scholarly journals Evaluation of Hypolipidemic and Hepatoprotective Effects of Linum usitatissimum L. Seeds on Hypercholesterolemic Rats

2021 ◽  
pp. 85-93
Author(s):  
Chaitali Pattanayak ◽  
Jyotirmayee Bahinipati ◽  
Vartika Srivastava ◽  
Sougata Sarkar
Keyword(s):  
Linum Usitatissimum ◽  
Cardiovascular Effects ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Standard Drug ◽  
Group Iii ◽  
Linum Usitatissimum L ◽  
Chronic Progressive Disease ◽  
Hepatoprotective Effects ◽  
Flax Seeds

Background: Hyperlipidaemia is a chronic progressive disease, which encompasses various genetic and acquired conditions resulting in inappropriately elevated lipid levels in humans.  Several preclinical and clinical studies have demonstrated that dietary supplementation with Linum Usitatissimum have beneficial cardiovascular effects like antihypertensive action, antiatherogenic effects, lowering of cholesterol, anti-inflammatory action and inhibition of arrhythmia. There are few studies on hepatoprotective effects of flax seeds in hyperlipidemic animal models. Aim and objectives: Hence, this study was undertaken to evaluate the hypolipidemic and hepatoprotective effect of Linum seeds. Methods: The study was conducted for the period of two months in Department of Pharmacology KIMS, Bhubaneswar. Total 36 Albino wistar rats were taken and divided into 6 groups containing 6 rats each. Group II was hypercholesterolemic (HC) control, Group III was treatment control and Group IV to VI rats were given different doses of extract. Blood samples were taken at the end of two months. Results: All the values are expressed as Mean±SD (standard deviation). Significant decrease in lipid parameters and liver enzymes is seen at the end of two months in all 3 groups receiving the extract, where the highest dose of extract used, is near to the standard drug. Conclusion: From this study, it can be concluded that the addition of the flaxseeds to the diet may alleviate the rise in circulating cholesterol levels induced by the high cholesterol diet through its content of alfa-linolenic acid (ALA) and lignins. The hepatoprotective role of flaxseed in hypercholesterolaemia has also been demonstrated in this this study.

Beneficial effects of linum usitatissimum L. on dyslipidemia, oxidative stress and inflammatory cytokines in hypercholesterolemic rats

2019 ◽  
Vol 49 (4) ◽  
pp. 777-790 ◽  
Author(s):  
Sarra Dali ◽  
Djamil Krouf ◽  
Zoheir Mellouk ◽  
Nawal Taleb-Dida
Keyword(s):  
Oxidative Stress ◽  
Linum Usitatissimum ◽  
Hdl Cholesterol ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Casein Diet ◽  
Content Type ◽  
Beneficial Effects ◽  
Linum Usitatissimum L ◽  
Male Wistar Rats

Purpose This paper aims to study the effects of a diet supplemented with flaxseeds on dyslipidemia, oxidative stress and proinflammatory cytokines, in rats consuming a high-cholesterol diet. Design/methodology/approach Male Wistar rats (n = 30) weighing (250 ± 5 g) of which 10 were control and 20 were rendered hypercholesterolemic (HC) by feeding a diet enriched with 1% of cholesterol, for 15 days. After this phase, rats were divided into two groups; hypercholesterolemic group (HC) (n = 10), fed 20% casein diet enriched with 1% cholesterol; and hypercholesterolemic rats fed the same diet (n = 10), but additionally supplemented with flaxseeds (Linum usitatissimum) (Lu) powder, i.e. HC-Lu. Animals of the control group (n = 10) were fed the casein diet. All the animals were maintained on the respective diets for four weeks. Findings This study showed that in HC-Lu as compared to HC group, plasma total cholesterol, triacylglycerols and non-HDL cholesterol concentrations were respectively 2.4-, 1.5- and 3-fold lower. Also, the lipid peroxidation was reduced in red blood cells, organs (liver, heart and aorta) and lipoproteins (HDL2, HDL3 and VDL-LDL). A higher superoxide dismutase activity was observed in liver (+61%), heart (+62%) and aorta (+59%), whereas plasma proinflammatory cytokine (IL-1beta and IL-6) levels were decreased. Originality/value These results suggest that flaxseeds help to reduce hypercholesterolemia, oxidative stress and inflammation in patients with hypercholesterolemia.

