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2022 ◽  
Vol 2022 ◽  
pp. 1-10
Author(s):  
Yang Luo ◽  
Kim Kyung Yee

Information technology has brought great changes to China’s education. 5G technology provides a better guarantee for the sharing of curriculum resources, facing the extreme shortage of educational resources in China. The contradiction between limited educational resources and unlimited development needs of higher education has become increasingly prominent. How to effectively realize resource sharing among universities has become a problem that must be considered in the talent development of universities. In order to solve this problem, universities must improve the utilization rate of resources, maximize resource sharing, and establish a more perfect resource sharing mechanism under the background of 5G and Internet of Things. This paper analyzes the current situation of research at home and abroad, the current situation of resources development, and the application of online courses under the background of Internet of Things, thus constructing an overall framework of curriculum resource sharing mode. According to effective experiments, the offline curriculum education resource sharing and traditional resource sharing schemes in the background of 5G and Internet are compared, and the necessity and importance of applying 5G Internet of Things are verified.


2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Jian Feng ◽  
Weiliang Zhang ◽  
Sang-Bing Tsai

In this paper, the intelligent education cloud service platform is first constructed in view of the high cost consumption in the process of resource sharing scheduling in colleges and universities. Secondly, the hierarchical education resource sharing grid model is proposed. Specifically, according to the characteristics of the educational resource grid, the key factors affecting the performance of copy creation strategy are analysed, and a dynamic copy creation strategy is proposed. A multiresource equity distribution mechanism based on the concept of resource sharing equity is further proposed. The mechanism establishes a planning model according to the limited task resource demand and the amount of resources shared by the user at different times so that the global cumulative share vector of superior resources meets the dictionary order optimally. The simulation experiment shows that the grid sharing model proposed in this paper has better performance on the educational cloud service platform. The proposed resource allocation mechanism has achieved good results in ensuring the fair distribution of resources and ensuring high resource utilization when resource sharing users put forward multiple groups of time-changing resource demands.


Author(s):  
Bahrudin Bahrudin ◽  
Indra Jaya ◽  
Cecep Kustandi

This research is on the Implementation of special needs schools as Resources Center for Inclusive Education in Jakarta, Indonesia. This study aims to determine the implementation of special needs schools as organizers of inclusive educational resource centers. This research was conducted in a special needs school designated as an inclusive education resource center numbering 18 schools in Jakarta. This research uses a qualitative approach. Implementing the special needs schools' program as a resource center for inclusive education illustrates that the condition of inclusive education has not been maximized because there is still a lack of means to support the activities of inclusive educational resource centers. In addition, the need for training on inclusive education for teachers and education personnel becomes important for inclusive schools to do.


2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Xin Ge ◽  
Xin Tian

In view of the current problems in China’s special education resource centers, such as lack of functional cognition and unreasonable architectural function and spatial organization, which result in the inability to coordinate regional education resources, the formulation and implementation of special education ISP program are undertaken, and the development of integrated education is promoted. This paper draws on the concept of integrated education in developed areas and the design wisdom of resource centers. The research is carried out from the perspective of meeting the behavior patterns and special needs of different users, and the perfect and reasonable functional composition and the key points of special space design are put forward, and the feasible design strategies are expressed through establishing the model and plane layout.


2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Qian Cao

As a popular education major at present, e-commerce and innovation and entrepreneurship education are combined with research that has important strategic significance for talents. In the process of the coordinated development of the two, the sharing of educational resources is the core issue. For this reason, an e-commerce professional innovation and entrepreneurship education resource sharing platform has been constructed. The platform is divided into three hierarchical structures of resource layer, middle layer, and application layer, and detailed analysis is performed on the key modules in the construction of the educational resource sharing platform, including user login module, educational resource management module, system management module, and database design module; based on modular design, after logging in to the system, users can independently publish educational information and can also browse and retrieve shared resources. Experimental results show that the platform has a good operating effect, strong load capacity, rapid response of the system, and high safety performance, with a maximum safety of 97%.


Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 4706-4706
Author(s):  
Susan Bal ◽  
Ahmet Dogan ◽  
Hani Hassoun ◽  
Sham Mailankody ◽  
Sergio A Giralt ◽  
...  

