LABORATORY PROFILE OF INDOOR PATIENTS ADMITTED WITH ACUTE ENCEPHALITIC SYNDROME IN A TERTIARY CARE CENTRE OF NORTH-BENGAL

2021 ◽  
pp. 76-78
Author(s):  
Smarajit Banik ◽  
Debasis Chakrabarti ◽  
Sandip Saha ◽  
O P. Pandey ◽  
Dipanjan Bandyopadhyay

Background: Acute encephalitis syndrome (AES) is dened as the acute-onset of fever and a change in mental status (including signs and symptoms such as confusion, disorientation, delirium or coma) and/or new-onset of seizures (excluding simple febrile seizures) in a person of any age at any time of the year. Most AES is considered to be due to a viral-encephalitis, virus like West Nile, Herpes simplex virus, Flaviviruse like JE and dengue are more prevalent in South East Asia. Methods: This observational Cross sectional Study was conducted in the indoor patients of Department of Medicine at Tertiary care Hospital in North Bengal from May 2013 to April 2014. All consecutive patients of AES admitted during this period were included in the study. The study region covers the various districts of North Bengal. Template was generated in MS excel sheet and analysis was done on SPSS 20.0 software. Results: Among 104 acute encephalitis syndrome patients, 68 (65.38%) were male and 36 (34.62%) were female. The majority of pts (54.81%) were >40yrs of age. The lowest wbc count was 3000/cumm and highest was 21,200/cumm with mean wbc count being 10462.56±3567.832/cumm. Asignicant number 56 (53.85%) of patients had serum potassium levels between 2.5-3.5meq/dl. The no. of JE Positive patients was 75 (72.12%) which may be due to the local endemicity of the disease Conclusions: Majority of cases were in the age-group of more than 40 years, with male predominance. The no. of JE Positive patients was 75 (72.12%) which may be due to the local endemicity of the disease.

2021 ◽  
pp. 71-73
Author(s):  
Sharma S ◽  
Chakrabarti D ◽  
Saha S ◽  
Banik S ◽  
Mondal S

Introduction: The clinical features of Acute Encephalitis syndrome (AES) vary widely across the world and little documentation is available from North Bengal. Materials and methods: A cross –sectional observational study was conducted at the Department of Medicine of a teaching hospital in North Bengal. 104 AES cases were enrolled and clinically evaluated and investigated as per the study protocol. Results:JE (72%) was most common causative agent followed by HSV Encephalitis (11.5%), Scrub Typhus (9.6%) and Dengue Encephalitis (2.88%). Male cases were predominant than female in our study. Fever and altered sensorium were most common presentation followed by seizures (51.9%), headache (29.8%), vomiting (18.2%), and hemiplegia (4.8%). Neurological evaluation revealed 80% of the patients had neck stiffness followed by positive Babinski sign (45.19%) and hypertonia (35%). Conclusions: JE is the commonest cause of AES in North Bengal and seizures are the commonest neurological manifestation after altered sensorium.


2021 ◽  
Vol 9 (2) ◽  
pp. 34-37
Author(s):  
Pankaj Kumar Jain ◽  
Kamalesh Katara ◽  
S. Jelia

Introduction: Acute poisoning represents a real health threat in the world. It is a common cause of admission to emergency department and in intensive care unit. Periodic clinical and epidemiological studies are required to understand the pattern of poisoning. This study aims to analyze epidemiological aspect, clinical profile, and outcome of acute poisoning in a tertiary care hospital. Material and Methods: A cross sectional study was conducted at Government Medical College Hospital, Kota, Rajasthan. 102 admitted patients were taken for study from January 2020 to August 2020. Epidemiological variables age, sex, type of poison, mode of exposure, clinical presentation and outcome were studied. Results: The median age was 30.23 years with a male predominance (54.9%). The circumstances of poisoning were suicidal, accidental and unknown in 88.2%, 9.8%, and 1.96% respectively. Ingestion was the major route of exposure (98%) followed by inhalation (1.96%). The majority 33(32.4%) of cases were of Organophosphorus poisoning followed by 17(16.7%) cases of Rodenticide poisoning. The main symptoms were nausea and vomiting in 90(88.2%) cases. Convulsions were noted in 3(2.9%) patients. Gastric lavage was done for 92(90.19%). 8 patients (7.84%) were needed mechanical ventilation. 7 patients (6.86%) were needed vasoactive drugs. The rate of mortality was 8.82%. The aluminium phosphide poisoning was responsible for 44.4% deaths. Conclusion: Study revealed the high mortality associated with acute poisoning. Appropriate approach towards poisoning at tertiary care center and prevention remains the best strategy for reducing morbidity and mortality.


