scholarly journals Regulation of Autophagy and Inflammation Through Physical Exercise in Patients with Chronic Kidney Disease: Protective Factor in Individuals Affected by COVID-19

2021 ◽  
pp. 66-76
Author(s):  
Matheus Ribeiro Bizuti ◽  
Júlia Leão Batista Simões ◽  
Gabriel Rossi Francisco ◽  
Gabrielli Drechsler ◽  
Fabiana Brum Haag ◽  
...  
Keyword(s):  
Physical Activity ◽  
Chronic Kidney Disease ◽  
Immune System ◽  
Kidney Disease ◽  
Physical Exercise ◽  
Protective Factor ◽  
Severe Form ◽  
World Health ◽  
Increased Risk ◽  
Health Organization

In March 11, 2020, the World Health Organization (WHO) characterized the rapid and uncontrollable spread of the new Coronavirus as a pandemic, given that this disease has high severity and morbidity and mortality. The epicenter of the SARS-CoV-2 outbreak was the city of Wuhan, China. Individuals with associated comorbidities, such as patients with chronic kidney disease (CKD), are at increased risk of being affected by the severe form of the disease. In this sense, it is known that people with CKD have a more sedentary lifestyle, with reduced physical exercise. Thus, physical exercise is able to modulate the inflammatory process resulting from CKD, acting as a regulator of the immune system, as well as assisting in the control of renal autophagy. It appears that physical activity contributes to the improvement of the population's quality of life and acts as an effect of disease prevention. Hence, people who live with CKD in times of the pandemic of COVID-19, by adopting physical activity as a life practice, will have the consequence of strengthening the immune system by modulating inflammation and increasing the control of renal autophagy. Therefore, the practice of exercise is suggested when facing COVID-19.

Risk Factor Identification, Classification and Prediction Summary of Chronic Kidney Disease

2020 ◽  
Vol 13 ◽  
Author(s):  
Pramila Arulanthu ◽  
Eswaran Perumal
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Diagnosis ◽  
Medical Data ◽  
Machine Learning Algorithms ◽  
World Health ◽  
Medical Field ◽  
Data Set ◽  
Medical Issues ◽  
Health Organization

: The medical data has an enormous quantity of information. This data set requires effective classification for accurate prediction. Predicting medical issues is an extremely difficult task in which Chronic Kidney Disease (CKD) is one of the major unpredictable diseases in medical field. Perhaps certain medical experts do not have identical awareness and skill to solve the issues of their patients. Most of the medical experts may have underprivileged results on disease diagnosis of their patients. Sometimes patients may lose their life in nature. As per the Global Burden of Disease (GBD-2015) study, death by CKD was ranked 17th place and GBD-2010 report 27th among the causes of death globally. Death by CKD is constituted 2·9% of all death between the year 2010 and 2013 among people from 15 to 69 age. As per World Health Organization (WHO-2005) report, 58 million people expired by CKD. Hence, this article presents the state of art review on Chronic Kidney Disease (CKD) classification and prediction. Normally, advanced data mining techniques, fuzzy and machine learning algorithms are used to classify medical data and disease diagnosis. This study reviews and summarizes many classification techniques and disease diagnosis methods presented earlier. The main intention of this review is to point out and address some of the issues and complications of the existing methods. It is also attempts to discuss the limitations and accuracy level of the existing CKD classification and disease diagnosis methods.

scholarly journals The Unravelled Link between Chronic Kidney Disease and Hepatitis C Infection

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Fabrizio Fabrizi ◽  
Piergiorgio Messa ◽  
Paul Martin
Keyword(s):  
Chronic Kidney Disease ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Kidney Disease ◽  
Renal Disease ◽  
Chronic Renal Disease ◽  
World Health ◽  
Adjusted Relative Risk ◽  
Hepatitis C Infection ◽  
Increased Risk

The 2011 report of the World Health Organization General Assembly on noncommunicable diseases identified chronic kidney disease as a worldwide health issue posing a heavy economic burden. Hepatitis C virus infection, which is responsible for over 1 million deaths resulting from cirrhosis and liver cancer, is linked to chronic kidney disease in several ways; some forms of renal disease are precipitated by hepatitis C and patients with end-stage chronic renal disease are at increased risk for acquiring HCV. The aim of this review is to update the evidence on the relationship between hepatitis C infection and chronic kidney disease. Information has been accumulated in the last decade indicating that HCV plays an adverse effect on the incidence and progression of chronic kidney disease; a novel meta-analysis of observational studies (seven longitudinal studies; 890,560 unique individuals) found a relationship between hepatitis C seropositivity and incidence of reduced estimated glomerular filtration rate (adjusted relative risk, 1.70; 95% CI, 1.20; 2.39; P=0.002) in the adult general population. In addition to conventional risk factors, hepatitis C may be an additional factor for the development of chronic kidney disease, and an atheromasic activity of hepatitis C virus has been mentioned. The link between hepatitis C and atherosclerosis could also explain the excess risk of cardiovascular mortality that has been observed among hepatitis C virus seropositive patients undergoing maintenance dialysis. A number of biologically plausible mechanisms related to hepatitis C virus have been hypothesized to contribute to atherosclerosis. Implementation of effective treatment intervention towards hepatitis C is required to decrease the healthcare burden of hepatitis C and to prevent the progression of chronic renal disease.

