Checklist of freshwater fishes from Loreto, Peru

This study presents an extensive review of published and unpublished occurrence records of fish species in the Loreto department. Located in the northeast of the country, Loreto is the most geographically extensive region in the Peruvian territory. Despite the increase in fish collections in Loreto in recent years, the ichthyofauna of this department needs to be more documented. Based on a database of scientific collections and bibliographic information, an updated checklist of the freshwater fishes from Loreto is presented. The results reveal a rich and diversified ichthyofauna, with 873 species distributed in 331 genera, 50 families and 15 orders. The main groups are Characiformes (42.6%), Siluriformes (34.8%), Gymnotiformes (8.6%) and Cichliformes (7.4%). Part of the ichthyofauna has restricted distribution for Loreto (4.7%). In addition, 9.0% of species from Loreto are used in fisheries. Meanwhile, 219 species (25%) were categorized according to the IUCN criteria where only six species (0.7%) are currently considered threatened species (CR, EN or VU). The results presented in this work indicate that this department needs more studies to know the biodiversity of fish, likewise, the information presented constitutes a contribution to the knowledge of fish diversity that would support environmental management actions and decision-making aimed at conserving one of the most diverse departments of Peru.

Yet Another Automated Gleason Grading System (YAAGGS) by weakly supervised deep learning

The Gleason score contributes significantly in predicting prostate cancer outcomes and selecting the appropriate treatment option, which is affected by well-known inter-observer variations. We present a novel deep learning-based automated Gleason grading system that does not require extensive region-level manual annotations by experts and/or complex algorithms for the automatic generation of region-level annotations. A total of 6664 and 936 prostate needle biopsy single-core slides (689 and 99 cases) from two institutions were used for system discovery and validation, respectively. Pathological diagnoses were converted into grade groups and used as the reference standard. The grade group prediction accuracy of the system was 77.5% (95% confidence interval (CI): 72.3–82.7%), the Cohen’s kappa score (κ) was 0.650 (95% CI: 0.570–0.730), and the quadratic-weighted kappa score (κquad) was 0.897 (95% CI: 0.815–0.979). When trained on 621 cases from one institution and validated on 167 cases from the other institution, the system’s accuracy reached 67.4% (95% CI: 63.2–71.6%), κ 0.553 (95% CI: 0.495–0.610), and the κquad 0.880 (95% CI: 0.822–0.938). In order to evaluate the impact of the proposed method, performance comparison with several baseline methods was also performed. While limited by case volume and a few more factors, the results of this study can contribute to the potential development of an artificial intelligence system to diagnose other cancers without extensive region-level annotations.

Diachronous development of Great Unconformities before Neoproterozoic Snowball Earth

The Great Unconformity marks a major gap in the continental geological record, separating Precambrian basement from Phanerozoic sedimentary rocks. However, the timing, magnitude, spatial heterogeneity, and causes of the erosional event(s) and/or depositional hiatus that lead to its development are unknown. We present field relationships from the 1.07-Ga Pikes Peak batholith in Colorado that constrain the position of Cryogenian and Cambrian paleosurfaces below the Great Unconformity. Tavakaiv sandstone injectites with an age of ≥676 ± 26 Ma cut Pikes Peak granite. Injection of quartzose sediment in bulbous bodies indicates near-surface conditions during emplacement. Fractured, weathered wall rock around Tavakaiv bodies and intensely altered basement fragments within unweathered injectites imply still earlier regolith development. These observations provide evidence that the granite was exhumed and resided at the surface prior to sand injection, likely before the 717-Ma Sturtian glaciation for the climate appropriate for regolith formation over an extensive region of the paleolandscape. The 510-Ma Sawatch sandstone directly overlies Tavakaiv-injected Pikes granite and drapes over core stones in Pikes regolith, consistent with limited erosion between 717 and 510 Ma. Zircon (U-Th)/He dates for basement below the Great Unconformity are 975 to 46 Ma and are consistent with exhumation by 717 Ma. Our results provide evidence that most erosion below the Great Unconformity in Colorado occurred before the first Neoproterozoic Snowball Earth and therefore cannot be a product of glacial erosion. We propose that multiple Great Unconformities developed diachronously and represent regional tectonic features rather than a synchronous global phenomenon.

