Impact of Sugar on Vision

2021 ◽  
Author(s):  
Grace Ogbonna ◽  
Rosemary Ehigbo ◽  
Ogbonna Hannah
Keyword(s):  
Oxidative Stress ◽  
Human Body ◽  
Aqueous Humour ◽  
Low Vision ◽  
The Body ◽  
Vision Impairment ◽  
Post Mortem ◽  
Normal Concentration ◽  
Post Mortem Interval ◽  
Patients With Diabetes

Sugar forms an integral part of the human body, and contributes to normal body function. However, sugar in high quantities can be detrimental to the body especially to the eye. In the normal concentration, sugar in the form of glucose is found in the aqueous humour, and tears, and serves to provide nourishment to the avascular cornea, and lens respectively. Sugar at this stage may also be used to determine the post mortem interval of a cadaver. However, when in excess as may be seen in patients with diabetes, sugar can cause oxidative stress to the cornea, lens, and retina resulting in cornea oedema, cataract, retinal aneurysm which can contribute significantly to the prevalence of low vision, and vision impairment.

scholarly journals Colorimetry-Based Detection of Nitric Oxide from Exhaled Breath for Quantification of Oxidative Stress in Human Body

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1055
Author(s):  
Muni Raj Maurya ◽  
Haseena Onthath ◽  
Hagar Morsy ◽  
Najam-US-Sahar Riyaz ◽  
Muna Ibrahim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Human Body ◽  
Ph Effect ◽  
High Sensitivity ◽  
Fast Response ◽  
The Body ◽  
Bromophenol Blue ◽  
Exhaled Breath ◽  
Vis Spectroscopy

Monitoring exhaled breath is a safe, noninvasive method for determining the health status of the human body. Most of the components in our exhaled breath can act as health biomarkers, and they help in providing information about various diseases. Nitric oxide (NO) is one such important biomarker in exhaled breath that indicates oxidative stress in our body. This work presents a simple and noninvasive quantitative analysis approach for detecting NO from exhaled breath. The sensing is based on the colorimetric assisted detection of NO by m-Cresol Purple, Bromophenol Blue, and Alizaringelb dye. The sensing performance of the dye was analyzed by ultraviolet–visible (UV–Vis) spectroscopy. The study covers various sampling conditions like the pH effect, temperature effect, concentration effect, and selective nature of the dye. The m-Cresol Purple dye exhibited a high sensitivity towards NO with a detection limit of ~0.082 ppm in the linear range of 0.002–0.5 ppm. Moreover, the dye apprehended a high degree of selectivity towards other biocompounds present in the breath, and no possible interfering cross-reaction from these species was observed. The dye offered a high sensitivity, selectivity, fast response, and stability, which benchmark its potential for NO sensing. Further, m-Cresol Purple dye is suitable for NO sensing from the exhaled breath and can assist in quantifying oxidative stress levels in the body for the possible detection of COVID-19.

scholarly journals Dysregulation of miR-381-3p and miR-23b-3p in skeletal muscle could be a possible estimator of early post-mortem interval in rats

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11102
Author(s):  
Vanessa Martínez-Rivera ◽  
Christian A. Cárdenas-Monroy ◽  
Oliver Millan-Catalan ◽  
Jessica González-Corona ◽  
N. Sofia Huerta-Pacheco ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
In Silico Analysis ◽  
Forensic Analysis ◽  
The Body ◽  
Control Group ◽  
Post Mortem ◽  
Rt Pcr ◽  
Post Mortem Interval ◽  
Silico Analysis

