Objective — to assess the oxidative status and severity of inflammatory processes in patients with hypertension (AH) and subclinical hypothyroidism (SH) and their relationship to the rate of aging.
Materials and methods. 98 patients (38 men and 61 women) of young and middle age with a median age of 48.3 years were examined. All patients were divided into 3 groups: controls — healthy volunteers (n = 20), comparison group — euthyroid patients with AH and signs of autoimmune thyroiditis (AIT) (n = 36); main group — patients with AH and SH with signs of AIT (n = 42). Thyroid parameters, markers of oxidative stress (total superoxide dismutase, T‑SOD, total antioxidant activity, TAA, total hydroperoxides, THP), inflammatory markers (C‑reactive protein, SRP, tumor necrosis factor‑alpha, TNF‑a) were evaluated in all patients. The rate of aging was determined by estimating the biological age and age delta according to the methods of A. G. Gorelkin, B. B. Pinhasov (BA1, dBA1 respectively) and V. P. Voitenko (BA2, dBA2, respectively), as well as by determining the content of sirtuin 1 (SIRT1).
Results. Significant differences were found between the controls and the comparison group in the rate of aging by both methods (p < 0.05), between the control and the main group in the levels of CRP (p = 0.000), TNF‑a (p = 0.000), aging rates by both methods (p < 0.05), as well as between the comparison and the main groups in the values of CRP (p = 0.001), TNF‑a (p = 0.000), THP (p = 0.041), T‑SOD (p = 0.048), SIRT1 (p = 0.001), dBA2 (p = 0.030). Correlation analysis revealed a significant (p < 0.05) direct relationship between the rate of aging and the level of CRP, free thyroxine, THP, THP/TAA index, and the inverse relationship between the rate of aging and T‑SOD, TAA in the comparison group. A significant direct relationship (p < 0.05) between CRP and BA1, a direct relationship between TNF‑a and thyroid‑stimulating hormone (TSH) levels and a direct association of T‑SOD with TSH and inverse one with BA1 were found in the main group.
Conclusions. Patients with AH have a decrease in the rate of aging and a significant increase in SIRT1 compared with euthyroid patients with AH, that indicates a probable association with a slowing of aging rates. A significant increase in THP and a decrease in and T‑SOD levels, along with the presence of a connection with TSH and BA1, indicates a violation of redox processes in this category of patients and its association with aging rates. Patients with AH and SH also showed signs of metabolic inflammation, which was confirmed by a significant increase in the levels of TNF‑a, CRP, as well as by the presence of a direct link between TNF‑a and TSH. BA and aging rates increased with increasing CRP levels in euthyroid patients with AH, but no association between CRP and TSH was observed.