scholarly journals Serum Hepcidin as an Inflammatory Marker in Chronic Kidney Disease

2020 ◽  
pp. 40-45
Author(s):  
Jyothi Elizabeth Roy ◽  
B. Shanthi ◽  
V. S. Kalai Selvi
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Iron Homeostasis ◽  
Inflammatory Marker ◽  
The Body ◽  
Strong Positive Correlation ◽  
Cross Sectional ◽  
Mean Values ◽  
Serum Hepcidin ◽  
The Mean

Background: Hepcidin is known to be the central regulator of iron homeostasis in the body. It is up-regulated by inflammation and downregulated by anemia. CKD is a state of chronic inflammation seen in kidney. Previous work has shown that serum hepcidin levels were increased in patients with CKD. This was surprising as these patients had a chronic inflammatory state and co-existent anemia. Aim and Objectives: The aim of the study is to estimate the levels of hepcidin in CKD patients and to check the correlation of hepcidin to inflammation in chronic kidney disease. Methods: This cross-sectional study was conducted at the Department of Biochemistry, Central Laboratory, Sree Balaji Medical College and Hospital, Chromepet, Chennai during January 2017 - June 2018 among 50 patients of chronic kidney disease in the age group of 18-60 years. The blood samples were collected using vacutainer system. Samples for serum hepcidin, ferritin and hsCRP were collected in red topped plain vacuum tube. The samples were centrifuged at 3000 rpm for 15 minutes. The samples were then processed, and values were obtained. The data were analysed using SPSS package. Results: The mean values of s. Hepcidin, s. ferritin and hsCRP levels were found to be increased in the study population. The mean value of s. hepcidin was found to have strong positive correlation with the mean values of s. ferritin and hsCRP with r-value > 0.7. Conclusion: Hepcidin levels are elevated in CKD and hepcidin is a predictor of inflammation since it correlated well with the inflammatory markers hsCRP and ferritin levels.

scholarly journals Increased Interleukin-6 as Infl ammatory Response and Magnesium Defi ciency in Pre-dialysis Chronic Kidney Disease of Indonesian Children

2021 ◽  
Vol 9 (2) ◽  
pp. 93
Author(s):  
Astrid Kristina Kardani ◽  
Ninik Asmaningsih Soemyarso ◽  
Jusli Aras Aras ◽  
Risky Vitria Prasetyo ◽  
Mohammad Sjaifullah Noer
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Interleukin 6 ◽  
Inverse Correlation ◽  
Cross Sectional Study ◽  
The Body ◽  
Cross Sectional ◽  
Duration Of Illness ◽  
History Of ◽  
Spearman’S Correlation

Chronic kidney disease (CKD) is a serious health problem in children, with increasing morbidity and mortality rates throughout the world. Children with CKD tend to experience magnesium (Mg) defi ciency that can stimulate an infl ammatory response in the body. One of the infl ammatory responses is an increase of Interleukin-6 (IL-6).  Study to analyze the correlation between Mg and IL-6 in pre-dialysis CKD children. The methods a cross sectional study was conducted in Dr Soetomo General Academic Hospital from November 2018 to April 2019. Children with pre-dialyis CKD were included in this study. Variables of serum Mg level (mg/dL) and infl ammatory marker (IL-6) were measured from the blood and analyzed by ELISA method. The correlation between Mg and IL-6 was analyzed with Spearman’s correlation test with p <0.05.  Result a total of 47 children (27 boys vs 20 girls) between 3 months to 18 years old, with pre-dialysis CKD and no history of magnesium supplementation were included. The primary disease that causes of CKD were lupus nephritis (38.3%), nephrotic syndrome (23.4%), urologic disorder (23.4%),  tubulopathy (10.6%) and others (4.3%). The average IL-6 level was 55.42±43.04 pg/dL and Mg level was 2.06±1.54 mg/dL. There were no signifi cant correlation between IL-6 level and Mg level with staging of CKD and duration of illness (p>0.05), but there was a signifi cant correlation between serum Mg level and IL-6 level (r=-0.748; p<0.001). Magnesium levels have a signifi cant inverse correlation with IL-6 levels in pre-dialysis CKD children. The lower the Mg levels in the blood, the higher IL-6 levels and vice versa. 

