carnitine

International Journal of Human Anatomy ◽

10.14302/issn.2577-2279.ijha-19-3026 ◽

2019 ◽

Vol 1 (4) ◽

pp. 13-28

Author(s):

Abdelmonem Awad Hegazy ◽

Manal Mohammad Morsy ◽

Rania Said Moawad ◽

Gehad Mohammad Elsayed

Keyword(s):

Fatty Acids ◽

Semen Analysis ◽

Protective Role ◽

The Body ◽

Albino Rats ◽

Adult Rats ◽

Fatty Acids Metabolism ◽

Group 3 ◽

Group 2

Background Hypothyroidism is a metabolic disorder affecting the functions of many tissues in the body including the testis. Testis is rich in the polyunsaturated fatty acids content and lacks strong intrinsic antioxidant system making it prone to such oxidative stress. L-carnitine (LC) regulates long chain fatty acids metabolism; and is considered a valuable antioxidant factor. Aim It was to evaluate the effect of hypothyroidism induced by propylthiouracil (PTU) on rats’ testes and the possible protective role of LC. Methods Forty-eight adult male albino rats were used in this work. The animals were divided into three groups with sixteen animals in each. Group 1 (Control): Animals were kept without medications. Group 2 (PTU-treated): was subjected to administration of PTU; while group 3 (PTU and LC) received both PTU and LC. By the end of the experiment “30 days”, blood samples were taken for hormonal assay; then animals were anaesthetized and sacrificed. Specimens were homogenized for biochemical analysis; epididymal content of each rat was obtained immediately for semen analysis. Testes’ specimens were harvested, prepared and examined by light microscope examination. Results Induced hypothyroidism was noticed to cause histopathological, morphometric and biochemical changes in rat’s testes. LC protected the testicular specimens against such changes; it also improved the seminal quality and quantity as well as testicular structure and biochemistry. Conclusion Hypothyroidism could result in hazards to the structure of testis. Fortunately co-administration of LC might reduce such hazards.

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Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents

Molecular Psychiatry ◽

10.1038/s41380-018-0047-z ◽

2018 ◽

Vol 24 (10) ◽

pp. 1478-1488 ◽

Cited By ~ 19

Author(s):

Xinyu Zhou ◽

Lanxiang Liu ◽

Xinghui Lan ◽

David Cohen ◽

Yuqing Zhang ◽

...

Keyword(s):

Fatty Acids ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Polyunsaturated Fatty Acids ◽

Children And Adolescents ◽

Purine Metabolism ◽

Major Depressive ◽

Diagnostic Biomarkers ◽

Fatty Acids Metabolism

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Abstract 197: Metabolic Syndrome Severely Alters Major Metabolic Pathways in the Pig Myocardium

Circulation ◽

10.1161/circ.140.suppl_2.197 ◽

2019 ◽

Vol 140 (Suppl_2) ◽

Author(s):

Maryam Karimi ◽

Olivia Ziegler ◽

Jun Feng ◽

Anny Usheva

Keyword(s):

Metabolic Syndrome ◽

Fatty Acids ◽

Left Ventricular ◽

Metabolic State ◽

Tissue Samples ◽

Increased Risk ◽

Significant Step ◽

Fatty Acids Metabolism ◽

Obesogenic Diet ◽

Altered Gene

Introduction: Obesity and metabolic syndrome (MetS) are rapidly expanding worldwide. One of the most concerning implications of this trend is the association between MetS and the increased risk of cardiovascular disease (CVD) . There is a little data on cross-talk between metabolomics alterations and myocardial functionality. Hypothesis: Because of the pleiotropic nature of CVD and of MetS, it is unlikely that single metabolite or metabolic pathway underlies the development of CVD in MetS. Understanding the global metabolic state of the MS myocardium using high throughput metabolomics and transcriptomics may provide novel insights. Methods: Yorkshire swine received obesogenic diet (MetS). Control (LD) animals received regular chow. Tissue samples from identical myocardial left ventricular territories are analyzed by: targeted LC/MS-MS for LV polar metabolites, MetaboAnalyst 4.0; RNA-seq. Results: MetS vs LD demonstrates: elevated blood fasting glucose, triglycerides, LDL, cholesterol, blood pressure. LC-MS-MS shows diet impact on 287 metabolites availability in MetS together with altered gene expression of traditional enzymes that are involved in C - glycolysis, fatty acids metabolism, ketone body formation, transport, and utilization. Conclusions: Transcriptionally controlled fuel gauge in the MetS heart enzymatically turns down glucose and fatty acids oxidation and activates nutritional ketolysis. This study represents a significant step towards characterizing the metabolic state of the heart in MetS and provides potential avenues for therapeutic advance.

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Curcumin ameliorates protein expression changes involved in mitochondrial fatty acids metabolism in heart of mice fed a high-fructose diet

10.21203/rs.3.rs-17918/v1 ◽

2020 ◽

Author(s):

Cecilia Gabriela Meléndez-Salcido ◽

Katya Vargas-Ortiz ◽

Oscar Gerardo Silva-Gaona ◽

María Cristina León-García ◽

Luz Arcelia Ortega-Hernández ◽

...

Keyword(s):

Gene Expression ◽

Fatty Acids ◽

Beneficial Effect ◽

Therapeutic Potential ◽

Cardiometabolic Disease ◽

Control Group ◽

Standard Diet ◽

High Fructose Diet ◽

High Fructose ◽

Fatty Acids Metabolism

Abstract Background: It has been proposed that curcumin modulates the gene expression of different signaling pathways, improve the fatty acids metabolism and exerts a potential beneficial effect on cardiometabolic disease, but this has not been thoroughly demonstrated. In the present study, we evaluated the effect of curcumin upon the expression of PPARα, CPT1, MCAD, VLCAD and ACAA2 in heart of mice fed a high-fructose diet (HFD). Methods: Twenty-four mice C57BL/6 were divided into four groups (n=6) and treated for 15 weeks. Control group (C) received standard diet (SD), Curcumin group (C+Cur), Fructose group (F) and Fructose with Curcumin group (F+Cur). The groups were treated with 0.75% w/w curcumin mixed in the SD and 30% w/v fructose in water, respectively. Heart proteins expression were analyzed by Western Blot. Results: Curcumin supplementation increased PPARα and ACAA2 expression and decreased CPT1 and MCAD expression in heart of mice fed a HFD. However, it did not modify the VLCAD expression. Conclusions: Curcumin regulated PPARα, CPT1 and MCAD expression and increased ACAA2 expression; suggesting a therapeutic potential in the prevention of alterations in mitochondrial fatty acids metabolism in heart of mice fed a HFD.

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