ABOUT DYNAMICS OF THE GEOPOLITICAL POSITION OF THE NORTH-EAST OF RUSSIA IN THE 17-TH-21-ST CENTURIES

Purpose: In the article, the changes in the geopolitical situation on the North-East for four preceding, partial centuries are considered. Methodology: Up to the inclusion in the structure of Russia, this extensive region (2.3 million km2) with the considerable natural-resources potential has actually existed out of the world geopolitical processes, basically, because of the extremeness of the natural climatic conditions, remoteness from the centers of world civilization and limited technical and technological capabilities in those times. Result: The different stages in the state of the geopolitical position of the region in prior centuries are identified and their repeatedly and multidirectional varying characteristics during the period in question are reported. It is also emphasized that the measures attempted by Russia for strengthening of the geopolitical position on the North-East gave rise abroad to the negative response consonant with the current ones practically at all considered stages. The current stage is considered as a period of the drastically varying external geopolitical conditions and increased technical capabilities when the geopolitical significance of the North-East for Russia increases by a factor of many times. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of About Dynamics of the Geopolitical Position of the North-East of Russia in the 17-th-21-st Centuries is presented in a comprehensive and complete manner.

Regional Gene Repression by DNA Double-Strand Breaks in G1 Phase Cells

ABSTRACT DNA damage responses (DDR) to double-strand breaks (DSBs) alter cellular transcription programs at the genome-wide level. Through processes that are less well understood, DSBs also alter transcriptional responses locally, which may be important for efficient DSB repair. Here, we developed an approach to elucidate the cis-acting responses to DSBs in G1 phase cells. We found that DSBs within a gene body silence its expression, as well as the transcription of local undamaged genes at a distance defined by the spread of γ-H2AX from the DSB. Importantly, DSBs not only repress ongoing transcription but also block the inducible expression of regional genes. DSB-mediated transcriptional repression depends on DDR signaling but does not require the generation of inaccessible chromatin. Our findings demonstrate that in G1 phase cells, DDR signaling establishes a robust and extensive region of transcriptional repression spreading from DSB sites and introduce an approach to study the mechanistic impact of targeted DNA breaks in nearly any chromatin environment.

Building a cluster: shocks, cavities, and cooling filaments in the group–group merger NGC 6338

We present deep Chandra, XMM–Newton, Giant Metrewave Radio Telescope, and Hα observations of the group–group merger NGC 6338. X-ray imaging and spectral mapping show that as well as trailing tails of cool, enriched gas, the two cool cores are embedded in an extensive region of shock-heated gas with temperatures rising to ∼5 keV. The velocity distribution of the member galaxies show that the merger is occurring primarily along the line of sight, and we estimate that the collision has produced shocks of Mach number $\mathcal {M}$ = 2.3 or greater, making this one of the most violent mergers yet observed between galaxy groups. Both cool cores host potential AGN cavities and Hα nebulae, indicating rapid radiative cooling. In the southern cool core around NGC 6338, we find that the X-ray filaments associated with the Hα nebula have low entropies (<10 keV cm2) and short cooling times (∼200–300 Myr). In the northern core, we identify an Hα cloud associated with a bar of dense, cool X-ray gas offset from the dominant galaxy. We find no evidence of current jet activity in either core. We estimate the total mass of the system and find that the product of this group–group merger will likely be a galaxy cluster.

Impact craters on Pluto and Charon indicate a deficit of small Kuiper belt objects

The flyby of Pluto and Charon by the New Horizons spacecraft provided high-resolution images of cratered surfaces embedded in the Kuiper belt, an extensive region of bodies orbiting beyond Neptune. Impact craters on Pluto and Charon were formed by collisions with other Kuiper belt objects (KBOs) with diameters from ~40 kilometers to ~300 meters, smaller than most KBOs observed directly by telescopes. We find a relative paucity of small craters ≲13 kilometers in diameter, which cannot be explained solely by geological resurfacing. This implies a deficit of small KBOs (≲1 to 2 kilometers in diameter). Some surfaces on Pluto and Charon are likely ≳4 billion years old, thus their crater records provide information on the size-frequency distribution of KBOs in the early Solar System.

