scholarly journals Clinicohormonal Parameters as a Primary Step to Differentiate Normosmic Idiopathic Hypogonadotropic Hypogonadism and Kallmann Syndrome in a Tertiary Care Hospital in Eastern India

2021 ◽  
Author(s):  
Ram Chandra Bhadra ◽  
Dona Saha ◽  
Arjun Baidya
Keyword(s):  
Genetic Disorder ◽  
Hormone Replacement ◽  
Hypogonadotropic Hypogonadism ◽  
Tertiary Care ◽  
Serum Testosterone ◽  
Kallmann Syndrome ◽  
Care Hospital ◽  
Cross Sectional ◽  
Idiopathic Hypogonadotropic Hypogonadism ◽  
Male Predominance

Introduction: Idiopathic hypogonadotropic hypogonadism is a rare gonadal dysgenesis in which puberty does not take place naturally. It occurs due to insufficient pulsatile secretion of Gonadotrophin-Releasing Hormone (GnRH) and the resulting Follicle-Stimulating Hormone (FSH) and Luteinising Hormone (LH) deficiency leads to absence of or delayed sexual maturation. Kallmann syndrome is an uncommon genetic disorder characterised by hypogonadotropic hypogonadism associated with anosmia or hyposmia. When anosmia is absent, the same is referred as normosmic Idiopathic Hypogonadotropic hypogonadism (nIHH). Aim: To find out the significant differences between Kallmann syndrome and nIHH based on clinical features and biochemical assessment as a primary measure to initiate the treatment early. Materials and Methods: This hospital based cross-sectional observational cohort study was conducted in Department of Endocrinology, Nilratan Sircar Medical College and Hospital, Kolkata, India. The study was done on 55 cases of IHH presenting to the department with delayed secondary sexual characteristics. Results: Out of these 55 cases, 45 (81.8%) were of nIHH and only 10 (18.2%) cases were of Kallmann Syndrome. It was found that both the conditions show male predominance. Smell abnormalities were present only in Kallmann group. The level of serum testosterone was significantly higher (p<0.05) in nIHH subjects (mean-35.59 ng/dL) than patients with Kallmann Syndrome (mean-14.90 ng/dL). Patients with Kallmann syndrome showed significantly reduced pubic and axillary hair development and absence of gonadal development. Conclusion: Absence of puberty with anosmia/hyposmia with low serum FSH and LH, drastically reduced serum testosterone, are factors that point towards the diagnosis of Kallmann syndrome even in absence of genetic study, which is helpful for initiation of hormone replacement therapy for treatment.

Clinical Profile of Polycystic Ovarian Syndrome Patients In Tertiary Care Hospital

2021 ◽  
Vol 8 (3) ◽  
pp. 99-103
Author(s):  
Dr. Urmila Gavali ◽  
Dr. Mayuri Pawar ◽  
Dr. Gautam Aher ◽  
Dr. Suhas Shinde
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Genetic Disorder ◽  
Tertiary Care ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Clinical Presentations ◽  
Complex Genetic Disorder ◽  
Uncertain Etiology ◽  
Ovarian Syndrome

ABSTRACT: Background: Polycystic ovarian syndrome (PCOS)is common gynecological endocrinopathy characterized by chronic anovulation and hyperandrogenism affecting 5-10% of women worldwide.  It is a heterogenous, multifactorial, complex genetic disorder with uncertain etiology and is one of the most common treatable cause of infertility. AIM: To study the various clinical presentations in polycystic ovarian syndrome. MATERIALS AND METHODS: Present study is cross sectional observational study carried out in tertiary care centre. This study was performed in the Out Patient Department of Obstetrics and Gynecology. RESULTS: The mean age of 41 patients in the study was 23.6 years. Most common presenting symptom in patients is menstrual irregularities (89%) followed by infertility and hirsutism. USG (abdo+pelvis) showing polycystic ovarian syndrome ovaries. Around 39% patients with PCOS developed insulin resistance. KEYWORDS: - Amenorrhea, Infertility, Oligomenorrhea, Polycystic Ovarian Syndrome.

scholarly journals Epidemiological study on admission of infectious diseases in pediatrics department of a tertiary care hospital, Jharkhand, India

