The objectives of this study were to (1) study OTOP (One Tambon One Product) entrepreneurs’ competencies in Praiwan Subdistrict, Tak Bai District, Narathiwat Province, and (2) upgrade sustainability OTOP entrepreneurs’ competencies in Praiwan Subdistrict, Tak Bai District, Narathiwat Province. The mixed-method research technique was used in this study; the sample was 286 OTOP entrepreneurs in Praiwan Subdistrict, Tak Bai District, Narathiwat Province; and the interviewees were seven groups of OTOP (One Tambon One Product) entrepreneurs in Praiwan Subdistrict, Tak Bai District, Narathiwat Province. Questionnaires and interview forms were used to gather data, then analyzed using percentage, mean, and standard deviation statistics. The research results can be summarized as follows: 1) In Praiwan Subdistrict, Tak Bai District, Narathiwat Province, Overall, OTOP (One Tambon One Product), entrepreneurs’ competencies, are at a high level. The character feature was the most important, followed by the knowledge feature, and the skill feature was the least important; and 2) upgrading sustainability OTOP (One Tambon One Product) entrepreneurs’ competencies in Praiwan Subdistrict, Tak Bai District, Narathiwat Province by arranging course training workshops including product photography workshop, online marketing, Facebook page, live broadcasting, group storytelling, packaging, and branding.