The Impact of Inflammatory Profile on Selenium Levels in Hemodialysis Patients

2020 ◽  
Vol 19 (1) ◽  
pp. 42-49
Author(s):  
Marcelo R. Bacci ◽  
Lívia S.S. Cabral ◽  
Glaucia L. da Veiga ◽  
Beatriz da C.A. Alves ◽  
Neif Murad ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Inflammatory Marker ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Biochemical Tests ◽  
Cross Sectional ◽  
Inflammatory Profile ◽  
The Impact

Introduction: Hemodialysis stands out as an eligible treatment for patients with chronic kidney disease. The subsequent inflammatory process resulting from this disease and hemodialysis per se is exacerbated in this therapy. Selenium (Se) is an essential trace element that can participate in the inhibition of pro-oxidant and pro-inflammatory processes and could be considered a measurement that indicates the progression of chronic kidney disease and inflammation. Objective: The present study investigated selenemia in hemodialysis patients of the ABC region of São Paulo and aimed to establish the correlation between an inflammatory marker and selenemia in this conditions disease. Methods: This is an observational cross-sectional study of the Faculdade de Medicina do ABC in patients submitted to hemodialysis three times a week for at least six months. The eligible group composed of 21 patients, who filled out forms and underwent biochemical tests (colorimetric enzyme methods, flow cytometer, turbidimetric method and mass spectrometry). Results: The study population showed, women (70%), men (30%) with a mean age of 47 ± 17 years, Caucasians (36%) and non-Caucasian (64%), hypertensive (68%), smokers (53%) and non-smokers (64%). There was a hegemonic prevalence of systolic arterial hypertension (SAH) 68.1% in relation to diabetes mellitus (DM) (50%). Pre and post hemodialysis (HD) selenemia showed statistical significance, which did not occur with Creactive protein. There was a predominance of females in our sample; the pre- and post- HD selenemia were within the normal range of the reference values; there was a statistically significant correlation between pre and post-HD selenemia; there was no correlation with statistical significance between values of pre and post-HD C-reactive protein. Conclusion: Our data showed that there was no direct relationship between pre- and post- HD inflammation and pre- and post-HD selenemia.

scholarly journals Spectrum and dosing of urate-lowering drugs in a large cohort of chronic kidney disease patients and their effect on serum urate levels: a cross-sectional analysis from the German Chronic Kidney Disease study

2019 ◽  
Author(s):  
Jan T Kielstein ◽  
Markus Heisterkamp ◽  
Jiaojiao Jing ◽  
Jennifer Nadal ◽  
Matthias Schmid ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Multivariate Regression Analysis ◽  
Serum Urate ◽  
Suboptimal Control ◽  
Cross Sectional ◽  
The Mean ◽  
Disease Study ◽  
Sectional Analysis

