Platelet Gel for the Surgical Treatment of Onychocryptosis

2008 ◽  
Vol 98 (4) ◽  
pp. 296-301 ◽  
Author(s):  
Antonio Córdoba-Fernandez ◽  
Rafael Rayo-Rosado ◽  
José María Juarez-Jiménez
Keyword(s):  
Clinical Trial ◽  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Positive Control ◽  
The Other ◽  
Platelet Gel ◽  
Experimental Conditions ◽  
The Mean ◽  
Clinically Significant ◽  
Mean Time

Background: The growth factors derived from platelets contained in platelet-rich plasma comprise a series of molecules that favor the production of collagen with the proliferation of fibroblasts and new blood vessels. These substances exert their effect on the cells, acting in all the stages of cicatrization, especially in hemostasis and early fibroplasia. Methods: Thirty-five patients (70 feet) were selected, operated on both sides for ingrown hallux nails, and subjected to two different experimental conditions in a crossover clinical trial with positive control of treatment. Two main variables were analyzed: on one side, the bleeding, according to three preestablished categories, and on the other, the mean time of cicatrization in days. Results: Significant differences (P < .001) were found between the two groups for bleeding. We observed that cicatrization time did not differ significantly between the two treatments. Conclusion: The use of platelet gel for the treatment of onychocryptosis by single nonincisional matricectomy can guarantee good hemostasis, with a significant reduction in bleeding, but does not produce a clinically significant reduction in cicatrization time. (J Am Podiatr Med Assoc 98(4): 296–301, 2008)

scholarly journals Effect of Platelet Rich Plasma Injection Effect on Knee Osteoarthritis in Elderly: Single Dose versus Double Dose Randomized Clinical Trial

2021 ◽  
pp. 84-89
Author(s):  
Hassan Amir Us Saqlain ◽  
Syed Sajid Hussain ◽  
Niaz Hussain Keerio ◽  
Masood Ahmed Qureshi ◽  
Nuresh Kumar Valecha ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Single Dose ◽  
United Arab Emirates ◽  
Platelet Rich Plasma ◽  
The Other ◽  
Double Dose ◽  
Group A ◽  
The Mean ◽  
Group B

Objective: This study aims to evaluate the effect of platelet rich plasma (PRP) and compare between single and double dose regimens among patients diagnosed with osteoarthritis admitted to the orthopedic department of Al Qassimi Hospital Sharjah, United Arab Emirates. Methods: 200 patients were allocated into two groups in this randomized clinical trial. Patients were chosen to participate in this study after an informed consent. The trial took place at the Al Qassimi Hospital Sharjah, United Arab Emirates from July 2019 to July 2020. All patients had knee osteoarthritis, half of them received single dose PRP (group A) and the other half received double dose PRP (group B). All patients were adults and older than 18 years of age. Patients were followed up using Western Ontario and McMaster Universities Arthritis Index (WOMAC). The follow up was done prior to the administration of PRP, at 1 month, 3 month and 6 months after administration. Data was analyzed using SPSS program. Ethical approval was gained from the hospital as well as from patients. Results: The mean age of the patients was 48.5 ± 8.3 years. The study included 200 participants, among them, 60 were females and 140 were males. There was improvements in all parameters of WOMAC at 3 and 4 weeks following administration of PRP. The effect of PRP continued until 6 months of follow up with no differences between the two groups. Group A baseline WOMAC parameters (pain, stiffness, physical function and total score) mean score were 15.8, 6.24, 43.01 and 65.22 respectively. At the follow up, the mean scores were 4.73, 1.78, 13.88 and 19.56 respectively. This shows significant improvement. On the other hand, group B baseline mean scores were 16.31, 6.81, 40.89 and 64.77 respectively. At the final follow up of group B, the parameters mean scores were 4.40, 1.11, 13.64 and 20.27 respectively. Both groups were compared to each other and no benefit for the double dose over the single dose (P value, 0.66). Conclusion: Previous results suggests improvement in functionality in both groups of the trial. There was pain and stiffness relief among all patients. It is concluded that double dose has no additional effect to the single dose regimen.

scholarly journals Effect of gingival retraction cord and retraction paste on gingival tissue in fixed prosthodontics impression

2014 ◽  
Vol 3 (2) ◽  
pp. 20-27
Author(s):  
Mohammad Shamsuzzaman ◽  
Sheikh Md Shahriar Quader ◽  
Shakila Fatema ◽  
Md Abdul Gofur ◽  
Khaleda Akter
Keyword(s):  
The Other ◽  
Gingival Tissue ◽  
Hemorrhage Control ◽  
Fixed Prosthodontics ◽  
Abutment Teeth ◽  
The Mean ◽  
Mean Time ◽  
Reduced Time