scholarly journals Physical Exercise in People with Chronic Kidney Disease—Practices and Perception of the Knowledge of Health Professionals and Physical Activity and Sport Science Professionals about Their Prescription

2022 ◽  
Vol 19 (2) ◽  
pp. 656
Author(s):  
Víctor Martínez-Majolero ◽  
Belén Urosa ◽  
Sonsoles Hernández-Sánchez
Keyword(s):  
Physical Activity ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Physical Exercise ◽  
Health Professionals ◽  
Chi Square ◽  
Sport Science ◽  
Ex Post ◽  
Ex Post Facto ◽  
Training Programmes

There is evidence on the need to include physical exercise as a treatment for diseases. A large number of professionals are involved in this, but it is not known how physical exercise is prescribed and which professionals are involved. This research has two objectives: (a) to find out the current practices in Spain regarding the prescription of physical exercise in patients with Chronic Kidney Disease (CKD) and (b) to analyse the perception that different health and physical activity professionals have of their knowledge to prescribe of physical exercise in the treatment of CKD. This is an empirical research with an ex post facto retrospective analysis of the information in a descriptive and correlational way. A total of 692 health and sports professionals participated. A questionnaire validated by a committee of experts was administered. Descriptive analyses were carried out and the differences in the study variables were analysed using Chi-square tests and one-factor Analysis of Variance. From the results obtained, we conclude there is a need to develop specific training programmes in the field of physical exercise for health professionals, as well as the establishment of multiprofessional teams for the prescription of physical exercise in CKD treatment, including physical exercise professionals (Cafyde).

scholarly journals Physical activity in chronic kidney disease and the EXerCise Introduction To Enhance trial

2020 ◽  
Vol 35 (Supplement_2) ◽  
pp. ii18-ii22 ◽  
Author(s):  
Francesca Mallamaci ◽  
Anna Pisano ◽  
Giovanni Tripepi
Keyword(s):  
Physical Activity ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Clinical Outcomes ◽  
Sedentary Lifestyle ◽  
Public Health Problem ◽  
Epidemiological Studies ◽  
Dialysis Patients ◽  
Increased Risk ◽  
Reduced Physical Activity

Abstract It is well known from observational studies that sedentary lifestyle and reduced physical activity are common in dialysis and chronic kidney disease (CKD) patients and associate with an increased risk of morbidity and mortality in this patient population. Epidemiological studies indicate that CKD patients undergo physical activity ~9 days/month and 43.9% of dialysis patients report not exercising at all. On the basis of awareness about the strong link between sedentary lifestyle and adverse clinical outcomes, the National Kidney Foundation and Kidney Disease: Improving Global Outcomes have provided specific recommendations for physical activity in patients with kidney disease. Given the fact that CKD is a public health problem and it is still debated which type of exercise should be prescribed in these patients, this review focuses on the most robust evidence accumulated so far on the beneficial effect of various types of physical exercise on clinical outcomes in CKD and dialysis patients. This review does not treat this very important topic in another CKD category of patients, such as kidney-transplanted patients, for whom a special issue should be dedicated.

scholarly journals Vitamin D and atherosclerosis

2021 ◽  
Vol 12 (1) ◽  
pp. 99-108
Author(s):  
Vesna Lazić ◽  
Biljana Mijović ◽  
Miloš Maksimović ◽  
Olivera Rašević ◽  
Maida Mulić ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
World Health ◽  
Risk Marker ◽  
Increased Risk ◽  
The World ◽  
Calcium And Phosphorus ◽  
Health Organization

Cardiovascular diseases rank first on the mortality list globally or 31%. The basic measure of prevention in accordance with the recommendations of the World Health Organization is a change in risk lifestyle in terms of diet, physical activity, tobacco and alcohol consumption. Vitamin D was previously recognized as a regulator of calcium and phosphorus ratio, bone remodeling or the main controller of skeletal pathophysiology. However, vitamin D enjoys great interest in clinical and epidemiological research in terms of its possible impact on reducing the risk of cardiovascular diseases. Among other things, vitamin D deficiency is associated with an increased risk of endothelial dysfunction. Although the deficiency has been identified as a risk marker for cardiovascular diseases, the mechanism of action of vitamin D on the path from endothelial dysfunction to cardiovascular diseases has not been fully revealed. The findings in this segment of activity of vitamin D would be significant in terms of reducing morbidity and mortality from cardiovascular diseases.