Abstract Background Despite a plethora of studies on the effect of urate-lowering therapy (ULT) in patients with chronic kidney disease (CKD), current guidelines on the treatment of hyperuricaemia and gout vary, especially concerning the need for dose adjustment of allopurinol, whose main metabolite is accumulating with declining renal function. Data on allopurinol dosing and its relationship to renal function, co-medication and sex and the resulting urate level in large cohorts are missing. Methods We studied a subgroup of 2378 patients of the German Chronic Kidney Disease (GCKD) study to determine prescription patterns of ULT among CKD patients under nephrological care and the relationship of ULT dose to urate levels. Prescription and dosing of ULT were manually abstracted from the patient’s paper charts at the baseline visit, in which all currently used medications and their dosing were recorded. Results In this cohort, 39.6% were women, the mean estimated glomerular filtration rate (eGFR) was 51.3 ± 19.3 mL/min/1.73 m2 and the mean age was 59.0 ± 12.4 years. Of the 2378 examined patients, 666 (28.0%) received ULT. The dose of ULT was available for 572 patients. The main ULT agent was allopurinol (94.4%), followed by febuxostat (2.9%) and benzbromarone (2.6%). Of the 540 patients who used allopurinol with a reported daily dose, 480 had an eGFR <60 mL/min/1.73 m2 and 320 had an eGFR <45 mL/min/1.73 m2, 31.5% of the latter (n = 101) received a dose >150 mg/day, the recommended maximal dose for this level of eGFR. The prescribed dose was not related to eGFR: the median eGFR for patients taking 100, 150 and 300 mg/day was 40 [interquartile range (IQR) 32–49], 43 (34–52) and 42 (35–54) mL/min/1.73 m2, respectively. Patients with lower doses of allopurinol had higher serum urate levels than patients with higher (than recommended) allopurinol doses. Sex, alcohol intake, eGFR, use of diuretics and treatment with allopurinol were independent determinants of serum urate levels in multivariate regression analysis. Conclusions The most frequently used drug to lower serum urate levels in this CKD cohort was allopurinol. Even in patients regularly seen by nephrologists, the dose of allopurinol is often not adjusted to the current eGFR. Patients with higher ULT doses achieved better control of their serum urate levels. Lowering of serum urate in CKD patients requires balancing potential adverse effects of allopurinol with suboptimal control of serum urate levels.

Association Between Sensorineural Hearing Loss and Various Stages of Chronic Kidney Disease

2021 ◽  
Author(s):  
Shashank Kotian ◽  
Ashok S. Naik ◽  
Manjunath Revanasiddappa ◽  
Maniyankode Krishnamohan Goutham
Keyword(s):  
Chronic Kidney Disease ◽  
Hearing Loss ◽  
Kidney Disease ◽  
Pure Tone Audiometry ◽  
Sensorineural Hearing ◽  
Age Group ◽  
Cross Sectional ◽  
Stage 4 ◽  
Ckd Stage ◽  
The Mean

Abstract Objectives To compare the proportion of sensorineural hearing impairment (SHI) among patients of chronic kidney disease (CKD) stages 3&4 with CKD stage 5. Materials and Methods This is a cross-sectional study of 30 patients with CKD stages 3 and 4 and 30 patients in stage 5. All patients had an audiological evaluation with pure tone audiometry. Results Our study had 49 males (82%) and 11 females (18%), with the age ranging from 20 to 60 years (mean: 45.13 years). The mean SHI values in stage 3&4 were 28.44 dB and in CKD stage 5 was 31.22 dB. In the right ear, the mean hearing loss in stage 3, stage 4, and stage 5 was 28.17 dB, 28.67 dB, and 31.84 dB, respectively. In the left ear, the mean SHI values in stage 3, stage 4, and stage 5 were 27.05 dB, 31.89 dB, and 30.61 dB, respectively.The mean SHI in stage 3&4 for age group 20 to 30 years was 13.66 dB, for 31 to 40 years was 26.33 dB, for 41 to 50 years was 35.18 dB, for 51 to 60 years was 37.12 dB. The mean SHI in stage 5 for the age group of 20 to 30 years was 16.48 dB, for 31 to 40 years was 28.29 dB, for 41 to 50 years was 31.82 dB, for 51 to 60 years was 34.35 dB. There was a significant correlation between hearing loss and CKD with respect to age (p < 0.001). The duration of renal illness and associated comorbidities was not a significant contributor to hearing loss in our study (p > 0.05). Conclusion As per our study, with progression in the stage of chronic kidney disease, the hearing loss also increased indicating a possible link between the two. We also noted that the hearing loss increased with the increasing age.

scholarly journals Status of Chronic Kidney Disease Patients Registered in National Kidney Center, Banasthali, Kathmandu

2015 ◽  
Vol 1 (4) ◽  
pp. 19-23 ◽  
Author(s):  
D Mishra ◽  
P Koirala
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Preventive Measures ◽  
Public Health Problem ◽  
Medication Cost ◽  
Cross Sectional ◽  
Average Patient ◽  
The Mean ◽  
Cross Sectional Design ◽  
The Needy

