scholarly journals Pathological Features of COVID-19 Pneumonia Diagnosed Following an Autopsy

2021 ◽  
Vol 45 (4) ◽  
pp. 145-149
Author(s):  
Hyun Lyoung Koo ◽  
Hee Joo Kwon ◽  
Won Tae Lee
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory System ◽  
Microscopic Examination ◽  
Diffuse Alveolar Damage ◽  
Pathological Features ◽  
Pathological Findings ◽  
Immunohistochemical Stain ◽  
First Case ◽  
Novel Coronavirus ◽  
Inflammatory Infiltrates

After initial emergence at the end of 2019, coronavirus disease 19 (COVID-19) rapidly spread to become a pandemic. The causative agent is recognized as a novel coronavirus, named as severe acute respiratory syndrome coronavirus 2, which is known to primarily affect the respiratory system. We present the case of a 60-year-old man who was diagnosed to have COVID-19 pneumonia following an autopsy. Microscopic examination of the lung tissue showed acute (exudative) phase of diffuse alveolar damage, inflammatory infiltrates in alveolar spaces and interstitium, atypical pneumocytes with prominent nucleoli and expanded cytoplasm, and thrombi in small arterioles. Some megakaryocytes were observed, which were positive for immunohistochemical stain for CD61. The pathological findings observed in this case were consistent with those of previously published reports of COVID-19 pneumonia. This is the first case of COVID-19 pneumonia diagnosed with an autopsy in Korea.

Novel Coronavirus Disease (COVID-19): A Narrative Review Based on Current Status

2020 ◽  
Vol 18 ◽  
Author(s):  
Rina Das ◽  
Dinesh Kumar Mehta ◽  
Meenakshi Dhanawat
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Symptoms ◽  
Virus Disease ◽  
Relevant Literature ◽  
World Health ◽  
Current Status ◽  
Future Research ◽  
Treatment And Prevention ◽  
First Case ◽  
Novel Coronavirus

Abstract:: A novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared and expanded globally by the end of year in 2019 from Wuhan, China, causing severe acute respiratory syndrome. During its initial stage, the disease was called the novel coronavirus (2019-nCoV). It was named COVID-19 by the World Health Organization (WHO) on 11 February 2020. The WHO declared worldwide the SARS-CoV-2 virus a pandemic on March 2020. On 30 January 2020 the first case of Corona Virus Disease 2019 (COVID-19) was reported in India. Now in current situation the virus is floating in almost every part of the province and rest of the globe. -: On the basis of novel published evidences, we efficiently summarized the reported work with reference to COVID-19 epidemiology, pathogen, clinical symptoms, treatment and prevention. Using several worldwide electronic scientific databases such as Pubmed, Medline, Embase, Science direct, Scopus, etc were utilized for extensive investigation of relevant literature. -: This review is written in the hope of encouraging the people successfully with the key learning points from the underway efforts to perceive and manage SARS-CoV-2, suggesting sailent points for expanding future research.

scholarly journals The First Case of Reactive Arthritis Associated with SARS-CoV-2-Infection in A 4-Year Old Child

2020 ◽  
Author(s):  
Stephanie Gabriele Werner ◽  
Hans-Eckhard Langer
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Reactive Arthritis ◽  
Virus Disease ◽  
The Novel ◽  
Case Presentation ◽  
Corona Virus ◽  
First Case ◽  
Novel Coronavirus ◽  
The Right

Abstract Background: The novel coronavirus SARS‐CoV‐2 (severe acute respiratory syndrome coronavirus 2) and its associated disease COVID‐19 (Corona Virus Disease 19) has become a worldwide pandemic since its first cases in December 2019 in Wuhan Province in China. In Germany the pandemic started in February 2020.Case presentation: A 4 year old boy was presented and suffered from pain in the right hip. Arthrosonography demonstrated a significant effusion in the involved joint. The extended history revealed a slight but long lasting cold before. Serological findings were inconspicuous except for positive ELISA (Enzyme-linked Immuno Sorbent Assay) - test for SARS-CoV-2. Conclusion: In conclusion we believe that we can report the first case of reactive arthritis associated with SARS-CoV-2 in children.

scholarly journals Guillain-Barré Syndrome associated with the coronavirus disease 2019 (COVID-19)

2020 ◽  
pp. 10.1212/CPJ.0000000000000879 ◽  
Author(s):  
Seyed Amir Ebrahimzadeh ◽  
Abdoreza Ghoreishi ◽  
Nasrin Rahimian
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Symptoms ◽  
Guillain Barre Syndrome ◽  
Unknown Etiology ◽  
Neurologic Complications ◽  
Wuhan City ◽  
First Case ◽  
Guillain Barré Syndrome ◽  
Novel Coronavirus ◽  
Guillain Barré

In December 2019, the first case of pneumonia with unknown etiology was reported in Wuhan city, China. The identified pathogen was a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).1 Since then, the virus has spread rapidly worldwide. Although Coronavirus disease 2019 (COVID-19) typically presents with upper or lower respiratory symptoms, there have been rare reports of significant neurologic complications.2,3 Recently, a few reports presented cases of Guillain-Barré syndrome (GBS) after COVID-19.4,5 In this report, we describe 2 cases of GBS that occurred following COVID-19.

