scholarly journals Extra-Uterine Fibroids

2020 ◽  
Author(s):  
Rakesh Kumar Gupta ◽  
Poonam Wasnik
Keyword(s):  
Histopathological Examination ◽  
Uterine Fibroids ◽  
Growth Patterns ◽  
Reproductive Age ◽  
Uterine Neoplasms ◽  
Cell Of Origin ◽  
Diagnostic Challenge ◽  
History Of ◽  
Disseminated Peritoneal Leiomyomatosis ◽  
Metastasizing Leiomyoma

Leiomyomas are the most common gynecologic and uterine neoplasms. Uterine leiomyomas present in approximately 25% of women during reproductive age. Extrauterine leiomyomas (EULs) are rarer and usually arise in the genitourinary tract, however, may arise at nearly any anatomic location and possess a great diagnostic challenge. Moreover, the EULs may also present with unusual growth patterns such as disseminated peritoneal leiomyomatosis, intravenous leiomyomatosis, benign metastasizing leiomyoma, parasitic leiomyoma, and retroperitoneal mass. However, the cell of origin from smooth muscle cells and histological benign characteristics is similar to their uterine counterpart. The presence of a synchronous uterine leiomyoma or history of previous hysterectomy is a considerable evidence for the diagnosis of these abnormally located and unusual growth pattern displaying EULs. Different imaging modalities like ultrasonography, computed tomography, and magnetic resonance imaging are helpful in the diagnosis of EULs, however, sometimes a histopathological examination is required for the confirmation.

scholarly journals Recurrent Leiomyomatosis Peritonealis Disseminata: Sonographic and Laparoscopic Correlation

2012 ◽  
Vol 6 (3) ◽  
pp. 327-332
Author(s):  
Ulrich Honemeyer ◽  
Lisa Montgomery ◽  
Kallie Appleton ◽  
Thomas G Tullius ◽  
Jason R Ross ◽  
...  
Keyword(s):  
Health Care Professionals ◽  
Obstet Gynecol ◽  
Spindle Cell ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Histological Evaluation ◽  
Laparoscopic Treatment ◽  
Leiomyomatosis Peritonealis Disseminata ◽  
History Of ◽  
Disseminated Peritoneal Leiomyomatosis

ABSTRACT We present a 39-year-old G0P0 with history of infertility treatment-caused ovarian hyperstimulation and uterine fibroids, who was found to have a rare pathological presentation. Peritoneal lesions were identified during laparoscopic treatment for this patient's fibroids. Histological evaluation of these lesions revealed leiomyomatosis peritonealis disseminata (LPD), also known as disseminated peritoneal leiomyomatosis. While LPD can often be confused for metastatic leiomyosarcoma due to the histological presence of fibroblasts, myofibroblasts, smooth muscle, collagen, and spindle cell appearance, cases of LPD are generally benign, and present no need for therapy in asymptomatic cases. We present a discussion based on the clinical and sonographic presentation of LPD, its pathophysiology, treatment options and prognosis. A question set has been designed to reinforce comprehension of this presentation and associated topics for health care professionals. How to cite this article Honemeyer U, Ross JR, Barnard JJ, Appleton K, Tullius TG Jr, Montgomery L, Plavsic SK. Recurrent Leiomyomatosis Peritonealis Disseminata: Sonographic and Laparoscopic Correlation. Donald School J Ultrasound Obstet Gynecol 2012;6(3):327-332.

scholarly journals Leiomyoma of the vulva: a diagnostic challenge

2018 ◽  
Vol 7 (3) ◽  
pp. 1246
Author(s):  
Shilpi Saxena ◽  
Suyash Goel ◽  
Alok D. Sen
Keyword(s):  
Smooth Muscle ◽  
Histopathological Examination ◽  
Critical Role ◽  
Final Diagnosis ◽  
Reproductive Age ◽  
Pathological Examination ◽  
Diagnostic Challenge ◽  
Duct Cyst ◽  
Smooth Muscle Tumors ◽  
Rule Out

