scholarly journals Understanding the social determinants of TB and HIV in South Asia

Author(s):  
Bishwajit Ghose ◽  
Cheng Zhaohui ◽  
He Zhifei

South Asian population suffer a particularly wide range of infectious diseases among which TB and HIV appear to produce most profound influence across various dimensions of social life, healthcare and the economy. Although the countries in this region have a relatively lower prevalence of HIV/AIDS compared to other developing regions until now, the future looks rather bleak in terms of preparedness for emerging healthcare realities. Tuberculosis on the other hand, has always been a major public health problem plaguing the healthcare system and the economy for decades. Moreover, the emergence of the drug resistant (MDR-TB & XDR-TB) strains are making the existing intervention and prevention strategies less effective and posing ever-growing threats to the underdeveloped healthcare infrastructure. Understanding the underlying social-determinants of these diseases can prove crucial to design more comprehensive intervention approaches. This article aims to clarify why the healthcare system in South Asia needs to adopt a social-determinants-of-health (SDOH) approach as a long-term strategy for more efficient prevention and control of TB and HIV infection.

2014 ◽  
Author(s):  
Bishwajit Ghose ◽  
Cheng Zhaohui ◽  
He Zhifei

South Asian population suffer a particularly wide range of infectious diseases among which TB and HIV appear to produce most profound influence across various dimensions of social life, healthcare and the economy. Although the countries in this region have a relatively lower prevalence of HIV/AIDS compared to other developing regions until now, the future looks rather bleak in terms of preparedness for emerging healthcare realities. Tuberculosis on the other hand, has always been a major public health problem plaguing the healthcare system and the economy for decades. Moreover, the emergence of the drug resistant (MDR-TB & XDR-TB) strains are making the existing intervention and prevention strategies less effective and posing ever-growing threats to the underdeveloped healthcare infrastructure. Understanding the underlying social-determinants of these diseases can prove crucial to design more comprehensive intervention approaches. This article aims to clarify why the healthcare system in South Asia needs to adopt a social-determinants-of-health (SDOH) approach as a long-term strategy for more efficient prevention and control of TB and HIV infection.


2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Evangelia A Pavlatou

The transmission of a wide range of diseases, related to the infection by pathogenic microorganisms is a major public health problem that daily endangers the safety of human population. Silver has been thoroughly studied and used against bacteria due to its antimicrobial properties. Nanostructured silver gathers all the advantages of the silver itself, as well as the advanced performance of the nanomaterials. Thus, currently, silver nanoparticles constitute the most widely used kind of nanoparticles in biomedicine, due to their attractive antimicrobial properties. A variety of physical and chemical methods are employed for the AgNPs synthesis. However, many of them include the use of toxic reagents or require large amounts of energy, during the synthesis process. For this reason, many eco-friendly methods are proposed in order to synthesize AgNPs. Hence, biogenic synthesis of AgNPs, utilizing biological resources opens a novel route for the development of alternative production processes.These methods seem to have significant advantages, as the extracts contribute positively to the formation and enhancement of the antimicrobial activity of AgNPs, also acting as protective agents of the produced particles. In this review an integrated approach of AgNPs bio-synthetic methods using microorganisms, such as bacteria and fungi, plants and plant extracts, as well as several templates, like DNA and viruses is discussed, shedding light on the comparative advantages of them.


Author(s):  
Ned Bertz

The presence of Bollywood films in Africa has a long history, one embedded in larger cultural and commodity exchanges between the continent and South Asia. “Bollywood” is a modern signifier for older film industries located in colonial and postcolonial India, with the largest export being commercial Hindi-Urdu movies produced in Bombay. Their circulation played out distinctly in different parts of Africa, based on colonial connections, Indian diasporic networks, regional trading linkages, and audience tastes. East Africa first saw the arrival of Indian films in the 1920s, imported by diasporic Indian entrepreneurs who opened movie theaters and screened Hollywood and British films as well. Indian and African communities both consumed Bombay movies and they increasingly came to lead East African box office shares for decades, even as moviegoing declined toward the end of the 20th century. Bollywood films reached South Africa in the 1930s and later were the preserve of isolated Indian communities under Apartheid in cities like Durban, home to a large South Asian population as a result of colonial indentured labor flows. Hindi and Tamil movies formed a cultural touchstone for settled diasporic populations who engaged with representations from a perceived homeland, although Bollywood films were mainstreamed in South African society in the 1990s. In West Africa, lacking robust Indian diasporic networks, Lebanese traders introduced Bollywood films in the 1950s. They became immensely popular among African audiences in places like northern Nigeria and Senegal. As in East Africa, West African audiences interpreted foreign films in line with localized cultural and political values. By the 1990s, Nigerians were making some movies that riffed off popular Indian films in a global milieu of cultural mixing. In North Africa, distributors first marketed Indian movies in the 1950s to Egypt, where they attained a cult following. Bollywood stars and paraphernalia gained social prominence, although the public screening of films dwindled in the 1990s, forcing Arab fans to rely on alternate circulations, which continued into the early 21st century throughout the continent thanks to satellite television and other media technologies. The long-standing popularity of Bollywood in Africa should be no surprise given the worldwide spread of Bombay films from their inception, a tradition of exchange between South Asia and Africa, especially across Indian Ocean and imperial worlds, and Africans’ historically vigorous participation in regional and global cultural economies.


