scholarly journals Effects of Soya Bean Oil and Vitamin C on Lipid Peroxidation and Antioxidant Biomarkers in Ethanol -Induced Oxidative Stress in Wistar Rats.

2013 ◽  
Vol 4 (6) ◽  
pp. 28-31 ◽  
Author(s):  
Mallo, J. M.
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Vitamin C ◽  
Wistar Rats ◽  
Soya Bean

scholarly journals In Vivo Protective Effects of Gallic Acid Isolated from Peltiphyllum Peltatum Against Sodium Fluoride-Induced Oxidative Stress in Rat Erythrocytes

2013 ◽  
Vol 64 (4) ◽  
pp. 553-559 ◽  
Author(s):  
Seyed Fazel Nabavi ◽  
Solomon Habtemariam ◽  
Antoni Sureda ◽  
Akbar Hajizadeh Moghaddam ◽  
Maria Daglia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Vitamin C ◽  
Gallic Acid ◽  
Sodium Fluoride ◽  
Enzyme Activities ◽  
Control Group ◽  
Rat Erythrocytes ◽  
Pre Treatment

Abstract Gallic acid has been identified as an antioxidant component of the edible and medicinal plant Peltiphyllum peltatum. The present study examined its potential protective role against sodium fluoride (NaF)-induced oxidative stress in rat erythrocytes. Oxidative stress was induced by NaF administration through drinking water (1030.675 mg m-3 for one week). Gallic acid at 10 mg kg-1 and 20 mg kg-1 and vitamin C for positive controls (10 mg kg-1) were administered daily intraperitoneally for one week prior to NaF administration. Thiobarbituric acid reactive substances, antioxidant enzyme activities (superoxide dismutase and catalase), and the level of reduced glutathione were evaluated in rat erythrocytes. Lipid peroxidation in NaF-exposed rats significantly increased (by 88.8 %) when compared to the control group (p<0.05). Pre-treatment with gallic acid suppressed lipid peroxidation in erythrocytes in a dose-dependent manner. Catalase and superoxide dismutase enzyme activities and glutathione levels were reduced by NaF intoxication by 54.4 %, 63.69 %, and 42 % (p<0.001; vs. untreated control group), respectively. Pre-treatment with gallic acid or vitamin C significantly attenuated the deleterious effects. Gallic acid isolated from Peltiphyllum peltatum and vitamin C mitigated the NaF-induced oxidative stress in rat erythrocytes.

scholarly journals The effect of vitamin C on Endosulfan-induced oxidative stress parameters in prepubertal rats

Biomedicine ◽  
2020 ◽  
Vol 39 (2) ◽  
pp. 333-338
Author(s):  
Kalaivani Manokaran ◽  
Vasanthalaxmi Krishnananda Rao ◽  
Nilima . ◽  
Manjula Shimoga Durgoji Rao ◽  
Sucheta Prasanna Kumar
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Wistar Rats ◽  
Statistical Significance ◽  
Treated Group ◽  
Reproductive Organs ◽  
Protective Role ◽  
Control Group ◽  
Group I ◽  
Testicular Weight

Introduction and Aim: Oxidative stress plays a very important role in endosulfan-induced toxic effects on reproductive organs. Vitamin C is a potent antioxidant which plays an important role in decreasing oxidative stress. The present study was aimed to investigate the protective role of vitamin C against endosulfan-induced testicular toxicity in Wistar rats. To investigate a protective effect of vitamin C against endosulfan induced toxicity on biochemical changes. Materials and Methods: Seventy male neonatal Wistar rats were divided into  seven groups. The group  I was taken as the control group, the endosulfan-treated were grouped into II (3 mg/kg body weight (BW) and group III (6 mg/kg BW), Group IV (9 mg/kg BW) and Group V (12 mg/kg BW). Group VI (9 mg/kg BW) and group VII (12 mg/kg BW) were pretreated with vitamin C (20 mg/kg BW) for 60 days. After  the experimental procedures, the testicular weight, lactate dehydrogenase (LDH) enzyme and testosterone in plasma, LDH, steroidogenic enzymes 3?-HSD and 17?-HSD in testis were evaluated. One-way ANOVA was used to determine the statistical significance. Results: Significant improvement in the testicular weight (P<0.05) , LDH (P<0.05) levels both in plasma and testis, increase in testosterone(P<0.001) and steroidogenic enzyme levels(P<0.001) was observed in the group pretreated with vitamin C treated group when compared to the endosulfan treated group. Conclusion: Vitamin C decreases the toxic effect of endosulfan on testis. The present action might be  due to its antioxidative properties.

scholarly journals The subchronic effects of 3,4-methylendioxymethamphetamine on oxidative stress in rat brain

2014 ◽  
Vol 66 (3) ◽  
pp. 1075-1081
Author(s):  
Ivan Simic ◽  
Violeta Iric-Cupic ◽  
Rada Vucic ◽  
Marina Petrovic ◽  
Violeta Mladenovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Rat Brain ◽  
Wistar Rats ◽  
Superoxide Radical ◽  
Reduced Glutathione ◽  
Oxidative Stress Markers ◽  
Sod Activity ◽  
Stress Markers ◽  
Male Wistar Rats