Background The post-mortem interval (PMI) is the time elapsed since the dead of an individual until the body is found, which is relevant for forensic purposes. The miRNAs regulate the expression of some genes; and due to their small size, they can better support degradation, which makes them suitable for forensic analysis. In the present work, we evaluated the gene expression of miR-381-3p, miR-23b-3p, and miR-144-3p in skeletal muscle in a murine model at the early PMI. Methods We designed a rat model to evaluate the early PMI under controlled conditions. This model consisted in 25 rats divided into five groups of rats, that correspond to the 0, 3, 6, 12 and 24 hours of PMI. The 0 h-PMI was considered as the control group. Muscle samples were taken from each rat to analyze the expression of miR-381-3p, miR-23b-3p, and miR-144-3p by quantitative RT-PCR. The gene expression of each miRNA was expressed as Fold Change (FC) and compared among groups. To find the targets of these miRNAs and the pathways where they participate, we performed an in-silico analysis. From the gene targets of miR-381-3p identified in the silico analysis, the EPC1 gene was selected for gene expression analysis by quantitative RT-PCR in these samples. Also, to evaluate if miR-381-3p could predict the early PMI, a mixed effects model was calculated using its gene expression. Results An upregulation of miR-381-3p was found at 24 h-PMI compared with the control group of 0 h-PMI and (FC = 1.02 vs. FC = 1.96; p = 0.0079). This was the opposite for miR-23b-3p, which had a down-regulation at 24 h-PMI compared to 0 h-PMI (FC = 1.22 vs. FC = 0.13; p = 0.0079). Moreover, the gene expression of miR-381-3p increased throughout the first 24 h of PMI, contrary to miR-23b-3p. The targets of these two miRNAs, participate in biological pathways related to hypoxia, apoptosis, and RNA metabolism. The gene expression of EPC1 was found downregulated at 3 and 12 h of PMI, whereas it remained unchanged at 6 h and 24 h of PMI. Using a multivariate analysis, it was possible to predict the FC of miR-381-3p of all but 6 h-PMI analyzed PMIs. Discussion The present results suggest that miR-23b-3p and miR-381-3p participate at the early PMI, probably regulating the expression of some genes related to the autolysis process as EPC1 gene. Although the miR-381-3p gene expression is a potential estimator of PMI, further studies will be required to obtain better estimates.

scholarly journals What the Polish Mother Does Not Say. Zbylut Grzywacz Against the Myth

2019 ◽  
Vol 67 (4 SELECTED PAPERS IN ENGLISH) ◽  
pp. 103-123
Author(s):  
Dorota Kudelska
Keyword(s):  
Human Body ◽  
Social Position ◽  
The Body ◽  
National Museum ◽  
Post Mortem ◽  
Body Form ◽  
Polish Version ◽  
The World ◽  
The Dead

The Polish version of the article was published in Roczniki Humanistyczne vol. 62, issue 4 (2014). The article presents the art of Zbylut Grzywacz in the context of his post-mortem exhibition in the Kraków National Museum in 2009. The subjects of the analysis are his paintings from the 1970s and 1980s, presenting women through a simple rough treatment of human body form, without an academic idealization. The destruction of the form conforms to the deconstruction of the myth of a Polish Mother. It is due to the change of a social position of the figures whom Grzywacz gives the roles of guardians of tradition, as well as due to their mental and moral degradation. The artist uses an irony in showing his knowledge of the tradition of showing a human body in an academic nude (what he denies), in a Flemish art of showing torn animal meat (with the Rembrandt’s reflection) and Holbein’s tradition of the post-mortem decay (The Body of the Dead Christ in the Tomb). One of the main themes in Grzywacz’s paintings is the loneliness, especially distinct in a representation of symbolically naked persons among insensible pedestrians. The Polish Mother—here she doesn’t belong to any society. The explicitness and the picturesque materiality covers a certain “crack” in the world presented inside the hard-to-comprehend present-day multitude of Grzywacz’s paintings. Behind the cover of the foreground tale, as one could think on the basis of the sketchbooks, there is a kind of an “unpresented world”, in which the author incessantly tells us about the pain of his existence with no anaesthetization by grotesque.

scholarly journals Battle between plants as antioxidants with free radicals in human body

2020 ◽  
Vol 9 (3) ◽  
pp. 191-199 ◽  
Author(s):  
Fatemeh Jamshidi-kia ◽  
Joko Priyanto Wibowo ◽  
Mostafa Elachouri ◽  
Rohollah Masumi ◽  
Alizamen Salehifard-Jouneghani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Human Body ◽  
Defense Mechanisms ◽  
Natural Antioxidants ◽  
Redox Status ◽  
The Body ◽  
Antioxidant Agents ◽  
Endogenous Antioxidants

Free radicals are constructed by natural physiological activities in the human cells as well as in the environment. They may be produced as a result of diet, smoking, exercise, inflammation, exposure to sunlight, air pollutants, stress, alcohol and drugs. Imbalanced redox status may lead to cellular oxidative stress, which can damage the cells of the body, resulting in an incidence of various diseases. If the endogenous antioxidants do not stop the production of reactive metabolites, they will be needed to bring about a balance in redox status. Natural antioxidants, for example plants, play an important part in this context. This paper seeks to report the available evidence about oxidative stress and the application of plants as antioxidant agents to fight free radicals in the human body. For this purpose, to better understand oxidative stress, the principles of free radical production, the role of free radicals in diseases, antioxidant defense mechanisms, and the role of herbs and diet in oxidative stress are discussed.

