The Proton in Biochemistry: Impacts on Bioenergetics, Biophysical Chemistry, and Bioorganic Chemistry

The proton is the smallest atomic particle, and in aqueous solution it is the smallest hydrated ion, having only two waters in its first hydration shell. In this article we survey key aspects of the proton in chemistry and biochemistry, starting with the definitions of pH and pKa and their application inside biological cells. This includes an exploration of pH in nanoscale spaces, distinguishing between bulk and interfacial phases. We survey the Eigen and Zundel models of the structure of the hydrated proton, and how these can be used to explain: a) the behavior of protons at the water-hydrophobic interface, and b) the extraordinarily high mobility of protons in bulk water via Grotthuss hopping, and inside proteins via proton wires. Lastly, we survey key aspects of the effect of proton concentration and proton transfer on biochemical reactions including ligand binding and enzyme catalysis, as well as pH effects on biochemical thermodynamics, including the Chemiosmotic Theory. We find, for example, that the spontaneity of ATP hydrolysis at pH ≥ 7 is not due to any inherent property of ATP (or ADP or phosphate), but rather to the low concentration of H+. Additionally, we show that acidification due to fermentation does not derive from the organic acid waste products, but rather from the proton produced by ATP hydrolysis.

Particle Theory: A New Theory That May Reconcile General Relativity and Quantum Theory

In an attempt to reconcile General Relativity and Quantum Mechanics, Particle Theory is a concept that may try to address this issue. This theory explains the effects accurately calculated by General Relativity in an alternate and real, physical way, and is therefore an alternative to GR. The theory states that indivisible atomic particles are instead divided into even smaller particles (called “EM particles”) held together by a central potential, the speed of light being the limit to their velocities. The “shedding” of these particles are responsible for the static and magnetic fields we observe. This also creates a “screening” effect that, for an atomic particle at rest, blocks about half of what this theory defines as the “true gravitational potential”, which is just twice the Newtonian value (mediated by what this theory defines as “gravity particles”). When an atomic system of particles starts moving in a certain direction, the act of shedding and the internal movement decreases as the particles orient themselves in the direction of the velocity, which reduces the screening effect, where we start to observe the relativistic effects of General (and Special) Relativity.

Precision Physics in Penning Traps Using the Continuous Stern-Gerlach Effect

Abstract“A single atomic particle forever floating at rest in free space” (H. Dehmelt) would be the ideal object for precision measurements of atomic properties and for tests of fundamental theories. Such an ideal, of course, can ultimately never be achieved. A very close approximation to this ideal is made possible by ion traps, where electromagnetic forces are used to confine charged particles under well-controlled conditions for practically unlimited time. Concurrently, sensitive detection methods have been developed to allow observation of single stored ions. Various cooling methods can be employed to bring the trapped ion nearly to rest. Among different realisations of ion traps we consider in this chapter the so-called Penning traps which use static electric and magnetic fields for ion confinement. After a brief discussion of Penning-trap properties, we consider various experiments including the application of the “continuous Stern-Gerlach effect”, which have led recently to precise determinations of the masses and magnetic moments of particles and antiparticles. These serve as input for testing fundamental theories and symmetries.

Awareness of Medical Applications of Ozonated Water Therapy Among Dental Students

Ozone (O3) happens to be a triple atomic particle that comprises three oxygen iotas with an atomic load of 47.98 g/mol. Ozone is a thermokinetic coseismal particle which, contingent upon framework conditions like temperature and weight, has a short half-life and breaks down into sub-atomic oxygen (O2). Ozone is utilized as medication in many conditions. The study aimed to assess the awareness of medical applications of ozonated water therapy among dental students. A cross sectional study was done with a self-administered questionnaire with 10 questions circulated among 100 dental students. The questionnaire assessed the awareness about ozone water therapy in medical applications, their medicinal uses, antiinflammatory activity, mechanism of action and side effects. The responses were recorded and analysed.87% of the respondents were not aware of medical uses of Ozone water therapy .73% were not aware of antiinflammatory activity of Ozone water therapy.83 % were not aware of the mechanism of action of Ozone water therapy .85% were not aware of side effects of Ozone water therapy. The awareness about the use of Ozone water therapy in medical applications is very less among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modifications should be incorporated to improve the awareness levels.

Вероятность процессов захвата электронов у атомов аргона ионами -=SUP=-3-=/SUP=-Не-=SUP=-2+-=/SUP=- при различных параметрах удара

We have measured the absolute values of total cross sections of capture of one and two electrons by He^2+ ions from argon atoms. The differential scattering cross sections have been determined for fast atoms and singly charged helium ions formed in each of these processes (without and with additional ionization of the formed slow argon ion). Measurements have been taken for He^2+ ions with kinetic energy of 6 keV in scattering angle range 0–2.5°. Based on the measured differential cross sections using different model atomic particle interaction potentials, we have calculated the cross sections of these processes as functions of the impact parameter. The probabilities of realization of these processes with electron density distribution in different shells in the target atom have been compared. The applicability of the expressions for the screened Coulomb interaction potentials in the description of scattering of particles that have captured electrons has been demonstrated.