Smooth muscle tumours of vulva are rare and therefore can be missed clinically. Our patient, 48-year-old lady presented with lump in the left vulva that was clinically diagnosed as Bartholin duct cyst. The lumpectomy was done under local anaesthesia and the lesion was sent for pathological examination. On gross examination the mass was 3.5 cm in diameter. The microscopic examination revealed the lump to be leiomyoma and no necrosis or atypia was present. The final diagnosis of “vulval leiomyoma” was given. Postoperative period was uneventful, and the patient is on regular follow up and there has been no recurrence. Leiomyoma should be kept as a differential diagnosis when a lady presents in late reproductive age group with unilateral swelling in vulvar region which is firm in consistency and the lump must be sent for histopathological examination for definitive diagnosis and rule out malignancy. The pathologists play a critical role in recognition and management of smooth muscle tumors of the vulva and to rule out leiomyosarcoma.

scholarly journals Degenerated fibroid - a diagnostic challenge

2016 ◽  
Vol 6 (1) ◽  
pp. 292
Author(s):  
Sonal Bhuyar ◽  
Bhavana Sontakke ◽  
Pooja Mukund Rajbhara
Keyword(s):  
Ovarian Tumor ◽  
Unusual Case ◽  
Uterine Fibroids ◽  
Total Abdominal Hysterectomy ◽  
Large Mass ◽  
Abdominal Hysterectomy ◽  
Diagnostic Challenge ◽  
Malignant Ovarian Tumor ◽  
History Of ◽  
Leiomyoma Of The Uterus

Leiomyoma of the uterus is the most common type of tumor affecting the female pelvis and arises from uterine smooth muscle. The size of leiomyoma varies from microscopic to giant; giant myoma is exceedingly rare. We report an unusual case of a large, cystic, uterine leiomyoma mimicking a primary malignant ovarian tumor on sonography and CT. A 39 year old infertile nulliparous woman presented with a history of lump in abdomen since 2 years and 6 months of amenorrhea. Sonography and CT examination showed a large mass that filled the abdomen. A preoperative diagnosis of a primary malignant ovarian tumor was made. The patient underwent laparotomy with total abdominal hysterectomy preserving tubes and ovaries. The histology revealed a leiomyoma with extensive hyaline degeneration. The current established management of uterine fibroids may include expectant, surgical, or medical management or uterine artery embolization or a combination of these treatments. A surgical approach is preferred for management of giant leiomyomas. Leiomyomas should be considered in the differential diagnosis of a multilocular and predominantly cystic adnexal mass.

scholarly journals Management of Fibroids Prior to in Vitro Fertilization. Case Reports

2021 ◽  
Author(s):  
Teresa Gastañaga-Holguera ◽  
Virginia González González ◽  
Marta Calvo Urrutia ◽  
Isabel Campo Gesto ◽  
Marta Vidaurreta Lázaro ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Case Reports ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Surgical Approaches ◽  
Uterine Neoplasms ◽  
Vitro Fertilization ◽  
First Case ◽  
Pharmacologic Treatments

Abstract BACKGROUND. Uterine fibroids are common benign uterine neoplasms in women in reproductive age and pregnancy desire. Several surgical approaches for symptomatic fibroids are available, such as surgical or pharmacologic treatments. We report three cases of fibroids treatment in women with primary sterility. CASE PRESENTATION. The first case of a successful in vitro fertilization (IVF) after ulipristal acetate (UPA) as an alternative treatment to reduce the fibroids size in a patient with two previous abdominal myomectomies, resulting in an evolutive pregnancy. The second patient underwent several myomectomies (both abdominal and hysteroscopic) in a long period of time. And the third one of a successful IVF after UPA in a patient with a submucous fibroid which induced myoma migration leading to its prolapse.CONCLUSIONS. Myomectomy appears to be the gold standard treatment for fibroids in women with reproductive desires. Nevertheless, more series are essential for establishing the safety of UPA as a treatment of symptomatic fibroids prior to pregnancy.

scholarly journals Evaluation of genital tuberculosis as a cause of female infertility in a tertiary care hospital in North India

2018 ◽  
Vol 6 (1) ◽  
pp. 386
Author(s):  
Neelima Agarwal ◽  
Manisha Gupta ◽  
Alpana Agrawal
Keyword(s):  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Early Stage ◽  
Tertiary Care ◽  
Endometrial Biopsy ◽  
Reproductive Age ◽  
North India ◽  
Care Hospital ◽  
Diagnostic Challenge ◽  
Genital Tuberculosis

