scholarly journals An Insight into Biofunctional Curcumin/Gelatin Nanofibers

2021 ◽  
Author(s):  
Nand Jee Kanu ◽  
Eva Gupta ◽  
Venkateshwara Sutar ◽  
Gyanendra Kumar Singh ◽  
Umesh Kumar Vates
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Sustained Release ◽  
Present Report ◽  
Healing Process ◽  
Release Profile ◽  
Critical Periods ◽  
Optimum Diameter ◽  
Healing Of Wounds ◽  
Insight Into

Electrospinning (ESPNG) was used to synthesize ultrathin (UT) and uniform nanofibers (from 5 nm to a few hundred nanometers) of various materials which have biomedical applications (BAs) such as dressing of wounds, drug discharge, and so on and so forth. In the first half of the report, there is an audit on the nanofibers having low diameter so that it could have larger surface area to volume proportion, likewise with that it would have sufficient porosity and improved mechanical properties required for wound healing. Nanofibrous mats (NMs) with high biocompatibility could be utilized during healing of wounds by sustained release of curcumin (Cc) and oxygen. The ESPNG was understood through in-depth numerical investigation in the present report. Furthermore, the process parameters (PMs) were reviewed in depth for their contributions in synthesizing UT - Curcumin/Gelatin (Cc/G) nanofibers (NFs) of optimum diameter. The aim of the discussion was to demonstrate that simply optimizing biofunctional (BF) - Cc/G NFs might not be enough to satisfy experts until they are also given access details about the complete ESPNG method (mathematical mechanism) to improve hold over the synthesis of NMs (suitable for BAs) for the release profile of Cc throughout critical periods of healing process.

scholarly journals Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 982
Author(s):  
Gustavo Carreño ◽  
Adolfo Marican ◽  
Sekar Vijayakumar ◽  
Oscar Valdés ◽  
Gustavo Cabrera-Barjas ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Polyvinyl Alcohol ◽  
Sustained Release ◽  
Release Kinetics ◽  
Dicarboxylic Acids ◽  
Release Profile ◽  
Significant Activity ◽  
Crosslinking Degree ◽  
Aliphatic Dicarboxylic Acids

A series of hydrogels with a specific release profile of linezolid was successfully synthesized. The hydrogels were synthesized by cross-linking polyvinyl alcohol (PVA) and aliphatic dicarboxylic acids, which include succinic acid (SA), glutaric acid (GA), and adipic acid (AA). The three crosslinked hydrogels were prepared by esterification and characterized by equilibrium swelling ratio, infrared spectroscopy, thermogravimetric analysis, mechanical properties, and scanning electron microscopy. The release kinetics studies of the linezolid from prepared hydrogels were investigated by cumulative drug release and quantified by chromatographic techniques. Mathematical models were carried out to understand the behavior of the linezolid release. These data revealed that the sustained release of linezolid depends on the aliphatic dicarboxylic acid chain length, their polarity, as well as the hydrogel crosslinking degree and mechanical properties. The in vitro antibacterial assay of hydrogel formulations was assessed in an Enterococcus faecium bacterial strain, showing a significant activity over time. The antibacterial results were consistent with cumulative release assays. Thus, these results demonstrated that the aliphatic dicarboxylic acids used as crosslinkers in the PVA hydrogels were a determining factor in the antibiotic release profile.

scholarly journals Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Polymers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 2959 ◽  
Author(s):  
Sindi P. Ndlovu ◽  
Kwanele Ngece ◽  
Sibusiso Alven ◽  
Blessing A. Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Antimicrobial Activity ◽  
Wound Healing ◽  
Antimicrobial Agents ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Delayed Wound Healing

Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

scholarly journals Carbon Nanotubes-Based Hydrogels for Bacterial Eradiation and Wound-Healing Applications

