scholarly journals Cohort Analysis of Incidence/Mortality of Liver Cancer in Japan through Logistic Curve Fitting

2013 ◽  
Vol 14 (10) ◽  
pp. 5891-5893 ◽  
Author(s):  
Etsuji Okamoto
Keyword(s):  
Liver Cancer ◽  
Curve Fitting ◽  
Cohort Analysis ◽  
Logistic Curve

scholarly journals Role of local treatment including radiotherapy in Barcelona Clinic of Liver Cancer stage C patients: a nationwide cohort analysis in South Korea

2019 ◽  
Vol Volume 11 ◽  
pp. 1373-1382 ◽  
Author(s):  
Jeongshim Lee ◽  
Won Sup Yoon ◽  
Woong Sub Koom ◽  
Chai Hong Rim
Keyword(s):  
Liver Cancer ◽  
South Korea ◽  
Cohort Analysis ◽  
Local Treatment ◽  
Cancer Stage

scholarly journals Long-Term Trend of Liver Cancer Mortality in Serbia, 1991–2015: An Age-Period-Cohort and Joinpoint Regression Analysis

Healthcare ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 283
Author(s):  
Irena Ilic ◽  
Sandra Sipetic Grujicic ◽  
Jovan Grujicic ◽  
Djordje Radovanovic ◽  
Ivana Zivanovic Macuzic ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Mortality ◽  
Direct Method ◽  
Cohort Analysis ◽  
Temporal Trends ◽  
Joinpoint Regression ◽  
Mortality Trends ◽  
Annual Percent Change ◽  
Period Effects ◽  
The World

Background and Objectives: Trends of liver cancer mortality vary widely around the world. The purpose of this study was to assess the trend of liver cancer mortality in Serbia. Material and Methods: Descriptive epidemiological study design was used in this research. The age-standardized rates (ASRs, per 100,000) were calculated using the direct method, according to the World standard population. Temporal trends were assessed using the average annual percent change (AAPC) with 95% confidence interval (95% CI), according to joinpoint regression. An age-period-cohort analysis was used to evaluate the underlying factors for liver cancer mortality trends. Results: In Serbia from 1991 to 2015, over 11,000 men and nearly 8000 women died from liver cancer. The trend in liver cancer mortality significantly decreased both in men (AAPC = −1.3%; 95% CI = −1.7 to −0.9) and women (AAPC = −1.5%; 95% CI = −1.9 to −1.1). For liver cancer mortality, statistically significant cohort and period effects were observed in both genders. Conclusions: The downward trends in liver cancer mortality in Serbia are recorded during the past decades.

Nonsymmetrical double logistic analysis of ambulatory blood pressure recordings

2005 ◽  
Vol 98 (4) ◽  
pp. 1511-1518 ◽  
Author(s):  
Geoffrey A. Head ◽  
Christopher M. Reid ◽  
Elena V. Lukoshkova
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Arterial Pressure ◽  
Curve Fitting ◽  
Animal Studies ◽  
Similar Rate ◽  
Rate Of Change ◽  
Logistic Curve ◽  
Fitting Procedure ◽  
Logistic Method

We developed an asymmetric double logistic curve-fitting procedure for circadian analysis that can determine the rate of change in variables during the day-to-night separately from the night-to-day transition for use in animal studies. We now have applied this procedure to 24-h systolic (SAP) and diastolic arterial pressure (DAP) and heart rate ambulatory recordings from 302 patients. In 292 cases, all parameters showed a pattern of higher day and lower night values. In men there was a similar rate of transition between day and night or from night to day for both SAP and DAP that lasted 3–4 h, indicating a symmetrical diurnal pattern. By contrast, women showed a faster rate of decrease in mean arterial pressure in the evening compared with men ( P < 0.05) and therefore showed an asymmetric diurnal SAP pattern. For both men and women, there was a markedly greater rate of morning increase in heart rate compared with the rate of evening decrease (2.2- and 1.9-fold, respectively, P < 0.001). The logistic method provided a better fit than the square-wave or the cosinor method ( P < 0.001) and more appropriately detected nondippers. We conclude that analysis of ambulatory recordings by a new logistic curve-fitting method reveals more rapid reductions in evening SAP in women than men but both have two- to threefold more rapid morning rates of tachycardia. The ability of the double logistic method to determine the diurnal blood pressure rates of change independently is key to determining new markers for cardiovascular risk.