Author(s):  
Renu Sulakhe Vasant ◽  
Lavanya K. M. Rao ◽  
Nageswara Rao V.

Background: Low birth weight (LBW) is one of the commonest cause for infant and childhood morbidity and mortality. The majority of low birth weight in developing countries is due to intrauterine growth retardation, while most low birth weight in industrialized countries is due to preterm birth. LBW is the single most important factor determining the survival chances of the child. The objectives of the study were to assess the proportion of low birth weight among babies delivered by mothers at a tertiary care hospital and to analyse the relationship between low birth weight and certain socio-demographic factors.Methods: A cross-sectional study conducted in a tertiary care centre for a period of six months.Results: The prevalence of LBW was 23.5%. The proportion of mothers having low birth weight was maximum in women aged less than 18 years (35%) and more than 30 years (26.5%). Muslim women had a higher proportion of LBW (28.8%). LBW was more in women belonging to joint family (30.0%), low per capita income group and illiterates.Conclusions: The prevalence of LBW still continues to be high, almost one fourth of the babies are LBW. Different socio-demographic characteristics of the population are still the important factors determining the occurrence of LBW.


Author(s):  
Swathi Karanth M.P ◽  
Somashekar M ◽  
Anushree Chakraborty ◽  
Swapna R ◽  
Akshata J.S ◽  
...  

Background: The shorter regimen was widely accepted and advocated for MDR-TB treatment compared tothe conventional longer regimen. Evaluating the performance of both regimens in a programmatic setting will help in tailoring the treatment regimen of MDR-TB. Objectives: 1. To estimate the duration of sputum smear conversion in the shorter MDR-TB regimen. 2. To compare the treatment outcomes of the shorter MDR-TB regimen with that of the longer conventional MDR regimen in a programmatic set up in India. 3. To estimate the adverse drug reactions in the shorter MDR-TB regimen. Methods: A retrospective cross-sectional study was conducted on 320 patients enrolled under programmatic management of drug resistant tuberculosis (PMDT) from April 2017 to May 2019 at a nodal DRTB center and a tertiary care hospital in India. Demographic and clinical characteristics of those who received a shorter MDR-TB regimen were recorded. Treatment outcomes of both regimens were recorded. Treatment success is defined as ‘disease cured and treatment completed’, whereas treatment failure was considered when the treatment was either terminated or changed due to lack of bacteriological conversion at the end of an extended intensive phase or culture reversion in the continuation phase. Results: The treatment success observed in the shorter MDR-TB regimen was 61.25%, which was significantly higher than the conventional longer regimen (p=0.0007). Treatment failures were higher with a shorter MDR-TB regimen (p=0.0001). Conclusion: Treatment success with the shorter MDR-TB regimen though higher than the conventional regimen, is still way behind the target treatment success rate. Improving treatment adherence remains pivotal for achieving end TB targets.


2021 ◽  
Vol 8 (3) ◽  
pp. 99-103
Author(s):  
Dr. Urmila Gavali ◽  
Dr. Mayuri Pawar ◽  
Dr. Gautam Aher ◽  
Dr. Suhas Shinde

ABSTRACT: Background: Polycystic ovarian syndrome (PCOS)is common gynecological endocrinopathy characterized by chronic anovulation and hyperandrogenism affecting 5-10% of women worldwide.  It is a heterogenous, multifactorial, complex genetic disorder with uncertain etiology and is one of the most common treatable cause of infertility. AIM: To study the various clinical presentations in polycystic ovarian syndrome. MATERIALS AND METHODS: Present study is cross sectional observational study carried out in tertiary care centre. This study was performed in the Out Patient Department of Obstetrics and Gynecology. RESULTS: The mean age of 41 patients in the study was 23.6 years. Most common presenting symptom in patients is menstrual irregularities (89%) followed by infertility and hirsutism. USG (abdo+pelvis) showing polycystic ovarian syndrome ovaries. Around 39% patients with PCOS developed insulin resistance. KEYWORDS: - Amenorrhea, Infertility, Oligomenorrhea, Polycystic Ovarian Syndrome.