Use of entomotoxicology in estimating post-mortem interval and determining cause of death

2017 ◽  
Vol 295 ◽  
pp. 56-63
Author(s):  
Joanna Stojak ◽  
Keyword(s):  
Cause Of Death ◽  
Current Knowledge ◽  
The Body ◽  
Toxic Substances ◽  
Post Mortem ◽  
Toxicological Analysis ◽  
Post Mortem Interval ◽  
The Impact

Entomotoxicology allows the estimation of the post-mortem interval and the determination of the cause of death in cases in which the corpse has decomposed and the tissues necessary for toxicological analysis are no longer available. Obtaining information about toxic substances potentially present in the body is possible by isolation of larvae and pupae of true flies (Diptera) and/or adult forms of, e.g., beetles (Coleoptera) present on or near the corpse. This article was intended to summarize the current knowledge in the field of entomotoxicology, including examples from the literature, and to present the impact of selected toxic substances and medicines on the development of necrophagous larvae of insects.

XII. Tables of the weights of the human body and internal organs in the sane and insane of both sexes at various ages, arranged from 2614 post-mortem examinations

1861 ◽  
Vol 151 ◽  
pp. 241-262 ◽  
Keyword(s):  
Old Age ◽  
Human Body ◽  
Causes Of Death ◽  
Lunatic Asylum ◽  
The Body ◽  
Average Weight ◽  
Average Height ◽  
Post Mortem ◽  
Internal Organs ◽  
Human Organs

These Tables have been compiled from notes of 2086 examinations made at St. Marylebone Infirmary, between 1839 and 1847; and of 528 examinations in cases of insanity made at the Somerset Lunatic Asylum, between 1848 and the end of December 1860, comprehending in all a period of twenty-one years. The calculations alone have been the labour of many months; a task, which, owing to the pressure of daily duties in a large establishment, I could not now have completed but for the able assistance of my relative Major Boyd. The Tables are submitted with a hope that they may aid in forming a standard of the weight of the human organs from early infancy to old age. The cases are arranged at eighteen periods of life, under eighteen different heads, showing the average height and weight of the body (the measurement of the head, and weight of the spinal marrow in. No. 2), the average weight of the encephalon and its several parts; also of each lung, of the heart, and of all the abdominal viscera. The assigned causes of death are given in the margin; also the variations in weight of the lungs, heart, and liver.

scholarly journals The Dead Body as a 'Lieu De Mémoire'. The Body-Object and the Living Body in Caitlin Doughty’s Nonfiction

Linguaculture ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 87-101
Author(s):  
Cristina-Mihaela Botîlcă
Keyword(s):  
Human Body ◽  
The Body ◽  
First Century ◽  
Western Society ◽  
Post Mortem ◽  
Dead Body ◽  
Personal Memory ◽  
Living Body ◽  
The Dead ◽  
Twenty First Century

Between Pierre Nora’s lieux de mémoire and Paul Ricoeur’s body-object there appears to be a relation of community and personal memory. Before death, the human body holds three meanings: material, symbolic, and functional, but post-mortem the body also becomes a place where both community and individual can update their relationship with death and mortality. In the twenty-first century, secularization of death practices inevitably leads to a secular view of the body. In Cailin Doughty’s nonfiction, the body seems to stand at the crossroad between spirituality and secularization, so between the meaning of the body and the body as a lieu. This paper will discuss how Nora’s and Ricoeur’s interpretations of memory and body apply to Doughty’s representation of the dead body within a death denying twenty-first century Western society.

scholarly journals The role of selenium in cardiology

Kardiologiia ◽  
2021 ◽  
Vol 61 (3) ◽  
pp. 96-104
Author(s):  
T. A. Kuropatkina ◽  
N. A. Medvedeva ◽  
O. S. Medvedev
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Free Radicals ◽  
Cardiovascular Diseases ◽  
Vascular Injury ◽  
Human Body ◽  
Cell Injury ◽  
The Body ◽  
Selenium Status