2021 ◽  
Vol 11 (20) ◽  
pp. 9550
Author(s):  
Tejal V. Patil ◽  
Dinesh K. Patel ◽  
Sayan Deb Dutta ◽  
Keya Ganguly ◽  
Aayushi Randhawa ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Wound Healing ◽  
Surface Functionalization ◽  
Biomedical Applications ◽  
Healing Process ◽  
Wound Healing Process ◽  
Polymer Hydrogels ◽  
Antibacterial Potential ◽  
Nanoscale Level

Biocompatible nanomaterials have attracted enormous interest for biomedical applications. Carbonaceous materials, including carbon nanotubes (CNTs), have been widely explored in wound healing and other applications because of their superior physicochemical and potential biomedical properties to the nanoscale level. CNTs-based hydrogels are widely used for wound-healing and antibacterial applications. CNTs-based materials exhibited improved antimicrobial, antibacterial, adhesive, antioxidants, and mechanical properties, which are beneficial for the wound-healing process. This review concisely discussed the preparation of CNTs-based hydrogels and their antibacterial and wound-healing applications. The conductive potential of CNTs and their derivatives is discussed. It has been observed that the conductivity of CNTs is profoundly affected by their structure, temperature, and functionalization. CNTs properties can be easily modified by surface functionalization. CNTs-based composite hydrogels demonstrated superior antibacterial potential to corresponding pure polymer hydrogels. The accelerated wound healing was observed with CNTs-based hydrogels.

scholarly journals A case study of dushta vrana treated with apamarga kshar with jatyadi taila pichu.

2019 ◽  
Vol 7 (05) ◽  
Author(s):  
Shubham P. Hajari
Keyword(s):  
Wound Healing ◽  
Medical Literature ◽  
Healing Process ◽  
Local Treatment ◽  
Tissue Type ◽  
Healing Ulcer ◽  
Short Period ◽  
Healing Of Wounds

 The treatment and healing of Wounds are some of the oldest subjects discussed in the medical Literature. The same events, in the same order, occur in every healing process regardless of the tissue type or the inciting injury. Knowledge of Wound healing allows Surgeons to manipulate wounds to achieve optimal results in a short period. In Ayurveda non healing ulcer can be correlated with Dushta Vrana. Application of Kshar karma for shodhana and ropana of  Dushta Vrana is one among the Sixty upakramas of Vrana. Pratisaarniya Kshar is indicated for Dushta Vrana in Ksharpakavidhi Adhayaya (Sutrasthana chapter 11) of Sushruta Samhita. Kshar has chhedana (excision), Bhedana (incision), and Lekhana (scrapping) properties along with Tridoshhara (equilibrium of Vata, Pitta, Kapha) properties, thus considered as a good curative measure for local treatment of Dushta vrana. A case report of an open traumatic ulcer successfully treated by local application of Apamarga Kshar Pichu,Haridra,Jatyadi Taila has been presented here.

A case study of dushta vrana treated with apamarga kshar pichu

2020 ◽  
Vol 8 (03) ◽  
Author(s):  
Sangram Indore
Keyword(s):  
Wound Healing ◽  
Medical Literature ◽  
Healing Process ◽  
Local Treatment ◽  
Tissue Type ◽  
Healing Ulcer ◽  
Short Period ◽  
Healing Of Wounds

The treatment and healing of Wounds are some of the oldest subjects discussed in the medical Literature. The same events, in the same order, occur in every healing process regardless of the tissue type or the inciting injury. Knowledge of Wound healing allows Surgeons to manipulate wounds to achieve optimal results in a short period. In Ayurveda non healing ulcer can be correlated with Dushta Vrana. Application of Kshar karma for shodhana and ropana of Dushta Vrana is one among the Sixty upakramas of Vrana. Pratisaarniya Kshar is indicated for Dushta Vrana in Ksharpakavidhi Adhayaya (Sutrasthana chapter 11) of Sushruta Samhita. Kshar has chhedana (excision), Bhedana (incision), and Lekhana (scrapping) properties along with Tridoshhara (equilibrium of Vata, Pitta, Kapha) properties, thus considered as a good curative measure for local treatment of Dushta vrana.  A case report of an open traumatic ulcer successfully treated by local application of Apamarga Kshar Pichu has been presented here.

