scholarly journals Dose-dependent and strain-dependent anti-obesity effects ofLactobacillus sakeiin a diet induced obese murine model

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6651 ◽  
Author(s):  
Yosep Ji ◽  
Young Mee Chung ◽  
Soyoung Park ◽  
Dahye Jeong ◽  
Bongjoon Kim ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Murine Model ◽  
The Body ◽  
Related Data ◽  
Body Weight Reduction ◽  
Inflammatory Conditions ◽  
History Of ◽  
Underlying Mechanisms ◽  
Different Strains ◽  
Dose Dependent

BackgroundOverweight and abdominal obesity, in addition to medical conditions such as high blood pressure, high blood sugar and triglyceride levels, are typical risk factors associated with metabolic syndrome. Yet, considering the complexity of factors and underlying mechanisms leading to these inflammatory conditions, a deeper understanding of this area is still lacking. Some probiotics have a reputation of a relatively-long history of safe use, and an increasing number of studies are confirming benefits including anti-obesity effects when administered in adequate amounts. Recent reports demonstrate that probiotic functions may widely differ with reference to either intra-species or inter-species related data. Such differences do not necessarily reflect or explain strain-specific functions of a probiotic, and thus require further assessment at the intra-species level. Various anti-obesity clinical trials with probiotics have shown discrepant results and require additional consolidated studies in order to clarify the correct dose of application for reliable and constant efficacy over a long period.MethodsThree different strains ofLactobacillus sakeiwere administered in a high-fat diet induced obese murine model using three different doses, 1 × 1010, 1 × 109and 1 × 108CFUs, respectively, per day. Changes in body and organ weight were monitored, and serum chemistry analysis was performed for monitoring obesity associated biomarkers.ResultsOnly one strain ofL. sakei(CJLS03) induced a dose-dependent anti-obesity effect, while no correlation with either dose or body or adipose tissue weight loss could be detected for the other twoL. sakeistrains (L338 and L446). The body weight reduction primarily correlated with adipose tissue and obesity-associated serum biomarkers such as triglycerides and aspartate transaminase.DiscussionThis study shows intraspecies diversity ofL. sakeiand suggests that anti-obesity effects of probiotics may vary in a strain- and dose-specific manner.

scholarly journals Dose dependent anti-obesity effect of three different Lactobacillus sakei strains using a diet induced obese murine model

2018 ◽  
Author(s):  
Yosep Ji ◽  
Young Mee Chung ◽  
Soyoung Park ◽  
Dahye Jeong ◽  
Bongjoon Kim ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Murine Model ◽  
Overweight And Obesity ◽  
The Body ◽  
Lactobacillus Sakei ◽  
Related Data ◽  
Body Weight Reduction ◽  
Underlying Mechanisms ◽  
Different Strains ◽  
Dose Dependent

Overweight and obesity are considered as a major cause of various conditions related to metabolic syndrome. Yet, considering the complex interacting factors leading to pathogenicity and underlying mechanisms, it remains a poorly defined area. Some probiotics have a reputation of a relatively long history of safe use, and an increasing number of studies are confirming benefits including anti-obesity effects when administered in adequate amounts. Recent reports demonstrate that probiotic functions may widely differ with reference to either intra-species or inter-species related data. Such differences do not necessarily reflect or explain strain specific functions of a probiotic, and thus require further assessment at the intra-species level. Various anti-obesity clinical trials with probiotics have shown discrepant results and require more consolidated studies in order to clarify the correct dose of application for reliable and constant efficacy over a long period. In this study three different strains of Lactobacillus sakei were administered in a high fat diet induced obese murine model using three different doses, 1x1010 CFU, 1x109 CFU and 1x108 CFU, respectively, per day. Changes in body and organ weight were monitored, and serum chemistry analysis was performed for monitoring obesity associated biomarkers. The results show that only one strain of L. sakei (CJLS03) induced a dose dependent anti-obesity effect, while no correlation with either dose or body and adipose tissue weight loss could be detected for the other two L. sakei strains (L338 and L446). The body weight reduction mainly correlated with adipose tissue and obesity associated serum biomarkers such as triglycerides. This study suggests that anti-obesity effects of probiotics may vary in a strain and dose specific manner.

scholarly journals Dose dependent anti-obesity effect of three different Lactobacillus sakei strains using a diet induced obese murine model