Selenium is an important micronutrient that is essential for the functioning of the human body. Being a component of the active center of several antioxidant enzymes selenium prevents cell injury by free radicals. Decline in selenium-containing enzymes results in progression of oxidative stress and chronic inflammation, which are considered as possible causes for the development of many cardiovascular diseases. This review focuses on mechanisms for prevention of myocardial and vascular injury through the adequate selenium supply to the body. The importance of monitoring and correction of the selenium status in appropriate patients is underlined.

scholarly journals Some parameters of the oxidative stress in lens, humour aqueous and serum of patients with diabetes and age-related cataract

2003 ◽  
Vol 131 (3-4) ◽  
pp. 137-142 ◽  
Author(s):  
Lepsa Zoric
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Lipid Peroxidation ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Age Related ◽  
Lipid Oxidation Products ◽  
Patients With Diabetes

Contemporary hypothesis considers the oxidative stress as a crucial event in age-related processes in the body, as well as in the age-related cataract formation. The secondary aging factors accelerate ageing processes. One of them is diabetes. With the aim of investigation of the noninsulin-dependent diabetes (Type II) influence on cataract genesis here were analyzed contents of the lipid oxidation products (lipid peroxides - LP) and total sulfhydryle groups (TSH) in the lens? corticonuclear blocks and antioxidative capacity in their humour aqueous expressed as percent of induced malondyaldehyde (% iMDA) in 14 samples obtained from patients with cataract and diabetes mellitus type II (without diabetic complications) and compared to 66 samples of patients with cataract without diabetes, as well as some parameters of the oxidative stress in serums (content of vitamin C, acrobat - A dehydroascorbate - DA and their relation, vitamin E, glutathione - GSH peroxidase - P and catalase - Cat activity, content of malondyaldehyde - MDA and % iMDA) of 27 patients with age-related cataract and diabetes mellitus type II (without complications), and compared to the other 135 age-related cataract patients. Also were analyzed frequencies of the secondary senium diseases in a clinical group of 162 patients with cataract and sex and age matched 55 examined people without cataract, as a control group. Patients with diabetes and cataract have lower values of almost all investigated parameters of antioxidative defense in their serum and higher level of the lipid peroxidation products. Level of glutathione in their serums is significantly lower (p<0.05). Intensity of lipid peroxidation in corticonuclear lens blocks is higher in patients with diabetes, whereas their total sulfhydryle groups and % iMDA in humour aqueous shows lower antioxidant capacity in the same group, probably because of higher intensity of oxidative stress. Also, by investigation of frequencies of the secondary ageing diseases in patients with age-related cataract and age and sex matched control subjects, by a logistic regression was found high odds ratio (2.506) for diabetes. Results confirm hypothesis of the oxidative stress role in the age-related cataract genesis, and especially of patients with diabetes mellitus.

Human curiosities and the Royal Society, 1699-1751

1996 ◽  
Vol 50 (1) ◽  
pp. 13-27 ◽  
Keyword(s):  
Human Body ◽  
Royal Society ◽  
Direct Evidence ◽  
The Body ◽  
Post Mortem ◽  
Special Provision ◽  
Body Knowledge

Although anatomy is primarily concerned with the structure, and physiology with the functioning of the human body, knowledge of both is essential to the surgeon and the physician. This certainly applies to the living ‘human curiosities’ in the present paper: they and post-mortem specimens have been selected to illustrate myology and osteology, two branches of anatomical science with which the Royal Society was long preoccupied. The second charter of the Royal Society made special provision for it ‘to demand and receive the bodies of executed criminals, and to anatomize them, as the College of Physicians and the Company of Surgeons of London use or enjoy’, but there is little direct evidence that this prerogative was exercised. The College of Physicians encountered practical difficulties in obtaining the bodies of the four executed criminals to which they were entitled, as seen by its president Sir Hans Sloane’s petitions to Parliament in 1721 and 1723 (when they became law). Entries in Sloane’s ‘Humana’ Catalogue suggest that he made other arrangements for his own collections: 14. The sceleton of a man made by Mr. Verier of the body of a Highwayman executed at Tiburn and bought by me 3.4.6. ... 534. The kidneys of a malefactor hang’d at Tyburn wherein appear two ureters & 2 basons in each kidney, which ureters join before their insertion into the bladder. Given me by Dr. Rutty.

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