Homotopic contralesional excitation suppresses spontaneous circuit repair and global network reconnections following ischemic stroke

Understanding circuit-level changes that affect the brain's capacity for plasticity will inform the design of targeted interventions for treating stroke recovery. We combine optogenetic photostimulation with optical neuroimaging to examine how contralesional excitatory activity affects cortical remodeling after stroke in mice. Following photothrombosis of left primary somatosensory forepaw (S1FP) cortex, mice received chronic excitation of right S1FP, a maneuver mimicking the use of the unaffected limb during recovery. Contralesional excitation suppressed perilesional S1FP remapping and was associated with abnormal patterns of evoked activity in the unaffected limb. Contralesional stimulation prevented the restoration of resting-state functional connectivity (RSFC) within the S1FP network, RSFC in several networks functionally-distinct from somatomotor regions, and resulted in persistent limb-use asymmetry. In stimulated mice, perilesional tissue exhibited suppressed transcriptional changes in several genes important for recovery. These results suggest that contralesional excitation impedes local and global circuit reconnection through suppression of several neuroplasticity-related genes after stroke.

Promotion of Polish Cinema Abroad as an Element of Nation Branding. Case Study of “Cold War” (2018) by Pawel Pawlikowski

The subject of this article is nation branding in the culture market, namely the role cinematography plays in creating a nation brand. Sustainability and sustainable development in the film industry is conditioned by variety in cultural promotion channels. The aim of the authors is to prove that appropriately organised cinematography promotion abroad can positively influence the image of a given country. The first section deals with the relationship between media and sustainable development, as well as with theoretical definitions of branding and the nation brand. Subsequently, cinematography in the context of branding is discussed. The core of this work is a case study of film promotion abroad from the institutional perspective of the Polish Film Institute. The promotional strategy for “Cold War” (2018) directed by Paweł Pawlikowski has been analysed, as this motion picture is considered one of the biggest successes of post-1989 Polish cinematography. Factors positively influencing its popularity were analysed alongside their influence on the general perception of Polish cinema abroad. Based on the results of empirical studies, the authors present their discussion of the functional state and the role of Polish cinematography on the global circuit, as well as attempt to verify its importance in relation to sustainability.

Extensive layer clouds in the global electric circuit: their effects on vertical charge distribution and storage

A fair-weather electric field has been observed near the Earth's surface for over two centuries. The field is sustained by charge generation in distant disturbed weather regions, through current flow in the global electric circuit. Conventionally, the fair-weather part of the global circuit has disregarded clouds, but extensive layer clouds, important to climate, are widespread globally. Such clouds are not electrically inert, becoming charged at their upper and lower horizontal boundaries from vertical current flow, in a new electrical regime—neither fair nor disturbed weather; hence it is described here as semi-fair weather . Calculations and measurements show the upper cloud boundary charge is usually positive, the cloud interior positive and the lower cloud boundary negative, with the upper charge density larger, but of the same magnitude (∼nC m −2 ) as cloud base. Globally, the total positive charge stored by layer clouds is approximately 10 5 C, which, combined with the positive charge in the atmospheric column above the cloud up to the ionosphere, balances the total negative surface charge of the fair-weather regions. Extensive layer clouds are, therefore, an intrinsic aspect of the global circuit, and the resulting natural charging of their cloud droplets is a fundamental atmospheric feature.