2018 ◽  
Author(s):  
Yosep Ji ◽  
Young Mee Chung ◽  
Soyoung Park ◽  
Dahye Jeong ◽  
Bongjoon Kim ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Murine Model ◽  
Overweight And Obesity ◽  
The Body ◽  
Lactobacillus Sakei ◽  
Related Data ◽  
Body Weight Reduction ◽  
Underlying Mechanisms ◽  
Different Strains ◽  
Dose Dependent

Overweight and obesity are considered as a major cause of various conditions related to metabolic syndrome. Yet, considering the complex interacting factors leading to pathogenicity and underlying mechanisms, it remains a poorly defined area. Some probiotics have a reputation of a relatively long history of safe use, and an increasing number of studies are confirming benefits including anti-obesity effects when administered in adequate amounts. Recent reports demonstrate that probiotic functions may widely differ with reference to either intra-species or inter-species related data. Such differences do not necessarily reflect or explain strain specific functions of a probiotic, and thus require further assessment at the intra-species level. Various anti-obesity clinical trials with probiotics have shown discrepant results and require more consolidated studies in order to clarify the correct dose of application for reliable and constant efficacy over a long period. In this study three different strains of Lactobacillus sakei were administered in a high fat diet induced obese murine model using three different doses, 1x1010 CFU, 1x109 CFU and 1x108 CFU, respectively, per day. Changes in body and organ weight were monitored, and serum chemistry analysis was performed for monitoring obesity associated biomarkers. The results show that only one strain of L. sakei (CJLS03) induced a dose dependent anti-obesity effect, while no correlation with either dose or body and adipose tissue weight loss could be detected for the other two L. sakei strains (L338 and L446). The body weight reduction mainly correlated with adipose tissue and obesity associated serum biomarkers such as triglycerides. This study suggests that anti-obesity effects of probiotics may vary in a strain and dose specific manner.

scholarly journals Pain at the crossroads between nature and culture

2013 ◽  
pp. 145-148
Author(s):  
Francesco N. Gaspa ◽  
Giuliano Pinna
Keyword(s):  
Social Contexts ◽  
Point Of View ◽  
The Body ◽  
Research Perspective ◽  
Related Data ◽  
Nature And Culture ◽  
History Of ◽  
Pain And Suffering ◽  
Specific Meaning ◽  
Pain Stimuli

Pain and suffering represent unavoidable experiences that have left a deep mark on the history of mankind. In this review, pain is examined from an anthropological point of view, because there is no pain without suffering, and every biophysical event is brought to the consciousness of an individual by an emotional signal. The body is an entity that changes from culture to culture and operates within particular historical and social contexts. Each society incorporates the concept of pain into its particular worldview, assigning it a specific meaning and value. Few human experiences can be read in as many different keys: from neuroscience to linguistic research, perspective selection, and emotional and cognitive functions. Although pain is currently regarded as a destructive force that is per se pathological, it is actually a form of protection. In today’s society, pain is experienced as a problem in itself, a disease within a disease, and its physiopathological aspects have been extensively characterized. But pain must also be analyzed within its anthropological, sociological, political, and economic contexts. The phenomenon of pain lies at the crossroads between nature and culture, and analysis from this perspective is essential for explaining the multiplicity of related data. The ‘‘anthropology of pain’’ explains, among other things, the assortment of reactions to identical pain stimuli among individuals and groups: for example, the higher opposition to pain observed among individuals living in poverty, the phenomenon of ‘‘combat analgesia’’, and the wide variety of analgesics used by traditional populations.

scholarly journals Preclinical Research on a Mixture of Red Ginseng and Licorice Extracts in the Treatment and Prevention of Obesity

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2744
Author(s):  
Yulong Zheng ◽  
Eun-Hye Lee ◽  
Ji-Hyun Lee ◽  
Gyo In ◽  
JongHan Kim ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Accumulation ◽  
Serum Triglyceride ◽  
The Body ◽  
Composition Analysis ◽  
Serum Triglyceride Level ◽  
Dependent Manner ◽  
Obese Mice ◽  
Ampk Pathway ◽  
Dose Dependent

