scholarly journals Intraperitoneal and local ozone applications in veterinary oncology treatment [abstract]

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Adriano Caquetti
Keyword(s):  
Veterinary Medicine ◽  
Side Effects ◽  
Life Quality ◽  
Great Loss ◽  
Loss Of Life ◽  
Locomotor Disability ◽  
Therapeutic Results ◽  
Oncology Treatment

The elevated incidence of some non treatable, or with low therapeutic results, side effects in certain areas of veterinary medicine such as oncology, orthopaedics, wounds and infections in dogs, cats, and horses is notoriously reported and differentiated in several infirmities. These side effects manifest in symptoms acting as locomotor disability, pain, and in some cases, they result in a great loss of life quality in animals and their owners alike. Therefore, intraperitoneal and local ozone applications have brought relevant results and are now being used as complementary or, in certain cases, only treatment. The goal of this lecture is to show the use as well as the results and techniques used in oncological pathologies treated with intraperitoneal and local ozone applications which did not respond ,or had low therapeutic results, to conventional veterinary treatment. All this demonstrates that Intraperitoneal as well as local ozone applications are powerful tools available to veterinarians in order to promote relief, comfort, or, possibly, cure to animals.

Sexual Dysfunction: Hypoactive Sexual Desire Disorder

2018 ◽  
Author(s):  
John E Buster
Keyword(s):  
Side Effects ◽  
Sexual Dysfunction ◽  
Sexual Desire ◽  
Family Relationships ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Life Quality ◽  
Premenopausal Women ◽  
Reproductive Hormones ◽  
Hypoactive Sexual Desire Disorder ◽  
Desire Disorder

Healthy female sexual functioning is driven by sexual desire. Sexual desire, traditionally defined as sexual thoughts and fantasies, is a natural life force and an art form affecting all aspects of a woman’s interpersonal and professional life. Virtually, all diagnostic categories of female sexual dysfunction, including arousal disorder, anorgasmia, and sexual pain disorder are linked to, caused by, or aggravated by loss of sexual desire. Decreased sexual desire is a diagnosis (hypoactive sexual desire disorder, HSDD) with its own International Classification of Diseases code (F52.0).. Impact is often subtle. HSDD may express as seemingly unrelated emotional disturbances that degrade life quality in family relationships, in the workplace, or both. For some women, it is severely distracting. The diagnosis of HSDD is made when symptoms are sufficient to cause distress. In older women, HSDD is heavily impacted by menopause-associated withdrawal of reproductive hormones, particularly testosterone and estradiol. HSDD greatly improves with transdermal replacement of these steroids. Side effects of transdermal hormones are minimal but response can be gratifying. In premenopausal women, HSDD behaves more as a psychoendocrine disorder that is responsive in some patients to flibanserin, a nonhormonal 5-HT1A receptor agonist. Side effects of flibanserin are significant but manageable. This review contains 12 figures, 6 tables, and  references. Key Words: estradiol, flibanserin, hypoactive sexual desire disorder, menopause, selective serotonin reuptake inhibitors, sexual desire, sexuality, testosterone, transdermal, women

scholarly journals n-3 Polyunsaturated Fatty Acids and Their Derivates Reduce Neuroinflammation during Aging

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 647 ◽  
Author(s):  
Corinne Joffre ◽  
Anne-Laure Dinel ◽  
Mathilde Chataigner ◽  
Véronique Pallet ◽  
Sophie Layé
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Beneficial Effect ◽  
Life Quality ◽  
Inflammatory Signaling ◽  
Resolution Of Inflammation ◽  
Loss Of Life ◽  
Immunomodulatory Properties ◽  
The Brain

Aging is associated to cognitive decline, which can lead to loss of life quality, personal suffering, and ultimately neurodegenerative diseases. Neuroinflammation is one of the mechanisms explaining the loss of cognitive functions. Indeed, aging is associated to the activation of inflammatory signaling pathways, which can be targeted by specific nutrients with anti-inflammatory effects. Dietary n-3 polyunsaturated fatty acids (PUFAs) are particularly attractive as they are present in the brain, possess immunomodulatory properties, and are precursors of lipid derivates named specialized pro-resolving mediators (SPM). SPMs are crucially involved in the resolution of inflammation that is modified during aging, resulting in chronic inflammation. In this review, we first examine the effect of aging on neuroinflammation and then evaluate the potential beneficial effect of n-3 PUFA as precursors of bioactive derivates, particularly during aging, on the resolution of inflammation. Lastly, we highlight evidence supporting a role of n-3 PUFA during aging.

