Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect

Osteoarthritis (OA) is a degenerative joint disease in the musculoskeletal system with a relatively high incidence and disability rate in the elderly. It is characterized by the degradation of articular cartilage, inflammation of the synovial membrane, and abnormal structure in the periarticular and subchondral bones. Although progress has been made in uncovering the molecular mechanism, the etiology of OA is still complicated and unclear. Nevertheless, there is no treatment method that can effectively prevent or reverse the deterioration of cartilage and bone structure. In recent years, in the field of pharmacology, research focus has shifted to disease prevention and early treatment rather than disease modification in OA. Biologic agents become more and more attractive as their direct or indirect intervention effects on the initiation or development of OA. In this review, we will discuss a wide spectrum of biologic agents ranging from DNA, noncoding RNA, exosome, platelet-rich plasma (PRP), to protein. We searched for key words such as OA, DNA, gene, RNA, exosome, PRP, protein, and so on. From the pharmacological aspect, stem cell therapy is a very special technique, which is not included in this review. The literatures ranging from January 2016 to August 2021 were included and summarized. In this review, we aim to help readers have a complete and precise understanding of the current pharmacological research progress in the intervention of OA from the biological aspect and provide an indication for the future translational studies.

LITERARY REVIEW ON AGEING PROCESS AND IT'S NATURAL AYURVEDA APPROACH

In Ayurveda, Ageing is termed as ‘Jara’ for which some rules are given to make it healthy with longevity. This is the phase anticipatory care should be taken so that ageing process can be deferred and old age related diseases can be barred. Jara as natural prodigy of human body takes place in two ways i.e. Kalaja and Akalaja. Body gets affected from various factors like diet pattern, food particles, lifestyle, environment, etc. changes or degenerative changes are the nature of universe. These changes are known as Swabhaav in Ayurveda in which a constant decline may found in Shareera in old age. Ageing starts in different attributes at different period; thus, the ancient classics give a detailed version on the physiological, psychological and biological aspects of ageing including growth, puberty and senility.There are enough matter in relation to the establishment and termination of life which can be understood as theory as Theory of Innate Destruction (Swabhawoparamavada), Theory of Disturbance in Fundamental Principle of Body, Theory related to Kala (Time Factor), Theory Related to Environmental and other Biological Aspect. Jara management can be done via programming of lifestyle in such a way that Akalaj Jara can be avoided and Kalaj Jara can be delayed. For this purpose not only the Rasayana drugs but Ayurvediya Dinacharya, Ritucharya and other regimens in the way of ideal lifestyle is to be followed.

BURNOUT SYNDROME. HOW THE PANDEMIC OF A NEW CORONAVIRUS INFECTION AFFECTS MENTAL HEALTH

In May 2019, the WHO General Assembly approved the 11th version of the ICD, in which emotional burnout is designated as an independent condition due to professional activity. In March 2020, the world was declared a pandemic of CAVID-19, a disease that can be considered as an occupational disease when infecting medical workers in the workplace. Coronavirus in occupational medicine is considered as a new biological factor, the influence of which on all body systems is constantly being studied and updated with new data. Not only the biological aspect of the impact of SARS-CoV-2 is relevant for the health of medical workers, but also the impact on mental health of the situation caused by the pandemic.

Factors Influencing Marginal Bone Loss around Dental Implants: A Narrative Review

Implant supported dental prostheses are increasingly used in dental practice. The aim of this narrative review is to present the influence of transmucosal surface of prosthetic abutment and implant on peri-implant tissue. The article describes causes of bone loss around the dental implant. Moreover, properties of different materials are compared and discussed. The advantages, disadvantages, and biomechanical concept of different implant-abutment connections are presented. The location of connections in relation to the bone level and the influence of microgap between the abutment and implant are described. Additionally, the implant abutments for cemented and screwed prosthetic restorations are compared. The influence of implant and abutment surface at the transmucosal level on peri-implant soft tissue is discussed. Finally, the biological aspect of abutment-implant connection is analyzed.

Jaring Kekop (Gillnet) Fishery and Its Sustainability Level in Ranau Lake, South Sumatera

Fishing activity to catch hampala (Hampala macrolepidota) using gillnet in the Ranau Lake has been quite intensive. However, there is a type of net developed by fishers to catch hampala in the same waters, namely “jaring kekop.” The existence of this net will increase the intensity of fishing in Ranau Lake which is already high, thus affecting the availability of stocks. The purpose of this research is to describe technical and biological characteristic of kekop net and to analyze the sustainability of kekop net fishery to catch hampala in Ranau Lake, South Sumatera. Data was collected by field survey method through direct interviews with fishers, observation and measurement of fishing unit, and participated in the fishing operation trips. The result showed that the jaring kekop used by fishers in Ranau Lake can be classified into the set gillnet with slightly different operation method from the common set gillnet. The SPR (spawning potential ratio) analysis of hampal fish obtained a value of 72% or > 40%, which means that the average fish caught is gonad ripe or fit to catch (SL50 > Lm). The sustainability values of the jaring kekop fishery were 51.4 for technical aspect, 6.5 for biological aspect, and 65.2 for social-economic aspect. From these sustainability values, it can be seen that the jaring kekop fishery in Lake Ranau is sustainable enough. Key words: jaring kekop, hampala fsih, characteristic, sustainability, Ranau Lake

