METHODOLOGICAL APPROACHES TO IMPROVING THE REGULATORY AND METHODOLOGICAL FRAMEWORK IN THE FIELD OF DESIGN AND CAPITAL REPAIR OF APARTMENT BUILDINGS

The design and execution of works on capital repair of apartment buildings are regulated by the current normative legal and normative-technical documents. Their actualization is conditioned by the development of technologies, new forms of work organization in repair-construction production as well as by the necessity to remove administrative barriers to intensify the processes of designing and execution of works on major repair in specific conditions without residents' resettlement in order to provide safety conditions, comfortable living environment and, as a result, to prolong the periods between repairs in the process of buildings operation.

Return to Work After Pectoralis Major Repair

Background: Pectoralis major repair (PMR) is an infrequent injury that occurs during resistance training, most commonly during the eccentric phase of muscle contraction. As the incidence of weight training continues to increase, it is important to understand the outcomes after PMR. Purpose: To evaluate the rate and duration of return to work in patients undergoing PMR. Study Design: Case series; Level of evidence, 4. Methods: Consecutive patients undergoing PMR from 2010 to 2016 at a single institution were retrospectively reviewed at a minimum of 1 year postoperatively. Patients completed a standardized and validated work questionnaire, as well as a visual analog scale for pain, American Shoulder and Elbow Surgeons survey, Single Assessment Numerical Evaluation, and a satisfaction survey. Results: Of the 60 eligible patients who had a PMR, 49 (81.7%) were contacted at the final follow-up. Of the 49 patients, 46 (93.9%) had been employed within 3 years before surgery (mean ± SD age, 40.4 ± 8.2 years; follow-up, 3.9 ± 2.8 years). Of these, 45 (97.8%) returned to work by 1.6 ± 2.1 months postoperatively, and 41 (89.1%) returned to the same level of occupational intensity. Patients who held sedentary, light-, medium-, or high-intensity occupations returned to work at a rate of 100.0%, 100.0%, 83.3%, and 66.7% by 0.8 ± 1.0, 0.8 ± 1.0, 1.3 ± 2.7, and 3.3 ± 2.7 months, respectively. Five of 6 patients (83.3%) with workers’ compensation returned to their previous occupations by 5.0 ± 1.6 months, while 100% of those without workers’ compensation returned to work by 1.1 ± 1.7 months ( P < .001). Overall, 44 patients (95.7%) were satisfied with the procedure, and 40 (87.0%) would have the operation again if presented the opportunity. A single patient (2.2%) required revision PMR. Conclusion: Approximately 98% of patients who underwent PMR returned to work by 1.6 ± 2.1 months postoperatively. Patients with higher-intensity occupations took longer to return to their preoperative levels of occupational intensity. Information regarding return to work is imperative in preoperative patient consultation to manage expectations.

NUDT16L1 (TIRR) knockdown increases genome editing efficacy

Введение. Эффективная точная коррекция мутаций очень важна для внедрения CRISPR-Cas в качестве инструмента для потенциальной генной терапии. Механизм направленной гомологичной репарации (НГР), активируемый после внесения нуклеазой двунитевого разрыва, позволяет корректировать все существующие типы мутаций. Однако НГР не является доминирующим механизмом в клетке, что ограничивает ее эффективность. В нашем исследовании впервые описано, как фактор репарации NUDT16L1 может контролировать эффективность НГР при редактировании с помощью CRISPR-Cas. Цель: исследовать влияние нокдауна и гиперэкспрессии NUDT16L1 на эффективность НГР. Методы. Исследование проводили на клеточной культуре HEK293T. Систему CRISPR-Cas в плазмиде, а также вектор для гиперэкспрессии NUDT16L1 доставляли путём липофекции. Для нокдауна гена NUDT16L1 использовали малые интерферирующие РНК. Результаты. Нокдаун NUDT16L1 повышает уровень НГР в плазмидном и геномном локусах, что проявляется повышением доли GFP-позитивных клеток в 1,8-3,6 раз. Заключение. Нокдаун гена NUDT16L1 может быть использован для повышения эффективности исправления патогенных вариантов ДНК методом геномного редактирования. Introduction. Effective precise knock-in is crucial for implementing CRISPR-Cas9 system as an efficient instrument for potential gene therapy. Homology directed repair (HDR) pathway allows correction of all types of existing mutations. However, HDR is not a major repair pathway of the cell that limits its efficiency. In our study, we present for the first time how repair factors NUDT16L1 controls HDR efficiency. Aim: to study an influence of NUDT16L1 knockdown and overexpression on the HDR efficacy. Methods. HEK293T culture was used to perform the research. Plasmid CRISPR-Cas system along with NUDT16L1 overexpression vector were delivered with lipofection. For NUDT16L1 knockdown small interfering RNAs were used. Results. We discovered that knockdown of NUDT16L1 enhances HDR both in the plasmid and genomic loci increasing eGFP signal from 1.8 to 3.6 times in HEK293T cells. Conclusion. NUDT16L1 knockdown could be used for enhancing of the pathogenic mutations correction through genome editing.

Cataloging of Unit Replacement Based on Long Run Repair Average Cost Rate (ACR) Based on Weibull Distribution Model

Large amounts of money are lost each year in the real-estate industry because of poor schedule and cost control, In Industry the investigated failure and repair pattern, reliabilities of generators, compressors, turbines, using simple statistical tools and simulation techniques. The repair duration is divided into the 1) Major repair 2) Minor repair, In major repair having (repair hour greater than a threshold valve) and Minor repair having (repair hour less than (or)equal to threshold valve). This approach is mainly for Weibull distribution method. In Weibull analysis is a common method for failure analysis and reliability engineering used in a wide range of applications. In this paper, the applicability of Weibull analysis for evaluating and comparing the reliability of the schedule performance of multiple projects is presented, while the successive performance of multiple projects is presented, while the successive repair times are increasing and are exposing to Weibull distribution, under these assumptions, an optimal replacement policy ‘T’ in which we replace the system, when the repair time reaches T. It can be determined that an optimal repair replacement policy T* such that long run average cost and the corresponding optimal replacement policy T* can be determined analytically.

