A Machine Learning Ensemble Based on Radiomics to Predict BI-RADS Category and Reduce the Biopsy Rate of Ultrasound-Detected Suspicious Breast Masses

We developed a machine learning model based on radiomics to predict the BI-RADS category of ultrasound-detected suspicious breast lesions and support medical decision-making towards short-interval follow-up versus tissue sampling. From a retrospective 2015–2019 series of ultrasound-guided core needle biopsies performed by four board-certified breast radiologists using six ultrasound systems from three vendors, we collected 821 images of 834 suspicious breast masses from 819 patients, 404 malignant and 430 benign according to histopathology. A balanced image set of biopsy-proven benign (n = 299) and malignant (n = 299) lesions was used for training and cross-validation of ensembles of machine learning algorithms supervised during learning by histopathological diagnosis as a reference standard. Based on a majority vote (over 80% of the votes to have a valid prediction of benign lesion), an ensemble of support vector machines showed an ability to reduce the biopsy rate of benign lesions by 15% to 18%, always keeping a sensitivity over 94%, when externally tested on 236 images from two image sets: (1) 123 lesions (51 malignant and 72 benign) obtained from two ultrasound systems used for training and from a different one, resulting in a positive predictive value (PPV) of 45.9% (95% confidence interval 36.3–55.7%) versus a radiologists’ PPV of 41.5% (p < 0.005), combined with a 98.0% sensitivity (89.6–99.9%); (2) 113 lesions (54 malignant and 59 benign) obtained from two ultrasound systems from vendors different from those used for training, resulting into a 50.5% PPV (40.4–60.6%) versus a radiologists’ PPV of 47.8% (p < 0.005), combined with a 94.4% sensitivity (84.6–98.8%). Errors in BI-RADS 3 category (i.e., assigned by the model as BI-RADS 4) were 0.8% and 2.7% in the Testing set I and II, respectively. The board-certified breast radiologist accepted the BI-RADS classes assigned by the model in 114 masses (92.7%) and modified the BI-RADS classes of 9 breast masses (7.3%). In six of nine cases, the model performed better than the radiologist did, since it assigned a BI-RADS 3 classification to histopathology-confirmed benign masses that were classified as BI-RADS 4 by the radiologist.

Three-state majority-vote model on small-world networks

In this work, we study the opinion dynamics of the three-state majority-vote model on small-world networks of social interactions. In the majority-vote dynamics, an individual adopts the opinion of the majority of its neighbors with probability 1-q, and a different opinion with chance q, where q stands for the noise parameter. The noise q acts as a social temperature, inducing dissent among individual opinions. With probability p, we rewire the connections of the two-dimensional square lattice network, allowing long-range interactions in the society, thus yielding the small-world property present in many different real-world systems. We investigate the degree distribution, average clustering coefficient and average shortest path length to characterize the topology of the rewired networks of social interactions. By employing Monte Carlo simulations, we investigate the second-order phase transition of the three-state majority-vote dynamics, and obtain the critical noise $$q_c$$ q c , as well as the standard critical exponents $$\beta /\nu$$ β / ν , $$\gamma /\nu$$ γ / ν , and $$1/\nu$$ 1 / ν for several values of the rewiring probability p. We conclude that the rewiring of the lattice enhances the social order in the system and drives the model to different universality classes from that of the three-state majority-vote model in two-dimensional square lattices.

Pelaksanaan Sistem Pemerintahan Presidensial Dengan Multi Partai Di Indonesia

The government system in post-reform Indonesia is a presidential system with many parties. The advantage of this system is that it is more democratic because many parties are considered to accommodate the wishes and interests of people from various backgrounds through political parties, while the weakness is that it is difficult for the ruling party if it is not in the majority. The purpose of this study was to determine the implementation of a presidential system of multi-party governance in post-reform Indonesia. The results of the study are that in a presidential government system with many parties (multi-party system) such as in Indonesia, it will cause problems if no political party wins the election with a majority vote, the President must build a coalition with a number of political parties that have representatives in the House of Representatives (DPR). DPR). Since the holding of the 1999 and 2004 elections, there have been efforts to simplify political parties, by reducing the number of election participants through the electoral threshold and then changing since 2009 to reducing the number of political parties that may sit in parliament by using the minimum threshold requirement (parliamentary threshold). However, this method has not been successful because there are still relatively many political parties sitting in parliament, this is due to the parliamentary threshold that is too small. Ideally, the parliamentary threshold, which was previously 4% in the 2019 election, is raised to 8% in the 2024 election. Thus, a strong, effective and stable presidential government system with only 4 (four) to 6 (six) political parties will be realized.

