‘Seeing’ proximal representations: Testing attitudes to the relationship between vision and images

Corrections applied by the visual system, like size constancy, provide us with a coherent and stable perspective from ever-changing retinal images. In the present experiment we investigated how willing adults are to examine their own vision as if it were an uncorrected 2D image, much like a photograph. We showed adult participants two lines on a wall, both of which were the same length but one was closer to the participant and hence appeared visually longer. Despite the instruction to base their judgements on appearance specifically, approximately half of the participants judged the lines to appear the same. When they took a photo of the lines and were asked how long they appeared in the image their responses shifted; now the closer line appeared longer. However, when they were asked again about their own view they reverted to their original response. These results suggest that many adults are resistant to imagining their own vision as if it were a flat image. We also place these results within the context of recent views on visual perspective-taking.

Pooling and Comparing Noise Annoyance Scores and “High Annoyance” (HA) Responses on the 5-Point and 11-Point Scales: Principles and Practical Advice

The use of different noise annoyance scales across studies and socio-acoustic surveys, in particular the popular 5-point verbal and 11-point numerical scales, has made the evaluation, comparison, and pooling of noise annoyance responses among studies a taxing issue. This is particularly the case when “high annoyance” (HA) responses need to be compared and when the original studies used different scales; thus, there are different so-called cutoff points that define the part of the scale that indicates the HA status. This paper provides practical guidance on pooling and comparing the respective annoyance data in both the linear and logistic regression context in a statistically adequate manner. It caters to researchers who want to carry out pooled analyses on annoyance data that have been collected on different scales or need to compare exposure–HA relationships between the 5-point and 11-point scales. The necessary simulation of a cutoff point non-native to an original scale can be achieved with a random assignment approach, which is exemplified in the paper using original response data from a range of recent noise annoyance surveys. A code example in the R language is provided for easy implementation of the pertinent procedures with one’s own survey data. Lastly, the not insignificant limitations of combining and/or comparing responses from different noise annoyance scales are discussed.

Prediction of Neural Diameter From Morphology to Enable Accurate Simulation

Accurate neuron morphologies are paramount for computational model simulations of realistic neural responses. Over the last decade, the online repository NeuroMorpho.Org has collected over 140,000 available neuron morphologies to understand brain function and promote interaction between experimental and computational research. Neuron morphologies describe spatial aspects of neural structure; however, many of the available morphologies do not contain accurate diameters that are essential for computational simulations of electrical activity. To best utilize available neuron morphologies, we present a set of equations that predict dendritic diameter from other morphological features. To derive the equations, we used a set of NeuroMorpho.org archives with realistic neuron diameters, representing hippocampal pyramidal, cerebellar Purkinje, and striatal spiny projection neurons. Each morphology is separated into initial, branching children, and continuing nodes. Our analysis reveals that the diameter of preceding nodes, Parent Diameter, is correlated to diameter of subsequent nodes for all cell types. Branching children and initial nodes each required additional morphological features to predict diameter, such as path length to soma, total dendritic length, and longest path to terminal end. Model simulations reveal that membrane potential response with predicted diameters is similar to the original response for several tested morphologies. We provide our open source software to extend the utility of available NeuroMorpho.org morphologies, and suggest predictive equations may supplement morphologies that lack dendritic diameter and improve model simulations with realistic dendritic diameter.

Detection of Bolt Looseness Based on Average Autocorrelation Function

Bolted connections are widely used in multiple engineering fields including aerospace and mechanical engineering due to their numerous advantages like the ability to bear relatively heavy loads, low costs, easy installation, and implementation. Bolt looseness may lead to costly disasters in industries and some cases of injuries. A new method for bolt looseness detection based on average autocorrelation function is proposed. It does not usually directly extract the looseness damage feature from the original response signal to detect the bolt looseness, but it uses the average autocorrelation function value at time lag T = 0 of the vibration pixel displacement signal to establish the looseness damage index. In terms of structural arrangement of this paper, firstly, the theoretical background of the proposed method is given. Then, an experimental system for bolt looseness detection based on computer vision is designed, and a verification experiment is carried out with the bolted connection plate as the experimental object. The results show that the proposed method can effectively obtain the location of the looseness damage of the bolted connection plate, which provides a new technical reference for the online monitoring of the looseness damage of bolted connection plate.