Background: Female genital tuberculosis (FGTB) poses a great diagnostic challenge in women of reproductive age. It causes significant morbidity or short and long term sequelae, especially infertility. The disease often remains silent or may present with non-specific symptomatology. As a result, the prevalence of genital tuberculosis is largely underestimated. A high degree of suspicion aided by intensive investigations is important in the diagnosis of the disease, especially in its early stage, so that treatment may improve the prospects of cure before the tubes are damaged beyond recovery. Objectives were to find out the prevalence of genital tuberculosis in females presenting with infertility in a tertiary care hospital over a given period of time, and diagnostic comparison of endometrial tuberculosis by histopathological examination (HPE) and GeneXpert.Methods: The prospective observational study was conducted over one year duration. A total of 96 endometrial samples were collected from the women, satisfying the inclusion and exclusion criteria.Results: On HPE, out of 96 patients, proliferative endometrium (anovulatory) was found in 38 cases (39.6%), non-specific endometritis in 2 cases (2.08%) and 2 cases (2.08%) were found positive for tubercular endometritis. GeneXpert scored negative in our study.Conclusions: Endometrial biopsy shows not only the tuberculous endometritis, but also gives additional information about local factors of endometrium concerning non-specific and specific infections and anovulatory cycles. GeneXpert if positive on endometrial biopsy is a reliable test for FGTB and treatment can be started on its basis.

scholarly journals Benign metastasizing leiomyoma – a case of benign metastasis

JRSM Open ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 205427042110644
Author(s):  
Diogo André ◽  
Fabiana Gouveia ◽  
Helena Luís ◽  
Mónica Caldeira ◽  
Filipe Perneta ◽  
...  
Keyword(s):  
Abdominal Mass ◽  
Female Genital Tract ◽  
Uterine Fibroids ◽  
Pulmonary Nodules ◽  
Rare Condition ◽  
Childbearing Age ◽  
History Of ◽  
Metastasizing Leiomyoma ◽  
Benign Tumours ◽  
Abdominal Lesions

Leiomyomas are benign tumours of smooth muscle cells that most often affect the female genital tract, but their metastasis to extra-uterine locations represent rare, yet misunderstood phenomena. The authors present a clinical case of a 42-year-old woman, who underwent a hysterectomy 15 years ago due to myomas, admitted with multiple pulmonary nodules and abdominal mass, diagnosed by imaging tests, in the context of haemoptysis. The anatomopathological exams of the pulmonary and abdominal lesions were compatible with the diagnosis of benign metastatic leiomyoma. Benign metastatic leiomyoma is a rare condition that particularly affects women of childbearing age, with a history of hysterectomy for uterine fibroids. Hence, this entity must be considered in the differential diagnosis of women with pulmonary nodules of uncertain aetiology.

scholarly journals Multisystemic Benign Metastasizing Leiomyoma: An Unusual Condition with an Atypical Clinical Presentation

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Fernando Matos ◽  
Cristina Santiago ◽  
Duarte Silva
Keyword(s):  
The Body ◽  
Reproductive Age ◽  
Low Back ◽  
Soft Tissue Density ◽  
Benign Metastasizing Leiomyoma ◽  
Essential Condition ◽  
Atypical Clinical Presentation ◽  
History Of ◽  
Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rarely found entity with few documented cases in the literature, usually occurring in women of reproductive age with a history of myomectomy or hysterectomy. The leiomyomas can metastasize to several organs, the lungs being the most commonly affected. We report a case of a 40-year-old female patient who presented at our institution with low back pain. She underwent a lumbar MR that revealed the presence of an expansive and compressive mass in the body of L4. This mass was biopsied, corresponding to a metastasizing leiomyoma with no malignant characteristics. Subsequently, a CT examination showed several soft tissue density round masses in both lungs, but the most striking feature was a 12 cm mass located in the left iliac crest. There was asymmetrical uterus enlargement, caused by the presence of several leiomyomas. Since the lesions were estrogen and progesterone positive, hormone suppression consisting of oophorectomy followed by anastrozole was the chosen treatment. No signs of progression were observed at the 6-month follow-up. This case is one of the very few that occurred in a woman with no previous uterine intervention, adding further evidence that surgery is not an essential condition for this entity to develop.