2022 ◽  
Vol 50 (1) ◽  
Author(s):  
Yogendra Shah ◽  
Sarad Paudel ◽  
Kishor Pandey ◽  
Govind Prasad Gupta ◽  
Eddie Samuneti Solo ◽  
...  

AbstractTuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis complex (MTBC) in humans and animals. Numbers of multi drug resistance TB (MDR-TB), extrapulmonary TB (EPTB) and zoonotic TB cases are increasingly being reported every year in Nepal posing a major public health problem. Therefore, the Government of Nepal should act immediately to strengthen the screening facilities across the country to be able to identify and treat the TB infected patients as well as detect zoonotic TB in animal species. Endorsement of One Health Act by the Government of Nepal is an opportunity to initiate the joint programs for TB surveillance among human and animal species using one health approach to reduce the TB burden in Nepal.


PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252211
Author(s):  
Carmen Ranftler ◽  
Dietmar Nagl ◽  
Andreas Sparer ◽  
Andreas Röhrich ◽  
Michael Freissmuth ◽  
...  

Clostridioides difficile (C. difficile) infection is a major public health problem worldwide. The current treatment of C. difficile-associated diarrhea relies on the use of antibacterial agents. However, recurrences are frequent. The main virulence factors of C. difficile are two secreted cytotoxic proteins toxin A and toxin B. Alternative research exploring toxin binding by resins found a reduced rate of recurrence by administration of tolevamer. Hence, binding of exotoxins may be useful in preventing a relapse provided that the adsorbent is innocuous. Here, we examined the toxin binding capacity of G-PUR®, a purified version of natural clinoptilolite-tuff. Our observations showed that the purified clinoptilolite-tuff adsorbed clinically relevant amounts of C. difficile toxins A and B in vitro and neutralized their action in a Caco-2 intestinal model. This conclusion is based on four independent sets of findings: G-PUR® abrogated toxin-induced (i) RAC1 glucosylation, (ii) redistribution of occludin, (iii) rarefaction of the brush border as visualized by scanning electron microscopy and (iv) breakdown of the epithelial barrier recorded by transepithelial electrical resistance monitoring. Finally, we confirmed that the epithelial monolayer tolerated G-PUR® over a wide range of particle densities. Our findings justify the further exploration of purified clinoptilolite-tuff as a safe agent in the treatment and/or prevention of C. difficile-associated diarrhea.


2017 ◽  
Vol 4 (3) ◽  
pp. 1067
Author(s):  
Ranganatha A. Devaranavadagi ◽  
Srinivasa S.

Background: Typhoid fever is caused by Salmonella typhi. It is a major public health problem in India. Typhoid fever is endemic in many developing countries. Wide variations in the clinical manifestations of typhoid fever make its diagnosis a challenging task. This study was conducted to understand the wide range of clinical manifestations, complications and antibiotic sensitivity patterns of typhoid fever in children.Methods:Prospectively, 113 children admitted in pediatric unit with confirmed Typhoid fever from September 2015 to December 2016 at KIMS hospital, Bangalore were included. In each case, age, sex, presenting complaint, laboratory investigations and antibiotic sensitivity pattern are collected and analysed.Results: Out of 113 cases, 72 cases (63.8.1%) were males, 41 cases (36.2%) were females. The most common age group was 5-10 years. The most common symptom was fever, seen in 100% cases, followed by anorexia (61%), vomiting (44%) and abdominal pain (18%). The most common sign observed was toxic look in 68% of the cases, followed by coated tongue in 49% and hepatomegaly in 44%. Leucocytopenia was found in 34% of cases. Eosinopenia was found in 39% of cases. Anaemia was found in 16% of cases. Thrombocytopenia was found in 15% of cases. Blood culture was positive in 20% of cases. Use of municipal water for drinking was found in 65% of cases. Outside eating was found in 40% of cases. Unhygienic practices were found in 64% of cases. Duration of hospital stay varied from 3-10 days. No mortality reported.Conclusions:Typhoid fever is most commonly observed with unhygienic practices and eating of unhealthy outside food. This major public health issue can be tackled by bringing awareness among people regarding disease transmission and its various preventive measures. 