scholarly journals Pharmacological Evaluation of Chrozophora tinctoria as Wound Healing Potential in Diabetic Rat’s Model

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Harikesh Maurya ◽  
Monika Semwal ◽  
Susheel Kumar Dubey
Keyword(s):  
Wound Healing ◽  
Disease Control ◽  
Povidone Iodine ◽  
Diabetic Rats ◽  
Control Group ◽  
Standard Drug ◽  
Group Iii ◽  
Group I ◽  
Elevated Blood Glucose Level ◽  
Pharmacological Potential

Objective. The study was designed to evaluate pharmacological potential of hydroalcoholic leaves extract of Chrozophora tinctoria intended for wound healing in diabetic rats’ model. Methods. The method used to evaluate the pharmacological potential of hydroalcoholic leave extract was physical incision rat model. In this model, cutting of the skin and/or other tissues with a sharp blade has been made and the rapid disruption of tissue integrity with minimal collateral damage was observed shortly. Animals used in the study were divided into four groups that consist of six animals in each group. Group I serves as normal control, Group II serves as disease control, Group III was used as standard treatment (Povidone iodine 50 mg/kg b.w.), and Group IV was used for test drug (C. tinctoria 50 mg/kg b.w.). Result. The hydroalcoholic leave extract of Chrozophora tinctoria has been significantly observed to heal the wound (98%) in diabetic rats within 21 days, while standard drug (Povidone iodine) healed the wound about 95% in the same condition. The oral dose (50 mg/kg b.w.) of Chrozophora tinctoria was also found to improve the elevated blood glucose level in comparison to disease control group, which increased after the oral administration of Streptozotocin. Conclusion. The Chrozophora tinctoria has significant wound healing potential in the animal having physically damaged tissue in diabetic condition.

scholarly journals Probiotic sugar confectionery fortified with flax seeds (Linum usitatissimum L.)

2020 ◽  
Vol 57 (5) ◽  
pp. 1964-1970 ◽  
Author(s):  
Meghmala Waghmode ◽  
Aparna Gunjal ◽  
Neha Patil
Keyword(s):  
Linum Usitatissimum ◽  
Linum Usitatissimum L ◽  
Flax Seeds

The content of selected elements in common flax seeds (Linum usitatissimum L.) depending on the cultivar and weather conditions

2020 ◽  
Author(s):  
Leszek Bednorz ◽  
Leszek Bednorz ◽  
Magdalena Kluza-Wieloch ◽  
Renata Nowińska ◽  
Agnieszka Waśkiewicz
Keyword(s):  
Linum Usitatissimum ◽  
Weather Conditions ◽  
Linum Usitatissimum L ◽  
Flax Seeds

scholarly journals The Natural Antioxidants Curcumin and Silymarin Afforded Hepatoprotective Effects against Deferasirox-Induced Hepatotoxicity

2021 ◽  
Author(s):  
Enass Y. Osman ◽  
Souzan E. Abo-Elnasr ◽  
Shaimaa Mohammed Zaher ◽  
Norhan Ahmed AbuoHashish
Keyword(s):  
Total Bilirubin ◽  
Curcuma Longa ◽  
Natural Antioxidants ◽  
Group Iv ◽  
Control Group ◽  
Distilled Water ◽  
Oral Gavage ◽  
Once Daily ◽  
Group Iii ◽  
Hepatoprotective Effects