scholarly journals Interleukin 4: Its Role in Hypertension, Atherosclerosis, Valvular, and Nonvalvular Cardiovascular Diseases

2019 ◽  
Vol 25 (1) ◽  
pp. 7-14
Author(s):  
Kamal M. Kassem ◽  
Mahboob Ali ◽  
Nour-Eddine Rhaleb
Keyword(s):  
Risk Factors ◽  
Immune System ◽  
Cardiovascular Diseases ◽  
Cardiac Fibrosis ◽  
Ventricular Remodeling ◽  
World Health ◽  
Interleukin 4 ◽  
Immune Reactivity ◽  
Increased Risk ◽  
Health Organization

Hypertension is one of the major physiological risk factors for cardiovascular diseases, and it affects more than 1 billion adults worldwide, killing 9 million people every year according to World Health Organization. Also, hypertension is associated with increased risk of kidney disease and stroke. Studying the risk factors that contribute to the pathogenesis of hypertension is key to preventing and controlling hypertension. Numerous laboratories around to globe are very active pursuing research studies to delineate the factors, such as the role of immune system, which could contribute to hypertension. There are studies that were conducted on immune-deficient mice for which experimentally induced hypertension has been ameliorated. Thus, there are possibilities that immune reactivity could be associated with the development of certain type of hypertension. Furthermore, interleukin 4 has been associated with the development of pulmonary hypertension, which could lead to right ventricular remodeling. Also, the immune system is involved in valvular and nonvalvular cardiac remodeling. It has been demonstrated that there is a causative relationship between different interleukins and cardiac fibrosis.

scholarly journals Validation of the Brazilian version of WHODAS 2.0 in patients on hemodialysis therapy

2018 ◽  
Vol 31 (0) ◽  
Author(s):  
Shamyr Sulyvan Castro ◽  
Camila Ferreira Leite ◽  
Juliana Elisa Baldin ◽  
Marilita Falangola Accioly
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
World Health Organization ◽  
World Health ◽  
World Health Organization Quality ◽  
Brazilian Version ◽  
The World ◽  
Health Organization

Abstract Introduction: Chronic kidney disease and hemodialysis normally have an impact on the functioning. Objective: To validate the Brazilian version of the World Health Organization Disability Assessment Schedule 2.0 in individuals with chronic kidney disease on hemodialysis treatment. Methods: The 36-item version was applied to interview 51 individuals with chronic kidney disease undergoing dialysis treatment. To ascertain the instrument’s applicability, its internal consistency and test-retest stability were studied. To check the validity, a convergent/divergent analysis was performed. Results: The participants answered the questions on the main instrument at two timepoints and on the World Health Organization Quality of Life Abbreviated instrument and the Kidney Disease Quality of Life - Short FormTM 1.3 once each. Cronbach’s α coefficient was appropriate in all domains except the “Getting along” domain. The test-retest coefficients were above the recommended value (> 0.70). Convergent and divergent validity analysis also showed consistent results by correlation coefficient assessment. Conclusion: The instrument is valid and reliable. This study supports the use of the questionnaire by presenting its appropriate psychometric properties. We suggest that some care should be taken specifically in the sexual questions of the “Getting along” domain.

scholarly journals How to be physically active while social distancing? You need to exercise!

2021 ◽  
Vol 90 (2) ◽  
pp. 157-162
Author(s):  
Leonardo Gomes de Oliveira Luz ◽  
Marcos de Sá Rego Fortes ◽  
Geraldo de Albuquerque Maranhão Neto
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Activity Level ◽  
World Health ◽  
Moderate Physical Activity ◽  
Physically Active ◽  
Social Distancing ◽  
Insufficient Physical Activity ◽  
Health Organization ◽  
The Impact

Introduction: A coronavirus epidemic began in November 2019 (COVID-19) in the Chinese city of Wuhan. However, the current scenario shows the coexistence of other pandemics, the insufficient physical activity level and obesity, the effect of this combination tends to enhance the complications attributed to coronavirus infection. In this scenario, among other strategies to combat COVID-19, social distancing, and active lifestyle compatible with a healthy immune function are recommended. Objective: The aim of this study was to analyse the impact of COVID-19 pandemic over the populational habitual physical activity and recommend the inclusion of a physical exercise routine in your daily life. Conclusion: Moderate physical activity is indicated in order to meet the recent recommendations of the World Health Organization and to optimize the immune response. Therefore, the daily physical exercise should be included, especially at home in longer periods of social distancing.