2017 ◽  
Vol 16 (4) ◽  
pp. 545-553 ◽  
Author(s):  
Mohammad Yousuf Rathor ◽  
Mohammad Arif Shahar ◽  
Ahmad Marzuki Bin Omar ◽  
Azarisman SM Shah ◽  
Mohammad Hadzri Hasmoni ◽  
...  

Objective: Patients beliefs determine their response to an illness and its management especially if it is chronic. Studies assessing patient’s knowledge of their epilepsy are scarce. We report the first objective study evaluating knowledge, attitude and practices of epilepsy patients referred to a tertiary care centre in East Coast of Malaysia.Materials and Methods: A cross sectional study using pre-tested, semi-structured questionnaire among consenting epilepsy patients.Results: The demographic details and responses to a questionnaire assessing their insight towards epilepsy were recorded. Among 132 respondents, 51.5% were male and 48.5 % were female. Their age ranged from 14 to 70 years (mean = 31.63 ± 13.41). Majority (53.8%) of them aged equal or less than 30 years. The median number of years they had epilepsy was 8.0 (4.0, 18.8) years and average duration of seizure prior to seeking medical attention was 1.0 (0.3, 4.5) years. The average number of years they were receiving treatment from a hospital was 5.50 ± 5.84. Most (90.9%) did not know the cause of epilepsy; however 93.9 % were aware that it can be treated with modern drugs. While only 22.7 % believed that faith healers can treat epilepsy, 74.2% had tried other forms of treatment. Negative attitude was reflected in the belief that epilepsy is due to supernatural powers (1.5%) and that epilepsy is contagious (17.4 %). Positive attitude included that PWE can take a job (66.7%), allowing a child with epilepsy to study (80%), not objecting children to play with a child with epilepsy (54.5%), marry (65.9%) and having children (58.3%).Conclusions: Patients with epilepsy are not knowledgeable about their disorder. This is true regardless of age, educational background, or number of years with epilepsy. The results suggest that there is a critical need to enhance epilepsy education and improve attitudes towards epilepsy beyond seizure control.Bangladesh Journal of Medical Science Vol.16(4) 2017 p.545-553


Author(s):  
Ram Chandra Bhadra ◽  
Dona Saha ◽  
Arjun Baidya

Introduction: Idiopathic hypogonadotropic hypogonadism is a rare gonadal dysgenesis in which puberty does not take place naturally. It occurs due to insufficient pulsatile secretion of Gonadotrophin-Releasing Hormone (GnRH) and the resulting Follicle-Stimulating Hormone (FSH) and Luteinising Hormone (LH) deficiency leads to absence of or delayed sexual maturation. Kallmann syndrome is an uncommon genetic disorder characterised by hypogonadotropic hypogonadism associated with anosmia or hyposmia. When anosmia is absent, the same is referred as normosmic Idiopathic Hypogonadotropic hypogonadism (nIHH). Aim: To find out the significant differences between Kallmann syndrome and nIHH based on clinical features and biochemical assessment as a primary measure to initiate the treatment early. Materials and Methods: This hospital based cross-sectional observational cohort study was conducted in Department of Endocrinology, Nilratan Sircar Medical College and Hospital, Kolkata, India. The study was done on 55 cases of IHH presenting to the department with delayed secondary sexual characteristics. Results: Out of these 55 cases, 45 (81.8%) were of nIHH and only 10 (18.2%) cases were of Kallmann Syndrome. It was found that both the conditions show male predominance. Smell abnormalities were present only in Kallmann group. The level of serum testosterone was significantly higher (p<0.05) in nIHH subjects (mean-35.59 ng/dL) than patients with Kallmann Syndrome (mean-14.90 ng/dL). Patients with Kallmann syndrome showed significantly reduced pubic and axillary hair development and absence of gonadal development. Conclusion: Absence of puberty with anosmia/hyposmia with low serum FSH and LH, drastically reduced serum testosterone, are factors that point towards the diagnosis of Kallmann syndrome even in absence of genetic study, which is helpful for initiation of hormone replacement therapy for treatment.