A Novel Hydrocolloid Film Based on Pectin, Starch and Gunnera tinctoria and Ugni molinae Plant Extracts for Wound Dressing Applications

2020 ◽  
Vol 20 (4) ◽  
pp. 280-292 ◽  
Author(s):  
Constanza Sabando ◽  
Walther Ide ◽  
Maité Rodríguez-Díaz ◽  
Gustavo Cabrera-Barjas ◽  
Johanna Castaño ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Bioactive Compounds ◽  
Water Uptake ◽  
Pressure Ulcer ◽  
Plant Extracts ◽  
Wound Dressing ◽  
Aqueous Media ◽  
Release Profile ◽  
Healing Property

Background: The biodegradable and biocompatible nature of pectin-based films is of particular interest in wound dressing applications, due to its non-toxicity, pH-sensitivity and gelling activity. An approach to improve the mechanical properties, the release profile of bioactive compounds as well as the performance in wet environments of pectin-based films is mixing with other biopolymers. Objective: To prepare hydrocolloid films based on crosslinked pectin / starch blend loaded with bioactive extracts from leaves of G. tinctoria and U. molinae with controlled release of bioactive compounds and healing property. Method: The hydrocolloid films were characterized by FTIR, SEM, and TGA-FTIR techniques and their tensile properties, water uptake, and polyphenolic release profile in aqueous media were evaluated. The dermal anti inflammatory activity of the hydrocolloid films was assessed by the mouse ear inflammation test. The wound healing property of the loaded hydrocolloid films was explored in a rat model and in a clinical trial (sacrum pressure ulcer). Results: The films showed an adequate water-uptake capacity between 100-160%. The release of active compounds from the hydrocolloid films followed the Korsmeyer-Peppas equation. The mechanical properties of hydrocolloid films were not affected by the plant extracts within the concentration range used. The incorporation of the bioactive extracts in the polysaccharide films inhibited the topical edematous response by about 50%. The topical application of the loaded hydrocolloid film on the pressure ulcer is completely closed after 17 days without showing any adverse reaction. Conclusion: A novel hydrocolloid matrix was produced from crosslinked starch-pectin, which exhibited suitable chemical-physical properties to be used as a carrier of plant extracts with wound healing properties.

scholarly journals A Review on Revolutionary Natural Biopolymer-Based Aerogels for Antibacterial Delivery

Antibiotics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 648 ◽  
Author(s):  
Esam Bashir Yahya ◽  
Fauziah Jummaat ◽  
A. A. Amirul ◽  
A. S. Adnan ◽  
N. G. Olaiya ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Metallic Nanoparticles ◽  
Biomedical Applications ◽  
Chronic Wound ◽  
Healing Process ◽  
Wound Healing Process ◽  
Physical Chemical ◽  
The Relationship ◽  
Plants Extract

A biopolymer-based aerogel has been developed to become one of the most potentially utilized materials in different biomedical applications. The biopolymer-based aerogel has unique physical, chemical, and mechanical properties and these properties are used in tissue engineering, biosensing, diagnostic, medical implant and drug delivery applications. Biocompatible and non-toxic biopolymers such as chitosan, cellulose and alginates have been used to deliver antibiotics, plants extract, essential oils and metallic nanoparticles. Antibacterial aerogels have been used in superficial and chronic wound healing as dressing sheets. This review critically analyses the utilization of biopolymer-based aerogels in antibacterial delivery. The analysis shows the relationship between their properties and their applications in the wound healing process. Furthermore, highlights of the potentials, challenges and proposition of the application of biopolymer-based aerogels is explored.

scholarly journals Scar-Free Healing of Wounds Resulting Commonly from Domestic Accidents