Chronic kidney disease is a worldwide public health problem. In Nepal, Chronic kidney disease patients are increasing and the management of this disease is very expensive compared to other chronic diseases? We assessed the socioeconomic status of chronic kidney disease patients registered in National Kidney Centre, Banasthali, Kathmandu. The study used descriptive cross sectional design. Ninety six samples were collected between 15- 31 October, 2012.The mean age of the patients was 47 years, with almost half of the patients (46%) from 41-60 years age group. Among the patients, 65 % were male, 85% were married, 80% were literate, 57% were past smoker and 75% were drinker and 59% were from Kathmandu valley. Likewise, most of them were Newar, work as housewife as the main occupation. One third (37%) had to sell their property for the treatment. On an average patient spent Rs.240000 per year in dialysis. Similarly, medication cost was Rs.180000 and transplantation cost was Rs.500000 to 1000000. Preventive measures of the disease and subsidy in the treatment will be beneficial for the needy people. DOI: http://dx.doi.org/10.3126/jmmihs.v1i4.11997Journal of Manmohan Memorial Institute of Health Sciences Vol. 1, Issue 4, 2015Page : 19-23 

scholarly journals Evaluation of Salivary Glucose and Creatinine for Screening of Diabetes and Kidney Disease

2020 ◽  
Author(s):  
Marziye Aghazadeh ◽  
Paria Motahari
Keyword(s):  
Kidney Disease ◽  
Pearson Correlation ◽  
Cross Sectional Study ◽  
Serum Glucose ◽  
The Body ◽  
Diagnostic Methods ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Multiple Organs ◽  
The Mean

Objective: Diabetes mellitus is a multifactorial metabolic disorder that affects multiple organs of the body, one of the most important of which is chronic kidney disease. Early diagnosis of this disease is suggested as an important strategy to reduce the complications of the disease worldwide. Since the measurement of salivary creatinine and glucose is an easy and noninvasive method, the aim of this study was to evaluate the serum and salivary levels of creatinine and glucose for screening of diabetes and kidney disease. Materials and Methods: This cross-sectional study was performed on 50 seemingly healthy individuals referred to the Department of Oral Medicine of the Faculty of Dentistry. Serum andsalivary creatinine levels were measured in these individuals. Data (mean + standard deviation) were presented for variables. Data were analyzed by SPSS 19 software. Pearson correlation coefficient was used to determine the correlation between serum and salivary levels of creatinine and glucose. P-values less than 0.05 were considered significant. Results: The mean salivary and serum creatinine levels was reported to be 0.27 (+ 0.29) and 0.90 (+0.12) mg/dl, respectively. Also, the mean salivary and serum glucose levels were reported to be 3.1 (+ 0.7) and 88.92 (+6.16) mg/dl, respectively. The results of Pearson correlation test showed no significant correlation between serum and salivary glucose and cratinine. Conclusion: The use of non-invasive diagnostic methods such as saliva is of great value. The study found no association between serum and salivary creatinine and glucose in seemingly healthy subjects.

THE STUDY ON SERUM WITH eGFR IN PATIENTS OF CHRONIC KIDNEY DISEASE

2021 ◽  
pp. 23-25
Author(s):  
Brahmarshi Das ◽  
Narendranath Hait ◽  
Titol Biswas ◽  
Debarshi Jana
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Cross Sectional Study ◽  
Newly Diagnosed ◽  
Creatinine Concentration ◽  
Cross Sectional ◽  
Ckd Stage ◽  
The Mean ◽  
Stage 1