Ionisation effects on precipitation

<p>Cloud processes leading to rainfall generation are suspected to be influenced by droplet charge. Droplet charging is abundant, and even in layer clouds, charging of droplets readily occurs at the horizontal cloud-air boundary. Droplet charging in such circumstances is proportional to the vertical current driven through the cloud by the global electric circuit. Small global circuit variations from natural influences, such as solar modulation of cosmic rays can be used to investigate this, but an alternative is presented by artificial introduction of ionisation. The atmospheric nuclear weapons test period, which reached its peak 1962-1964, caused exceptional anthropogenic disturbance to the global circuit, through the increased ionisation from steady sedimentation of stratospheric radioactive debris.</p><p>Measurements of the vertical current J<sub>z</sub> made at Kew Observatory near London (51°28′N, 0°19′W) were several times greater than normal during 1962-1964, as a result of the widespread extra ionisation in the lower atmosphere. At Lerwick, Shetland (60°09′N, 1°08′W) where deposition of radioactive material occurred, the atmospheric electrical parameters were strongly affected by the enhanced ionisation. To investigate tropospheric ionisation effects on local cloud processes, rainfall days at Lerwick in 1962-64 have been analysed by considering reduced and enhanced ionisation periods. During the enhanced ionisation, the Lerwick rainfall distribution shifted towards heavier rainfall and is significantly different from the rainfall distribution for reduced ionisation days; the Lerwick cloud was also significantly optically thicker during the enhanced ionisation. This contrasts with other years of the Kew record, when J<sub>z</sub> was relatively undisturbed. Whilst the ionisation conditions of 1962-64 were exceptional, controlled methods of enhancing tropospheric ionisation by non-radioactive means - such as corona emission - may nevertheless be promising for local rainfall modification, or even geoengineering of cloud properties.</p>

Art and Our Surrounds: Emergent and Residual Languages

This essay undertakes a review of recent books by T.J. Demos ( Decolonizing Nature: Contemporary Art and the Politics of Ecology (2016) and Against the Anthropocene: Visual Culture and Environment Today (2017)) and Jens Andermann ( Tierras en trance: Arte y naturaleza después del paisaje (Lands Entranced: Art and Nature after Landscape, 2018)). Demos and Andermann participate in the paradigm shift taking place under the name of eco-criticism, forging connections between the debates around environmental crisis and the fields in which they have written and published previously - art criticism and visual culture and Latin American literary and cultural studies, respectively. Both authors take on the challenge of thinking through the perceptual and conceptual habits that have dominated a relationship to our environment under capitalist modernity (such as the concept of landscape) and how artistic practices might be said to rework those habits. While Demos maps recent efforts to engage ecological concerns and “decolonize nature” across the globe, Andermann looks back to the twentieth century Latin American archive, constructing a local genealogy that harbors an ecological and political thinking that anticipates what is now lived as global crisis; their projects intersect in contemporary Latin American activist art that has gained enough attention to figure as part of a global circuit. The review considers the overlapping points as well as the striking disjuncture in both projects in relation to the different knowledge formations, archives and languages from which each author speaks.

Festivity and the contemporary: Worldly affinities in Southeast Asian art1

What is the place of the festival in the global system of contemporary art, and in that system’s history? Can the large, recurring surveys that are its most prominent exhibitions today even be considered festivals? Such questions become more pressing as sites newly embraced by that system take their place on a global event calendar, and as the events increasingly resemble those held elsewhere or merge with the market in the form of art fairs. What becomes of community and locality, of spontaneity and participation, as that market ‐ and art history ‐ takes up the uncommodified fringes and untold stories of contemporary art’s ever widening geography? This article stems from my research for a recent volume entitled Artist-to-Artist: Independent Art Festivals in Chiang Mai 1992‐98, concerning a series of artist-initiated festivals held in northern Thailand in the 1990s known as the Chiang Mai Social Installation. These gatherings, and others like them, suggest that while national representation was the usual ticket to participation on a global circuit, the agencies and currency of national representation were not essential determinants of contemporaneity; and that it was localism, rather than any internationalism, that underpinned the worldly affinities discovered amongst artists in Southeast Asia at that time. The sites of this becoming contemporary were festive, sites of celebration and expenditure rather than work and accumulation. What does this mean for contemporary art’s history and theory, and how might it change our understanding of the region’s art and its international currency today?

Simulation of a Radial Pump Fast Startup and Analysis of the Loop Response Using a Transient 1D Mean Stream Line Based Model

A predictive transient two-phase flow rotodynamic pump model has been developed in the Code for Analysis of THermalhydraulics during an Accident of Reactor and safety Evaluation (CATHARE-3). Flow inside parts of the pump (suction, impeller, diffuser and volute) is computed according to a one-dimensional discretisation following a mean flow path. Transient governing equations of the model are solved using an implicit resolution method and integrated along the curvilinear abscissa of the element. This model has been previously qualified at the component scale by comparison to an existing experimental database. The present study aims at extending the validation at the system scale: a whole experimental test loop is modelled. The ability of the transient pump model to predict flow rate, head and torque as a function of time during a 1-s pump fast start-up is evaluated. The transient evolution of the pressure upstream and downstream from the centrifugal pump is well predicted by the simulation compared to the measurements. Local quantities such as pressure and velocity inside elements of the circuit are analysed. In the considered case, inertial effects of the global circuit are dominant when compared to pump inertial effects due to the high characteristic lengths of the pipes. The main perspective of this work consists in the simulation of similar pump transients, in cavitating conditions.