Abstract Introduction Dysproteinemia refers to a spectrum of gammopathies in which an aberrant clone(s) of late stage B lymphoid cells or plasma cells produces monoclonal immunoglobulins and/or fragments. The spectrum includes incidentally noted benign conditions like monoclonal gammopathy of undetermined significance (MGUS) to life threatening diseases such as multiple myeloma (MM) and systemic light chain (AL) amyloidosis. Exploitation of normal plasma cell biology forms the basis of treatments used in both MM and AL amyloidosis. In recent years, immunotherapeutic strategies targeting plasma cells have redefined the treatment landscape of MM and could be particularly useful in AL amyloidosis which is distinguished by a low burden of less proliferative disease and a paucity of high risk genetics. We sought to characterize the expression of potentially clinically relevant and/or immunotherapeutic targets in amyloidogenic plasma cells. Methods All patients diagnosed with systemic AL amyloidosis at Memorial Sloan Kettering Cancer Center, NY between January 1, 2012, and December 31, 2018, who had unstained bone marrow samples were identified. Decalcified formalin fixed paraffin embedded bone marrow biopsy sections were stained for G protein-coupled receptor, class C group 5 member D (GPRC5D), Cyclin D1 (CCND1), B-cell lymphoma 2 (BCL2), and B-cell maturation antigen (BCMA) expression using standard laboratory developed Immunohistochemistry (IHC) assays in a CLIA compliant setting. We scored the biopsies for percentage expression, and intensity of staining. We also obtained the demographic details, staging, and cytogenetic information for the patients from whom these samples were obtained. Results During the queried period, 32 unstained samples were available for testing from 27 unique patients. There were 27 diagnostic and 5 patients had additional samples from the time of relapse. The median age was 63 years (range 41-73). 64% of patients were male and 75% had lambda restricted plasma cells. Cytogenetic abnormalities using fluorescence in situ hybridization (FISH) were reviewed, t(11;14) was seen in 38% samples. The median clonal PC burden in BM at diagnosis was 10% (range 2-80%) and 36% had >10% plasma cells. In clonal PCs, the median BCL2 expression was 100% (range 80-100%) with a staining intensity of 2 (range 1-3). 84% (27) samples had BCL2 expression meeting threshold used in the Bellini study. CCND1 expression could be tested in 16 samples median expression 100% (range 20-100%) and median staining intensity 2 (range 1-3). Patients with CCND1 expression also had 100% BCL2 staining. GPRC5D expression was available in 18 samples and all samples tested expressed GPRC5D with median 80% (range 30-100%) with median intensity 1 (range 1-3). BCMA expression was available for 25 samples, with median expression 80% (range 50-100%) with a median staining intensity 2 (range 1-3). Among the five patients with samples from diagnosis and relapse, samples retained their expression of BCL2, BCMA, and GPRC5D. Among samples with t(11;14) by FISH, 92% expressed BCL2 (per Bellini study) and 58% expressed CCND1. Conclusion Cell surface expression of novel targets has enabled the development of several efficacious therapeutic strategies in MM. Amyloidogenic plasma cells express GPRC5D, BCMA and BCL2. Our data provides the rationale for careful investigation and development of targeted agents (BCL2 inhibitors, e.g.venetoclax) and immunotherapeutic strategies directed at GPRC5D and BCMA in AL amyloidosis. Figure 1 Figure 1. Disclosures Dogan: Roche: Consultancy, Research Funding; Peer View: Honoraria; Seattle Genetics: Consultancy; Takeda: Consultancy, Research Funding; Physicians' Education Resource: Honoraria; EUSA Pharma: Consultancy. Hassoun: Celgene, Takeda, Janssen: Research Funding. Mailankody: Fate Therapeutics: Research Funding; Allogene Therapeutics: Research Funding; Bristol Myers Squibb/Juno: Research Funding; Plexus Communications: Honoraria; Legend Biotech: Consultancy; Evicore: Consultancy; Jansen Oncology: Research Funding; Physician Education Resource: Honoraria; Takeda Oncology: Research Funding. Giralt: SANOFI: Membership on an entity's Board of Directors or advisory committees; AMGEN: Membership on an entity's Board of Directors or advisory committees; JENSENN: Membership on an entity's Board of Directors or advisory committees; GSK: Membership on an entity's Board of Directors or advisory committees; JAZZ: Membership on an entity's Board of Directors or advisory committees; BMS: Membership on an entity's Board of Directors or advisory committees; PFIZER: Membership on an entity's Board of Directors or advisory committees; CELGENE: Membership on an entity's Board of Directors or advisory committees; Actinnum: Membership on an entity's Board of Directors or advisory committees. Landau: Takeda: Research Funding; Genzyme: Honoraria; Takeda, Janssen, Caelum Biosciences, Celgene, Pfizer, Genzyme: Membership on an entity's Board of Directors or advisory committees.


Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 3524-3524
Author(s):  
Sary El Daker ◽  
Daniel Freeman ◽  
Jeeyeon Baik ◽  
Menglei Zhu ◽  
Pratip Chattopadhyay ◽  
...  