2020 ◽  
Vol 7 (9) ◽  
pp. 3493
Author(s):  
Nisha Murmu ◽  
Pushpa . ◽  
Anit Kujur ◽  
Vidya Sagar ◽  
Vivek Kashyap
Keyword(s):  
Hand Hygiene ◽  
Infectious Diseases ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Male Predominance ◽  
Prime Concern ◽  
The Family

Background: Infectious diseases have a major contribution in the mortality and morbidity among children in India. The aim of our study was to assess the infectious diseases and the sociodemographic characteristics along with the assessment of awareness on mode of transmission of these diseases among the family members.Methods: This was a cross-sectional study done in Department of Pediatrics, RIMS, Ranchi, for a period of 6 months by consecutive sampling. Pre-tested, semi structured questionnaire was used for data collection and analysed in SPSS version 20.Results: A total of 220 children were included in the study. Majority of patients (60%) comprised of under 5 age group with male predominance (55%), with 84.1% children fully immunized, among which 54.1% were institutional deliveries and approx. 85.9% children were breast fed for more than 6 months. Malaria, being an endemic disease of Jharkhand affected maximum children (38.2%). Sanitation, (toilet facilities) was about 27% and hand hygiene was only 5% in the family members of the patients admitted. Thus lack of awareness and poor hand hygiene was an important finding in our result.Conclusions: Health education among the community should be the prime concern for the reduction of the diseases.

LABORATORY PROFILE OF INDOOR PATIENTS ADMITTED WITH ACUTE ENCEPHALITIC SYNDROME IN A TERTIARY CARE CENTRE OF NORTH-BENGAL

2021 ◽  
pp. 76-78
Author(s):  
Smarajit Banik ◽  
Debasis Chakrabarti ◽  
Sandip Saha ◽  
O P. Pandey ◽  
Dipanjan Bandyopadhyay
Keyword(s):  
Tertiary Care ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Study Region ◽  
Male Predominance ◽  
Acute Encephalitis Syndrome ◽  
Acute Encephalitis ◽  
Wbc Count ◽  
North Bengal

Background: Acute encephalitis syndrome (AES) is dened as the acute-onset of fever and a change in mental status (including signs and symptoms such as confusion, disorientation, delirium or coma) and/or new-onset of seizures (excluding simple febrile seizures) in a person of any age at any time of the year. Most AES is considered to be due to a viral-encephalitis, virus like West Nile, Herpes simplex virus, Flaviviruse like JE and dengue are more prevalent in South East Asia. Methods: This observational Cross sectional Study was conducted in the indoor patients of Department of Medicine at Tertiary care Hospital in North Bengal from May 2013 to April 2014. All consecutive patients of AES admitted during this period were included in the study. The study region covers the various districts of North Bengal. Template was generated in MS excel sheet and analysis was done on SPSS 20.0 software. Results: Among 104 acute encephalitis syndrome patients, 68 (65.38%) were male and 36 (34.62%) were female. The majority of pts (54.81%) were >40yrs of age. The lowest wbc count was 3000/cumm and highest was 21,200/cumm with mean wbc count being 10462.56±3567.832/cumm. Asignicant number 56 (53.85%) of patients had serum potassium levels between 2.5-3.5meq/dl. The no. of JE Positive patients was 75 (72.12%) which may be due to the local endemicity of the disease Conclusions: Majority of cases were in the age-group of more than 40 years, with male predominance. The no. of JE Positive patients was 75 (72.12%) which may be due to the local endemicity of the disease.

scholarly journals Disease staging according to international scoring system in newly diagnosed patients with multiple myeloma

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Saira Parveen Sheikh ◽  
Syed Muhammad Irfan ◽  
Sadia Sultan Sheikh
Keyword(s):  
Multiple Myeloma ◽  
Scoring System ◽  
Tertiary Care ◽  
Stage Iii ◽  
Outcome Variable ◽  
Care Hospital ◽  
Newly Diagnosed ◽  
Cross Sectional ◽  
Male Predominance ◽  
Disease Staging