2021 ◽  
Vol 6 (4) ◽  
Keyword(s):  
Wound Healing ◽  
Amino Acid ◽  
Growth Factor ◽  
Healing Process ◽  
Keloid Scar ◽  
Skin Cells ◽  
Common Causes ◽  
Research Findings ◽  
Healing Of Wounds ◽  
Epidermal Growth

Scalds and cuts are common causes of childhood injuries at home. Although the impairments are often non-fatal, timely and effective treatments for them may not only help prevent infections, but also facilitate faster recovery from the injuries and scarless wound healing. Skin growth factors including the 53-amino acid human epidermal growth factor (EGF) and the 146-amino acid human basic fibroblast growth factor (bFGF) have been shown to play important physiological functions in promoting the growth and regeneration of our skin cells. Moreover, they have been employed individually to enhance the healing process of various types of wound. The specific bioactivities exhibited by EGF and bFGF in the epidermal and dermal layers, respectively, strongly support the notion that they may function cooperatively in wound healing. In this communication, making use of our own recombinant EGF (rEGF) and bFGF (rbFGF) products, which share the same primary structures with their native counterparts, we present research findings to demonstrate that rEGF and rbFGF work collaboratively to promote healing of various types of wound, including scalds, punctures and lacerations. More importantly, despite the severity of the injuries, subsequent to their treatments with rEGF and rbFGF, the healed wounds were virtually scar-free and devoid of the formation of an outgrowth scar, a keloid scar.

Attack of the NETs! NETosis primes IL-1β-mediated inflammation in diabetic foot ulcers

2020 ◽  
Vol 134 (12) ◽  
pp. 1399-1401
Author(s):  
Man K.S. Lee ◽  
Gopalkrishna Sreejit ◽  
Prabhakara R. Nagareddy ◽  
Andrew J. Murphy
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcers ◽  
Wound Healing Process ◽  
Inflammasome Activation ◽  
Diabetic Foot Ulcers ◽  
Nlrp3 Inflammasome Activation ◽  
Improve Wound Healing ◽  
Insight Into

Abstract In volume 133 issue 4 of Clinical Science, Liu et al. showed that neutrophils release extracellular traps (NETs) in the setting of diabetes which acts as a stimulus for NLRP3 inflammasome activation in macrophages to promote IL1β-dependent exacerbation of inflammation. They also provide evidence to show that degrading NETs improves the wound healing process. These findings provide an insight into how NETs communicate with other cells in the vicinity (e.g. macrophages) to exacerbate the inflammatory response. Most importantly, they provide novel avenues to improve wound healing process such as diabetic foot ulcers (DFUs) by targeting NETs.

Study of the resistor material of an automotive spark plug by use of the charge-up effect along with elemental mapping in an electron microprobe

1991 ◽  
Vol 49 ◽  
pp. 742-743
Author(s):  
D. R. Liu ◽  
S. S. Shinozaki ◽  
J. S. Park ◽  
B. N. Juterbock
Keyword(s):  
Electron Microprobe ◽  
Present Report ◽  
Coated Sample ◽  
Valuable Insight ◽  
Elemental Mapping ◽  
Spark Plug ◽  
Carbon Coated ◽  
Electron Image ◽  
Electron Imaging ◽  
Insight Into

The electric and thermal properties of the resistor material in an automotive spark plug should be stable during its service lifetime. Containing many elements and many phases, this material has a very complex microstructure. Elemental mapping with an electron microprobe can reveal the distribution of all relevant elements throughout the sample. In this work, it is demonstrated that the charge-up effect, which would distort an electron image and, therefore, is normally to be avoided in an electron imaging work, could be used to advantage to reveal conductive and resistive zones in a sample. Its combination with elemental mapping can provide valuable insight into the underlying conductivity mechanism of the resistor.This work was performed in a CAMECA SX-50 microprobe. The spark plug used in the present report was a commercial product taken from the shelf. It was sectioned to expose the cross section of the resistor. The resistor was known not to contain the precious metal Au as checked on the carbon coated sample. The sample was then stripped of carbon coating and re-coated with Au.

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