scholarly journals Physical Activity Participation During the COVID-19 Pandemic

2020 ◽  
Vol 1 (1) ◽  
pp. 32-34
Author(s):  
Taemin Ha ◽  
Brian Dauenhauer
Keyword(s):  
Physical Activity ◽  
Vigorous Physical Activity ◽  
World Health ◽  
Moderate Intensity ◽  
Sedentary Behaviors ◽  
Unhealthy Lifestyle ◽  
Increased Risk ◽  
The World ◽  
Health Organization ◽  
Health Enhancing Physical Activity

Physical activity is a significant factor in enhancing quality of life due to its various physical and mental benefits. According to the World Health Organization (WHO, 2010), the recommended amount of physical activity for adults (>17 years old) is a minimum of 150 minutes of moderate-intensity activity or 75 minutes of vigorous-intensity activity every week, while the recommended amount for children and adolescents (5-17 years old) is at least 60 minutes of moderate-to-vigorous physical activity daily. However, when coronavirus disease 2019 (COVID-19) was declared a pandemic on March 11th, 2020 (WHO, 2020a), people around the world had to adapt to new lifestyles involving shelter-in-place and social distancing orders. This phenomenon has disrupted the ability to reach the recommended amount of physical activity for people of all ages (Carvalho & Gois, 2020). The sedentary behaviors adopted during this unprecedented time could, for many people, give rise to an unhealthy lifestyle, which by extension may lead to an increased risk of coronavirus. The purpose of this paper is to review the issue and discuss ways to participate in health-enhancing physical activity during the COVID-19 pandemic.

scholarly journals KADAR KALSIUM SERUM PADA LATIHAN FISIK INTENSITAS SEDANG MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANG

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Quincy R. Rompas
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Blood Serum ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
World Health ◽  
Moderate Intensity ◽  
The Mean ◽  
Health Organization

Abstract: Sedentary lifestyle according to World Health Organization (WHO) has been identified as the fourth biggest leading cause of death in the world in which already caused approximately 3,2 millions death globaly. Physical exerciseis defined as any body movement produced by the contraction of skeletal muscles that result in a substantial increase over resting energy expenditure. In muscle contraction, calcium is an essential substance for the muscle tissue to contract, so a maintaned calcium level is required in order for the process to be successfully achieved. The goal of this study is to know if there is a difference between blood serum calcium levelbefore and after moderate intensity physical exercise. This study was a pre-experimental study with one group pretest-posttest design approach and purposive sampling method was used to collect the samples. Thirty male and female medical students were evaluated to determine the blood serum calcium level. The mean blood serum calcium level before the physical activity were 9,227 mg/dL and the mean blood serum calcium level after the physical activity were 9,140 mg/dL. Based on Wilcoxon matched-pairs test, the correlation between physical activity and blood serum calcium were not significant (p=0.206). The result of the study suggests that there is no difference of the blood serum calcium before and after moderate intensity physical exercise. Keywords: serum calcium level, moderate intensity physical exercise, medical student     Abstrak: Keadaan fisik yang inaktif atau yang biasa disebut dengan Sedentary lifestyle menurut World Health Organization (WHO) telah diidentifikasikan sebagai faktor risiko penyebab kematian nomor empat di dunia yang diperkirakan telah menyebabkan kematian sekitar 3,2 juta orang secara global. Latihan fisik merupakan pergerakan tubuh dalam bentuk apa saja yang disebabkan oleh aktivitas sistem muskuloskeletal yang dalam prosesnya memerlukan energi. Pada proses kontraksi otot, kalsium merupakan unsur yang esensial sehingga diperlukan pasokan kalsium yang cukup agar proses ini dapat berlangsung dengan baik. Tujuan penelitian ini adalah untuk mengetahui bagaimana perbandingan kadar kalsium serum sebelum dan sesudah latihan fisik intensitas sedang pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi. Penelitian ini adalah penelitian pra-eksperimen dengan pendekatan one group pretest-posttest design dengan pengambilan sampel dengan carapurposive sampling. Tiga puluh orang mahasiswa Fakultas Kedokteran dipilih menjadi responden untuk diperiksa kadar kalsium serumnya. Dari hasil penelitian pengukuran kadar kalsium serum responden didapatkan nilai rata-rata sebelum latihan fisik sebesar 9,227 mg/dL dan nilai rata-rata sesudah latihan fisik sebesar 9,140 mg/dL. Berdasarkan uji statistik dengan Wilxocon test didapatkan nilai signifikansi sebesar 0,206. Dengan hasil penelitian ini dapat diambil kesimpulan bahwa tidak ada perbedaan kadar kalsium yang signifikan antara sebelum dan sesudah latihan fisik intesitas sedang. Kata kunci: kadar kalsium serum, latihan fisik intensitas sedang, mahasiswa fakultas kedokteran

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