scholarly journals Protective Effect of Cucurbita maxima against Maximal Electroshock Induced Convulsions

2021 ◽  
pp. 91-101
Author(s):  
Nagnath R. Kadam ◽  
P. K. Mohanty ◽  
Ashish Jain
Keyword(s):  
Protective Effect ◽  
Albino Rats ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Cucurbita Maxima ◽  
Hydroalcoholic Extract ◽  
Indigenous Plant ◽  
Wistar Albino Rats ◽  
Electroshock Seizures ◽  
Different Doses

In the present investigation, an indigenous plant, Cucurbita maxima was studied for its protective effect against maximal electroshock (MES) induced convulsions in Wistar albino rats. The rats were pretreated with different doses (100, 200, 400 mg/kg) of hydroalcoholic extract of seeds of Cucurbita maxima for 14 days and then, they were subjected to maximal electroshock seizures (40 mA for 0.2 sec) treatment. Hydroalcoholic extract of Cucurbita maxima seeds at 200 and 400 mg/kg doses significantly reduced the duration of hind limb extension along with the protection of rats against maximal electroshock induced seizures. The reference standard i.e., phenytoin (20 mg/kg) provided complete protection. Thus, present study revealed anticonvulsant effect of Cucurbita maxima against maximal electroshock-induced convulsions in rats.

scholarly journals Anticonvulsant activity of nicardipine in experimentally induced seizures in wistar albino rats.

2020 ◽  
Vol 9 (3) ◽  
pp. 413
Author(s):  
Kayalvizhi M. K. ◽  
Sathiya Vinotha A. T.
Keyword(s):  
Experimental Animal ◽  
Anticonvulsant Activity ◽  
Albino Rats ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Standard Drug ◽  
Wistar Albino Rats ◽  
Electroshock Seizures ◽  
Experimentally Induced

Background: The objective of the study was to evaluate the anticonvulsant activity of nicardipine in wistar albino rats.Methods: Anticonvulsant activity of nicardipine in a dose 10 mg/kg, and its effect with the standard drug lamotrigine (5 mg/kg) was studied in a maximal electroshock seizures (MES) experimental animal model.Results: Nicardipine in dose of 10 mg/kg showed significant anticonvulsant effect (p<0.001) and combination with standard drug lamotrigine (p<0.001) also showed more significant anticonvulsant effect in MES model.Conclusions: Nicardipine is having anticonvulsant activity and it also potentiates the anticonvulsant effect of lamotrigine in MES model.

scholarly journals Protective Effect of Hydroalcoholic Extract of Aloe Vera Supplemented by Zinc on the Testis of Wistar Albino Rats Exposed to Cadmium

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2128-2133
Author(s):  
Sushanth N K ◽  
Vijayalakshmi S ◽  
Dayanand Reddy G ◽  
Sunil Kumar K N ◽  
Shakila R
Keyword(s):  
Body Weight ◽  
Protective Effect ◽  
Environmental Pollutants ◽  
Aloe Vera ◽  
Reproductive Organs ◽  
Health Concern ◽  
Control Group ◽  
Albino Rats ◽  
Hydroalcoholic Extract ◽  
Wistar Albino Rats

Infertility is a major health concern that may be caused due to inadequate fertility hormones or poor quality of reproductive parameters. The environmental pollutants such as cadmium is one of the causative factors for inducing infertility in men. Cadmium accumulates in various tissues and affects reproductive organs, especially testis which is highly sensitive to cadmium poisoning. In this experiment, protective effect of hydroalcoholic extract (HAE) of Aloe vera with and without zinc has been evaluated. Zinc, protects the testes from damages resulting due to cadmium. Aloe vera is a very good source of antioxidants such as vitamin C and E. In this experiment male Wistar albino rats were grouped into 5. The control group received only the vehicle. Experimental groups were administered in Cd group with 10mg/Kg body weight of CdCl2, in Cd+Zn group 40mg/Kg body weight of CdCl2 and 40mg/Kg bodyweight of ZnCl2, in Cd+AV group 10mg/Kg body weight of CdCl2 and 200mg/Kg body weight of HAE of Aloe vera and in Cd+AV+Zn 10mg/Kg body weight of CdCl2, 200mg/Kg body weight of HAE of Aloe vera and 40mg/Kg bodyweight of ZnCl2. The results showed that cadmium caused extensive testicular damage which was protected by HAE of Aloe vera and zinc. Hence, protective effect of HAE of Aloe vera  was exhibited clearly in cadmium treated rats, however, supplementing Aloe vera with zinc provided better protection.

scholarly journals Evaluation of anticonvulsant activity of amlodipine in albino rats