scholarly journals Benign Metastasizing Leiomyoma: A Rare Type of Lung Metastases—Two Case Reports and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Rokana Taftaf ◽  
Sandra Starnes ◽  
Jiang Wang ◽  
Ralph Shipley ◽  
Tariq Namad ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Progesterone Receptors ◽  
Pulmonary Nodules ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Benign Metastasizing Leiomyoma ◽  
Ct Guided ◽  
First Case ◽  
History Of ◽  
Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rare disease that usually occurs in women of reproductive age. They typically have history of uterine leiomyoma treated with hysterectomy. BML can metastasize to distant organs, with the lung being the most common organ. We report two patients who presented with benign metastasizing leiomyoma to the lung. Our first case was a fifty-two-year-old female who presented with multiple lung masses, with a past medical history of uterine leiomyoma who underwent hysterectomy 17 years ago. A CT-guided biopsy showed benign appearing spindle cells and pathology confirmed her diagnosis with additional positive estrogen/progesterone receptor stains. Our second case was a fifty-six-year-old female who presented with multiple cavitary pulmonary nodules. She subsequently underwent a video-assisted thoracoscopic surgery (VATS) with wedge resection of one of the nodules. Pathology confirmed the diagnosis based on morphology and immunohistochemical staining strongly positive for estrogen/progesterone receptors. Benign metastasizing leiomyoma is a rare condition which may affect women of reproductive age. This should be considered in the differential in patients who present with multiple pulmonary nodules, especially with a history of uterine leiomyoma. Additional stains, such as estrogen/progesterone receptors, may need to be done to confirm the diagnosis.

Primary telangiectatic osteosarcoma of the cervical spine

2012 ◽  
Vol 16 (4) ◽  
pp. 373-378 ◽  
Author(s):  
Mazda K. Turel ◽  
Vivek Joseph ◽  
Vandita Singh ◽  
Vinu Moses ◽  
Vedantam Rajshekhar
Keyword(s):  
Cervical Spine ◽  
Aneurysmal Bone Cyst ◽  
Histopathological Examination ◽  
Bone Cyst ◽  
Biological Behavior ◽  
Adjuvant Radiation ◽  
Diagnostic Challenge ◽  
Telangiectatic Osteosarcoma ◽  
History Of ◽  
Glue Embolization

Telangiectatic osteosarcoma (TOS) is one of the 8 subtypes of osteosarcoma that infrequently affects the spine. The radiopathological features of TOS overlap with those of more benign entities, most commonly the aneurysmal bone cyst), and therefore is a significant diagnostic challenge. It is a rare but well-described entity in the thoracolumbar and sacral spine, and to the authors' knowledge has not been previously reported in the cervical spine. The authors report the case of a 15-year-old boy who presented with a 6-month history of neck pain and torticollis. He underwent preoperative glue embolization followed by a staged subtotal C-5 spondylectomy and posterior fusion for a C-5 vertebral body lytic expansile lesion. Histopathological examination showed the lesion to be TOS. The surgery was followed by adjuvant radiation and chemotherapy with a favorable outcome at the 1-year follow-up. This report reiterates that TOS is an important differential diagnosis for aneurysmal bone cyst and giant-cell tumor of the spine, as its biological behavior and clinical outcome differ from those of these more benign lesions, which it mimics.

Clinical case the combination of uterine leiomyoma and pregnancy

2017 ◽  
pp. 65-68
Author(s):  
M.V. Makarenko ◽  
◽  
D.O. Hovsieiev ◽  
L.I. Martynova ◽  
K.V. Mesropyan ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
Uterine Leiomyoma ◽  
Clinical Case ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Choice Of Treatment ◽  
Fetal Malformations ◽  
History Of ◽  
Medical Examinations

This article describes the clinical case mix uterine fibroids and pregnancy 11–12 weeks diagnosed with trisomy 21 in the fetus hrosomi. The history of the study of uterine fibroids, current views on the pathogenesis, etiology and treatment. Highlighted describes the practical value that indicates the need for regular preventive medical examinations of women of reproductive age, the importance of planning pregnancy and choice of treatment for fetal malformations and tumors of the uterus. Key words: uterine fibroids, pregnancy, surgery.

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