The rights and wrongs of measles vaccination

1995 ◽  
Vol 84 (03) ◽  
pp. 156-163 ◽  
Author(s):  
John M. English
Keyword(s):  
Immune System ◽  
Side Effects ◽  
Age Groups ◽  
Primary Vaccination ◽  
Duration Of Action ◽  
Permanent Disability ◽  
Loss Of Life ◽  
Mortality And Morbidity ◽  
Measles Vaccination ◽  
Immunization Programmes

AbstractThere is controversy regarding immunization. This paper concentrates on measles although the evidence is more broadly based. Both mortality and morbidity figures strongly suggest that despite a few casualties the campaign has saved many lives and much suffering, even though its goal of eliminating measles has not yet been achieved. Unfortunately the immunizing effect of the vaccine has a shorter duration of action than the disease itself, and this has led to outbreaks of measles amongst older age-groups immunized as babies. Morbidity and mortality are higher when measles is contracted at older ages. A revaccination campaign is under way. Side effects from revaccination are less frequent than with primary vaccination.The incidence of a variety of chronic diseases, some of which are related to the immune system, has risen concurrently with the various immunization programmes. Opponents fear that the two phenomena are connected, and that by proceeding with immunization we are fundamentally damaging the race. While the evidence for such a connection is weak, it cannot entirely be dismissed as it is equally hard to disprove. We should remain alert to the possibility and research it honestly while continuing with the campaign, since abandoning it would undoubtedly result in much more loss of life and permanent disability.

Double-Blind Evaluation of Domperidone in Acute Vomiting and Dyspeptic Disorders

1981 ◽  
Vol 9 (2) ◽  
pp. 143-147 ◽  
Author(s):  
I Agorastos ◽  
N P Zissis ◽  
I Kaprinis ◽  
G Goulis
Keyword(s):  
Side Effects ◽  
Rating Scale ◽  
Second Phase ◽  
Double Blind Trial ◽  
Duration Of Treatment ◽  
Double Blind ◽  
Blind Trial ◽  
Therapeutic Results ◽  
The Difference ◽  
Symptom Rating

The anti-emetic effects of domperidone were evaluated under double-blind conditions in twenty-four patients with acute vomiting randomly assigned to treatment either with 10 mg i.m. domperidone (six females, five males) or with placebo (seven females, six males). The therapeutic results were better with domperidone and the differences from placebo were statistically significant (p < 0.02). In a second randomized, crossover, double-blind trial, domperidone (10 mg t.i.d.) evaluated according to a nine-symptom rating scale, in eighteen dyspeptic patients, proved significantly more effective than placebo. The duration of treatment was 6 weeks and the drugs were crossed-over after 3 weeks. The difference between the two groups was most marked during the second phase of the trial. No side-effects were reported.

scholarly journals Possible Effects of Proton Pump Inhibitors on Hearing Loss Development

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Michał Wiciński ◽  
Bartosz Malinowski ◽  
Oskar Puk ◽  
Karol Górski ◽  
Dawid Adamkiewicz ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Side Effects ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Life Quality ◽  
Circulatory System ◽  
Whole Body ◽  
Over The Counter ◽  
The Impact

For their being considered safe and as over-the-counter (OTC) drugs, proton pump inhibitors (PPI) are one of the most frequently used medicines nowadays. However, for the last couple of years, many researches analyzing PPI were conducted and these studies shed light on PPI side effects and mechanisms of these processes. Particularly, interesting is the impact of PPI on hearing loss development. However, this side effect seems to be local and its mechanisms are complex and systemic and involve changes in the whole body. This paper summarizes how through, inter alia, alterations in circulatory system, respiratory system, central nervous system, and metabolic changes PPI can cause hearing impairment, which can occur at every age and is connected with long-term use of this group of drugs. Another important finding is the role of PPI in acceleration of presbycusis development which is disturbing with regard to the fact that elders are the group who most frequently use PPI in the long term. Hearing loss is the factor which gravely decreases life quality, especially among elders who are the most afflicted group; thus, administration of PPI should be considered carefully, taking under consideration all benefits and all potential side effects.

STUDY THE STATUS USING IMMUNOSUPRESSANTS, SIDE EFFECTS OF IMMUNOSUPRESSANTS AND COMPLICATIONS ON RENAL TRANSPLATATION PATIENTS

2015 ◽  
pp. 39-44
Author(s):  
Tam Vo ◽  
Thi Hong Van Le ◽  
Thi Loc Nguyen
Keyword(s):  
Renal Transplantation ◽  
Side Effects ◽  
Life Quality ◽  
Key Words Renal Transplantation ◽  
Cross Sectional ◽  
Urinary Infections ◽  
Study Results ◽  
The Status ◽  
Centre Hospital ◽  
Stage Renal Disease

Renal transplantation is the most effective therapy in treatment the end stage renal disease. Donated kidney can be transplanted from living donors or brain dead donors renal transplantation reduces the mortality and life quality versus hemodialysis. HLA gene is the most basic examination in renal transplantation. Objectives: to study the status of using the immunosupressants, side effects of immunosuppressants and complications on renal transplantation patients. Materials and Methods: 66 patients at Hue Centre Hospital from 11/2013 - 9/2014 . A Cross-sectional and prospective study. Results and conclusions: 3 patients had acute renal rejection and 4 patients had chronic renal rejection. The complications in the groups transphlanted over 1 years were diabietes, diarrhea, varicella, thrombopenia. Hyperuricemia was 39.4%, drugs hepatitis was 12.1%. After renal transplantation, were 13.6% had urinary infections, no case of heart failure was domanted. Key words: renal transplantation, immunosuppressants, complications.