2017 ◽  
Vol 6 (3) ◽  
pp. 664
Author(s):  
Roopa B. ◽  
Janardhan M. ◽  
Venkata Rao Y.
Keyword(s):  
Experimental Animal ◽  
Anticonvulsant Activity ◽  
Low Dose ◽  
Combination Group ◽  
Albino Rats ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Standard Drug ◽  
Dose Dependent ◽  
Electroshock Seizures

Background: The objective of the study was to evaluate the anticonvulsant activity of amlodipine in albino rats.Methods: Anticonvulsant activity of amlodipine was done in three graded doses (1 mg/kg, 2 mg/kg, 4 mg/kg), and combination group with low dose of amlodipine (1 mg/kg) and standard drug (phenytoin) in maximal electroshock seizures (MES) experimental animal model.Results: Amlodipine in dose of 2, 4 mg/kg showed dose dependent significant anticonvulsant effect and combination of low dose amlodipine and low dose of standard drug also showed significant anticonvulsant effect in MES model.Conclusions: Amlodipine is having anticonvulsant activity and also potentiated the anticonvulsant effect of phenytoin in MES model. 

Potential anticonvulsants: Substituted N-benzylidene derivatives of 10-(4-aminopiperazino)-10,11-dihydrodibenzo[b,f]thiepins

1983 ◽  
Vol 48 (4) ◽  
pp. 1173-1186 ◽  
Author(s):  
Václav Bártl ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
Marie Bartošová ◽  
Miroslav Protiva
Keyword(s):  
Acute Toxicity ◽  
Water Soluble ◽  
Hypotensive Activity ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Soluble Salts ◽  
Sleeping Time ◽  
Central Depression ◽  
Derivatives Of ◽  
Electroshock Seizures

Reactions of 10-(4-aminopiperazino)-10,11-dihydrodibenzo[b,f]thiepins XIVa-XIVd with benzaldehyde, 3,4-dimethoxybenzaldehyde, 4-dimethylaminobenzaldehyde, salicylaldehyde, 3-ethoxy-4-hydroxybenzaldehyde, 2-(2-dimethylaminoethoxy)benzaldehyde, 3-(2-dimethylaminoethoxy)benzaldehyde and 3-ethoxy-4-(2-dimethylaminoethoxy)benzaldehyde afforded a series of 19 hydrazones IIIa-Xc. Some of them showed the expected anticonvulsant effect but only towards pentetrazole; antagonism of maximal electroshock seizures was not observed. In general, the products have a character of tranquillizers: in higher does they produce central depression, potentiate the thiopental sleeping time, have hypothermic action; in single cases antiamphetamine, antireserpine, antihistamine and cataleptic effects were observed. The water-soluble salts of the basic hydrazones VIIIa, VIIIc, IXc and Xc, administered parenterally, showed a rather high acute toxicity and revealed also adrenolytic and hypotensive activity.

Effects of Carbon Dioxide and Oxygen on Properties of Experimental Seizures in Mice

1955 ◽  
Vol 184 (1) ◽  
pp. 202-208 ◽  
Author(s):  
Dixon M. Woodbury ◽  
Lawrence T. Rollins ◽  
Joyce R. Henrie ◽  
Joseph C. Jones ◽  
Tada Sato
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Concentration ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Low Oxygen ◽  
Excitatory Effect ◽  
The Brain ◽  
Electroshock Seizures ◽  
Tonic Phase ◽  
Convulsant Dose

The influence of various concentrations of carbon dioxide and oxygen on the pattern of maximal electroshock seizures (MES), on pentylenetetrazol (Metrazol)-induced seizures, and on recovery time (RT50) from MES has been studied in mice. The major results are summarized as follows: Increasing the concentration of carbon dioxide in 20% oxygen resulted in marked changes in the MES pattern. The duration of the tonic flexor component was increased, and the duration of the tonic extensor component and of the entire tonic phase was decreased; the ratio of flexion to extension was increased markedly. These changes indicate an anticonvulsant effect of carbon dioxide. Carbon dioxide in a concentration of 15.6% protected 50% of mice against a 97% convulsant dose (CD97) of Metrazol. Hypoxia, induced by inhalation of 15 or 10% oxygen, decreased the duration of the tonic flexor component and increased the duration of the tonic extensor component of the MES; the duration of the entire tonic phase was increased; the ratio of flexion to extension was slightly decreased. These changes indicate an excitatory effect of low oxygen concentrations on the brain, under the stated conditions. Hyperoxia, induced by inhalation of 50, 75 or 90% oxygen, in contrast to hypoxia, resulted in effects on MES similar to those produced by inhalation of carbon dioxide. The RT50 was slightly, but not significantly, decreased by hypoxia (15% oxygen), unchanged by hyperoxia (50% oxygen), and markedly increased by an increase in carbon dioxide concentration. Carbon dioxide (5 and 10%) combined with hypoxia (10% oxygen) produced effects on MES pattern and RT50 similar to those produced by carbon dioxide in 20% oxygen.