The anti-obesity effects of RL (a 3:1 mixture of Panax ginseng saponin fractions and Glycyrrhiza glabra L. extracts) on 3T3-L1 adipocytes and C57BL/6J obese mice were evaluated at different concentrations. We investigated the anti-obesity effects of RL through lipid accumulation inhibition rate, serum lipid composition analysis, adipose tissue size, adipogenic transcription factors and AMPK pathway. RL inhibited the lipid accumulation of 3T3-L1 adipocytes in a dose-dependent manner at concentrations of 50–200 μg/mL without cytotoxicity (50–400 μg/mL). Oral administration of RL at the highest concentration (400 mg/kg/day) did not cause significant liver toxicity in high-fat diet-induced obese mice. RL stimulated adiponectin secretion in a dose-dependent manner and primarily mediates the AMPK pathway to inhibit triglyceride synthesis and attenuate adipocyte hypertrophy. RL significantly reduced weight in obese mice, but none of the body weight, adipose tissue weight, serum triglyceride level, and AMPK pathway activation degree showed any difference between dosing concentrations of 200 and 400 mg/kg/day. Therefore, 200 mg/kg/day of RL is the optimal preclinical concentration, which can be a reference concentration for conversion into a human clinical trial dose.

scholarly journals The impact of abdominal adiposity measured by sonography on the pulmonary function of pre-menopausal females

2015 ◽  
Vol 10 ◽  
Author(s):  
Zied Rasslan ◽  
Roberto Stirbulov ◽  
Roberto Saad Junior ◽  
Sergio Tercio Curia ◽  
Carlos Alberto Da Conceição Lima ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Pulmonary Function ◽  
Negative Influence ◽  
Normal Weight ◽  
The Body ◽  
Abdominal Adipose Tissue ◽  
Total Adipose Tissue ◽  
History Of ◽  
Subcutaneous Abdominal Adipose Tissue ◽  
The Impact

Background: The Body Mass Index (BMI) is a widely used parameter to study obesity; however it does not assess the distribution of body adiposity. Ultrasonography is a reliable method of measuring subcutaneous (SAT), visceral (VAT) and Total adipose tissue of the abdomen (TAT) to determine the influence of abdominal fat on pulmonary function by directly measuring abdominal adipose tissue. Methods: Eighty pre-menopausal, non-smoker, sedentary females with no history of pulmonary disease were subdivided into three groups: 25 normal-weight, 28 overweight, 27 obese. Absolute and predictive spirometric values were obtained: FVC, FEV1, FEV1/FVC, IC, ERV. Results: A positive correlation between increased %IC and decreased %ERV was observed with increased BMI (p < 0.02; 0.001 respectively); %FVC, %FEV1 and %ERV decreased significantly as SAT (p = 0.01, p = 0.02; p < 0.001) and TAT (p = 0.01, p = 0.03, p < 0.001) increased, whereas VAT was negatively correlated only with %ERV (p < 0.001). Increments of 5 mm in TAT, VAT and SAT were followed by a reduction of 0.83 %, 0.81 %, 1.90 % in %FVC, respectively, as well as a reduction of 4.25 %, 4.31 % and 9.44 % in %ERV, respectively. Conclusions: Subcutaneous abdominal adipose tissue deposition in obese females has a greater negative influence on pulmonary function than visceral adipose tissue deposition.

What Does Fat Do?

2021 ◽  
pp. 47-90
Author(s):  
Nathan Denton
Keyword(s):  
Adipose Tissue ◽  
Energy Metabolism ◽  
Health Effects ◽  
White Adipose Tissue ◽  
Evolutionary History ◽  
The Body ◽  
Major Type ◽  
History Of

Despite how much we may think and talk about fat in our lives and in society, we rarely take a moment to consider what it actually does. Contemplating the evolutionary history of fat is probably the last thing on someone’s mind when their trousers feel a bit tight. We love to hate fat, especially on our own bodies, but fat is not inherently bad. On the contrary, our hatred and fear is being directed at an ancient organ that is essential for life. Perpetually misunderstood, fat’s bad reputation derives from our preoccupation with the negative health effects associated with having too much of it. In order to succeed in the monolithic battle against obesity threatening the planet’s health and wealth, we must first understand fat itself, more specifically white adipose tissue, the major type of fat in the body. In order to understand the nature of fat, however, we must first consider energy metabolism more generally. The next section considers how the body handles fat, carbohydrate, and protein under various conditions to illustrate the central role that adipose tissue plays in our bodies each and every day.