P470 Ustekinumab Trough Levels are not Associated with Clinical Response in Inflammatory Bowel Disease Patients

Background Ustekinumab (UST) has been shown to effectively induce and maintain remission in inflammatory bowel disease (IBD). Only a few studies thus far have focused on UST pharmacokinetics suggesting that both, trough levels after i.v. induction as well as trough levels during stable maintenance might be associated with clinical and endoscopic response to UST. Data from real-world cohorts in this setting are scarce. Therefore, the aim of our study was to assess whether clinical response to UST was associated with a specific pharmacokinetic pattern. Methods All IBD patients treated with UST in one tertiary IBD centre between January 2017 and August 2020 were retrospectively retrieved from the database. Disease activity was assessed by Harvey-Bradshaw index (HBI) and partial Mayo score in Crohn’s disease (CD) and ulcerative colitis (UC) pts; respectively. Clinical response was defined as a decrease of HBI of ≥2 points or partial Mayo score ≥3 points. Patients not responding to therapy by week 16, or loosing original response received dose escalation from 90mg s.c. every 8 weeks to 90mg every 4 weeks. UST through levels were assessed by commercially available ELISA kit (IDKmonitor®) at week 8 after i.v. induction and/or during maintenance therapy after a minimum period of 16 weeks of treatment. Results In total, 61 IBD patients were included (mean age 38 years, range 22–70; 38 women; 54 CD/6 UC/1 IBD-U). All patients were antiTNF experienced, minority (11; 18%) had also been treated with vedolizumab prior UST. Thirty-nine pts (64%) were responders, out of these 15 pts (38%) required dose escalation at some point of the treatment due to secondary loss of response. UST through levels at week 8 were significantly higher than the maintenance levels (mean 5.6±SEM 0.7µg/mL vs. 2.2±0.3µg/mL; p<0.001). There were no significant differences between responders and non-responders neither in trough levels after induction (5±0.8µg/mL vs. 6.4±1.1µg/mL, p=n.s.), nor in trough levels during maintenance therapy (2.3± 0.4µg/mL vs. 1.9 ±0.4µg/mL, p=n.s.). Patients requiring dose escalation did not differ from stable responders in maintenance trough levels (2.4±0,6 µg/mL vs. 2,3 ±0,4 µg/mL). Conclusion In this limited size real-world cohort of IBD patients, we found no difference in pharmacokinetics between reponders and non-reponders to ustekinumab.

Themistius on Concept Formation

This paper reconstructs the account of concept formation developed in the 4th Century A.D. by Themistius in the most ancient extant commentary on Aristotle’s Posterior Analytics. Themistius’ account can be contrasted with two widespread modern interpretations of Aristotle. Unlike psychological empiricists, Themistius ascribes an active role in concept formation to our innate capacity of understanding (νοῦς). Unlike intuitionists, he would not be satisfied by saying that νοῦς “intuits” or “spots” concepts. Rather, the question is what makes our νοῦς capable of “finding” and “recognizing” concepts in experience, and this can only be an understanding prior to all experience. Themistius seems to be responding here to Platonist arguments against Aristotle’s epistemology: postulating a “potential νοῦς” is not enough, for one can apply Meno’s dilemma to it and ask how it can recognize that it has found what it was looking for. But, contrary to the judgment of some modern scholars, Themistius never embraced the theory of recollection either (he rejects it decisively). He argued that both empiricism and Platonist innatism are wrong and developed a middle path marked by a strong interdependence between the perceptive and the rational capacity. This holds for all rational learning, and concept formation is its first stage: to form a concept means to learn something genuinely new, but also to recognize it as falling, e. g., under one of the ten categories. While being presented as a mere “paraphrasis” of Aristotle’s words, Themistius’ account is a well-advised and original response to the epistemological debates of his time.

