scholarly journals Increased prenatal brain growth in a transgenic mouse model decreases cranial development: An expensive tissue hypothesis for the skull

2018 ◽  
Author(s):  
Elisabeth K N López ◽  
Matthew J Ravosa
Keyword(s):  
Transgenic Mice ◽  
Hominid Evolution ◽  
Brain Growth ◽  
Wild Type ◽  
Cranial Development ◽  
Facial Skull ◽  
Maternal Resources ◽  
And Control ◽  
The Relationship ◽  
Expensive Tissue Hypothesis

In vertebrates, it has been argued that the development and evolution of an enlarged brain requires an increased basal metabolic rate or a compensatory reduction in the resources devoted to the formation of other metabolically costly tissues, leading to a reduction in the size of such organs. While the latter scenario is indirectly supported by comparative data, especially in primates, this inherently ontogenetic phenomenon has not been addressed in a mechanistic framework. Our experimental study investigates the relationship between brain growth and cranial development in ß-catenin transgenic mice with remarkably increased levels of prenatal neurogenesis. To evaluate associated changes in skull form and control for variation in maternal resources among mouse litters, we directly compare data from transgenic and wild-type littermates. Ossification patterns in the limbs and skull were also analyzed to control for within-subject variation in skeletal formation. Transgenic mice, with relatively larger brains, are characterized by a corresponding decrease in the degree of cranial ossification for a given age, in contrast to the presence of similar rates of postcranial ossification between transgenic and wild-type mice. This disparity is most pronounced in the neurocranial vault, which is supplied by a greater number of vessels in common with the brain than the facial skull. Mice with relatively larger brains had a decrease in cranial ossification. As modern humans are more encephalized than living apes and most extinct hominids, our findings provide unique insights into hominid evolution, particularly the “expensive tissue hypothesis” regarding energetic tradeoffs during neural and cranial development.

scholarly journals Increased prenatal brain growth in a transgenic mouse model decreases cranial development: An expensive tissue hypothesis for the skull

2018 ◽  
Author(s):  
Elisabeth K N López ◽  
Matthew J Ravosa
Keyword(s):  
Transgenic Mice ◽  
Hominid Evolution ◽  
Brain Growth ◽  
Wild Type ◽  
Cranial Development ◽  
Facial Skull ◽  
Maternal Resources ◽  
And Control ◽  
The Relationship ◽  
Expensive Tissue Hypothesis

In vertebrates, it has been argued that the development and evolution of an enlarged brain requires an increased basal metabolic rate or a compensatory reduction in the resources devoted to the formation of other metabolically costly tissues, leading to a reduction in the size of such organs. While the latter scenario is indirectly supported by comparative data, especially in primates, this inherently ontogenetic phenomenon has not been addressed in a mechanistic framework. Our experimental study investigates the relationship between brain growth and cranial development in ß-catenin transgenic mice with remarkably increased levels of prenatal neurogenesis. To evaluate associated changes in skull form and control for variation in maternal resources among mouse litters, we directly compare data from transgenic and wild-type littermates. Ossification patterns in the limbs and skull were also analyzed to control for within-subject variation in skeletal formation. Transgenic mice, with relatively larger brains, are characterized by a corresponding decrease in the degree of cranial ossification for a given age, in contrast to the presence of similar rates of postcranial ossification between transgenic and wild-type mice. This disparity is most pronounced in the neurocranial vault, which is supplied by a greater number of vessels in common with the brain than the facial skull. Mice with relatively larger brains had a decrease in cranial ossification. As modern humans are more encephalized than living apes and most extinct hominids, our findings provide unique insights into hominid evolution, particularly the “expensive tissue hypothesis” regarding energetic tradeoffs during neural and cranial development.

Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist

1999 ◽  
Vol 276 (3) ◽  
pp. R644-R651 ◽  
Author(s):  
Johan Lundkvist ◽  
Anna K. Sundgren-Andersson ◽  
Susanne Tingsborg ◽  
Pernilla Östlund ◽  
Catherine Engfors ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Serum Levels ◽  
Type I ◽  
Wild Type ◽  
Specific Expression ◽  
Protein Levels ◽  
Transgenic Phenotype ◽  
And Control