Aspergillus Spondylodiscitis After Spinal Stenosis Surgery: A Case Report

2020 ◽  
Vol 5 (3 And 4) ◽  
pp. 155-160
Author(s):  
Mohsen Aghapoor ◽  
◽  
Babak Alijani Alijani ◽  
Mahsa Pakseresht-Mogharab ◽  
◽  
...  
Keyword(s):  
Antifungal Drugs ◽  
The Body ◽  
Lower Limbs ◽  
Lumbar Pain ◽  
Case Presentation ◽  
Delay In Diagnosis ◽  
Death Case ◽  
Therapeutic Results ◽  
History Of ◽  
Probable Diagnosis

Background and Importance: Spondylodiscitis is an inflammatory disease of the body of one or more vertebrae and intervertebral disc. The fungal etiology of this disease is rare, particularly in patients without immunodeficiency. Delay in diagnosis and treatment of this disease can lead to complications and even death. Case Presentation: A 63-year-old diabetic female patient, who had a history of spinal surgery and complaining radicular lumbar pain in both lower limbs with a probable diagnosis of spondylodiscitis, underwent partial L2 and complete L3 and L4 corpectomy and fusion. As a result of pathology from tissue biopsy specimen, Aspergillus fungi were observed. There was no evidence of immunodeficiency in the patient. The patient was treated with Itraconazole 100 mg twice a day for two months. Pain, neurological symptom, and laboratory tests improved. Conclusion: The debridement surgery coupled with antifungal drugs can lead to the best therapeutic results.

Re-imagining Reproduction: Unsettling Metaphors in the History of Imperial Science and Commercial Surrogacy in India

Somatechnics ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 88-103 ◽  
Author(s):  
Kalindi Vora
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
The Body ◽  
Body Parts ◽  
Colonial History ◽  
Women's Bodies ◽  
Commercial Surrogacy ◽  
Art Practices ◽  
History Of ◽  
Travel Industry

This paper provides an analysis of how cultural notions of the body and kinship conveyed through Western medical technologies and practices in Assisted Reproductive Technologies (ART) bring together India's colonial history and its economic development through outsourcing, globalisation and instrumentalised notions of the reproductive body in transnational commercial surrogacy. Essential to this industry is the concept of the disembodied uterus that has arisen in scientific and medical practice, which allows for the logic of the ‘gestational carrier’ as a functional role in ART practices, and therefore in transnational medical fertility travel to India. Highlighting the instrumentalisation of the uterus as an alienable component of a body and subject – and therefore of women's bodies in surrogacy – helps elucidate some of the material and political stakes that accompany the growth of the fertility travel industry in India, where histories of privilege and difference converge. I conclude that the metaphors we use to structure our understanding of bodies and body parts impact how we imagine appropriate roles for people and their bodies in ways that are still deeply entangled with imperial histories of science, and these histories shape the contemporary disparities found in access to medical and legal protections among participants in transnational surrogacy arrangements.

Receptions of the Past: Commemoration, Racism, Desire

Somatechnics ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 288-303
Author(s):  
Michael Connors Jackman
Keyword(s):  
Critical Point ◽  
Social Relations ◽  
White Privilege ◽  
Body Politic ◽  
The Body ◽  
Race And Racism ◽  
Lesbian And Gay ◽  
The Past ◽  
History Of

This article investigates the ways in which the work of The Body Politic (TBP), the first major lesbian and gay newspaper in Canada, comes to be commemorated in queer publics and how it figures in the memories of those who were involved in producing the paper. In revisiting a critical point in the history of TBP from 1985 when controversy erupted over race and racism within the editorial collective, this discussion considers the role of memory in the reproduction of whiteness and in the rupture of standard narratives about the past. As the controversy continues to haunt contemporary queer activism in Canada, the productive work of memory must be considered an essential aspect of how, when and for what reasons the work of TBP comes to be commemorated. By revisiting the events of 1985 and by sifting through interviews with individuals who contributed to the work of TBP, this article complicates the narrative of TBP as a bluntly racist endeavour whilst questioning the white privilege and racially-charged demands that undergird its commemoration. The work of producing and preserving queer history is a vital means of challenging the intentional and strategic erasure of queer existence, but those who engage in such efforts must remain attentive to the unequal terrain of social relations within which remembering forms its objects.

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