Application of Curve Model Fitting Methods to Settlement Prediction

2014 ◽  
Vol 580-583 ◽  
pp. 651-654
Author(s):  
Ming Wu ◽  
Jia Lun Niu
Keyword(s):  
Curve Fitting ◽  
Model Fitting ◽  
Hyperbolic Model ◽  
Industrial Zone ◽  
Logistic Curve ◽  
Settlement Prediction ◽  
Curve Model ◽  
Simulation Results ◽  
Logistic Curve Model

Both Hyperbolic model and Logistic curve model have certain applicability to settlement prediction of soft sub-grade. Based on the observational settlement data of soft sub-grade in an industrial zone, the features of Hyperbolic model and Logistic curve model are studied. By using curve fitting methods with Origin software to predict the sub-grade settlement value and analyze the simulation results, compare these two models to determine which one is more reasonable. The results show that the Logistic curve model is more accurate and reasonable, it has the value of popularization and application in engineering.

scholarly journals Liver cancer mortality over six decades in an epidemic area: what we have learned

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10600
Author(s):  
Jian-Guo Chen ◽  
Jian Zhu ◽  
Yong-Hui Zhang ◽  
Yong-Sheng Chen ◽  
Jian-Hua Lu ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Liver Cancer ◽  
Cancer Mortality ◽  
Malignant Tumors ◽  
Cohort Analysis ◽  
Cancer Registration ◽  
Mortality Data ◽  
Cancer Etiology ◽  
The Past ◽  
Epidemic Area

Background and aims: Liver cancer is one of the most dominant malignant tumors in the world. The trends of liver cancer mortality over the past six decades have been tracked in the epidemic region of Qidong, China. Using epidemiological tools, we explore the dynamic changes in age-standardized rates to characterize important aspects of liver cancer etiology and prevention. Methods Mortality data of liver cancer in Qidong from 1958 to 1971 (death retrospective survey) and from 1972 to 2017 (cancer registration) were tabulated for the crude rate (CR), and age-standardized rate and age-birth cohorts. The average annual percentage change was calculated by the Joinpoint Regression Program. Results The natural death rate during 1958–2017 decreased from 9‰ to 5.4‰ and then increased to 8‰ as the population aged; cancer mortality rates rose continuously from 57/105 to 240/105. Liver cancer mortality increased from 20/105 to 80/105, and then dropped to less than 52/105 in 2017. Liver cancer deaths in 1972–2017 accounted for 30.53% of all cancers, with a CR of 60.48/105, age-standardized rate China (ASRC) of 34.78/105, and ASRW (world) of 45.71/105. Other key features were the CR for males and females of 91.86/105 and 29.92/105, respectively, with a sex ratio of 3.07:1. Period analysis showed that the ASRs for mortality of the age groups under 54 years old had a significant decreasing trend. Importantly, birth cohort analysis showed that the mortality rate of liver cancer in 40–44, 35–39, 30–34, 25–29, 20–24, 15–19 years cohort decreased considerably, but the rates in 70–74, and 75+ increased. Conclusions The crude mortality rate of liver cancer in Qidong has experienced trends from lower to higher levels, and from continued increase at a high plateau to most recently a gradual decline, and a change greatest in younger people. Many years of comprehensive prevention and intervention measures have influenced the decline of the liver cancer epidemic in this area. The reduction of intake levels of aflatoxin might be one of the most significant factors as evidenced by the dramatic decline of exposure biomarkers in this population during the past three decades.