Background & Objectives: Of the various gingival retraction systems available in the market, a cordless paste system is fairly new entrant into this field. This system promises to provide an easier method to obtain optimum retraction with excellent hemorrhage control. The present study was designed to clinically evaluate the efficacy of paste retraction system and medicated retraction cords on the basis of relative easy of working, hemorrhage control and amount of vertical gingival retraction. Methods: 40 subjects were selected requiring full veneer restoration where more than one abutment teeth were to be prepared. After the preparation of the abutment teeth flexible scales were used to measure the sulcus depth before retraction and after retraction. Medicated retraction cord technique was used on one abutment tooth and on the other abutment tooth paste retraction system was employed. Subjectively easy of placement and hemorrhage scores was assessed. Results: The mean time taken for paste retraction technique was 45.13 seconds and for medicated retraction cord technique was 105.4 seconds. In all the subjects paste retraction technique was relatively easier as compared with medicated retraction cord technique. Mean hemorrhage scores using paste retraction technique was 0.05 and using medicated retraction cord technique it was 1.70. Mean vertical gingival retraction using paste retraction technique was .36mm and using medicated retraction cord technique was 0.54mm Conclusion: Within the limitations of this study, paste retraction system requires reduced time for application, is easier to place, and provides excellent hemorrhage control in comparison to medicated retraction cord. However, medicated retraction cord provides increased amount of vertical retraction as compared to paste retraction technique. DOI: http://dx.doi.org/10.3329/updcj.v3i2.17995 Update Dent. Coll. j: 2013; 3 (2): 20-27

Effect of Different Intermediary Bases on Microleakage of a Restorative Material in Class II Box Cavities of Primary Teeth

2017 ◽  
Vol 40 (2) ◽  
pp. 82-87 ◽  
Author(s):  
Faika Y. Abdelmegid ◽  
Fouad S. Salama ◽  
Waleed M. Al-Mutairi ◽  
Saud K. Al-Mutairi ◽  
Sultan O. Baghazal
Keyword(s):  
Primary Teeth ◽  
In Vitro Study ◽  
Class Ii ◽  
Positive Control ◽  
Negative Control ◽  
The Other ◽  
Control Groups ◽  
Significant Difference ◽  
The Mean

Introduction The aim of this in vitro study was to assess and compare the effect of different intermediary bases on microleakage between tooth and a nanocomposite interface in Class II box cavities in primary teeth. Methods Standard Class II box cavities were prepared in 52 primary molars and randomly divided into 9 groups according to the intermediary base used (Multicore Flow, Fuji II LC, SDR, Smart Dentin Replacement, and Biodentine). All specimens were subjected to thermocycling and prepared for microleakage testing and evaluation. Results There was significant difference in the mean ranks of microleakage between the 9 groups, which was observed in the gingival side (p<0.0001) and the occlusal side (p<0.0001). The mean ranks microleakage was significantly higher with experimental SDR, experimental Multicore Flow, and positive control materials when compared with the other 6 groups. The microleakage mean ranks were statistically significantly lower in experimental Fuji II LC, experimental Biodentine, and all negative control groups when compared with the other 3 groups. Conclusions Microleakage is affected by the application of intermediate material. Experimental Biodentine and Fuji II LC showed the lowest microleakage while experimental SDR and experimental Multicore Flow showed the highest microleakage.

A Randomized, Controlled Clinical Trial of Four Anti-Dandruff Shampoos

1981 ◽  
Vol 9 (2) ◽  
pp. 152-156 ◽  
Author(s):  
Marvin Rapaport
Keyword(s):  
Clinical Trial ◽  
Test Preparation ◽  
The Other ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled ◽  
The Mean ◽  
Rate Of Improvement

A total of 199 patients were selected for a comparison of the anti-dandruff efficacy of four shampoos. After a 2-week lead-in (all patients used only Johnson's Baby Shampoo twice weekly) the patients were randomly assigned to Selsun Blue®, Head & Shoulders®, Flex®, or Tegrin®. The test preparation, which was unknown to the observer, was used twice weekly for 4 weeks. Loose and adherent dandruff were each rated on a scale of 0 to 20 (absent to severe) at the end of the lead-in (when a total score of 15 was required), and each week of study. The mean total pre-study score for all subjects was 19.5. At the end of the study the mean improvement scores were: 162 (Selsun Blue), 14.6 (Head & Shoulders), 13.5 (Flex), and 13.1 (Tegrin). The improvement was significantly greater (p < 0.05) on Selsun Blue than on any of the other shampoos. At the end of the study significantly (p < 0.05) more patients had total scores of zero on Selsun Blue (15) than on Tegrin or Head & Shoulders. In addition, the rate of improvement was significantly (p < 0.05) faster with Selsun Blue than with any of the other test preparations.