Author(s):  
Nisha Murmu ◽  
Pushpa . ◽  
Anit Kujur ◽  
Vidya Sagar ◽  
Vivek Kashyap

Background: Infectious diseases have a major contribution in the mortality and morbidity among children in India. The aim of our study was to assess the infectious diseases and the sociodemographic characteristics along with the assessment of awareness on mode of transmission of these diseases among the family members.Methods: This was a cross-sectional study done in Department of Pediatrics, RIMS, Ranchi, for a period of 6 months by consecutive sampling. Pre-tested, semi structured questionnaire was used for data collection and analysed in SPSS version 20.Results: A total of 220 children were included in the study. Majority of patients (60%) comprised of under 5 age group with male predominance (55%), with 84.1% children fully immunized, among which 54.1% were institutional deliveries and approx. 85.9% children were breast fed for more than 6 months. Malaria, being an endemic disease of Jharkhand affected maximum children (38.2%). Sanitation, (toilet facilities) was about 27% and hand hygiene was only 5% in the family members of the patients admitted. Thus lack of awareness and poor hand hygiene was an important finding in our result.Conclusions: Health education among the community should be the prime concern for the reduction of the diseases.


Author(s):  
KMS Mohamed Ali ◽  
K Girija

Blood stream infections are the most important and common cause of morbidity and mortality in tertiary care hospitals. Since the results are usually not available promptly a knowledge of epidemiologic and antimicrobial susceptibility pattern of blood pathogens is life saving and very useful for early treatment and recovery of patients. The aim of this study is to describe the epidemiological, bacterial profile and antimicrobial resistance pattern of bloodstream infections in a tertiary care centre.A prospective cross-sectional study was done on seven hundred and eight blood samples collected over a period of six months in the Microbiology laboratory. Blood samples collected under aseptic conditions were cultured by aerobic culture method. Identification of bacterial isolates were done using standard bacteriologic and biochemical testing methods and antibiotic sensitivity testing done by Kirby - Bauer disc diffusion method.Bacteria was isolated in 201 (28.3%) samples with highest rates among newborns 84(41.8%). The most frequent isolates were 111 (55.2%) followed by 49 (24.4%). Results showed high susceptibilities of CoNS 111 (100%) to Vancomycin, Linezolid and 51 (98%) to Meropenem. This study highlights the common prevalent bacteriological agents in bacteremia, their antibiotic susceptibility & resistance patterns. and multi drug resistant were the leading causes of septicaemia in our hospital with Vancomycin, Linezolid and Carbapenems the effective antibiotics against these pathogens respectively.


Author(s):  
Ashis Samuel John ◽  
Kamaxi M. Bhate

Background: Inadequate understanding by patients of medical prescription given to them adversely affects treatment compliance; which can result in treatment failure and increase the incidence of adverse effects. The study site is a tertiary care hospital in a metropolitan city and the patients attending here are particularly vulnerable in this regard both due to the heavy patient load in the outpatient department and their low socioeconomic status.Methods: This was a cross sectional study conducted in the pharmacy of K.E.M. Hospital, Mumbai over a period of 1 month. Study population included general outpatient department patients of the hospital. Patients were interviewed using a pre validated questionnaire and their knowledge of the prescription analysed under five key aspects including dose, timing, duration, side effects and purpose of each drug. Data was entered using Microsoft Excel and analyzed using SPSS 22 software.Results: The mean age of the population was 37.6, with a standard deviation of 12.4. A good overall knowledge of the prescription was present only in 12.4% patients. In 52% of patients, the level of knowledge ranged from ‘no knowledge to little knowledge’. Age and literacy had statistically significant associations with overall knowledge of prescription.Conclusions: There is a significant gap in prescription knowledge in the study population. Age and literacy of the patient has an effect on prescription knowledge.


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