Use of Natural Compounds as a potential therapeutic agent against COVID-19

2021 ◽  
Vol 26 ◽  
Author(s):  
Shadma Wahab ◽  
Irfan Ahmad ◽  
Safia Irfan ◽  
Mohammad Hassan Baig ◽  
Abd-ElAziem Farouk ◽  
...  
Keyword(s):  
Natural Products ◽  
Severe Acute Respiratory Syndrome ◽  
Drug Development ◽  
Respiratory System ◽  
Crucial Role ◽  
Therapeutic Agent ◽  
Natural Compounds ◽  
Current Status ◽  
Effective Vaccine ◽  
Novel Coronavirus

: The current 2019-nCoV outbreak is becoming extremely noxious and has affected the whole world. Its control is challenging because there is no effective vaccine or drug available for Coronavirus disease. The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), previously named as 2019 novel Coronavirus (2019-nCoV), primarily targets the human respiratory system to lung lesions and lethal pneumonia. Natural products have always shown a crucial role in the process of drug development against various diseases. They could be leads for further drug development to combat emergent mutants of the coronavirus. In this review, the current status of natural compounds and their derivatives acting against different species of CoV are discussed.

scholarly journals Does Concurrent Existence of Asthma or COPD Affect Susceptibility & Outcomes to Novel Coronavirus Infections?

The Physician ◽  
2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Akash Srinivasan ◽  
Indranil Chakravorty ◽  
Koottalai Srinivasan
Keyword(s):  
Respiratory Failure ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory System ◽  
Chronic Lung Disease ◽  
Lung Diseases ◽  
Healthcare Professionals ◽  
Chronic Lung Diseases ◽  
The World ◽  
Mobile Population ◽  
Novel Coronavirus

The SARS-CoV-2 virus causing COVID-19 pandemic across the world has highlighted the risk of human-to-human transmission, the speed of spread in a globally mobile population and the need for health services to be flexible in their responses to hitherto unknown challenges. One of the hallmarks of COVID-19 is severe acute respiratory syndrome presenting with widespread viral pneumonitis and respiratory failure. It is therefore not unusual for patients with chronic lung diseases such as asthma, COPD, and bronchiectasis to be concerned regarding their particular vulnerability. As healthcare professionals responsible for the care of such patients, it is important to understand how the SARS-CoV-2 virus impacts the respiratory system and the outcomes for patients with chronic lung disease. This review examines the evidence and offers sensible guidance until more is known.

scholarly journals The Potential Use of Electromagnetic Radiation to Combat Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Particles: A Numerical Analysis

2021 ◽  
Author(s):  
Haider Raad ◽  
Colin Terry
Keyword(s):  
Numerical Analysis ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory System ◽  
Electromagnetic Waves ◽  
Maximum Energy ◽  
The Novel ◽  
Virus Particles ◽  
Novel Coronavirus ◽  
The Waves ◽  
Potential Use

The novel coronavirus disease 2019 (COVID-19) has shown the danger that can be caused by small, airborne and contagious virus particles such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To prevent the mass spreading of such viruses, the use of electromagnetic waves could be used to combat the spreading of the virus. Particularly, the waves could force any virus particles to oscillate in resonance with the frequency of the wave and destroy themselves before the virus would enter the respiratory system. This paper describes the use of numerical simulations to analyze the effects of exposing a SARS-CoV-2 particle to electromagnetic waves at a range of frequencies and to determine which frequencies have the potential of causing resonance within the virus which would yield to the maximum energy absorption. Such technique could be utilized in preventive/protective devices and disinfection equipment.

scholarly journals Peculiar Histopathological Alterations of Enterocytes in a Patient Co-infected with Severe Acute Respiratory Syndrome Coronavirus 2 and Mycobacterium Tuberculosis: A Case Study

2021 ◽  
Author(s):  
Rana AL-Zaidi ◽  
Nasir AL-Noor ◽  
Adel Habbash
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Severe Acute Respiratory Syndrome ◽  
Right Hemicolectomy ◽  
The Novel ◽  
Pathological Findings ◽  
Epithelial Injury ◽  
Angiotensin Converting Enzyme 2 ◽  
Novel Coronavirus ◽  
Absorptive Enterocytes

Abstract The ongoing novel coronavirus disease 2019 (COVID-19) is principally defined by its respiratory symptoms. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the gastrointestinal tract (GIT) and although the pathogenesis of COVID-19 is understood, the exact pathological alterations following infection require further investigation. Here, we report our histopathological findings from a right hemicolectomy specimen from a patient coinfected with COVID-19 and Mycobacterium tuberculosis. Our observations showed that the novel SARS-CoV-2 can affect the GIT, causing epithelial injury and pathological alterations attributed to its ability to infect absorptive enterocytes by interacting with the angiotensin converting enzyme-2 (ACE2) receptor. These pathological findings are regarded as viral cytopathic changes and should be considered when evaluating gastrointestinal specimens from COVID-19-infected patients.