The interleukin-1 (IL-1) receptor antagonist (IL-1ra) is an endogenous antagonist that blocks the effects of the proinflammatory cytokines IL-1α and IL-1β by occupying the type I IL-1 receptor. Here we describe transgenic mice with astrocyte-directed overexpression of the human secreted IL-1ra (hsIL-1ra) under the control of the murine glial fibrillary acidic protein (GFAP) promoter. Two GFAP-hsIL-1ra strains have been generated and characterized further: GILRA2 and GILRA4. These strains show a brain-specific expression of the hsIL-1ra at the mRNA and protein levels. The hsIL-1ra protein was approximated to ∼50 ng/brain in cytosolic fractions of whole brain homogenates, with no differences between male and female mice or between the two strains. Furthermore, the protein is secreted, inasmuch as the concentration of hsIL-1ra in the cerebrospinal fluid was 13 (GILRA2) to 28 (GILRA4) times higher in the transgenic mice than in the control animals. To characterize the transgenic phenotype, GILRA mice and nontransgenic controls were injected with recombinant human IL-1β (central injection) or lipopolysaccharide (LPS, peripheral injection). The febrile response elicited by IL-1β (50 ng/mouse icv) was abolished in hsIL-1ra-overexpressing animals, suggesting that the central IL-1 receptors were occupied by antagonist. The peripheral LPS injection (25 μg/kg ip) triggered a fever in overexpressing and control animals. Moreover, no differences were found in LPS-induced (100 and 1,000 μg/kg ip; 1 and 6 h after injection) IL-1β and IL-6 serum levels between GILRA and wild-type mice. On the basis of these results, we suggest that binding of central IL-1 to central IL-1 receptors is not important in LPS-induced fever or LPS-induced IL-1β and IL-6 plasma levels.

From Container to Claustrum: Projective Identification in Couples

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Tamara Feldman
Keyword(s):  
Psychological Health ◽  
Projective Identification ◽  
The Self ◽  
The Other ◽  
Intimate Partners ◽  
And Control ◽  
The Relationship ◽  
As If

This paper is a contribution to the growing literature on the role of projective identification in understanding couples' dynamics. Projective identification as a defence is well suited to couples, as intimate partners provide an ideal location to deposit unwanted parts of the self. This paper illustrates how projective identification functions differently depending on the psychological health of the couple. It elucidates how healthier couples use projective identification more as a form of communication, whereas disturbed couples are inclined to employ it to invade and control the other, as captured by Meltzer's concept of "intrusive identification". These different uses of projective identification affect couples' capacities to provide what Bion called "containment". In disturbed couples, partners serve as what Meltzer termed "claustrums" whereby projections are not contained, but imprisoned or entombed in the other. Applying the concept of claustrum helps illuminate common feelings these couples express, such as feeling suffocated, stifled, trapped, held hostage, or feeling as if the relationship is killing them. Finally, this paper presents treatment challenges in working with more disturbed couples.

Content Analysis (Analisis Isi) terhadap Peraturan Daerah Bernuansa Syariat Islam di Kabupaten Banyumas

2019 ◽  
Vol 1 (2) ◽  
pp. 121
Author(s):  
Dody Nur Andriyan
Keyword(s):  
Disease Management ◽  
Public Interest ◽  
Islamic Law ◽  
Alcoholic Beverages ◽  
Public Issues ◽  
Criminal Sanctions ◽  
Qualitative Descriptive ◽  
Administrative Sanctions ◽  
And Control ◽  
The Relationship

Regional Regulation (Perda) which regulates public issues such as prostitution, alcoholic beverages, gambling, and the relationship between men and women turns out to be identified as a Regional Regulation with nuances of Islamic law. in Banyumas Regency there is a Regional Regulation which if used by the identification of Arfiansyah above, it can be referred to as a Regional Regulation with nuances of Islamic law. The regulation is: Banyumas District Regulation Number 15 of 2014 concerning Control, Supervision and Control of Circulation of Alcoholic Beverages and Regional Regulations of Banyumas Regency Number 16 of 2015 concerning Community Disease Management. This research has two formulations of the first problem related to the results of the content of the analysis on the Perda that are nuanced by Islamic law in Banyumas Regency. Both of the results of the analysis content on the Regional Regulations that are nuanced by Islamic law in Banyumas Regency are not contrary to Law-Invitation Number 12 of 2011? This research is a qualitative-descriptive study. The research method used is normative juridical. The main source of data is the Banyumas District Regulation Number 15 of 2014 concerning Control, Supervision and Control of Circulation of Alcoholic Beverages and Regional Regulations of Banyumas Regency Number 16 of 2015 concerning Community Disease Management. Interviews were also conducted with resource persons. Furthermore, the results of the analysis were carried out. Regional Regulation No. 15 of 2014 is actually a Regional Regulation that has a broad purpose of public interest, for the nation and state. So that the claim that Perda No 15 of 2014 as a Regional Regulation with nuances of Islamic law is not true. Regional Regulation No. 16 of 2015 is actually a Regional Regulation that has a broad purpose of public interest, for the nation and state. So that the claim that Perda No 16 of 2015 as a Regional Regulation with nuances of Islamic law is not true. Both of these Perda (Perda No 15 of 2014 and Perda No. 16 of 2015) are not in conflict with Law No. 12 of 2011 concerning the Establishment of Legislation. Both in terms of content, principles, goals, arrangements, administrative sanctions and criminal sanctions. Formally and procedurally the two Perda are in accordance with Law Number 12 of 2011