Reliability Analysis of a System with Multiple-Stage Policy Considering Type I and II Errors

2019 ◽  
Vol 26 (06) ◽  
pp. 1950028
Author(s):  
Mitsuhiro Imaizumi ◽  
Mitsutaka Kimura
Keyword(s):  
Type I Error ◽  
The Other ◽  
Renewal Processes ◽  
Type I ◽  
Numerical Examples ◽  
Markov Renewal Processes ◽  
The Mean ◽  
Mean Time ◽  
Server System ◽  
Multiple Stages

This paper formulates a stochastic model for a system with illegal access. The server has the function of IDS, and illegal access is checked in multiple stages which consist of simple check and detailed check. In this model, we consider type I and II errors of simple check and a type I error of detailed check. There are two cases where IDS judges the occurrence of illegal access erroneously. One is when illegal access does not occur, and the other is when illegal access occurs. We apply the theory of Markov renewal processes to a system with illegal access, and derive the mean time and the expected checking number until a server system becomes faulty. Further, an optimal policy which minimizes the expected cost is discussed. Finally, numerical examples are given.

Eating and ruminating behaviour in cattle given forages differing in fibre content

1989 ◽  
Vol 48 (3) ◽  
pp. 503-511 ◽  
Author(s):  
M. N. McLeod ◽  
B. R. Smith
Keyword(s):  
Dry Matter ◽  
The Other ◽  
Fibre Content ◽  
Eating Rate ◽  
High Fibre ◽  
Acid Detergent Fibre ◽  
The Mean ◽  
Voluntary Intake ◽  
Mean Time ◽  
Forage Diets

ABSTRACTA study was made of the effect of fibre level in forages on eating and rumination behaviour. Eight forage diets were prepared from the leaf and stem fractions of two grasses and two legumes and were given at hourly intervals to four steers under steady-state conditions. Eating and rumination behaviour were measured automatically by recording changes in intra-oesophageal pressure.Mean voluntary intake of leaf was higher than that of the stem fractions (9·9 v. 5·6 kg/day; P < 0·001). This was associated with a shorter mean retention time in the rumen of the leaf than that of the stem fractions (21·4 v. 30·6 h; P < 0·001) and a lower concentration (g/100 g dry matter (DM)) of fibre (52-0 neutral-detergent fibre (NDF) and 30·5 acid-detergent fibre (ADF) v. 68·2 NDF and 45·3 ADF). Similar values (P > 0·05) between diets were found for both the water and DM contents of the rumen (60·1 kg, 7·8 kg). Voluntary intake was not related to either.No difference was found between forage diets in the mean time (132 min) and number (18·7) of periods spent eating each day (P > 0·05). Legume leaf fractions were eaten at a faster rate (g/min) than either the grass leaf or the stem fractions. Voluntary intake was related to the rate at which food was eaten (r = 0·89; P < 0·01) but no relationship was found with the time taken to eat food (r = –0·14; P>0·05). Eating rate was related to the level of both NDF (r = –0·91; P < 0·01) and ADF (r = –0·96; P < 0·001).Differences between diets were found in rumination times (mean 425 min; P < 001), the number of boluses regurgitated during each period (27·6; P < 0·05) and during each day (485; P < 0·001), and in the weight of boluses (455 g; P < 0·05). No differences (P > 0·05) were found between diets in the mean number of rumination periods each day (17·6), the mean time spent ruminating during each period (24·3 min), the mean rate at which boluses were regurgitated (53·2 s per bolus), the interval between boluses (5·1 s), and the DM in a bolus (27·5 g). Rumination time and the number of boluses regurgitated either per period or per day were not related to the fibre content of the diet (P > 0·05).The regurgitated boluses from leaf fractions were chewed less than the stem fractions (43·7 v. 54·7 chews per bolus). The regurgitated boluses of lucerne leaf were chewed at a faster rate (1·13 chews per s; P > 0·05) than regurgitated digesta of the other diets which were chewed at similar rates (0·97 chews per s; P > 0·05). The total number of rumination chews made each day by animals given lucerne leaf (12 300) was much lower (P < 0·001) than that by animals given the other fractions (25 300). The number of chews made on each bolus was related to fibre levels in the diets (NDF, r = 0·78, P < 0·05; ADF, r = 0·91, P < 0·01).It is concluded that the voluntary intake of high-fibre diets is not always restricted by rumen fill or rumination. The ease with which forage is eaten should be investigated as a factor influencing intake of fibrous forages.