Stage 2 Registered Report: How responsibility attributions to self and others relate to outcome ownership in group decisions

Background: Responsibility judgements have important consequences in human society. Previous research focused on how someone's responsibility determines the outcome they deserve, for example, whether they are rewarded or punished. Here, in a pre-registered study (Stage 1 Registered Report: https://doi.org/10.12688/wellcomeopenres.16480.2), we investigate the opposite link: How outcome ownership influences responsibility attributions in a social context. Methods: In an online study, participants in a group of three perform a majority vote decision-making task between gambles that can lead to a reward or no reward. Only one group member receives the outcome and participants evaluate their and the other players' responsibility for the obtained outcome. Results: We found that outcome ownership increases responsibility attributions even when the control over an outcome is similar. Moreover, ownership had an effect on the valence bias: participants’ higher responsibility attributions for positive vs negative outcomes was stronger for players who received the outcome. Finally, this effect was more pronounced when people rated their own responsibility as compared to when they were rating another’s player responsibility. Conclusions: The findings of this study reveal how credit attributions can be biased toward particular individuals who receive outcomes as a result of collective work, both when people judge their own and someone else’s responsibility.

An Enhanced Machine Learning Topic Classification Methodology for Cybersecurity

In this research, we use user defined labels from three internet text sources (Reddit, Stackexchange, Arxiv) to train 21 different machine learning models for the topic classification task of detecting cybersecurity discussions in natural text. We analyze the false positive and false negative rates of each of the 21 model’s in a cross validation experiment. Then we present a Cybersecurity Topic Classification (CTC) tool, which takes the majority vote of the 21 trained machine learning models as the decision mechanism for detecting cybersecurity related text. We also show that the majority vote mechanism of the CTC tool provides lower false negative and false positive rates on average than any of the 21 individual models. We show that the CTC tool is scalable to the hundreds of thousands of documents with a wall clock time on the order of hours.

Faktor-Faktor Penyebab Terpilihnya Anggota Legislatif dari Partai Gerindra di Kabupaten Aceh Tamiang Pada Tahun 2019

Aceh Tamiang Regency is one of the regencies through the division in 2002 in Aceh Province. In the 2019 Legislative Election, the Gerindra Party of Aceh Tamiang Regency succeeded in defeating the Party that has always been the winning party in the previous period, namely the Aceh Party, a party with religious ideology or conservative Islam . The majority vote was won by the Great Indonesia Movement Party by getting 6 seats or 20% of the total seats in the Aceh Tamiang DPRK. This research was conducted with in-depth interviews with 5 (five) informants and Focus Group Discussions (DKT) with 5 (five) people, the informants answered about what factors led to the election of legislative members in Aceh Tamiang Regency in 2020. Many people assumes that money and the popularity of the main capital in winning the Pileg contestation. However, in the context of the 2019 Aceh Tamiang Pilleg, this was not entirely the case, many other factors led to the election of legislative members from the Gerindra Party. Because many candidates who have more financial capital but are not elected, the electability of legislative members is influenced by their good track record, massive performance of the success team, and the support of religious and community leaders

A Machine Learning Ensemble Based on Radiomics to Predict BI-RADS Category and Reduce the Biopsy Rate of Ultra-sound-Detected Suspicious Breast Masses

We developed a machine learning model based on radiomics to predict the BI-RADS category of ultrasound-detected suspicious breast lesions and support medical decision making towards short-interval follow-up versus tissue sampling. From a retrospective 2015-2019 series of ultrasound-guided core needle biopsies performed by four board-certified breast radiologists using six ultrasound systems from three vendors, we collected 821 images of 834 suspicious breast masses from 819 patients, 404 malignant and 430 benign according to histopathology. A balanced image set of biopsy-proven benign (n = 299) and malignant (n = 299) lesions were used for training and cross-validation of ensembles of machine learning algorithms supervised during learning by histopathological diagnosis as a reference standard. Based on a majority vote (over 80% of the votes to have a valid prediction of benign lesion), an ensemble of support vector machines showed an ability to reduce the biopsy rate of benign lesions by 15% to 18%, always keeping a sensitivity over 94%, when externally tested on 236 images from two image sets: 1) 123 lesions (51 malignant and 72 benign) obtained from the same four ultrasound systems used for training, resulting into a positive predictive value (PPV) of 45.9% (95% confidence interval 36.3-55.7%) versus a radiologists' PPV of 41.5% (p < 0.005), combined with a 98.0% sensitivity (89.6-99.9%); 2) 113 lesions (54 malignant and 59 benign) obtained from two ultrasound systems from vendors different from those used for training, resulting into a 50.5% PPV (40.4-60.6%) versus a radiologists' PPV of 47.8% (p < 0.005), combined with a 94.4% sensitivity (84.6-98.8%). Errors in BI-RADS 3 category (i.e., assigned by the model as BI-RADS 4) were 0.8% and 2.7% in the Testing set I and II, respectively. The board-certified breast radiologist accepted the BI-RADS classes assigned by the model in 114 masses (92.7%) and modified the BI-RADS classes of 9 breast masses (7.3%). In 6 of 9 cases the model performed better than the radiologist, since it assigned a BI-RADS 3 classification to histopathology-confirmed benign masses that were classified as BI-RADS 4 by the radiologist.