Concepts

The topic of concepts lies at the intersection of semantics and philosophy of mind. A concept is supposed to be a constituent of a thought (or ‘proposition’) rather in the way that a word is a constituent of a sentence that typically expresses a thought. Indeed, concepts are often thought to be the meanings of words (and will be designated by enclosing the words for them in brackets: [city] is expressed by ‘city’ and by ‘metropolis’). However, the two topics can diverge: non-linguistic animals may possess concepts, and standard linguistic meanings involve conventions in ways that concepts do not. Concepts seem essential to ordinary and scientific psychological explanation, which would be undermined were it not possible for the same concept to occur in different thought episodes: someone could not even recall something unless the concepts they have now overlap the concepts they had earlier. If a disagreement between people is to be more than ‘merely verbal’, their words must express the same concepts. And if psychologists are to describe shared patterns of thought across people, they need to advert to shared concepts. Concepts also seem essential to categorizing the world, for example, recognizing a cow and classifying it as a mammal. Concepts are also compositional: concepts can be combined to form a virtual infinitude of complex categories, in such a way that someone can understand a novel combination, for example, [smallest sub-atomic particle], by understanding its constituents. Concepts, however, are not always studied as part of psychology. Some logicians and formal semanticists study the deductive relations among concepts and propositions in abstraction from any mind. Philosophers doing ‘philosophical analysis’ try to specify the conditions that make something the kind of thing it is – for example, what it is that makes an act good – an enterprise they take to consist in the analysis of concepts. Given these diverse interests, there is considerable disagreement about what exactly a concept is. Psychologists tend to use ‘concept’ for internal representations, for example, images, stereotypes, words that may be the vehicles for thought in the mind or brain. Logicians and formal semanticists tend to use it for sets of real and possible objects, and functions defined over them; and philosophers of mind have variously proposed properties, ‘senses‘, inferential rules or discrimination abilities. A related issue is what it is for someone to possess a concept. The ‘classical view’ presumed concepts had ‘definitions’ known by competent users. For example, grasping [bachelor] seemed to consist in grasping the definition, [adult, unmarried male]. However, if definitions are not to go on forever, there must be primitive concepts that are not defined but are grasped in some other way. Empiricism claimed that these definitions were provided by sensory conditions for a concept’s application. Thus, [material object] was defined in terms of certain possibilities of sensation. The classical view suffers from the fact that few successful definitions have ever been provided. Wittgenstein suggested that concept possession need not consist in knowing a definition, but in appreciating the role of a concept in thought and practice. Moreover, he claimed, a concept need not apply to things by virtue of some closed set of features captured by a definition, but rather by virtue of ‘family resemblances’ among the things, a suggestion that has given rise in psychology to ‘prototype’ theories of concepts. Most traditional approaches to possession conditions have been concerned with the internal states, especially the beliefs, of the conceptualizer. Quine raised a challenge for such an approach in his doctrine of ‘confirmation holism’, which stressed that a person’s beliefs are fixed by what they find plausible overall. Separating out any particular beliefs as defining a concept seemed to him arbitrary and in conflict with actual practice, where concepts seem shared by people with different beliefs. This led Quine himself to be sceptical about talk of concepts generally, denying that there was any principled way to distinguish ‘analytic’ claims that express definitional claims about a concept from ‘synthetic’ ones that express merely common beliefs about the things to which a concept applies. However, recent philosophers suggest that people share concepts not by virtue of any internal facts, but by virtue of facts about their external (social) environment. For example, people arguably have the concept [water] by virtue of interacting in certain ways with H2O and deferring to experts in defining it. This work has given rise to a variety of externalist theories of concepts and semantics generally. Many also think, however, that psychology could generalize about people’s minds independently of the external contexts they happen to inhabit, and so have proposed ‘two-factor theories’, according to which there is an internal component to a concept that may play a role in psychological explanation, as opposed to an external component that determines the application of the concept to the world.

Solusi Persamaan Schrödinger Berbasis Panjang Minimal untuk Potensial Coulomb Termodifikasi

Abstrak – Persamaan Schrödinger adalah salah satu topik penelitian yang yang paling sering diteliti dalam mekanika kuantum. Pada jurnal ini persamaan Schrödinger berbasis panjang minimal diaplikasikan untuk potensial Coulomb Termodifikasi. Fungsi gelombang dan spektrum energi yang dihasilkan menunjukkan kharakteristik atau tingkah laku dari partikel sub atom. Dengan menggunakan metode pendekatan hipergeometri, diperoleh solusi analitis untuk bagian radial persamaan Schrödinger berbasis panjang minimal diaplikasikan untuk potensial Coulomb Termodifikasi. Hasil yang diperoleh menunjukkan terjadi peningkatan energi yang sebanding dengan meningkatnya parameter panjang minimal dan parameter potensial Coulomb Termodifikasi. Kata kunci: persamaan Schrödinger, panjang minimal, fungsi gelombang, energi, potensial Coulomb Termodifikasi Abstract – The Schrödinger equation is the most popular topic research at quantum mechanics. The Schrödinger equation based on the concept of minimal length formalism has been obtained for modified Coulomb potential. The wave function and energy spectra were used to describe the characteristic of sub-atomic particle. By using hypergeometry method, we obtained the approximate analytical solutions of the radial Schrödinger equation based on the concept of minimal length formalism for the modified Coulomb potential. The wave function and energy spectra was solved. The result showed that the value of energy increased by the increasing both of minimal length parameter and the potential parameter. Key words: Schrödinger equation, minimal length formalism (MLF), wave function, energy spectra, Modified Coulomb potential