scholarly journals The Novel Neurotoxic and Neuroimmunotoxic Capabilities of Aflatoxin B1 on the Nervous System: A Review

2020 ◽  
Vol 8 (3) ◽  
pp. 1
Author(s):  
Seidu A. Richard ◽  
Nana Y.B Manaphraim ◽  
Nii Korley Kortei
Keyword(s):  
Nervous System ◽  
Acid Metabolism ◽  
Muscle Coordination ◽  
The Novel ◽  
System A ◽  
The World ◽  
Almost All ◽  
Cellular Components ◽  
The Brain ◽  
Human Fluid

Aflatoxins B1(AFB1) is an ancillary lethal metabolite archetypally spawned by Aspergillus flavus as well as A. parasiticus mostly found all over the world but more in tropic and humid regions. AFB1 has been isolated is almost all food products. The isolation of AFB1 in humans was demonstrated using human fluid like urine, serum as well as breast milk. Also, AFB1 was isolated in human placenta in pregnant women. ELISA is extremely sensitive in detecting AFB1. AFB1 was capable of compromising the activities of the blood-brain barrier (BBB). AFB1 was capable of triggering peripheral and central nervous degeneration. Acute central nervous system (CNS) symptoms like coma, cerebral edema as well as death has been observed in AFB1 exposure to the brain. Also, symptoms of brain destruction such as dullness, restlessness, muscle tremor, convulsions, loss of memory, epilepsy, idiocy, loss of muscle coordination, and abnormal sensations have been associated with deficiencies of these neurotransmitter during AFB1exposure. AFB1 was capable of influencing the end products of proteins as well as amino acid metabolism leading to hyper-ammonemia which easily cross the BBB to trigger the synthesis of glutamate neurotransmitters which are cytotoxic to the brain cells and causes encephalopathy. Glutathione (GHS) depletion resulted in destruction to critical cellular components such as DNA, lipids and proteins via the 8,9 epoxides of AFB1.This review therefore elucidates the novel neurotoxic and neuroimmunotoxic roles of AFB1 on the CNS.

scholarly journals COVID-19 Vaccination: From Interesting Agent to the Patient

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 120
Author(s):  
Anis Daou
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gastrointestinal Tract ◽  
Circulatory System ◽  
The Novel ◽  
Lead Compound ◽  
Fda Approval ◽  
The World ◽  
The Central Nervous System ◽  
Novel Coronavirus

The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this review, the analysis looks into how the new branch of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) came into the forefront of the world like a pandemic. This review will break down the details of what COVID-19 is, the viral family it belongs to and its background of how this family of viruses alters bodily functions by attacking vital human respiratory organs, the circulatory system, the central nervous system and the gastrointestinal tract. This review also looks at the process a new drug analogue undergoes, from (i) being a promising lead compound to (ii) being released into the market, from the drug development and discovery stage right through to FDA approval and aftermarket research. This review also addresses viable reasoning as to why the SARS-CoV-2 vaccine may have taken much less time than normal in order for it to be released for use.

scholarly journals Research on the Neurobiology of COVID-19

2021 ◽  
Vol 245 ◽  
pp. 03045
Author(s):  
Yilun Tong
Keyword(s):  
Nervous System ◽  
Molecular Mechanism ◽  
The Novel ◽  
Neurologic Manifestations ◽  
Neurological Manifestations ◽  
Corona Virus ◽  
The World ◽  
Human Nervous System ◽  
Different Parts

More studies have shown the neurological manifestations of the novel corona virus (COVID-19) and have inferred the molecular mechanism by which it invades the nervous system. The neurological aspect of the COVID-19 pandemic has been differently interpreted and dealt with in different parts of the world. To review the neurological manifestations and the neurovirulent mechanism by which CoV attacks the human nervous system and to examine different perspectives on this very same topic, the research on PubMed and ScienceDirect is conducted. The mechanisms that CoV enter and attack the nervous system and the subsequent neurologic manifestations have been proposed and now seems quite clear. However, more studies have to be done directly on the effect of COVID-19 on the CNS as well as the PNS.

The Impact of COVID-19 on Stock Markets

2022 ◽  
pp. 250-262
Author(s):  
Aslı Aybars ◽  
Mehtap Öner
Keyword(s):  
Literature Review ◽  
Financial Markets ◽  
Stock Returns ◽  
Empirical Studies ◽  
The Novel ◽  
The World ◽  
Fast Pace ◽  
Novel Coronavirus ◽  
Almost All ◽  
The Impact

The novel coronavirus, COVID-19, which emerged at the end of 2019 and spread to the world at a very fast pace, resulted in a pandemic affecting the finance industry besides many other industries though at varying extents. Financial markets, which can be regarded as cornerstones of each and every country's economic success, have been adversely influenced due to the fear and uncertainty arising with the emergence of the novel coronavirus at different degrees. This chapter provides a summary of a literature review based on the impact of this pandemic on stock returns and volatility in the stock exchanges of different countries and regions of the world. What has been captured as a result of this literature review is that almost all of the financial markets around the world have been influenced due to the virus. Further, industry-wise empirical studies demonstrate that not all industries are affected at the same level or even in the same direction.