Investigation on protective effect of Terminalia bellirica (Roxb.) against drugs induced cardiotoxicity in wistar albino rats

2020 ◽  
Vol 261 ◽  
pp. 113080
Author(s):  
Rahul Chaudhary ◽  
Richa Singh ◽  
Rajeev Verma ◽  
Prashant Kumar ◽  
Nitin Kumar ◽  
...  
Keyword(s):  
Protective Effect ◽  
Albino Rats ◽  
Terminalia Bellirica ◽  
Wistar Albino Rats

Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats

2016 ◽  
Vol 47 (7) ◽  
pp. 506-514 ◽  
Author(s):  
Hatice Adiguzel Dundar ◽  
Muge Kiray ◽  
Mustafa Kir ◽  
Efsun Kolatan ◽  
Alper Bagriyanik ◽  
...  
Keyword(s):  
Protective Effect ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Screening of anticonvulsant effect of carvedilol on electrically induced convulsions in Wistar albino rats

2020 ◽  
Vol 9 (12) ◽  
pp. 1803
Author(s):  
Biacin Babu ◽  
Madhavrao Chavan
Keyword(s):  
Albino Rats ◽  
High Dose ◽  
Anticonvulsant Effect ◽  
Low Doses ◽  
Test Drug ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Wistar Albino Rats

Background: Epilepsy is one of the major central nervous system disorders. The parent study aimed to screen the anticonvulsant effect of carvedilol on electrically induced convulsions in Wistar albino rats.Methods: This study was done in Wistar albino rats. A total of 30 rats were divided into 6 groups each of six rats. group-I (0.9% normal saline), group-II diphenylhydantoin (10 mg/kg/BW/ip), group-III carvedilol (1mg/kg/BW/PO), group-IV carvedilol (2 mg/kg/BW/PO) and group-V carvedilol (4 mg/kg/BW/PO). All the groups were administered drugs and subjected to electric shock. Scores of seizures and percentage of protection were recorded to compare between the groups. One was ANOVA (post hoc) followed by Dunnet t test applied to find the statistically significant between the groups.Results: Group-I showed significant difference compared to other groups. Group-II showed significant difference with group-III and IV not with V. High dose of test drug and standard drug showed similar results in percentage of seizures prevention. Control and low doses of test drugs showed significant difference compared to standard and high dose of test drug in seizures prevention.Conclusions: High of carvedilol showed significant seizures prevention compared to low doses and control group.

scholarly journals Fluoxetine enhances maximal electroshock seizure threshold in Albino rat model when compared to phenytoin

2017 ◽  
Vol 7 (1) ◽  
pp. 138 ◽  
Author(s):  
Tanmoy Gangopadhyay ◽  
Ananya Mandal ◽  
Uma Shanker Keshri
Keyword(s):  
Seizure Threshold ◽  
Albino Rats ◽  
P Value ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Maximal Electroshock Seizure ◽  
Albino Rat ◽  
Co Morbidity ◽  
Significant Difference ◽  
Electroconvulsive Seizure

Background: Individuals with epilepsy have a higher incidence of psychiatric disorders than person without epilepsy. Epidemiological studies have shown that the co-morbidity of epilepsy and depression to be high as 50%. The conventional anti-depressants are believed to lower the seizure threshold making it difficult to treat the co-morbid depression, but animal studies have shown SSRIs, a common anti-depressant, to have anti-convulsant properties. So, we propose to study the anticonvulsant effects of fluoxetine, a SSRI, in albino rats against maximal electroshock seizure and to compare against a standard antiepileptic drug phenytoin.Methods: The anticonvulsant effect of fluoxetine was observed in model of maximal electroconvulsive seizure threshold in albino rats. The animals were divided into 3 groups having 6 animals each, receiving distilled water, fluoxetine and phenytoin respectively. The drugs were given orally, and the effect was observed on day 7, 14 and 21. Tonic hind-limb extension was taken as the parameter of electroshock seizure. The effects were compared against a standard anti-seizure drug phenytoin.Results: Fluoxetine showed significant elevation of the seizure threshold following 14 days of administration (P value 0.031). The effect was comparable to phenytoin with no significant difference after 7, 14 and 21 days of treatment (P-value 0.485, 0.699 and 0.818 respectively) though phenytoin showed significant anti-seizure effect since day 7 of treatment.Conclusions: Fluoxetine showed significant anti-seizure activity against electroconvulsive seizure in albino rats.

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