Objective: To determine the frequency of disease staging according to international scoring system in patients who are newly diagnosed with Multiple Myeloma (MM) at a tertiary care hospital at Karachi. Methods: This single center, non probability consecutive, cross sectional study was conducted from Nov 11, 2015 to May 11, 2016. After taking informed written consent, detailed history was taken and serum β2 microglobulin and albumin levels were checked to assess the study outcome variable i.e. stage of MM. All the collected information was entered in the prescribed performa. Results: Eighty newly diagnosed patients with multiple myeloma as per inclusion criteria were included. Sixty seven (83.75%) were male and 13(16.25) were females, with mean age of 58.35+10.077 years. Twenty seven patients (33.75%) were found to have stage-I disease, in 23 (28.75%) stage-II and stage-III in 30 (37.5%). Conclusion: Multiple myeloma is relatively common in 5th decade, with male predominance. International Staging System have great potential for characterizing and stratifying multiple myeloma and revealed a predominance of advanced stage III disease in our setting. How to cite this:Shaikh SP, Irfan SM, Sheikh SS. Disease staging according to international scoring system in newly diagnosed patients with multiple myeloma. Pak J Med Sci. 2019;35(1):90-94. doi: https://doi.org/10.12669/pjms.35.1.173 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Prevalence of Gastric Cancers among Patients Undergoing Upper Gastrointestinal Endoscopies in a Tertiary Care Hospital in Nepal: A Descriptive Cross-sectional Study

2020 ◽  
Vol 59 (233) ◽  
Author(s):  
Subash Bhattarai ◽  
Merina Gyawali ◽  
Sudeep Regmi
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Male Predominance ◽  
Gastric Cancers ◽  
Upper Gastrointestinal

Introduction: Gastric cancer is a common malignancy of the upper gastrointestinal tract. Gastric cancer is a common cause of death worldwide. This research aimed to study the prevalence of gastric cancer among patients undergoing upper gastrointestinal endoscopies. Methods: A descriptive, cross-sectional study was conducted in the Department of Medicine at Manipal Teaching Hospital, Nepal, from January 2018 to June 2020. A total of 2640 subjects underwent upper gastrointestinal endoscopies over the study period. Ethical approval was taken from the institutional review committee of Manipal College of Medical Sciences (MEMG/ IRC/ 383/GA). Data were analyzed by SPSS version 20. Results: The prevalence of gastric cancer among patients undergoing UGI endoscopies was 2.4%. The mean age of subjects was 58 ± 12.35 years (range of 31 to 96 years) with male predominance (M:F=1.9:1). Antrum was the most common site for gastric carcinoma. The most common morphology was ulcerative growth (61.6%). Adenocarcinoma (98.4%) was the most common histology, and the majority was of intestinal subtype (56.3%). Conclusions: Gastric cancer is not an uncommon finding in patients undergoing UGI endoscopies. Gastric cancers were commonly seen above 50 years of age and predominant in males. Patients with gastric carcinoma usually present late with advanced disease stages and unfavorable histopathology.

scholarly journals Evaluation of Drug Use Patterns in Intensive Care Unit of Tertiary Care Hospital: A Descriptive Cross-Sectional Study

2021 ◽  
Vol 10 (1) ◽  
pp. 31-35
Author(s):  
Rinku Ghimire ◽  
Rupesh Kumar Shreewastav
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Prescription Patterns ◽  
Male Predominance ◽  
The Mean

Background: Prescription of rational drugs is needed to save critically ill patients. This study was conducted to assess the prescription patterns of drugs in the intensive care unit. Materials and Methods: A descriptive cross-sectional study among patients admitted in intensive care unit from March 2020 to February 2021 after approval from the Institutional Review Committee (ref no. 344 /2019). Demographic profile, prescription patterns, the average number of drugs used, route of administration, and duration of hospitalization were recorded based on the pre-structured questionnaires. Convenient sampling was chosen. Data were analyzed by SPSS, version 20. Results: Prescription patterns of 225 were analyzed. The mean age was 55.60 ± 20.16 years with a male predominance of 131(58.2%). Cardiac disorders 57(25.3%) were the most common admitting diagnosis followed by pulmonary, neurological, and kidney disorders. The average length of hospital stay was 4.14 days (range 1-38 days). A total of 887 drugs were prescribed. The mean number of drugs prescribed per patient was 7.71 ± 1.92. Parenteral drugs accounted for 81.39%. Antibiotics were prescribed to all patients. Intravenous fluids were given to 62.2% of patients, blood and blood products to 21.33%. Thromboprophylaxis was used in 15 (6.7%) patients. Seven hundred twenty-two (81.39%) drugs were injectables, 129(14.54%) were used by the oral or nasogastric route and 36 (4.05%) were inhaled drugs. Conclusion: Newer generations antibiotics were the most commonly prescribed drugs. Pantoprazole, Metoclopramide, and Hydrocortisone were the top three most commonly prescribed individual drugs. There was marked underuse of thromboprophylaxis, analgesics, and sedatives.  

