This chapter examines the interaction of multinational enterprises (MNEs) with the political communities in which they operate. It first maps the actors involved and identifies their respective roles and interests. The chapter then considers the effects of MNEs on home and host communities and economies. This involves ideological themes that have influenced the regulatory debate not only historically, but also for the present and future. The chapter also explores the principal levels and methods of regulation, discussing the relationship between formal regulation by state bodies and informal regulation by non-state actors; outlining the available sources of regulatory rules and practices; and assessing the choices of legal jurisdiction between the national, bilateral, regional and multilateral levels. Integrated global production, dominated by MNEs, has led to changes in international and national regulatory environments away from ‘investor control’ towards ‘investor promotion and protection’. At the same time, with the end of the Cold War and the disintegration of the socialist system, there appears to be no serious alternative to the corporate capitalism espoused by MNEs, backed up by the ‘neoliberal’ system of market-led globalization. However, recent challenges to the ‘neoliberal’ ascendancy come from economic nationalism and protectionism as well as greater concern for corporate social responsibility and accountability.