F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 8 ◽  
Author(s):  
Ghose Bishwajit

Overview: South Asian countries have experienced a remarkable economic growth during last two decades along with subsequent transformation in social, economic and food systems. Rising disposable income levels continue to drive the nutrition transition characterized by a shift from a traditional high-carbohydrate, low-fat diets towards diets with a lower carbohydrate and higher proportion of saturated fat, sugar and salt. Steered by various transitions in demographic, economic and nutritional terms, South Asian population are experiencing a rapidly changing disease profile. While the healthcare systems have long been striving to disentangle from the vicious cycle of poverty and undernutrition, South Asian countries are now confronted with an emerging epidemic of obesity and a constellation of other non-communicable diseases (NCDs). This dual burden is bringing about a serious health and economic conundrum and is generating enormous pressure on the already overstretched healthcare system of South Asian countries.Objectives: The Nutrition transition has been a very popular topic in the field of human nutrition during last few decades and many countries and broad geographic regions have been studied. However there is no review on this topic in the context of South Asia  as yet. The main purpose of this review is to highlight the factors accounting for the onset of nutrition transition and its subsequent impact on epidemiological transition in five major South Asian countries including Bangladesh, India, Nepal, Pakistan and Sri Lanka. Special emphasis was given on India and Bangladesh as they together account for 94% of the regional population and about half world’s malnourished population.Methods: This study is literature based. Main data sources were published research articles obtained through an electronic medical databases search.


Author(s):  
Thalia Pacheco-Fernandez ◽  
Greta Volpedo ◽  
Chaitenya Verma ◽  
Abhay R. Satoskar

Leishmaniasis is a vector-borne Neglected Tropical Disease (NTD) transmitted by the sand fly and is a major public health problem worldwide. Infections caused by Leishmania clinically manifest as a wide range of diseases, such as cutaneous (CL), diffuse cutaneous (DCL), mucosal (MCL) and visceral leishmaniasis (VL). The host innate and adaptative immune responses play critical roles in the defense against leishmaniasis. However, Leishmania parasites also manipulate the host immune response for their survival and replication. In addition, other factors such as sand fly salivary proteins and microbiota also promote disease susceptibility and parasite spread by modulating local immune response. Thus, a complex interplay between parasite, sand fly and the host immunity governs disease severity and outcome. In this review, we discuss the host immune response during Leishmania infection and highlight the factors associated with resistance or susceptibility.


2019 ◽  
Vol 10 (2) ◽  
pp. 91-112
Author(s):  
Dale Hudson

Abstract With a primarily South Asian population, including both middle-class families and 'bachelors', the Gulf states unsettle assumptions about the Middle East and South Asia developed from western area studies. This article examines three documentaries ‐ From Gulf to Gulf to Gulf, Champ of the Camp and Sounds of the Sea ‐ that layer visual images of the Gulf with songs from India and Zanzibar. They document the inequities and the ways in which vulnerable populations navigate them to find dignity in a world that often dismisses them as victims (e.g., exploited migrants, oppressed women) or uses them to legitimize segregation in allegedly overcrowded cities. They reconfigure documentary practice to allow subjects to speak indirectly, protecting them from possible retaliation or stigma. By documenting through nonwestern popular songs, these films contribute to a recovery of connections between South Asia, the Gulf and East Africa that were interrupted by British colonialism and US imperialism.


Crisis ◽  
2014 ◽  
Vol 35 (2) ◽  
pp. 90-101 ◽  
Author(s):  
Melissa Pearson ◽  
Anthony B. Zwi ◽  
Amanda K. Rouse ◽  
Ravindra Fernando ◽  
Nicholas A. Buckley ◽  
...  

Background: Suicide is and has been a major public health problem in Sri Lanka and has generated a wide range of literature. Aims: This review aimed to systematically appraise what is known about suicide in Sri Lanka. The patterns and content of articles were examined and recommendations for further research proposed. Method: The paper describes the systematic search, retrieval, and quality assessment of studies. Thematic analysis techniques were applied to the full text of the articles to explore the range and extent of issues covered. Results: Local authors generated a large body of evidence of the problem in early studies. The importance of the method of suicide, suicidal intention, and the high incidence of suicide were identified as key foci for publications. Neglected areas have been policy and health service research, gender analysis, and contextual issues. Conclusion: The literature reviewed has produced a broad understanding of the clinical factors, size of the problem, and social aspects. However, there remains limited evidence of prevention, risk factors, health services, and policy. A wide range of solutions have been proposed, but only regulation of pesticides and improved medical management proved to be effective to date.


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