scholarly journals A cross sectional study of thrombocytopenia in malaria positive cases in a tertiary care hospital of Bareilly

2019 ◽  
Vol 6 (12) ◽  
pp. 5348
Author(s):  
Ajay K. Agarwal ◽  
Ghanshyam D. Katiyar ◽  
Swati Khan ◽  
Bharat C. Chaudhary ◽  
Mahendra Sharma ◽  
...  
Keyword(s):  
Ethylenediaminetetraacetic Acid ◽  
Tertiary Care ◽  
Plasmodium Species ◽  
Rapid Test ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Endemic Region ◽  
Cross Sectional ◽  
Male Predominance

Background: To find out correlation of thrombocytopenia with malaria. Malaria is a protozoal disease caused by infection with parasite of genus Plasmodium. Thrombocytopenia is a common and early sign of malarial infection and 60-80% thrombocytopenia is observed in malarial cases and present more frequently and severe in complicated P. falciparum malaria.Methods: A cross sectional study done in Central Pathological Lab of Department of Pathology, RMCH, Bareilly. Blood samples collected in ethylenediaminetetraacetic acid vial and blood smear was examined for malaria parasite within red blood cells. Malaria rapid test was done for detection of Plasmodium species and platelet count was done.Results: 780 cases of malaria was studied from September 2018 to December 2018, male predominance of 54.5%, maximum malarial positive cases 26.92% in the age group of 21-30 years, maximum 86.28% cases were of P. vivax, and thrombocytopenia was observed in 91.54% cases.Conclusions: Mostly developing countries with limited resources and trained health manpower are malaria-endemic region of world. Thrombocytopenia is associated with both P. vivax and P. falciparum infections. In our study significance association between malaria and thrombocytopenia has been observed. We suggest malaria should be a consideration in all patients with fever and thrombocytopenia.

scholarly journals Real Time-PCR (RT-PCR) Positivity for SARS-CoV-2 in Suspected COVID-19 Patients Presented in a Tertiary Care Hospital

2020 ◽  
pp. 67-70 ◽  
Author(s):  
Sarmistha Biswas ◽  
Khan Abul Kalam Azad ◽  
Mohammad Mahfuzul Hoque ◽  
Syed Ghulam Mogni Mowla ◽  
Sultana Shahana Banu ◽  
...  
Keyword(s):  
Virus Disease ◽  
Tertiary Care ◽  
Early Period ◽  
High Rate ◽  
World Health ◽  
Care Hospital ◽  
Rt Pcr ◽  
College Hospital ◽  
Cross Sectional ◽  
Male Predominance

Introduction: Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a newly emergent virus. World Health Organization declared COVID-19 as pandemic on March 11, 2020 for its rapid spreading. Not only to diagnose the disease (confirm case) but also to control and contain the transmission; test, trace and isolation are fundamental. RT-PCR for SARS-CoV-2 is used to detect and diagnose COVID-19 which started in Dhaka Medical College Hospital (DMCH) on 2nd April 2020. In this study we described our observation of RT-PCR done in patients presented in DMCH in the first month after starting the test. Methods: This observational, cross sectional study was done to find out the rate of RT-PCR positivity in suspected COVID -19 patients presented to DMCH from 2nd April to 3rd May, 2020 by the Department of Medicine in association with the Department of Virology. Data was collected from the registry book of the Department of Virology. The rate of RT-PCR for SARS-CoV-2 positivity among the suspected COVID-19 patients and demographical variable was observed. Results: Among the total studied patients (n=3206), 58.8% (n=1886) was male and mean age was 37.7(±14.38784) years. RT-PCR for SARS- CoV-2 was positive in 26.9% (n=864). Mean age was higher in patients positive for test (39.6± 15.9 year vs. 37±14.4 year). Male predominance was more marked in patients with positive PCR test (68.4 vs. 55.9). Conclusion: High rate of positivity of RT PCR for SARSCoV- 2 among the suspected patient for COVID 19 indicated high disease burden and transmission in this highly populated area in the early period of pandemic which should be considered as was alarming. J Bangladesh Coll Phys Surg 2020; 38(0): 67-70

scholarly journals An Epidemiological Study of Acute Poisoning In a Tertiary Care Centre