The effect of type of water supply on water quality in a developing community in South Africa

1997 ◽  
Vol 35 (11-12) ◽  
pp. 35-40 ◽  
Author(s):  
B. Genthe ◽  
N. Strauss ◽  
J. Seager ◽  
C. Vundule ◽  
F. Maforah ◽  
...  
Keyword(s):  
Water Quality ◽  
Water Supply ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
E Coli ◽  
Guideline Values ◽  
Developing Communities ◽  
Quality Guideline ◽  
And Control ◽  
The Relationship

Efforts to provide water to developing communities in South Africa have resulted in various types of water supplies being used. This study examined the relationship between the type of water supply and the quality of water used. Source (communal taps, private outdoor and indoor taps) and point-of-use water samples were examined for heterotrophic plate counts (HPC), total and faecal coliforms, E. coli, and coliphages. Ten percent of samples were also analysed for enteric viruses, Giardia and Cryptosporidium. Approximately 320 households were included in a case-control study. In addition, a cross-sectional study was conducted. Both studies examined the relationship between different types of water facilities and diarrhoea among pre-school children. The source water was of good microbial quality, but water quality was found to have deteriorated significantly after handling and storage in both case and control households, exceeding drinking water quality guideline values by 1-6 orders of magnitude. Coliphage counts were low for all water samples tested. Enteric viruses and Cryptosporidium oocysts were not detected. Giardia cysts were detected on one occasion in case and control in-house samples. Comparisons of whether in-house water, after handling and storage, complied with water quality guideline values demonstrated households using communal taps to have significantly poorer quality than households using private outdoor or indoor taps for HPC and E. coli (χ2 = 14.9, P = 0.001; χ2 = 6.6, P = 0.04 respectively). A similar trend (although not statistically significant) was observed for the other microbial indicators. The cross-sectional study demonstrated an apparent decrease in health risk associated with private outdoor taps in comparison to communal taps. This study suggests that a private outdoor tap is the minimum level of water supply in order to ensure the supply of safe water to developing communities.

MiR-335-5p Inhibits β-Amyloid (Aβ) Accumulation to Attenuate Cognitive Deficits Through Targeting c-jun-N-terminal Kinase 3 in Alzheimer’s Disease

2020 ◽  
Vol 17 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Dan Wang ◽  
Zhifu Fei ◽  
Song Luo ◽  
Hai Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Western Blot ◽  
Mrna Expression ◽  
Cognitive Deficits ◽  
Protein Levels ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
The Relationship

Objectives: Alzheimer's disease (AD), also known as senile dementia, is a common neurodegenerative disease characterized by progressive cognitive impairment and personality changes. Numerous evidences have suggested that microRNAs (miRNAs) are involved in the pathogenesis and development of AD. However, the exact role of miR-335-5p in the progression of AD is still not clearly clarified. Methods: The protein and mRNA levels were measured by western blot and RNA extraction and quantitative real-time PCR (qRT-PCR), respectively. The relationship between miR-335-5p and c-jun-N-terminal kinase 3 (JNK3) was confirmed by dual-luciferase reporter assay. SH-SY5Y cells were transfected with APP mutant gene to establish the in vitro AD cell model. Flow cytometry and western blot were performed to evaluate cell apoptosis. The APP/PS1 transgenic mice were used as an in vivo AD model. Morris water maze test was performed to assess the effect of miR- 335-5p on the cognitive deficits in APP/PS1 transgenic mice. Results: The JNK3 mRNA expression and protein levels of JNK3 and β-Amyloid (Aβ) were significantly up-regulated, and the mRNA expression of miR-335-5p was down-regulated in the brain tissues of AD patients. The expression levels of miR-335-5p and JNK3 were significantly inversely correlated. Further, the dual Luciferase assay verified the relationship between miR-335- 5p and JNK3. Overexpression of miR-335-5p significantly decreased the protein levels of JNK3 and Aβ and inhibited apoptosis in SH-SY5Y/APPswe cells, whereas the inhibition of miR-335-5p obtained the opposite results. Moreover, the overexpression of miR-335-5p remarkably improved the cognitive abilities of APP/PS1 mice. Conclusion: The results revealed that the increased JNK3 expression, negatively regulated by miR-335-5p, may be a potential mechanism that contributes to Aβ accumulation and AD progression, indicating a novel approach for AD treatment.