Combining DoV framework and methodological preconceptions to improve student’s electrical circuit solving strategies

Our research studies about student’s prior knowledge acting as learning difficulties (referred to as preconceptions) in electricity courses at university level led us to define knowledge as the association of two elements: a model and a domain of validity (DoV). This statement is the core of the DoV framework. This framework reveals its powerfulness in the way it helps teachers to map students’ cognitive structures, to identify their preconceptions as well as to derive effective teaching strategies. Quantitative experimentations we carry out indicate a lack of global circuit solving strategy among students. Especially, they highlight the fact that the difficulties encountered by those students in network analysis are not that much relying on the mastering of solving methods but on the method selection process. This lack of solving strategy prevents the students to grasp the domain of validity of the solving methods they master, so to associate the relevant methods with the suitable circuits. This paper depicts how the application of the DoV framework to this problem-solving process reveals to be a great tool to identify and tackle students’ (methodological) preconceptions as well as to formalize, rationalize and simplify complex solving strategies making them easier to explain, teach and learn.

Inferring circuit mechanisms from sparse neural recording and global perturbation in grid cells

A goal of systems neuroscience is to discover the circuit mechanisms underlying brain function. Despite experimental advances that enable circuit-wide neural recording, the problem remains open in part because solving the ‘inverse problem’ of inferring circuity and mechanism by merely observing activity is hard. In the grid cell system, we show through modeling that a technique based on global circuit perturbation and examination of a novel theoretical object called the distribution of relative phase shifts (DRPS) could reveal the mechanisms of a cortical circuit at unprecedented detail using extremely sparse neural recordings. We establish feasibility, showing that the method can discriminate between recurrent versus feedforward mechanisms and amongst various recurrent mechanisms using recordings from a handful of cells. The proposed strategy demonstrates that sparse recording coupled with simple perturbation can reveal more about circuit mechanism than can full knowledge of network activity or the synaptic connectivity matrix.

Environmentally Hardening IC Die Previously Assembled in Plastic Packages through Die Removal, Bond Pad Replating and Reassembly into Hermetic Packages

ABSTRACT Many integrated circuits (ICs) will operate well above their maximum rated temperature of +70°C or +125°C, but are often not packaged appropriately to reliably endure temperatures above +150C. Specifically, the original gold or copper bonds on the aluminum die bond pads are prone to Kirkendall or Horsting voiding, particularly at temperatures greater than +150°C. Also the mold compounds used in plastic packaging for IC assembly can degrade at these elevated temperatures. In some cases, commercial demand for higher temperature reliability can justify a separate offering of ICs assembled in hermetic, ceramic packages from the original component manufacturer (OCM). However, in most cases, the market demand is deemed insufficient. Global Circuit Innovations (GCI) has developed a high-yielding process, which can remove a semiconductor die (i.e., computer chip) from a plastic package, remove the original bond wires and/or ball bonds, plate the aluminum die bond pads with Electroless Nickel, Electroless Palladium, and Immersion Gold (ENEPIG), and then reassemble the now improved semiconductor die into a hermetic, ceramic package. Device Extraction, ENEPIG die bond pad plating and Repackaging (DEER) provides an improved die bond pad surface such that works well with either gold or aluminum bond wires in applications up to +250°C without mechanical or electrical connectivity degradation. GCI routinely exposes sample devices to +250°C bakes with 100% post bake yields so as to continuously ensure that any device processed with the DEER technology will reliably perform in high-temperature environments. Although the oil and gas industry has already expressed significant interest in the DEER process, with excellent lifetest and production application results demonstrating dramatically increased component lifetimes at elevated temperatures, this technology can also be leveraged for any application exposing ICs to harsh environments. Not only is the high-temperature reliability dramatically increased, but also the new hermetic, ceramic package protects the IC from a variety of elements and environments (i.e., corrosives and moisture).