Autoimmune and inflammatory disorder biologicals will power biotech market growth through to 2010

2006 ◽  
Vol 12 (3) ◽  
Author(s):  
Clare A C Churchill ◽  
Mark J Belsey
Keyword(s):  
Market Analysis ◽  
Inflammatory Disorder ◽  
Annual Growth Rate ◽  
Market Growth ◽  
Compound Annual Growth Rate ◽  
Antibody Therapeutics ◽  
Wide Range ◽  
Will Power ◽  
Strategic Market ◽  
Biological Market

Biologicals designed to treat arthritis, immune and inflammatory disorders (AIID) are currently powering biotechnology market growth. Datamonitor's biotechnology strategic market analysis team has therefore analysed this market to identify key biological products, together with growth drivers and resistors shaping the growth of this market. The AIID market covers a wide range of indications; however, the most prevalent are rheumatoid arthritis and psoriasis, which together represent a significant healthcare burden. A range of monoclonal antibody therapeutics such as Abbott/CAT's Humira are set to drive AIID biological market growth, together with Amgen/Wyeth's fusion protein Enbrel. Owing to very strong sales of Enbrel as a result of continued label expansion, Amgen is set to record the greatest biological AIID sales from 2004 to 2010. Many of the highly efficacious AIID biologicals such as Enbrel target TNF, which is rapidly emerging as the leading cytokine target for many AIID indications. Overall, AIID biologicals generated US$5.4bn in 2004, and this is set to rise to US$14.3bn by 2010: a strong compound annual growth rate of 17.9 per cent.

Cancer remains the dominant disease target for biotech through to 2010

1969 ◽  
Vol 12 (4) ◽  
Author(s):  
Fleur Pijpers ◽  
Mark J Belsey
Keyword(s):  
Recombinant Proteins ◽  
Inflammatory Disorder ◽  
Biological Products ◽  
Market Growth ◽  
Pharmaceutical Markets ◽  
Dominant Disease ◽  
Will Power ◽  
Reported Data ◽  
Strategic Market ◽  
Biological Market

The two leading therapeutic areas for biological products, in terms of current sales and pipeline focus, are oncology and AIID (arthritis, immune and inflammatory disorders). Datamonitor's biotechnology strategic market analysis team recently analysed the AIID market, since this sector is currently powering biotechnology market growth, owing to high demand for biologicals to treat rheumatoid arthritis and psoriasis (Belsey, M. and Churchill, C. (2006) 'Autoimmune and inflammatory disorder biologicals will power biotech market growth through to 2010', J. Comm. Biotechnol., Vol. 12, No. 2, pp. 237–241). In the current paper, we have analysed the oncology market, since biologicals designed to treat cancer indications have underpinned the development of the biotechnology market since its inception in the 1980s. Biological products treat a wide variety of cancers, of which the most prevalent are the 'big four' tumour types – breast cancer, lung cancer, prostate cancer and colorectal cancer. In terms of technology focus, both monoclonal antibody therapeutics and recombinant proteins are set to drive cancer biological market growth. Key growth drivers include mainly Genentech and Roche products, such as Avastin (bevacizumab), Rituxan (rituximab) and Herceptin (trastuzumab), as well as Amgen products, including the second-generation recombinant proteins Neulasta (pegfilgrastim) and Aranesp (darbepoetin alfa). Across the major pharmaceutical markets, oncology biologicals generated US$10.7bn in 2004 (based on company-reported data), which Datamonitor forecasts to rise to US$29.0bn by 2010.