Delegation and Control Revisited

2018 ◽  
Author(s):  
Dan Honig
Keyword(s):  
Foreign Aid ◽  
International Development ◽  
Local Knowledge ◽  
Entry And Exit ◽  
Country Ownership ◽  
Development Organization ◽  
Workplace Experience ◽  
And Control ◽  
The Relationship

This chapter traces the relationship between political authorizing environments, international development organization (IDO) management, and IDO field agents, drawing on the empirics presented in chapters 6 and 7. It digs into the experience of working for USAID as compared to DFID. It also extends the discussion of delegation to implementing contractors and brings this book’s theorizing of Navigation by Judgment into conversation with other foreign aid solutions aimed at incorporating local knowledge, such as establishing country offices or ensuring projects have country ownership. This chapter connects Part II’s empirics more tightly to the mechanisms theorized in Part I , particularly the role of authorizing environment insecurity and the need to “manage up” (Chapter 4) and their implications for the workplace experience of agents (Chapter 3) and the entry and exit of personnel.

Public Powers, Private Powers, and the Exploitation of Metals for Coinage

2018 ◽  
Author(s):  
Giovanna Bianchi
Keyword(s):  
Middle Ages ◽  
Field Research ◽  
Mineral Resources ◽  
Medieval Period ◽  
Early Medieval ◽  
Early Medieval Period ◽  
Italian Journal ◽  
Open Questions ◽  
And Control ◽  
The Relationship

In 1994, an article appeared in the Italian journal Archeologia Medievale, written by Chris Wickham and Riccardo Francovich, entitled ‘Uno scavo archeologico ed il problema dello sviluppo della signoria territoriale: Rocca San Silvestro e i rapporti di produzione minerari’. It marked a breakthrough in the study of the exploitation of mineral resources (especially silver) in relation to forms of power, and the associated economic structure, and control of production between the twelfth and thirteenth centuries. On the basis of the data available to archeological research at the time, the article ended with a series of open questions, especially relating to the early medieval period. The new campaign of field research, focused on the mining landscape of the Colline Metallifere in southern Tuscany, has made it possible to gather more information. While the data that has now been gathered are not yet sufficient to give definite and complete answers to those questions, they nevertheless allow us to now formulate some hypotheses which may serve as the foundations for broader considerations as regards the relationship between the exploitation of a fundamental resource for the economy of the time, and the main players and agents in that system of exploitation, within a landscape that was undergoing transformation in the period between the early medieval period and the middle centuries of the Middle Ages.

Cognitive Treatment for OCD

2012 ◽  
Author(s):  
Maureen L. Whittal ◽  
Melisa Robichaud
Keyword(s):  
Term Treatment ◽  
Future Directions ◽  
Cognitive Treatment ◽  
Long Term Treatment ◽  
Inflated Responsibility ◽  
And Control ◽  
The Relationship ◽  
Control Of Thoughts

The cornerstone of cognitive treatment (CT) for OCD is based upon the knowledge that unwanted intrusions are essentially a universal experience. As such, it is not the presence of the intrusion that is problematic but rather the associated meaning or interpretation. Treatment is flexible, depending upon the nature of the appraisals and beliefs, but can include strategies focused on inflated responsibility and overestimation of threat, importance and control of thoughts, and the need for perfectionism and certainty. The role of concealment and the relationship to personal values are important maintaining and etiological factors. The short-term and long-term treatment outcome is reviewed, along with predictors of treatment response and mechanisms of action, and the chapter concludes with future directions regarding CT for OCD.

Coercive Controlling Behaviors and Reporting Physical Intimate Partner Violence in Australian Women: An Exploration

2021 ◽  
pp. 107780122098593
Author(s):  
Brittany Patafio ◽  
Peter Miller ◽  
Arlene Walker ◽  
Kerri Coomber ◽  
Ashlee Curtis ◽  
...  
Keyword(s):  
Intimate Partner Violence ◽  
Partner Violence ◽  
Online Survey ◽  
Physical Violence ◽  
Intimate Partner ◽  
Physical Intimate Partner Violence ◽  
Differential Utility ◽  
And Control ◽  
The Relationship ◽  
Controlling Behaviors

This study explores two approaches to measuring coercive controlling behaviors (CCBs)—counting how many different CCB types and examining the frequency of each CCB experienced—to examine their utility in explaining the relationship between CCBs and physical intimate partner violence (IPV). Australian women aged 18–68 years ( n = 739; Mage = 31.58, SDage = 11.76) completed an online survey. Count and frequency CCB approaches yielded similar significant associations with increased physical IPV. Both approaches suggest that frightening behaviors in particular are significantly indicative of also experiencing physical IPV; however, when you count CCB types, public name-calling becomes important, whereas when you examine the frequency of each CCB type, jealousy/possessiveness becomes important. These findings suggest differential utility between measures of CCBs, which examine the frequency of specific CCB types and which count CCB types, and that both approaches are useful in understanding how coercion and control relate to physical violence within intimate relationships.

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