COVID-19 Beyond the Lungs

2022 ◽  
pp. 109-126
Author(s):  
Omar El Hiba ◽  
Hicham Chatoui ◽  
Nadia Zouhairi ◽  
Lahoucine Bahi ◽  
Lhoussaine Ammouta ◽  
...  
Keyword(s):  
Experimental Data ◽  
Nervous System ◽  
Clinical Symptoms ◽  
Case Reports ◽  
The World ◽  
Acute Pneumonia ◽  
The Brain ◽  
Cardinal Feature ◽  
Shed Light

Since December 2019, the world has been shaken by the spread of a highly pathogen virus, causing severe acute respiratory syndrome (SARS-Cov2), which emerged in Wuhan, China. SARS-Cov2 is known to cause acute pneumonia: the cardinal feature of coronavirus disease 2019 (COVID-19). Clinical features of the disease include respiratory distress, loss of spontaneous breathing, and sometimes neurologic signs such as headache and nausea and anosmia, leading to suppose a possible involvement of the nervous system as a potential target of SARS-CoV2. The chapter will shed light on the recent clinical and experimental data sustaining the involvement of the nervous system in the pathophysiology of COVID-19, based on several case reports and experimental data reporting the possible transmission of SARS-CoV2 throughout the peripheral nerves to the brain cardiorespiratory centers. Thus, understanding the role of the nervous system in the course of clinical symptoms of COVID-19 is important in determining the appropriate therapeutic approach to combat the disease.

Summing Up

2019 ◽  
pp. 145-158
Author(s):  
Dale Purves
Keyword(s):  
Nervous System ◽  
Cardiovascular System ◽  
Digestive System ◽  
Neural Function ◽  
Empirical Basis ◽  
Organ Systems ◽  
The World ◽  
Survival And Reproduction ◽  
Successful Behavior ◽  
The Brain

A major challenge in neuroscience today is to decipher the operating principle of the brain and the rest of the nervous system in the same straightforward way that biologists have come to understand the functions of other organs and organ systems (e.g., the cardiovascular system, the digestive system, and so on). The argument here has been that the function of nervous systems is to make, maintain, and modify neural associations that ultimately promote survival and reproduction in a world that sensory systems can’t apprehend. In this way, we and other animals can link the subjective domain of perception to successful behavior without ever recovering the properties of the world. Neural function on a wholly empirical basis may be the key to understanding how brains operate.

scholarly journals Hemosiderosis of Central Nervous System: a case report of a rare and underdiagnosed disease

2021 ◽  
Vol 10 (11) ◽  
pp. e270101119579
Author(s):  
Cássio Marques Perlin ◽  
Lanusa Alquino Colombo ◽  
Anderson Dillmann Groto ◽  
Bruno Gleizer da Silva Rigon
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Superficial Siderosis ◽  
Medical Clinic ◽  
Resonance Imaging ◽  
System A ◽  
Magnetic Resonance Imaging Mri ◽  
Brain And Spinal Cord ◽  
The Brain

Superficial Siderosis (SS) of Central Nervous System is a rare disease characterized by the deposit of hemosiderin in the brain and spinal cord. Clinically, it is characterized by progressive sensorineural ataxia and deafness associated with injury of superior motor neuron. The diagnosis is made by magnetic resonance imaging (MRI) of the encephalon and spinal cord. The objective of the study is to report the case of a patient with characteristic elements of the syndrome, accompanied in a private medical clinic.

scholarly journals Nonlinear Markov Chain Modelling of the Novel Coronavirus (Covid-19) Pandemic

2020 ◽  
Author(s):  
Muammer Catak ◽  
Necati Duran
Keyword(s):  
Markov Chain ◽  
Markov Chains ◽  
Markov Chain Model ◽  
Chain Model ◽  
The Novel ◽  
The World ◽  
The Usa ◽  
Novel Coronavirus ◽  
Almost All ◽  
Markov Chain Modelling

Almost all countries around the world are struggling against the novel coronavirus (Covid-19) pandemic. In this paper, a nonlinear Markov chains model is proposed in order to analyse and to understand the behaviour of the Covid-19 pandemic. The data from China was used to build up the presented model. Thereafter, the nonlinear Markov chain model is employed to estimate the daily new Covid-19 cases in some countries including Italy, Spain, France, UK, the USA, Germany, Turkey, and Kuwait. In addition, the correlation between the daily new Covid-19 cases and the daily number of deaths is examined.

scholarly journals Covid-19 and Related Myths in Indian Community

2021 ◽  
Vol 58 (2) ◽  
pp. 645-651
Author(s):  
Rutika Nikhar
Keyword(s):  
Incomplete Information ◽  
Medical Community ◽  
The Novel ◽  
Indian Community ◽  
Corona Virus ◽  
The People ◽  
The World ◽  
Almost All ◽  
Source Of Information

31ST December 2019, was the day the WHO came to know about the new corona virus after a cluster of pneumonia cases caused by the virus in Wuhan province of China. On March 11 2020 WHO declared COVID-19 as pandemic. Since then the world hasn’t remained the same. It has not only changed the medical community, but also the overall mind-sets and behaviour of people worldwide. What began as a Whatsapp forward, was soon analysed worldwide through various social platforms, media and publications. The novel corona virus SARS-CoV-2, has spread from Wuhan, China to almost ALL the continents and along with it spread the rumours and myths and misinformation regarding it. The virus killed tens of millions of people, and engraved fear in the minds of the hundreds of millions. The paranoia and panic led to people to form their own speculations and have their own conclusions. Not just the fear, but the incomplete information with respect to the virus and the disease in itself has caused confusion in not just common population but the medical fraternity as well. Months of research and studies on the virus and the disease has helped clear the myths surrounding it. But yet these myths still exist amongst the people receiving misinformation and rumours and among the ones who have no access to a legitimate source of information. So let’s bust some myths surrounding the virus that changed the world.

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