Behaviors and Trends toward Routine Maintenance and Major Repairs of Afridev Handpumps in Rural Malawi

Service provision for Afridev handpumps through community management in Malawi is a notable challenge. Essential preventative maintenance is often neglected, and repairs are undertaken on a reactive basis. The costs of major repairs are not recognized at community level and are typically neglected across the lifecycle of infrastructure or left to external stakeholders. The aim of this study was to investigate preventative maintenance and capital maintenance expenditure over the 15-year design lifecycle of 21,997 Afridev handpumps in Malawi, and how costs change based on different local tariff collection scenarios. A total of four tariff collection scenarios were investigated, for assets both subject and not subject to rehabilitation. The findings highlight poor initial capacity building into appropriate cost recovery and maintenance approaches. Major repair costs increase over the pump lifecycle when service consists of the replacement of low-cost, fast-wearing parts. Rehabilitation/major repair costs increase as a result but tend to be focused on simple longer-life components, such as pump rods. In both cases, a reliance on external support was highlighted, as larger costs are primarily covered by donors and Non-Governmental Organisations (NGOs). Proactive tariff scenarios may provide a greater capability of replacement throughout the lifecycle of major items when compared to reactive tariff scenarios. It is recommended that policy and practitioners should focus on capacity building of sustainable maintenance models that consider the full lifecycle costs of assets.

Cataloging Of Unit Replacement Based On Long Run Repair Average Cost Rate (Acr) Based On Weibull Distribution Model

Large amounts of money are lost each year in the real-estate industry because of poor schedule and cost control, In Industry the investigated failure and repair pattern, reliabilities of generators, compressors, turbines, using simple statistical tools and simulation techniques. The repair duration is divided into the 1)Major repair 2)Minor repair ,In major repair having(repair hour greater than a threshold valve)and Minor repair having(repair hour less than (or)equal to threshold valve).This approach is mainly for Weibull distribution method. In Weibull analysis is a common method for failure analysis and reliability engineering used in a wide range of applications. In this paper, the applicability of Weibull analysis for evaluating and comparing the reliability of the schedule performance of multiple projects is presented, while the successive performance of multiple projects is presented ,while the successive repair times are increasing and are exposing to Weibull distribution ,under these assumptions ,an optimal replacement policy ‘T’ in which we replace the system ,when the repair time reaches T. It can be determined that an optimal repair replacement policy T* such that long run average cost and the corresponding optimal replacement policy T* can be determined analytically.

Improving the Strategy of Maintaining Offshore Wind Turbines through Petri Net Modelling

In order to improve the operation and maintenance (O&M) of offshore wind turbines, a new Petri net (PN)-based offshore wind turbine maintenance model is developed in this paper to simulate the O&M activities in an offshore wind farm. With the aid of the PN model developed, three new potential wind turbine maintenance strategies are studied. They are (1) carrying out periodic maintenance of the wind turbine components at different frequencies according to their specific reliability features; (2) conducting a full inspection of the entire wind turbine system following a major repair; and (3) equipping the wind turbine with a condition monitoring system (CMS) that has powerful fault detection capability. From the research results, it is found that periodic maintenance is essential, but in order to ensure that the turbine is operated economically, this maintenance needs to be carried out at an optimal frequency. Conducting a full inspection of the entire wind turbine system following a major repair enables efficient utilisation of the maintenance resources. If periodic maintenance is performed infrequently, this measure leads to less unexpected shutdowns, lower downtime, and lower maintenance costs. It has been shown that to install the wind turbine with a CMS is helpful to relieve the burden of periodic maintenance. Moreover, the higher the quality of the CMS, the more the downtime and maintenance costs can be reduced. However, the cost of the CMS needs to be considered, as a high cost may make the operation of the offshore wind turbine uneconomical.

Condition assessment, rehabilitation and upgradation of stadia in Delhi using modern technology

<p>India organized the Commonwealth Games in New Delhi in 2010 for which some new stadia were built while some others were renovated. Delhi organized the Asian Games in 1982 successfully building new stadiums. The intervening period of over 25 years had witnessed major advancement in sports technology. Upgrading the stadia using advanced assessment methods and satisfy more stringent requirements were major challenges to ensure that their service lives are extended and that they remain versatile.</p><p>The stadia remodelled/retrofitted were Jawaharlal Nehru Stadium (JNS), Dr. S. P. Mukherjee Swimming Pool Complex, (SPM), Indira Gandhi Indoor Stadium Complex (IG), and Major Dhyan Chand Stadium. In JNS, the centrepiece of the Games, the open spectator stands needed to be covered accommodating the constraints imposed by the existing playing field. SPM, which was open to sky, required an indoor facility. The IG indoor stadium, hosting gymnastics, required major repair and retrofitting. The paper details these efforts</p>

Complex restoration of operation surfaces in large-sized products operated under conditions of chemical-biological and abrasive environment

A complex approach to large-sized parts restoration is shown. There are shown methods developed for parts operation surface restoration depending on a wear degree. There are presented modern technologies and equipment for worn-out surface diagnostics. A method for layer-by-layer restoration and large-sized parts worn-out surface strengthening during product major repair is described. Basic recommendations on operation to increase auger shaft life are given.