Marketspace: Leading therapeutic recombinant protein sales forecast and analysis to 2010

2005 ◽  
Vol 12 (1) ◽  
Author(s):  
Mark J Belsey ◽  
Alex K Pavlou
Keyword(s):  
Growth Rate ◽  
Recombinant Protein ◽  
Market Analysis ◽  
Annual Growth Rate ◽  
Product Class ◽  
Lower Growth ◽  
Compound Annual Growth Rate ◽  
Sales Forecast ◽  
Strategic Market ◽  
Product Sales

As part of Datamonitor's biotechnology strategic market analysis, the authors have performed an analysis of the top 20 therapeutic recombinant proteins (defined by 2010 forecast sales), providing a forecast from 2004 to 2010 of product sales by therapeutic and product class. Based on this analysis, which was conducted in June 2005, leading companies operating in this sector are identified. Market analysis indicates that the total compound annual growth rate (CAGR) of these products from 2004 to 2010 is set to be 7.7 per cent, which is lower than other biotech markets such as the monoclonal antibody market. This lower growth rate reflects the mature nature of the therapeutic recombinant protein market. The arthritis, immune and inflammatory disorders franchise is set to record the strongest growth, with a forecast 2004–10 CAGR of 16.8 per cent, while the diabetes and endocrinology franchise is set to record the weakest growth (1.6 per cent). The leading product class in terms of total forecast 2010 sales is the erythropoietin class, which is set to generate approximately one-third of total top 20 product sales. The strongest-growing product classes are set to be fusion protein and colony-stimulating factors, while insulins are forecast to be the weakest-growing sector. Amgen is set to continue to lead the recombinant protein market over the forecast period, with the company's contribution to top 20 recombinant protein market sales set to rise from one-third of total 2004 sales to one-half of total 2010 sales.

scholarly journals Trends in Sales and Industry Perspectives of Package Sizes of Carbonates and Confectionery Products

Foods ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1071
Author(s):  
Chloe Jensen ◽  
Kirsten Fang ◽  
Amanda Grech ◽  
Anna Rangan
Keyword(s):  
Qualitative Data ◽  
Size Control ◽  
Portion Size ◽  
Annual Growth Rate ◽  
Sales Data ◽  
Market Growth ◽  
Compound Annual Growth Rate ◽  
Food Package ◽  
Package Size ◽  
The Usa

Discretionary food package sizes are an important environmental cue that can affect the amount of food consumed. The aim of this study was to determine sales trends and reported food industry perspectives for changing food package sizes of carbonates and confectionery between 2005 and 2019. Changes in package sizes of carbonates and confectionery were investigated in Australia, the USA, Canada, and the UK. Sales data (units per capita and compound annual growth rate between 2005 and 2019) were extracted from the Euromonitor database. Qualitative data (market research reports) on industry perspectives on package size changes were extracted from industry and marketing databases. Carbonate sales data showed increased growth of smaller package sizes (<300 mL) and a decrease in sales of larger package sizes (≥2000 mL) in all four countries. In contrast, confectionery sales data showed no consistent trends across the selected countries. No growth was observed for smaller confectionery package sizes but an increase in growth of larger package sizes (50–99 g, >100 g), including share packages, was observed in Australia. Qualitative data (n = 92 articles) revealed key reasons identified by industry for changes in package size related to consumer health awareness, portion size control, convenience, market growth, and government or industry initiatives. Monitoring of discretionary food package sizes provides additional insights into consumers’ food environment.

scholarly journals Assessment of Exchange Options for Attracting External Financing by Small and Medium Businesses

2021 ◽  
pp. 549-563
Author(s):  
Elena Starchenko ◽  
Danil Verzhitskii
Keyword(s):  
Bank Loan ◽  
Direct Access ◽  
Sociological Research ◽  
Annual Growth Rate ◽  
External Financing ◽  
Processing Industry ◽  
Compound Annual Growth Rate ◽  
Wide Range ◽  
Medium Businesses ◽  
Exchange Options