The aim of the present study was to evaluate the subchronic effects of 3,4-methylenedioxymethamphetamine on several oxidative stress markers: index of lipid peroxidation (ILP), superoxide dismutase (SOD) activity, superoxide radical (O2.-) levels, and reduced glutathione (GSH) levels in the frontal cortex, striatum and hippocampus of the rat. The study included 64 male Wistar rats (200-250g). The animals were treated per os with of 5, 10, or 20 mg/kg of 3,4-methylenedioxymethamphetamine (MDMA) every day for 15 days. The subchronic administration of MDMA resulted in an increase in ILP, SOD and O2.-, and a decrease in GSH, from which we conclude that oxidative stress was induced in rat brain.

scholarly journals Amelioration of Hyperglycaemia, Oxidative Stress and Dyslipidaemia in Alloxan-Induced Diabetic Wistar Rats Treated with Probiotic and Vitamin C

Nutrients ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 151 ◽  
Author(s):  
Tagang Aluwong ◽  
Joseph Ayo ◽  
Alkali Kpukple ◽  
Olusola Oladipo
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Wistar Rats

scholarly journals Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ljiljana M. Popovic ◽  
Nebojsa R. Mitic ◽  
Dijana Miric ◽  
Boban Bisevac ◽  
Mirjana Miric ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Vitamin C ◽  
Inflammatory Response ◽  
Acute Exercise ◽  
Exercise Group ◽  
Vitamin Supplementation ◽  
Regular Exercise ◽  
Biological Macromolecules ◽  
Vitamin C Supplementation

Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting from exercise induces activation of inflammatory cells followed by the increased activity of myeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aim of this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.

scholarly journals Lipid Peroxidation and Antioxidant Enzymes Evaluation in Lactating Female Albino Rats Following Supplementation with Fermented Soya Bean and Vitamin C

2017 ◽  
Vol 05 (02) ◽  
pp. 24-31
Author(s):  
I. S. Malgwi ◽  
Y. Tanko ◽  
M. U. Kawu ◽  
E. D. Eze ◽  
H. A. Salami ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Vitamin C ◽  
Soya Bean ◽  
Albino Rats

scholarly journals Pengaruh Pemberian Vitamin C Terhadap Kualitas Spermatozoa Yang Terpapar Asap Rokok

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Frenky D. Awuy ◽  
Diana S. Purwanto ◽  
Yanti M. Mewo
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Free Radicals ◽  
Literature Review ◽  
Vitamin C ◽  
Cigarette Smoke ◽  
Google Scholar ◽  
Exclusion Criteria ◽  
Spermatozoa Motility

Abstract: Cigarettes can cause oxidative stress that may cause various health problems such as the decrease of spermatozoa quality. The disturbed state of  spermatozoa results in a decrease quality of the spermatozoa which may effect fertility. Vitamin C is an antioxidant which is believed to affect improving the quality of spermatozoa. This study aimed to determine the effect of vitamin C on the quality of spermatoza exposed to cigarette smoke. This research was conducted by literature review using three databases, namely Google Scholar, Pubmed, and ClinicalKey. After being selected based on inclusion and exclusion criteria, there were 10 articles research for assessment. The results show that the decrease in spermatozoa concentration is due to the nicotine contained in cigarette smoke. By giving vitamin C, it can reduce oxidative stress which can cause lipid peroxidation, and then reduce the decrease in spermatozoa concentration. There is also an improvement in spermatozoa motility and morphology after vitamin C administration. Vitamin C as an antioxidant plays a role in fighting free radicals, so that the spermatozoa cell membrane remains protected. In conclusion, consumption of vitamin C shows an effect to improve the quality of spermatozoa exposed to cigarette smoke, including increasing/improving the concentration, morphology, and motility of spermatozoa.Keywords: vitamin C, spermatozoa, smoker  Abstrak: Rokok menyebabkan terjadinya stres oksidatif yang dapat mengakibatkan berbagai gangguan kesehatan seperti penurunan kualitas spermatozoa. Keadaan spermatozoa yang terganggu mengakibatkan penurunan kualitas spermatozoa sehingga akan memengaruhi kesuburan. Vitamin C merupakan antioksidan yang dipercaya dapat memengaruhi peningkatan kualitas spermatozoa. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian vitamin C terhadap kualitas spermatoza yang terpapar asap rokok. Penelitian ini berbentuk literature review dengan pencarian data menggunakan tiga database yaitu Google Scholar, Pubmed, dan ClinicalKey. Setelah diseleksi berdasarkan kriteria inklusi dan eksklusi, didapatkan 10 artikel untuk dilakukan penilaian. Hasil penelitian menunjukkan bahwa penurunan konsentrasi spermatozoa disebabkan oleh kandungan nikotin dalam asap rokok. Pemberian vitamin C dapat menurunkan stres oksidatif yang dapat menyebabkan terjadinya peroksidasi lipid, kemudian menekan penurunan konsentrasi spermatozoa. Terdapat juga perbaikan motilitas dan morfologi spermatozoa setelah pemberian vitamin C. Vitamin C sebagai antioksidan berfungsi untuk menanggulangi radikal bebas, sehingga membran sel spermatozoa akan tetap terlindungi. Sebagai simpulan, pemberian vitamin C menunjukkan adanya pengaruh untuk meningkatkan kualitas spermatozoa yang terpapar asap rokok, meliputi peningkatan/perbaikan konsentrasi, morfologi, dan motilitas spermatozoa.Kata kunci: vitamin C, spermatozoa, asap rokok

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