Abstract Deferasirox belongs to a new is a bishydroxyphenyltriazoles iron chelator used for treatment of chronic iron overload. The use of Deferasirox is associated with hepatotoxicity. Silymarin is a benzo gamma-pyrones flavonoid which affords hepatoprotection and preserves hepatocyte membranes by its antioxidant effect. Curcumin is a poly-phenol compound naturally concentrated in the herb Curcuma longa. The present study was conducted to evaluate and compare the hepatoprotective effects of both silymarin and curcumin against deferasirox-induced hepatotoxicity in rats and to explore the potential mechanisms account for their hepatoprotective effects. The present study was carried out using 32 male wistar randomly assigned into 4 groups (8 rats each) as follows; Group1: served as normal control group in which rats received distilled water (0.5ml per rat) by oral gavage. Group II (Deferasirox group) in which hepatotoxicity was induced by oral administration of deferasirox in a dose of 100 mg/kg once daily for 4 weeks dissolved in distilled water for a concentration of 35mg/ml. Group III (deferasirox+ curcumin) in which rats received curcumin in a dose of 100 mg/kg daily dose by oral gavage for 4 weeks suspended in distilled water for a concentration of 35 mg/ml one hour before administration of deferasirox. Group IV (deferasirox+ silymarin) in which rats received silymarin in dose of 7.56 mg/kg once daily by oral gavage for 4 weeks suspended in distilled water for a concentration of 2.7mg/ml one hour before administration of deferasirox. At the end of the treatment period, all rats were sacrificed by cervical dislocation, blood samples were collected for measurement of ALT, AST, ALP and total bilirubin. Liver samples were used for measurement of MDA, GSH and IL-6. Histopathological and immunohistochemistry were also done. The present data revealed that rats pretreated with curcumin or silymarin exhibited significant reduction in ALT, AST, ALP, total bilirubin, IL-6 and MDA levels with significant elevation of GSH level compared to deferasirox group. In-between group comparison revealed that there was a more significant reduction in ALT, AST, ALP, total bilirubin, IL-6 and MDA in group IV compared to group III. In conclusion, both curcumin and silymarin represent natural protective agents against Deferasirox-induced hepatotoxicity due to their antioxidant and anti-inflammatory effects.

scholarly journals Agro-morphological characterization of flax (Linum usitatissimum L.) accessions at north-western part of Bangladesh

2020 ◽  
Vol 5 (4) ◽  
pp. 465-469
Author(s):  
A.K.M. Golam Sarwar ◽  
Md. Eakramul Haque ◽  
Most. Morshada Khatun ◽  
Md. Sabibul Haque
Keyword(s):  
Linum Usitatissimum ◽  
Agricultural Research ◽  
Block Design ◽  
Morphological Characterization ◽  
Growth And Yield ◽  
Research Station ◽  
Agricultural Crop ◽  
Linum Usitatissimum L ◽  
Flax Seeds

Flax (Linum usitatissimum L.), grown throughout the world for millennia. It is a multipurpose agricultural crop that can provide food, fuel and fibre. An agro-morphological characterization based on 13 traits of 26 flax accessions was carried out during the Rabi season 2017-2018 at the Agricultural Research Station, Bangladesh Agricultural Research Institute, Rangpur. The field experiment was laid out in a randomized completed block design having four replications. Flax seeds were sown in 3.0 m × 0.6 m plot with continuous line sowing (two lines). The seed germination (%) and vigour indices of all flax accessions varied from 44.1 – 77.7 and 44.1 – 119.4, respectively. A significant variation in all growth and yield attributing descriptors was observed except 1000-seed weight of flax. Among the accessions, BD-10708 possessed the highest seed yield (182.9 g plant–1) and yield attributing descriptors viz., number of capsules plant–1 (142) and seeds plant–1 (513) of flax. The performance of the local accesson Ulipur was observed poor compared to some of the test accessions of flax. Some of these flax accessions could be used as breeding materials in varietal developmental and improvement programmes with higher yield potentials of flax in Bangladesh.