Abstract INTRODUCTION Lymphoma cells are dependent on the tumor microenvironment (TME) for their survival and proliferation. Dissection of TME composition provides insight into lymphomagenesis, better prognostication, and enhancement of therapeutic options. Flow cytometry provides a robust approach for single-cell analysis. Nonetheless lack of well-defined comparator groups and/or a robust, reproducible approaches for analyzing the multidimensional data often limited such studies. In the current study, we analyzed the T cell background on a large reference set of follicular hyperplasia (FH) lymph node samples utilizing a robust standardized high dimensionality flow cytometry and a novel reproducible analytical pipeline. We then compared this baseline reference set with tumor infiltrating T cell subsets in follicular lymphoma (FL; in treatment naïve FL-NA and relapsed/refractory FL-RR sets). METHODS On behalf of the imCORE Network we analyzed 44 FH and 81 FL (35 FL-NA and 44 FL-RR) with 2 standardized flow cytometry panels (23 antigen/18-color) (Table 1). We evaluated the T cell subset distribution as well as immune checkpoint expression (TIGIT, TIM3, PD-1, CD96, LAG3, CTLA4, CD73) within analytically defined T cell clusters. Analysis was performed using semiautomated multi-step analytical pipeline as outlined in Figure 1. Using standardized instrument settings and an R-based algorithms (gaussNorm) to minimize technical variations in sample acquisition we analyzed the T-cells subpopulations using a dimensionality reduction technique (UMAP), combined with an unsupervised clustering algorithm (FlowSOM). Statistical analysis was performed using non-parametric Wilcoxon test. RESULTS In the 3 cohorts, several marked differences in the composition T cells subsets were observed. Compared to FH the FL lymph nodes were depleted for CD4 & CD8 naïve subsets (Table 2) and were characterized by an immune suppressive microenvironment enriched in specific subsets of activated T regulatory cells and exhausted memory effector cells. The pool of CD8 naïve cells was restored in FL-RR cases (Table 2). FL-NA nodes showed enrichment of T follicular regulatory cells (Tfr; Table 2) (0.9% vs 2.7%, p<0.0001) expressing FoxP3, dim to negative CD25, CD45RO, TIGIT, PD1, CTLA and CXCR5 (Table 2) and activated regulatory T cells (T-Reg) characterized by a highly suppressive phenotype CD25+, CTLA4+, TIGIT+ and PD1+ (Fig. 2B). Moreover, Tfr compartment was further expanded in relapsed/refractory FL cases (2.7% vs 4.5%, p=0.02). In association with the increase of Tfr cells, the concentration of CTLA4+, TIGIT+, PD1bright T follicular helper cells (Tfh) was reduced in FL-RR compared to FL-NA (Fig. 2C). The Tfr/Treg expansion was also associated with a marked increase in exhausted memory T cells in both CD4 and CD8 compartments (CD4 EM TP and CD8 EM DP, Table 2). In FL isolates the CD4 compartment was characterized by the expression of triple positive (CTLA4, TIGIT, PD1) phenotype in EM cells while the memory CD8 cells overexpressed TIGIT and PD1 (Fig. 2D). A smaller subpopulation of memory CD8 cells, almost undetectable in FH samples, characterized by the expression of CTLA4, PD1, TIGIT and TIM3 is expanded in FL isolates (Fig. 2D). CONCLUSION Our data suggest that change in balance between TFH and Tfr may lead to more aggressive therapy resistant disease in FL. The interplay between TFH and Tfr, has been postulated to shape the immune response in FL with TFH promoting germinal center formation and Tfr inhibiting TFH and follicular effector T cells. While both TFH and Tfr compartments are expanded in FL, in the relapsed/ refractory FL cases, the Tfr compartment is further expanded at the expense of TFH leading to more immunosuppressive background. Furthermore our study suggests a rational way of designing immune checkpoint inhibitor studies in FL. Effector memory T-cells in FL isolates show an exhausted phenotype characterized by the expression of the inhibitory receptors CTLA4, TIGIT, PD1 in the CD4 compartment, and TIGIT, PD1 in the CD8. In addition, the noteworthy expansion of TIM3+ memory CD8 cells in FL. Targeting these most highly expressed checkpoints in FL alone or in combination may provide an avenue for rational trial design. Figure 1 Figure 1. Disclosures Roshal: Celgene: Other: Provision of services; Auron Therapeutics: Other: Ownership / Equity interests; Provision of services; Physicians' Education Resource: Other: Provision of services. Dogan: Physicians' Education Resource: Honoraria; Peer View: Honoraria; Roche: Consultancy, Research Funding; Takeda: Consultancy, Research Funding; Seattle Genetics: Consultancy; EUSA Pharma: Consultancy.


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