scholarly journals COVID-19 Disease: a gastroenterologist’s perspective

JMS SKIMS ◽  
2020 ◽  
Vol 23 (2) ◽  
Author(s):  
Altaf Shah ◽  
Hilal Ahmad Dar
Keyword(s):  
Gastrointestinal Tract ◽  
Severe Acute Respiratory Syndrome ◽  
Angiotensin Converting Enzyme ◽  
Respiratory System ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Oral Transmission ◽  
First Case ◽  
Control And Prevention ◽  
Respiratory Droplets

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has rapidly resulted into pandemic, as first case of coronavirus disease 2019(covid-19) was detected in Wuhan, China in December; 2019.1As of 8 june, 2020, over 7 million infections and more than 402,000 deaths had been reported globally. Although the virus primarily affects the respiratory system and is transmitted via respiratory droplets, various gastrointestinal and hepatic manifestations are not uncommon. Angiotensin-converting enzyme 2 (ACE2), the major receptor of SARS-CoV-2, is expressed in the gastrointestinal tract and liver cells. The detection of SARS-CoV-2 viral RNA in patients’ stool and the potential for faecal–oral transmission has raised great concern and could pose a challenge for the control and prevention of COVID-19 disease.

scholarly journals Challenges and Strategies for Pakistan in the Third Wave of COVID-19: A Mini Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Kashif Kamran ◽  
Abid Ali
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Developing Country ◽  
Causative Agent ◽  
Respiratory System ◽  
Virus Disease ◽  
Large Population ◽  
Third Wave ◽  
The Third ◽  
The World ◽  
Novel Coronavirus

The world is currently gripped by the fear of the corona virus disease 2019 (COVID-19) pandemic. The causative agent of COVID-19 is a novel coronavirus known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that attacks humans without prejudice, and primarily targets the respiratory system. Pakistan is a developing country with a large population and a weak economy. Currently, it is facing a major challenge to cope with the outbreak of the COVID-19 pandemic, especially the third wave. This fatal virus has increased its presence many folds in Pakistan. On average, 100 deaths per day were being recorded in the late spring of 2021. Delay in the acquisition of vaccine has slowed down the vaccination program for this disease. This in turn will accelerate the spreading of virus, and thus will lead to a lockdown situation.

scholarly journals Clinical and pathological characteristics of 2019 novel coronavirus disease (COVID-19): a systematic reviews

2020 ◽  
Author(s):  
Yaqian Mao ◽  
Wei Lin ◽  
Junping Wen ◽  
Gang Chen
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthcare Worker ◽  
Clinical Symptoms ◽  
Early Recognition ◽  
Clinical Manifestations ◽  
Pathological Examination ◽  
Pathological Features ◽  
Pathological Characteristics ◽  
Pubmed Database ◽  
Novel Coronavirus

AbstractsImportanceIn 2002-2003, a severe pulmonary infectious disease occurred in guangdong, China. The disease was caused by severe acute respiratory syndrome coronavirus (SARS-CoV), 17 years apart, also happen in China, and also a novel coronavirus (SARS-CoV-2), this epidemic has posed a significant hazard to people’s health both China and the whole world.ObjectiveSummarized the latest epidemiological changes, clinical manifestations, auxiliary examination and pathological characteristics of COVID-19.Evidence ReviewPubMed database were searched from 2019 to 2020 using the index terms “novel coronavirus” or “COVID-19” or “2019-nCoV” or “SARS-CoV-2” and synonyms. Articles that reported clinical characteristics, laboratory results, imageological diagnosis and pathologic condition were included and were retrospectively reviewed for these cases. This paper adopts the method of descriptive statistics.Results34 COVID-19-related articles were eligible for this systematic review,Four of the articles were related to pathology. We found that Fever (86.0%), cough (63.9%) and Malaise/Fatigue (34.7%) were the most common symptoms in COVID-19. But in general, the clinical symptoms and signs of COVID-19 were not obvious. Compared with SARS, COVID-19 was transmitted in a more diverse way. The mortality rates of COVID-19 were 2.5%, and the overall infection rate of healthcare worker of COVID-19 was 3.9%. We also found that the pathological features of COVID-19 have greatly similar with SARS, which manifested as ARDS. But the latest pathological examination of COVID-19 revealed the obvious mucinous secretions in the lungs.InterpretationThe clinical and pathological characteristics of SARS and COVID-19 in China are very similar, but also difference. The latest finds of pathological examination on COVID-19 may upend existing treatment schemes, so the early recognition of disease by healthcare worker is very important.Key PointsQuestionWhat can we learn from the clinical manifestations and pathological features of 2019 novel coronavirus disease (COVID-19)?FindingsIn this review, we found COVID-19 was transmitted in a more diverse way than Severe acute respiratory syndrome (SARS). Fever, cough and Malaise/Fatigue were the most common symptoms. We also found that the SARS-CoV-2 has the same cell entry receptor ACE2 as SARS-CoV, and they have similar pathological mechanisms like Acute respiratory distress syndrome (ARDS).MeaningThis review aims to give people a more comprehensive understanding of COVID-19 and to continuously improve the level of prevention, control, diagnosis and treatment.

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