INTRODUCTION: Chronic Kidney Disease (CKD) is dened as a disease characterized by alterations in either kidney structure or function or both for a minimum of 3 months duration. According to the National Kidney Foundation criteria, 1 CKD has been classied into ve stages with stage 1 being the earliest or mildest CKD state and stage 5 being the most severe CKD stage. To stage CKD, it is necessary to estimate the GFR rather than relying on serum creatinine concentration. Glomerular ltration rate (GFR), either directly measured by computing urinary clearance of ltration marker such as inulin or estimated by calculating from different equations using serum creatinine. is the most commonly used parameter to assess kidney function. AIM AND OBJECTIVES: a) Establish relationship between serum CKD and eGFR MATERIAL AND METHOD: A Cross-sectional study on 100 cases of newly diagnosed Chronic Kidney Disease patients and matched control subjects is undertaken to study.100 Patients who are newly diagnosed as CKD are selected after proper initial screening. RESULT AND ANALYSIS: In case, the mean eGFR (mean± s.d.) of patients was 25.1500 ± 11.8929. In control, the mean eGFR (mean± s.d.) of patients was 87.2200 ± 17.8295. Difference of mean eGFR in two groups was statistically signicant (p<0.0001). In case, the mean creatinine (mean± s.d.) of patients was 3.6350 ± 2.4419 mg/dl. In control, the mean creatinine (mean± s.d.) of patients was .9435 ± .1317 mg/dl. Difference of mean creatinine in two groups was statistically signicant (p<0.0001). CONCLUSION: eGFR was strongly associated with CKD that also statistically signicant. The positive correlation was found in eGFR.

scholarly journals STUDY CROSS SECTIONAL : DUKUNGAN KELUARGA DENGAN KEPATUHAN HEMODIALISA PADA PASIEN GAGAL GINJAL KRONIS

2020 ◽  
Vol 8 (1) ◽  
pp. 106
Author(s):  
Chauverim Jeremi Gotlieb Paath ◽  
Gresty Masi ◽  
Franly Onibala
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Family Support ◽  
Cross Sectional Study ◽  
The Body ◽  
P Value ◽  
Electrolyte Balance ◽  
Sectional Study ◽  
Cross Sectional ◽  
Therapy Adherence

Abstract: Chronic Kidney Disease is progressive and irreversible kidney dysfunction where the body fails to maintain metabolim and fluid and electrolyte balance. Hemodialysis therapy is one of managements of CKD. Disobedience may causing failure of the therapy so it can increase mortality and morbidity numbers. Purpose: The purpose of this research is to find out the correlation beetween family support and hemodialysis adherence of patients with CKD. Method: this study used descriptive Analytic with Cross Sectional Study approach. This study involved 50 respondents with Chronic Kidney Disease using the total sampling technique. Data collection was done through the questionnaire about family’s support and hemodialysis therapy adherence of patient of CKD. The result of this study showed a significant correlation with p value=0,000 (α<0,05). Conclusion: There is a significant correlation beetween family support and hemodialysis therapy adherence of patients with CKD. Further studies are suggested to do other research about specification of family’s support with the example instrumental support.Key Words:     Chronic Kidney Disease, Family Support, Hemodialysis Therapy      Adherence. Abstrak: Gagal ginjal kronis merupakan gangguan fungsi ginjal yang progresif dan ireversibel dimana tubuh gagal untuk mempertahankan metabolisme dan keseimbangan cairan dan elektrolit. Terapi hemodialisa adalah salah satu penanganan gagal ginjal kronis. Ketidakpatuhan dapat menyebabkan kegagalan terapi sehingga meningkatkan angka mortalitas dan morbiditas. Dukungan keluarga merupakan salah satu faktor penting dalam meningkatkan kepatuhan terapi. Tujuan: ujuan penelitian ini untuk mengetahui hubungan dukungan keluarga dengan kepatuhan terapi hemodialisa pada pasien GGK. Desain Penelitian: Penelitian ini menggunakan Deskriptif Analitik dengan pendekatan cross-sectional Study. penelitian ini menggunakan 50 responden  dengan menggunakan teknik total sampling. Pengumpulan data dilakukan menggunakan kuesioner tentang dukungan keluarga dan kepatuhan menjalani terapi hemodialysis pada pasien CKD. Hasil dari penelitian ini menunjukan hubungan yang signifikan dengan nilai p=0,000 yang berarti nilai p<α=0,05. Kesimpulan: Dapat disimpulkan bahwa ada hubungan yang bermakna antara dukungan keluarga dengan kepatuhan hemodialisa pada pasien GGK. Bagi peneliti selanjutnya disarankan untuk melakukan penelitian tentang dukungan keluarga yang lebih spesifik contohnya dukungan instrumental. Kata Kunci: Gagal Ginjal Kronis, Dukungan Keluarga, Kepatuhan Hemodialisa

scholarly journals Correlation between the Serum Level of Interleukin-2 in Hemodialysis Patients and Severity of Renal Pruritus