Seroconversion of puppies to canine parvovirus and canine distemper virus: a comparison of two combination vaccines

2000 ◽  
Vol 36 (2) ◽  
pp. 137-142 ◽  
Author(s):  
MJ Coyne
Keyword(s):  
Canine Distemper Virus ◽  
Serum Antibody ◽  
Canine Parvovirus ◽  
The Other ◽  
Canine Distemper ◽  
Combination Vaccines ◽  
Antibody Titers ◽  
The Mean ◽  
To Receive ◽  
Mean Time

Sixty puppies were randomly assigned to receive one of two commercially available combination vaccines, and responses to the canine parvovirus and canine distemper virus components of the vaccines were determined by measuring serum antibody titers. The percentage of puppies that seroconverted to canine parvovirus was significantly higher and the mean time for seroconversion was significantly shorter for puppies that received one of the vaccines than for puppies that received the other vaccine. Percentages of puppies that seroconverted to canine distemper virus were not significantly different.

scholarly journals Treatment of Noninfectious Corneal Disorders With Plasma Rich in Growth Factors and ReGenerating Agent Matrix

2020 ◽  
Author(s):  
Ronald Mauricio Sanchez-Avila ◽  
Edmar Uribe-Badillo ◽  
Carlos Fernandez-Vega Gonzalez ◽  
Francisco Muruzabal ◽  
Borja De la Sen Corcuera ◽  
...  
Keyword(s):  
Growth Factors ◽  
Adverse Events ◽  
Corneal Ulcer ◽  
Eye Drops ◽  
Ocular Surface Disease Index ◽  
Corneal Ulcers ◽  
Corrected Visual Acuity ◽  
The Mean ◽  
Mean Time

Abstract Background: To provide the efficacy and safety of Plasma Rich in Growth Factors (PRGF) associated with tissue ReGeneraTing Agent (RGTA) drops for the treatment of noninfectious corneal ulcers.Methods: This retrospective study included patients from Fernandez-Vega University Institute between 2010 and 2019, with noninfectious corneal ulcers and no response to standard treatments. RGTA treatment was firstly applied (1 drop every two days), but if ulcer closure was not achieved, PRGF eye drops treatment was added (4 times/day). The time to reach the ulcer closure; the Best Corrected Visual Acuity (BCVA), intraocular pressure (IOP), Visual Analog Scale (VAS, in frequency and severity of symptoms), and Ocular Surface Disease Index (OSDI) were evaluated. The presence of adverse events along the follow-up period was also reported. Results: Seventy-four patients (79 eyes) were included in the study, forty-six eyes (62.2%) were women, and the mean age was 56.8 ± 17.3 years. The neurotrophic corneal ulcer was the most frequent disorder found in the patients of the study (n = 27, 34.2%), mainly due to the herpes virus (n = 15, 19.0%). The mean time of PRGF eye drops treatment associated with RGTA matrix was 4.2 ± 2.2 (1.5 -9.0) months, and the follow-up period was 44.9 ± 31.5 months. The ulcer closure was achieved in 76 eyes (96.2%). BCVA, VAS and OSDI improved significantly from the baseline (p<0.001), while IOP remained unchanged (p=0.665). No adverse events were recorded. Conclusions: The use of RGTA and PRGF in noninfectious ulcers was effective and safe, and it could be a therapeutic alternative for this type of corneal diseases.

scholarly journals Apheresis Platelet Rich-Plasma for Regenerative Medicine: An In Vitro Study on Osteogenic Potential

2021 ◽  
Vol 22 (16) ◽  
pp. 8764
Author(s):  
Stefano Pulcini ◽  
Lucia Merolle ◽  
Chiara Marraccini ◽  
Eleonora Quartieri ◽  
Daniele Mori ◽  
...  
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
In Vitro Study ◽  
Fold Increase ◽  
Positive Control ◽  
Osteogenic Potential ◽  
Standardized Protocol ◽  
Proliferation And Differentiation ◽  
Potential Methods

Background: Platelet-Rich Plasma (PRP) induces bone regeneration; however, there is low evidence supporting its efficacy in bone healing. The lack of a standardized protocol of administration represents the main obstacle to its use in the clinical routine for bone defects’ treatment. The purpose of this study was to characterize PRP and elucidate its osteogenic potential. Methods: Platelet count, fibrinogen levels, and growth factors concentration were measured in PRP obtained by four apheresis procedures. HOB-01-C1, a pre-osteocytic cell line, was used to examine the effects of different PRP dilutions (from 1% to 50%) on cell viability, growth, and differentiation. Gene expression of RUNX2, PHEX, COL1A1, and OCN was also assayed. Results: PRP showed a mean 4.6-fold increase of platelets amount compared to whole blood. Among the 36 proteins evaluated, we found the highest concentrations for PDGF isoforms, EGF, TGF-β and VEGF-D. PDGF-AA positively correlated with platelet counts. In three of the four tested units, 25% PRP induced a growth rate comparable to the positive control (10% FBS); whereas, for all the tested units, 10% PRP treatment sustained differentiation. Conclusions: This study showed that PRP from apheresis stimulates proliferation and differentiation of pre-osteocyte cells through the release of growth factors from platelets.

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