Introduction. The choice and justification of options for attracting investments are relevant for the development of any organization. The research objective was to assess exchange-traded options for attracting investment by small and medium businesses in the food and processing industry. Study objects and methods. The research featured small and medium businesses in the food and processing industry and their exchange options for attracting external financing. The study was based on system, situational, structural-functional, and process approaches, as well as methods of comparative and factor analysis, grouping, and sociological research techniques. Results and discussion. The authors described, analyzed, and classified ways to attract external financing by small and medium businesses. Exchange-traded options proved to be associated with the circulation of securities that differ in liquidity, direct access to the owners of funds, and access to a potentially unlimited amount of investment capital. The authors analyzed the existing exchange infrastructure for the businesses under consideration and assessed their potential for issuing securities. Based on such indicators as Average EBIT Margin and Compound Annual Growth Rate (CAGR), small and medium food-related enterprises can issuer securities, especially exchange-traded bonds. Exchange-traded bonds demonstrated a number of serious disadvantages, compared to a traditional bank loan. However, issuers of securities receive guaranteed advantages, e.g. more flexible conditions for raising funds on the exchange, the right to state subsidies for the payment of coupon income, partial compensation for the costs of placing securities, the absence of collateral, a wide range of private investors, etc. Using some real cases, the authors evaluated the liquidity of exchange-traded bonds of small and medium businesses in the food and processing industry according to a number of indicators of profitability and liquidity of securities. Conclusion. Exchange options can be used to finance small and medium food-related businesses, based on the established ex-change infrastructure, government incentives, potential of the food sector, average EBIT profitability, and revenue growth.

Study on the Effect of Bleaching Treatment on the Mechanical Properties of Kenaf Fibers

2020 ◽  
Vol 1000 ◽  
pp. 278-284
Author(s):  
Yuli Amalia Husnil ◽  
Evana Yuanita ◽  
Nurfitri Ramadhani ◽  
Mochamad Chalid
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Mechanical Strength ◽  
Natural Fiber ◽  
Fiber Composite ◽  
Annual Growth Rate ◽  
Kenaf Fiber ◽  
Market Growth ◽  
Compound Annual Growth Rate ◽  
Bleaching Treatment

Automotive industries are trying to reduce the weight of cars by replacing parts that are made of steel and aluminum with lighter material but equally strong. It is an emerging trend in these industries to utilize polypropylene reinforced with natural fiber as the alternative lightweight material. PP-natural fiber composite is projected to have market growth with compound annual growth rate (CAGR) of 9.5% within 2018-2025. Blending PP with natural fiber is a challenging process considering these two materials are not compatible enough to produce composite with desired mechanical properties. Prior treatment to the fiber is required to improve its compatibility with PP with cautionary that it does not degrading the mechanical strength of the fiber. The aim of this work was to study the effect of chemical treatment on Kenaf fiber to the tensile strength of the fiber. Kenaf fiber was bleached with NaClO solution at various concentration (1-10% v/w), temperature (25-55°C), and duration (1-6 hours). The effect of bleaching treatment to the chemical structure and the tensile strength of the fiber was analyzed using FTIR and UTM respectively. This study showed that the fiber with highest tensile strength was the one that treated with NaClO solution with concentration 1% v/w, at 25°C for 1 hour. This treatment removed impurities for the surface and reduced some amorphous part of the fiber. However further increasing NaClO concentration, mixing temperature and duration will damage the cellulose chain in Kenaf fiber which will decrease the mechanical strength of the fiber.

The anti-ageing secret of massively multiplayer online game: Managing its lifecycle

2021 ◽  
pp. 031289622098111
Author(s):  
Cheuk Hang Au ◽  
Kevin KW Ho
Keyword(s):  
Jel Classification ◽  
Annual Growth Rate ◽  
Online Game ◽  
Market Growth ◽  
Compound Annual Growth Rate ◽  
Secondary Sources ◽  
Massively Multiplayer Online Game ◽  
Toe Framework ◽  
Multiplayer Online Game

It is estimated that from 2015 to 2025, the Global Multiplayer Online Game (MMOG) market will be growing at a compound annual growth rate of 10.2%. However, rapid market changes have shortened the lifespan of many MMOGs. This market phenomenon may demotivate prospective market players and thus decelerate the market growth. To address the lifespan issue, we conducted a netnographic case study on ‘TalesRunner’, which has successfully operated for longer than many other MMOGs. Based on the data from over 5.2 million messages from its official forum, as well as data from different secondary sources, we established a lifecycle model of MMOG in conjunction with the Technology-Organization-Environment (TOE) framework and offered theoretical implications for both MMOG and lifecycle theory. JEL Classification: M15