O pojęciu „historyczności” według Karla Jaspersa oraz Carla Gustava Junga

I shall try to consider comparatively the notion of “historicity” in the sense given to it by Karl Jaspers and Carl Gustaw Jung in their “philosophies of history”, which were an original response to the crisis of modern historical scientificated consciousness. On the basis of Jaspers’ „Vom Ursprung und der Ziel der Geschichte” as well as Jung’s „Über die Entwicklung der Persönli- chkeit” I intend to explore a common point of their philosophical positions, which is: an individual historical existence, belonging as he/she does to the historical world that enters his/her life in a particular form, and, on the other hand, shaping the general historical reality through picking out and revealing the meanings and opportunities waiting to be unearthed in the sphere of his- toricity. Their concept of individual human being that, paradoxically, is just as much a historical existence in history as it remains outside history.

“Female Rebellion” in Anna Barkova’s Play Nastasya Kostyor (1923)

The article examines the figure of the woman warrior and the theme of the “female rebellion” in the hitherto understudied play by Anna Barkova Nastasya Kostyor (1923) in the context of gender studies. Characters, motifs, and the play’s plot are placed against the background of the Barkova’s early work that heavily focused on the “woman question” and invented “new” femininity drawing from the archetypal image of the female warrior in literature and art. The author argues that in this play, Barkova for the first time relates the figure of female warrior to eschatological ideas and utopianism of the Silver Age, namely to Sophia myth. The problem of the ambivalent nature of the female character is in the focus of discussion. The essay explores the sources of this character — from the mystical snake woman of Russian Symbolists to Joan of Arc and the “female ataman” Alena Arzamasskaya (the character of the so-called “Stepan Razin legend”). It describes radical gender inversions in Barkova’s play and explores its original response to the topoi of female warrior that are abundant in this work.

Non-Identity Theodicy

This book develops Non-Identity Theodicy as an original response to the problem of evil. It begins by recognizing that horrendous evils pose distinctive challenges for belief in God. To home in on these challenges, this book constructs an ethical framework for theodicy by sketching four cases of human action where horrendous evils are either caused, permitted, or risked, either for pure benefit (i.e. a benefit that does not avert a still greater harm) or for harm avoidance. This framework is then brought to bear on the project of theodicy. The initial conclusions drawn impugn the dominant structural approach of depicting God as causing or permitting horrors in individual lives for the sake of some merely pure benefit. This approach is insensitive to relevant asymmetries in the justificatory demands made by horrendous and non-horrendous evil and in the justificatory work done by averting harm and bestowing pure benefit. Next this book critiques Fall-based theodicies that depict God as permitting or risking horrors in order to avert greater harm. The second half of this book develops a theodicy that falls outside of the proposed taxonomy. Non-Identity Theodicy suggests that God allows evil because it is a necessary condition of creating individual people whom he desires to love. This approach to theodicy is unique because the justifying good recommended is neither harm-aversion nor pure benefit. It is not a good that betters the lives of individual human persons (for they would not exist otherwise), but it is the individual human persons themselves.

Dark Entrepreneurship, the ‘Dark Triad’ and Its Potential ‘Light Triad’ Realization in ‘Green Entrepreneurship’

This contribution seeks to achieve three main objectives. First it draws on a substantial, but often overlooked literature on wide-scale international decline in entrepreneurship as recorded in the ‘business dynamics’ literature. This has serious implications for academic study of entrepreneurship which must re-direct its focus to problems of entrepreneurial unattractiveness dating from at least the 1980s. More important, public policy makers and political ideologists need further to be apprised of the erroneous nature of many of their beliefs and further change the subsidy regimes they bestow on often unproductive entrepreneurship. Second, the contribution seeks one part of the explanation of the declining attractiveness of entrepreneurship in the psychology of the ‘dark triad’ of negative personality traits that has been connected to the literature on ‘dark entrepreneurship’ as a possible and partial, but important reason for the growing unattractiveness of entrepreneurship. The contribution devotes attention to the ‘Mindfulness’ movement in considering the detoxification of ‘dark entrepreneurship’. Finally, in what may be an original response to this analysis, the contribution draws attention to recent work on a putative ‘light triad’ of personality traits and applies it, possibly for the first time, to secondarily researched accounts of ‘green entrepreneurship’. The conclusion is that there may be a future for green entrepreneurship as a means for recovery in the current status of more traditional ‘business dynamics’.