2021 ◽  
Vol 9 (2) ◽  
pp. 34-37
Author(s):  
Pankaj Kumar Jain ◽  
Kamalesh Katara ◽  
S. Jelia
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Gastric Lavage ◽  
Acute Poisoning ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
College Hospital ◽  
Cross Sectional ◽  
Epidemiological Aspect ◽  
Male Predominance

Introduction: Acute poisoning represents a real health threat in the world. It is a common cause of admission to emergency department and in intensive care unit. Periodic clinical and epidemiological studies are required to understand the pattern of poisoning. This study aims to analyze epidemiological aspect, clinical profile, and outcome of acute poisoning in a tertiary care hospital. Material and Methods: A cross sectional study was conducted at Government Medical College Hospital, Kota, Rajasthan. 102 admitted patients were taken for study from January 2020 to August 2020. Epidemiological variables age, sex, type of poison, mode of exposure, clinical presentation and outcome were studied. Results: The median age was 30.23 years with a male predominance (54.9%). The circumstances of poisoning were suicidal, accidental and unknown in 88.2%, 9.8%, and 1.96% respectively. Ingestion was the major route of exposure (98%) followed by inhalation (1.96%). The majority 33(32.4%) of cases were of Organophosphorus poisoning followed by 17(16.7%) cases of Rodenticide poisoning. The main symptoms were nausea and vomiting in 90(88.2%) cases. Convulsions were noted in 3(2.9%) patients. Gastric lavage was done for 92(90.19%). 8 patients (7.84%) were needed mechanical ventilation. 7 patients (6.86%) were needed vasoactive drugs. The rate of mortality was 8.82%. The aluminium phosphide poisoning was responsible for 44.4% deaths. Conclusion: Study revealed the high mortality associated with acute poisoning. Appropriate approach towards poisoning at tertiary care center and prevention remains the best strategy for reducing morbidity and mortality.

scholarly journals Knowledge, practice and experiences of parents with a thalassemic child

2017 ◽  
Vol 4 (5) ◽  
pp. 1630 ◽  
Author(s):  
Amit Saxena ◽  
Mumtaz Sharif ◽  
Sadaf Siddiqui ◽  
Swati Singh
Keyword(s):  
Blood Transfusion ◽  
Financial Burden ◽  
Genetic Disorder ◽  
Good Practice ◽  
Tertiary Care ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Care Hospital ◽  
Cross Sectional ◽  
Adequate Knowledge

Background: Thalassaemia is a chronic disorder requiring lifelong transfusions and medications causing emotional and financial burden to the family. This study was done to assess the knowledge and awareness of parents having a thalassemic child and to ameliorate their experiences in the upbringing of their child.Methods:A cross sectional, descriptive study was conducted in Pediatric Ward of a Tertiary care Hospital in Navi Mumbai from May-August 2016 in which parents of 40 beta Thalassemia major children between age group of 6 months to 15 years were enrolled. Parents were interviewed through a questionnaire to assess their knowledge, awareness, the practices they follow in regard to the transfusion, treatment, vaccination and prevention of thalassemia. The study also focuses on the emotional suffering of the parents.Results: 47.5% of parents were aware of thalassemia being a genetic disorder.62.5% were aware of regular blood transfusion. 23 parents were aware of the regular medications taken by their children. 42.5% parents had adequate knowledge of the optional vaccines to be taken. 90% parents followed a good practice of getting their child for regular blood transfusion and 92.5% gave them regular medicines.31 parents would periodically get their child investigated but 65% of parents lacked in giving optional vaccines to the child.60% agreed to undergo MTP while only 45% knew about the antenatal detection.Conclusions:Majority of parents followed good practice and had a positive attitude, though the knowledge and awareness about the disease was inadequate. 

Sign in / Sign up

Export Citation Format

Share Document