Pharmacological Evaluation of Anti-ulcer Activity of Caesalpinia crista in Rats

2017 ◽  
Vol 10 (4) ◽  
pp. 3772-3779
Author(s):  
Kintu Patel ◽  
Bhagyabhumi Patel ◽  
Alkesh Patel ◽  
Samir Shah
Keyword(s):  
Inflammatory Cells ◽  
Control Group ◽  
Antiulcer Activity ◽  
Standard Group ◽  
Free Acidity ◽  
Rat Stomach ◽  
Ulcer Index ◽  
Standard Drug ◽  
Group Iii ◽  
Group I

In present study, we evaluated the antiulcer activity of the herbal preparation of Caesalpinia crista in rat models.  Experimental animals were divided into four groups. Rats of group I (disease control) treated with normal saline only, group II (standard group) treated with Omeprazole (2 mg/ kg; p.o.), group III and IV served as test groups and were treated with Caesalpinia crista extract (CE) in the dose of 250 mg/ kg and 500 mg/ kg orally respectively. Peptic ulcer was induced by ligating the pyloric portion of rat stomach and was done 45 min after the respective treatment. After 4 hour of pylorus ligation, rats were sacrificed. Parameters like ulcer index, percent ulcer protection, total and free acidity were estimated for evaluation of anti-ulcer activity. Histopathological evaluation was also performed. The aqueous extract of Caesalpinia crista seeds reduced the volume of gastric juice, free acidity, total acidity and ulcer index. It increased the pH of the gastric acid. Histopathology of the rat stomach revealed the presence of lesions and infiltration of inflammatory cells in control group. Moreover, animals treated with test drug and standard drug did not reveal any microscopic lesions. These findings suggest that Caesalpinia crista seeds may have anti-secretory and anti-ulcer activity and may be helpful for ulcer therapy. 

scholarly journals ANTIHEPATOTOXIC POTENTIALITY OF 2-3-6 TRIMETHYLOCT-6-ENAL AGAINST PARACETAMOL INDUCED LIVER DYSFUNCTION

2017 ◽  
Vol 9 (9) ◽  
pp. 59
Author(s):  
Suparna Datta ◽  
Manabendra Dutta Choudhury
Keyword(s):  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Liver Toxicity ◽  
Control Group ◽  
Protective Agent ◽  
Protective Activity ◽  
Standard Drug ◽  
Group Iii ◽  
Group I ◽  
Aspartate Amino Transferase

Objective: We investigated the liver protective activity of 2-3-6 trimethyloct-6-enal from the methanol extract of Pajanelia longifolia (Willd.) K. Schuman. The liver protective activity of 2,3,6 trimethyloct-6-enal was evaluated against paracetamol (2 mg/kg body weight per orally) induced liver toxicity in swiss albino mice.Methods: Considering the Spectral data (IR spectrum, 1HNMR spectrum and 13C NMR spectrum) the predictable structure of 2,3,6 trimethyloct-6-enal was elucidated. To study the liver protective activity of the compound, Swiss albino mice of either sex were divided into six groups and treated for 5 d. Group I and II served as normal and toxic control, Group III were treated with Silymarin as a standard drug (50 mg/kg), and Group IV to VI was treated with 2-3-6 trimethyloct-6-enal at the dose of 50 mg/kg, 150 mg/kg and 250 mg/kg b.w. p. o. respectively. The liver protective activity of the compound was measured on biochemical parameters such as aspertate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), triglycerides (TGL), total cholesterol (TC) and protein. Further antioxidant activity of the compound was also measured on antioxidant enzymatic and non-enzymatic levels such as reduced glutathione (GSH), lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)).Results: The study revealed that the compound has protective activity at the dose of 50, 150 and 250 mg/kg b.w. p. o. against paracetamol induced toxicity. In some biochemical parameters such as aspartate amino transferase and bilirubin, the compound has showed better result at a dose of 150 mg/kg compared to standard drug silymarin (value of aspartate amino transferase (compound) =71.10±0.12, (toxic) = 173.43±1.21, (silymarin) =79.86±0.02and total bilirubin (compound) = 1.04±0.11), (toxic) = 2.69±0.02, (silymarin) ==1.11±0.01. The findings were also confirmed by histopathological observations.Conclusion: 2,3,6 trimethyloct-6-enal from Pajanelia longifolia may be considered as a potent liver protective agent.