Mapping Cropland Burned Area in Northeastern China by Integrating Landsat Time Series and Multi-Harmonic Model

Accurate cropland burned area estimation is crucial for air quality modeling and cropland management. However, current global burned area products have been primarily derived from coarse spatial resolution images which cannot fulfill the spatial requirement for fire monitoring at local levels. In addition, there is an overall lack of accurate cropland straw burning identification approaches at high temporal and spatial resolution. In this study, we propose a novel algorithm to capture burned area in croplands using dense Landsat time series image stacks. Cropland burning shows a short-term seasonal variation and a long-term dynamic trend, so a multi-harmonic model is applied to characterize fire dynamics in cropland areas. By assessing a time series of the Burned Area Index (BAI), our algorithm detects all potential burned areas in croplands. A land cover mask is used on the primary burned area map to remove false detections, and the spatial information with a moving window based on a majority vote is employed to further reduce salt-and-pepper noise and improve the mapping accuracy. Compared with the accuracy of 67.3% of MODIS products and that of 68.5% of Global Annual Burned Area Map (GABAM) products, a superior overall accuracy of 92.9% was obtained by our algorithm using Landsat time series and multi-harmonic model. Our approach represents a flexible and robust way of detecting straw burning in complex agriculture landscapes. In future studies, the effectiveness of combining different spectral indices and satellite images can be further investigated.

Radiometric Identification of Signals by Matched Whitening Transform

Radiometric identification is the problem of attributing a signal to a specific source. In this work, a radiometric identification algorithm is developed using the whitening transformation. The approach stands out from the more established methods in that it works directly on the raw IQ data and hence is featureless. As such, the commonly used dimensionality reduction algorithms do not apply. The premise of the idea is that a data set is “most white” when projected on its own whitening matrix than on any other. In practice, transformed data are never strictly white since the training and the test data differ. The Förstner-Moonen measure that quantifies the similarity of covariance matrices is used to establish the degree of whiteness. The whitening transform that produces a data set with the minimum Förstner-Moonen distance to a white noise process is the source signal. The source is determined by the output of the mode function operated on the Majority Vote Classifier decisions. Using the Förstner-Moonen measure presents a different perspective compared to maximum likelihood and Euclidean distance metrics. The whitening transform is also contrasted with the more recent deep learning approaches that are still dependent on feature vectors with large dimensions and lengthy training phases. It is shown that the proposed method is simpler to implement, requires no features vectors, needs minimal training and because of its non-iterative structure is faster than existing approaches.

BiLSTM-5mC: A Bidirectional Long Short-Term Memory-Based Approach for Predicting 5-Methylcytosine Sites in Genome-Wide DNA Promoters

An important reason of cancer proliferation is the change in DNA methylation patterns, characterized by the localized hypermethylation of the promoters of tumor-suppressor genes together with an overall decrease in the level of 5-methylcytosine (5mC). Therefore, identifying the 5mC sites in the promoters is a critical step towards further understanding the diverse functions of DNA methylation in genetic diseases such as cancers and aging. However, most wet-lab experimental techniques are often time consuming and laborious for detecting 5mC sites. In this study, we proposed a deep learning-based approach, called BiLSTM-5mC, for accurately identifying 5mC sites in genome-wide DNA promoters. First, we randomly divided the negative samples into 11 subsets of equal size, one of which can form the balance subset by combining with the positive samples in the same amount. Then, two types of feature vectors encoded by the one-hot method, and the nucleotide property and frequency (NPF) methods were fed into a bidirectional long short-term memory (BiLSTM) network and a full connection layer to train the 22 submodels. Finally, the outputs of these models were integrated to predict 5mC sites by using the majority vote strategy. Our experimental results demonstrated that BiLSTM-5mC outperformed existing methods based on the same independent dataset.