scholarly journals Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation

2021 ◽  
Vol 8 ◽  
Author(s):  
Hong-Yue Lai ◽  
Hsin-Hwa Tsai ◽  
Chia-Jui Yen ◽  
Liang-Yi Hung ◽  
Ching-Chieh Yang ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Binding Protein ◽  
Cohort Analysis ◽  
Growth Factor Receptor ◽  
Study Cohort ◽  
Primary Resistance ◽  
Liver Cancer Cells ◽  
Egfr Expression

Despite the activation of autophagy may enable residual cancer cells to survive and allow tumor relapse, excessive activation of autophagy may eventually lead to cell death. However, the details of the association of autophagy with primary resistance in hepatocellular carcinoma (HCC) remain less clear. In this study, cohort analysis revealed that HCC patients receiving sorafenib with HBV had higher mortality risk. We found that high epidermal growth factor receptor (EGFR) expression and activity may be linked to HBV-induced sorafenib resistance. We further found that the resistance of EGFR-overexpressed liver cancer cells to sorafenib is associated with low activity of AMP-activated protein kinase (AMPK) and CCAAT/enhancer binding protein delta (CEBPD) as well as insufficient autophagic activation. In response to metformin, the AMPK/cAMP-response element binding protein (CREB) pathway contributes to CEBPD activation, which promotes autophagic cell death. Moreover, treatment with metformin can increase sorafenib sensitivity through AMPK activation in EGFR-overexpressed liver cancer cells. This study suggests that AMPK/CEBPD-activated autophagy could be a potent strategy for improving the efficacy of sorafenib in HCC patients.

scholarly journals Long-term trends of liver cancer mortality by gender in urban and rural areas in China: an age-period-cohort analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e020490 ◽  
Author(s):  
Yuanyuan Sun ◽  
Yanhong Wang ◽  
Mengmeng Li ◽  
Kailiang Cheng ◽  
Xinyu Zhao ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rural Women ◽  
Rural Areas ◽  
Cancer Mortality ◽  
Cohort Analysis ◽  
Age Group ◽  
Mortality Trends ◽  
Long Term Trends ◽  
Urban And Rural Areas

ObjectivesTo provide an up-to-date overview of long-term trends of liver cancer mortality and evaluate the effects attributable to age, period and cohort in Chinese population stratified by gender and urban/rural areas.MethodsPopulation and liver cancer mortality data were obtained based on the Disease Surveillance Points in China from 1991 to 2014. To examine the time trends of liver cancer mortality by gender in urban and rural areas in China, Joinpoint analysis was used to estimate the annual per cent change. The intrinsic estimator, a method of age-period-cohort analysis to estimate age, period and cohort effects simultaneously, was used to analyse the underlying mechanisms for liver cancer mortality trends in the aforementioned four groups.ResultsWe observed a significant decline in liver cancer mortality for urban men (average annual per cent change (AAPC)=−1.1%, P<0.05) and urban women (AAPC=−1.4%, P<0.05), while the liver cancer mortality remained stable for rural men (AAPC=−0.1%, P>0.05) and rural women (AAPC=−0.9%, P>0.05). Compared with the 15–19 age group, the liver cancer mortality risk of the 85 and above age group increased 65 and 42 times for urban and rural men, and 102 and 70 times for urban and rural women. From the 1990–1994 period to the 2005–2009 period, the risk increased 56% and 92% for urban and rural men, and 30% and 74% for urban and rural women. Compared with period and cohort effects, age effects were the most influential factor in liver cancer mortality.ConclusionsAs the status of ageing population in China gets worse, the burden caused by liver cancer mortality could still be a great challenge for China in the future. The disparity of liver cancer mortality trends between urban and rural residents can be attributed to period effects, referring to the unequal medical levels and resources between urban and rural areas.

scholarly journals Age-Period-Cohort Analysis of Liver Cancer Mortality in Korea

2016 ◽  
Vol 16 (18) ◽  
pp. 8589-8594 ◽  
Author(s):  
Jihwan Park ◽  
Yon Ho Jee
Keyword(s):  
Liver Cancer ◽  
Cancer Mortality ◽  
Cohort Analysis
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