Facts and Fiction: The Myth of Suvaṇṇabhūmi Through the Thai and Burmese Looking Glass

Most scholars think that the generic name ‘Golden Land’ (Sanskrit, Suvarṇabhūmi; Pali, Suvaṇṇabhūmi) was first used by Indian traders as a vague designation for an extensive region beyond the subcontinent, presumably in Southeast Asia. Some Pali sources specifically link Suvaṇṇabhūmi with the introduction of Buddhism to the region. The locus classicus is the Sri Lankan Mahāvaṃsa chronicle (fifth century AD) which states that two monks, Soṇa and Uttara, were sent there for missionary activities in the time of King Asoka (third century BC). However, no Southeast Asian textual or epigraphic sources refer to this legend or to the Pali term Suvaṇṇabhūmi before the second millennium AD. Conversely, one may ask, what hard archaeological evidence is there for the advent of Buddhism in mainland Southeast Asia? This article re-examines the appropriation of the name Suvaṇṇabhūmi in Thailand and Burma for political and nationalist purposes and deconstructs the connotation of the term and what it has meant to whom, where, and when. It also carefully confronts the Buddhist literary evidence and earliest epigraphic and archaeological data, distinguishing material discoveries from legendary accounts, with special reference to the ancient Mon countries of Rāmaññadesa (lower Burma) and Dvāravatī(central Thailand).

Patterns of tree species composition at watershed-scale in the Amazon ‘arc of deforestation’: implications for conservation

SUMMARYThe loss of biodiversity in transitional forests between the Cerrado and Amazonia, the two largest neotropical phytogeographic domains, is an issue of great concern. This extensive region is located within the ‘arc of deforestation’ zone where tropical forests are being lost at the fastest rate on the planet, but floristic diversity and variation among forests here is still poorly understood. We aimed to characterize the floristic composition of forests in this zone and explored the degree and drivers of differentiation within and across Araguaia and Xingu watersheds. In 10 sites we identified all trees with diameter ≥10 cm; these totaled 4944 individuals in 257 species, 107 genera and 52 families. We evaluated the data for multivariate variation using TWINSPAN and DCA to understand the species distribution among sites. There was a larger contribution from the Amazonian flora (169 species) than that of the Cerrado (109) to the transitional forests. Remarkably, 142 species (55%) were restricted to only one sampling site, while 29 species (>16%) are endemic to Brazil, suggesting potentially large loss of species and unique forest communities with the loss and fragmentation of large areas. Our results also suggest that watersheds may be a critical factor driving species distribution among forests in the Amazonian–Cerrado transition zone, and quantifying their role can provide powerful insight into devising better conservation strategies for the remaining forests.

Recent changes in the Norske Øer Ice Barrier, coastal Northeast Greenland

ABSTRACTIn Northeast Greenland, the Norske Øer Ice Barrier (NØIB) abuts Nioghalvfjerdsfjorden (79N) and Zachariae Isstrøm (ZI), two floating outlets of the Northeast Greenland Ice Stream. NØIB is an extensive region of perennially fast sea ice, which varies in size from year to year, but with complete breakup a rare event in the 20th century. It reportedly broke up in the 1950s and was seen to break up in 1997. Since 2000 the NØIB has broken up during 11 of the last 14 summers. The forcings driving the increased frequency of ice barrier breakup are poorly understood, and it is not clear if the breakup is a purely local phenomenon or an indicator of regional changes in the ocean and atmosphere. Here we use a logistic regression statistical model to show that the odds of breakup are linked to June positive degree days and July wind speeds at a nearby weather station. It is too soon to know if subtle changes detected on 79N and ZI in the last decade are connected to breakups of the NØIB but, if they are, it suggests a complex interaction between the atmosphere, ocean and outlet glaciers in this part of Greenland.