scholarly journals The source material in the creation of late-maturing variety of fiber-flax Fenix

2019 ◽  
pp. 36-39
Author(s):  
Elena Alexandrovna Trabyrova ◽  
Svetlana Mikhailovna Зуева ◽  
Sergey Mikhailovich Chekhalkov ◽  
Aminat Msostovna Konova ◽  
Anna Yurievna Gavrilova
Keyword(s):  
Environmental Factors ◽  
Linum Usitatissimum ◽  
Growing Season ◽  
Source Material ◽  
Standard Variety ◽  
Fiber Flax ◽  
Linum Usitatissimum L ◽  
Flax Seeds ◽  
Variety Testing ◽  
Flax Straw

In the comparative variety testing it was evaluated promising material of fiber-flax (Linum usitatissimum L.). The aim of the work was to identify the most valuable cultivar fiber-flax according to their  economic and biological characteristics, and adaptability to adverse environmental factors.  Valuable forms of fiber-flax on the main economically significant features were identified in the Smolensk region. The total length of the stem of A-11 and L-198 exceeded the standard S-108 by 8 - 10%. The duaration of the growing season in all studied varieties was 5 days longer than that of the standard variety.   L-198 exceeded the standard S-108, both in yield of flax straw and fiber content in the stem, the excess was 9 and 3%, respectively. The highest yield of flax seeds (0,58 t/ha) was also in L-198 (21% higher than in the standard). The yield of long fiber in the stem of this sample was 20,1%, which is 0,8% higher compared to the standard. The calculation of the economic efficiency of cultivation of the L-198 variety for fiber-flax seeds also showed its advantage over the S-108 standard.

scholarly journals Evaluation of anti-nociceptive, anti-inflammatory and hepatoprotective effects of methanol extract of Mazus pumilus (Burm. f.) Steenis (Mazaceae) herb

2021 ◽  
Vol 18 (4) ◽  
pp. 799-807
Author(s):  
Saiqa Ishtiaq ◽  
Ayesha Ilyas ◽  
Numera Irshad ◽  
Uzma Niaz ◽  
Uzma Hanif ◽  
...  
Keyword(s):  
Methanol Extract ◽  
Inflammatory Activity ◽  
Control Group ◽  
Tail Flick ◽  
Histopathological Analysis ◽  
Standard Drug ◽  
Rat Paw Edema ◽  
Hepatoprotective Effects ◽  
Anti Inflammatory ◽  
Different Doses

Purpose: This study was designed to investigate the anti-nociceptive, anti-inflammatory and hepatoprotective activities of the methanol extract of Mazus pumilus (Mazaceae) herb. Methods: Anti-nociceptive activity was determined using hot plate, tail flick and acetic acid-induced writing methods. Carrageenan-induced rat paw edema (0.1 mL of 1 %) model was used for the assessment of anti-inflammatory activity. The methanol extract was administered orally at three different doses (150, 300 and 600 mg/kg) to three separate groups in all the experiments. Diclofenac sodium (50 mg/kg) was used as standard drug while control group received DMSO (1 %, 10 mL/kg). The hepatocurative effect of methanol extract of M. pumilus (400 mg/kg) was determined in isoniazid (50 mg/kg) and rifampicin (100 mg/kg) induced liver injury. Silymarin (100 mg/kg) was used as standard drug for comparison. The control group received distilled water (10 mL/kg). Preliminary phytochemical screening was also carried out. Results: The methanol extract of M. pumilus significantly (p < 0.05) augmented latency time and reduced the number of writhes in the pain models at all doses used for the assessment of antinociceptive actions. The anti-inflammatory activity of different doses of extract was evaluated by measuring the reduction in the size of the paw. A significant (p < 0.05) hepatocurative effect was observed when administered after anti-tuberculosis drugs. Histopathological analysis of the liver tissues also revealed restored hepatocellular architecture. Conclusion: The results demonstrate the anti-nociceptive, anti-inflammatory and hepatoprotective effects of the methanol extract of M. pumilus, thus substantiating the ethnomedical claims associated with the herb.

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