Sustainable Operational Analysis of the Cultivation of Indonesian Thunnus albacares by Bioeconomic Approach

This study aimed to describe the characteristics and cultivation conditions of Thunnus albacares in Pelabuhan Perikanan Pantai (PPP, shore-port fisheries) of Labuhan Lombok, East Lombok. Data was collected by a simple random sample using a questionnaire for 30 fishing boats. Primary data was collected by interview with respondents and field observation, while secondary data was obtained from records of PPP in Labuhan Lombok, BPS and DKP, East Lombok. Results showed that East Lombok has a high potential for T. albacares cultivation as well as eco-friendly fishery cultivation; this is practiced by local fishermen who commonly use traditional boats sized 4-7 GT complete with fishing utilities, including handline rods and trolling rods. From a biological aspect, there was open access to T. albaceros in 2006, followed by biological overfishing in 2007, and economic overfishing in 2005, 2008, 2009, 2010 and 2011. The maximum sustainable yield (MSY) reached 922,518.18 kg per year (MSY level 3,313 per year). The resource optimization of T. albaceros reached the peak of maximum economic yield (MEY) valued at IDR 24,693,982,361, with fish haul efforts from 2,063 annual trips yielding 791,270.90 kg of tuna per year.

Bioecological aspect of lamasi (Barbonymus gonionotus) in mailil rever labuhanbatu district, indonesia

The existence of gold mining activities in mailil river can disrupt the stability of the ecosystem, fishing by using toxins, which may result in a decrease in fish populations in the river mailil. This study aims to obtain information related to biological and ecological aspects (Barbonymus gonionotus) in river Mailil, Village. This study was conducted from November 2020 to January 2021. The locations for sampling were determined based on information from the local community in Bandar Kumbul Village. Samples were caught using nets, traps, and nets Sampling was conducted from 09:00 am to 03:00 pm. The biological aspect being measured was the length-weight relationship of the fish using the linear allometric model (LAM). Meanwhile, the ecological aspect being measured was the condition factor using Fulton’s K equation and relative weight (Wr) equation. In this study, 54 silver barbs (B. gonionotus) were successfully caught as samples. The results of the length-weight relationship analysis indicated a negative allometric relationship with the value of b = 0.52 (b < 3). Furthermore, the value of Fulton’s K condition factor was 27.75, while the value of relative weight (Wr) condition factor was 100.07. These results indicated that river Mailil as an ecosystem and habitat of silver barbs is in the balance condition.Keywords: Length-weight relationship, Barbonymus gonionotus, aek mailil

Supperior Fishing Gear for Coral Reef Fishes in Western Seram Regency

Various fishing gears that are operated in the coral reef waters of Western Seram Regency have their own selectivity, capture various species of fish, and have an impact on the damage to coral reef ecosystems. This study aims to determine the leading reef fishing gears in Western Seram District. The survey method is through observations and interviews with fishermen who conduct fishing activities of coral species. Respondents are determined by propulsive sampling, the selection of superior fishing gear is done by the scoring method. The results showed that the fishing gear classified into the line fishing gear was superior to other fishing gear, where the bottom trolling were superior. The less favored coral fishing equipment especially from the biological aspect needs attention to improve the method and design of the fishing gear.

Non-immune Traits Triggered by Blood Intake Impact Vectorial Competence

Blood-feeding arthropods are considered an enormous public health threat. They are vectors of a plethora of infectious agents that cause potentially fatal diseases like Malaria, Dengue fever, Leishmaniasis, and Lyme disease. These vectors shine due to their own physiological idiosyncrasies, but one biological aspect brings them all together: the requirement of blood intake for development and reproduction. It is through blood-feeding that they acquire pathogens and during blood digestion that they summon a collection of multisystemic events critical for vector competence. The literature is focused on how classical immune pathways (Toll, IMD, and JAK/Stat) are elicited throughout the course of vector infection. Still, they are not the sole determinants of host permissiveness. The dramatic changes that are the hallmark of the insect physiology after a blood meal intake are the landscape where a successful infection takes place. Dominant processes that occur in response to a blood meal are not canonical immunological traits yet are critical in establishing vector competence. These include hormonal circuitries and reproductive physiology, midgut permeability barriers, midgut homeostasis, energy metabolism, and proteolytic activity. On the other hand, the parasites themselves have a role in the outcome of these blood triggered physiological events, consistently using them in their favor. Here, to enlighten the knowledge on vector–pathogen interaction beyond the immune pathways, we will explore different aspects of the vector physiology, discussing how they give support to these long-dated host–parasite relationships.