Assessment of Gaming Practices and its effect on scholastic performance of medical students in India: A Case Control study. (Preprint)

2020 ◽  
Author(s):  
Deodatt Madhav Suryawanshi ◽  
Divya Rajaseharan 2nd ◽  
Raghuram Venugopal 3rd ◽  
Ramchandra Goyal 4th ◽  
Anju Joy 5th
Keyword(s):  
Medical Students ◽  
Case Control ◽  
Annual Growth Rate ◽  
Gaming Addiction ◽  
Gaming Disorder ◽  
Compound Annual Growth Rate ◽  
Internal Assessment ◽  
Assessment Scores ◽  
Scholastic Performance ◽  
Excessive Gaming

BACKGROUND Introduction: Gaming is a billion-dollar industry growing at a Compound annual growth rate (CAGR) of 9 %- 14.3% with biggest market in South East Asian countries. Availability of Low-cost smart phones, ease of internet access has made gaming popular among youth who enjoy it as a leisure activity. According to the WHO excessive indulgence in Gaming can lead to Gaming disorder. Medical students indulging in excessive gaming can succumb to gaming disorder which can affect their scholastic performance. Hence this study was done to assess the gaming practices and its effect on scholastic performance. OBJECTIVE Objective: 1. To assess the various Gaming practices and the Prevalence of Gaming addiction among medical students. 2. To study the effect of Gaming practices on Scholastic performance of medical students. METHODS Methods: The present study used a case control design where the 448(N) study participants were recruited using non probability sampling technique.91 (Nc) cases who were Gaming for past 6 months were identified using rapid preliminary survey .91 controls (Nco) who never played games were selected and matched for age and sex. Internal Assessment scores (%) of cases and controls were compared. Snedecor F test and Student t test were used to find out the association between the hours of gaming and internal assessment scores (%) and difference of Internal assessment scores between cases and controls respectively. Odds ratio was calculated to identify the risk of Poor scholastic performance. Prevalence of Gaming addiction was assessed using Lemmen’s Gaming addiction scale (GAS). RESULTS Results: Frequency of gaming (hrs) was not associated with the Mean internal assessment scores (p>0.05). Male students (cases) showed significant reduction in both their internal assessment scores (p<0.001,<0.01) whereas no reduction was observed in Female cases. A negative correlation was observed between GAS and internal assessment scores (r=-0.02). Prevalence of Gaming addiction using GAS was found to be 6.2% among the study population(N=448) and 31% among Cases (Nc=91).The risk of low scores was (OR =1.80-1.89) times more in cases than controls. CONCLUSIONS Conclusions: Excessive Gaming adversely affects scholastic performance in males than females.Awareness about Gaming addiction needs to be created among students, parents and teachers. Institutionalized De-addiction services should be made available to medical students. CLINICALTRIAL No

scholarly journals Mini-review: antibody therapeutics targeting G protein-coupled receptors and ion channels

2020 ◽  
Vol 3 (4) ◽  
pp. 257-264
Author(s):  
Catherine J Hutchings
Keyword(s):  
Ion Channels ◽  
Research And Development ◽  
Small Molecules ◽  
G Protein ◽  
Clinical Studies ◽  
G Protein Coupled Receptors ◽  
Protein Targets ◽  
Antibody Therapeutics ◽  
Wide Range ◽  
G Protein Coupled

Abstract Antibodies are now well established as therapeutics with many additional advantages over small molecules and peptides relative to their selectivity, bioavailability, half-life and effector function. Major classes of membrane-associated protein targets include G protein-coupled receptors (GPCRs) and ion channels that are linked to a wide range of disease indications across all therapeutic areas. This mini-review summarizes the antibody target landscape for both GPCRs and ion channels as well as current progress in the respective research and development pipelines with some example case studies highlighted from clinical studies, including those being evaluated for the treatment of symptoms in COVID-19 infection.

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