2021 ◽  
Vol 5 (2) ◽  
pp. 320-326
Author(s):  
Radema Pranata ◽  
Yuli Kurniawati ◽  
Fitriani ◽  
Legiran ◽  
Soenarto Kartowigno ◽  
...  
Keyword(s):  
Informed Consent ◽  
Kidney Disease ◽  
Serum Level ◽  
Interleukin 2 ◽  
Hemodialysis Patients ◽  
Strong Positive Correlation ◽  
Cross Sectional ◽  
Positive Correlation ◽  
The Mean ◽  
Cross Sectional Design

A B S T R A C TRenal pruritus (RP) is a condition or symptom that is often found in end-stagechronic kidney disease (CKD) undergoing hemodialysis (HD). The etiology of RP ismultifactorial, one of it due to inflammation mediated by interleukin 2 (IL-2). Studyon the correlation between serum level of IL-2 and the severity of RP is still limited.This study will analyze the correlation between serum level of IL-2 in patientsundergoing HD and the severity of RP. Our method is cross sectional design atHemodialysis Installation of Dr. Mohammad Hoesin Hospital. Serum level of IL-2examined by ELISA, the severity of RP assessed by a 5 dimensional pruritus scale.Inclusion criteria in this study included HD patients with RP ≥ 9, age ≥ 18 years andwilling to sign informed consent. The results from 28 male (59.6%) and 19 female(40.4%) are the mean serum level of IL-2 (pg/ml) is 0.424 ± 0.077. The mean RPseverity score is 18.98 ± 2.74. A strong positive correlation between serum level ofIL-2 and the severity of RP (r = 0.750, p = 0,000). Our conclusion is the increase ofserum level IL-2 in line with severity of RP.

scholarly journals Antidiabetic and Other Therapies Used in Subjects with Diabetes and Chronic Kidney Disease in a Hospital-Based Clinic Population in Greece

2021 ◽  
Vol 10 (10) ◽  
pp. 2104
Author(s):  
Ilias Migdalis ◽  
Nikolaos Papanas ◽  
Ioannis Ioannidis ◽  
Alexios Sotiropoulos ◽  
Athanasios Raptis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Primary Care Physicians ◽  
Public Hospitals ◽  
Angiotensin Ii Receptor ◽  
Converting Enzyme Inhibitors ◽  
Cross Sectional ◽  
Mean Values ◽  
Dipeptidyl Peptidase 4 Inhibitors

(1) Background: Type 2 diabetes mellitus (T2DM) is the main cause of chronic kidney disease (CKD). In Greece, in a population from hospital-based diabetes clinics (n = 1759), the overall prevalence of diabetic chronic kidney disease (DCKD) was 45% including mild, moderate, and severe CKD. The aim of this study was to describe and analyze how T2DM patients with mild-to-severe CKD are managed by diabetologists in Greece and assess the achievement rates in glycemic, blood pressure and low-density lipoprotein-cholesterol (LDL-C) control. (2) Methods: This cross-sectional multicenter study took place from June 2015 to March 2016 and collected data from diabetes centers in public hospitals all over Greece. (3) Results: With regard to the anti-diabetes treatment, most participants were on metformin, DPP-4 (Dipeptidyl Peptidase-4 inhibitors) inhibitors and insulin. Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers were the most prescribed medications for hypertension. For the management of dyslipidemia, most participants were on statins. For patients with DCKD, the levels of HbA1c, blood pressure and LDL-C were 7.2%, 137.7/76.9 mmHg and 95.9 mg/dL, respectively (mean values). (4) Conclusions: The outcomes of this study suggest that management of DCKD can be further improved and should be enhanced. These results may contribute to the whole health care system in Greece. In addition, the better understanding of therapeutic strategies used by diabetologists treating these patients offers educational benefits to primary care physicians, which can result in an overall more successful and efficient management of subjects with T2DM and DCKD.

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