scholarly journals Difference in Estimation of Side Effects of Chemotherapy between Physicians and Patients with Early-Stage Breast Cancer: The Use of Patient Reported Outcomes (PROs) in the Evaluation of Toxicity in Everyday Clinical Practice

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 5922
Author(s):  
Mirjana Pavlović Mavić ◽  
Robert Šeparović ◽  
Ana Tečić Vuger ◽  
Ljubica Vazdar
Keyword(s):  
Breast Cancer ◽  
Clinical Practice ◽  
Side Effects ◽  
Early Stage ◽  
Subjective Assessment ◽  
Breast Cancer Patients ◽  
Patient Reported ◽  
Patient’S Experience ◽  
Oncology Treatment ◽  
Chemotherapy Patients

Knowledge about the patient’s experience and perception of side effects and their impact on daily life is crucial for the adequate planning of interventions to provide the highest attainable levels of quality of life during oncology treatment. We conducted a study on consecutive samples of 69 early breast cancer patients treated with four cycles of neoadjuvant or adjuvant anthracycline-based chemotherapy. Patients completed the questionnaire about side effects experienced after the previous cycle of chemotherapy. The questionnaire was a modified PRO for the evaluation of treatment toxicity consisting of 18 questions related to the very common and common side effects of doxorubicin and cyclophosphamide, valued from 0 to 3 according to the subjective assessment of the patient. During the same cycles of therapy, data were also collected by the physician who completed a questionnaire consisting of the same questions as the questionnaire for patients, on the same scale. Most of the side effects reported by patients were mild to moderate in intensity, while physicians reported side effects much less frequently. The results also indicated a disproportionate reporting, in which physicians reported statistically significantly fewer side effects than patients. This study reported a level of disagreement between patients and physicians in the experience of therapy toxicity. In conclusion, use of PRO in clinical practice can help us avoid physician subjectiveness in the estimation of side effects and determine the group of patients who can benefit from additional and individualized supportive care measures, which could lead to better adherence to therapy and ultimately best outcomes.

scholarly journals Metabolomic Study on the Therapeutic Effect of the Jianpi Yangzheng Xiaozheng Decoction on Gastric Cancer Treated with Chemotherapy Based on GC-TOFMS Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-23
Author(s):  
Chao Hou ◽  
Hua-Jian Chu ◽  
Xiao-Jun Dai ◽  
Yin-Qiu Wu ◽  
Zheng-Fei He ◽  
...  
Keyword(s):  
Side Effects ◽  
Metabolic Pathways ◽  
Life Quality ◽  
Pentose Phosphate ◽  
Glutathione Metabolism ◽  
Serum Samples ◽  
Chlorophyll Metabolism ◽  
Metabolic Characteristics ◽  
Metabolic Defects

Objective. This study aimed to find new biomarkers of prognosis and metabolomic therapy for gastric carcinoma (GC) treated with chemotherapy and investigate the metabolic mechanism of the Jianpi Yangzheng Xiaozheng (JPYZXZ) decoction in the treatment of GC. Methods. First, 36 patients with GC were randomly assigned to the treatment (chemotherapy plus JPYZXZ) and control (chemotherapy alone) groups. The clinical efficacy, side effects, and quality of life of patients in the two groups were evaluated after treatment. Then, the serum samples taken from 16 randomly selected patients (eight treatment cases and eight control cases with no evident pattern characters) and eight healthy volunteers were tested to identify the differential metabolite under the gas chromatography-time-of-fight mass spectrometry platform. The relevant metabolic pathways of differential substances were analyzed using multidimensional statistical analysis. Results. JPYZXZ combined with chemotherapy resulted in a lower risk of leucopenia, thrombocytopenia, and gastrointestinal reaction ( P  < 0.05). Additionally, patients in the treatment group showed a higher Karnofsky (KPS) scale ( P  < 0.05). Compared with healthy persons, patients with GC were found to have 26 significant differential metabolites after chemotherapy; these metabolites are mainly involved in 12 metabolic pathways, such as valine, leucine, and isoleucine biosynthesis. JPYZXZ primarily influences the pentose phosphate pathway; glutathione metabolism; glyoxylate and dicarboxylate metabolism; porphyrin and chlorophyll metabolism; and glycine, serine, and threonine metabolism of patients with GC treated with chemotherapy. Conclusions. The metabolic characteristics of patients with GC after chemotherapy are mainly various amino acid metabolic defects, especially L-glutamine, L-leucine, L-alloisoleucine, and L-valine. These defects lead to a series of problems, such as decreased tolerance and effectiveness of chemotherapy, increased side effects, decreased immunity, and shortened survival time. In addition, the remarkable upregulation of the gluconolactone level in patients with GC suggests the high proliferative activity of GC cells. Thus, gluconolactone may be used as a potential prognostic and diagnostic evaluation index. Moreover, JPYZXZ can reduce the incidence of ADRs and improve the life quality of patients by the correction of L-glutamine, L-leucine, L-alloisoleucine, and L-valine metabolism deficiency. In addition, gluconolactone metabolism is inhibited by JPYZXZ. Such inhibition may be one of the antitumor mechanisms of JPYZXZ.

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