The hourly precipitation frequencies in the tropical-belt version of WRF: sensitivity to cumulus parameterization and radiative schemes

The sensitivity of hourly precipitation to cumulus parameterizations and radiative schemes is explored by using the tropical-belt configuration of the Weather Research and Forecasting Model. The domain covers the entire tropical region from 45°S to 45°N with a grid spacing of about 45 km. A series of 5-year simulations with four cumulus parameterizations (New Tiedtke, NT; Kain-Fritsch, KF; New SAS, NS; and Tiedtke, TK) and two radiative schemes (RRTMG, CAM) are carried out. We focus on the frequencies of hourly precipitation above three thresholds (0.02 mm h-1, light drizzle rate; 0.2 mm h-1, moderate rate; and 2 mm h-1, heavy rate) between the observed CMORPH products and simulations. The sensitivity is higher for precipitation frequency than amount, and frequency is dominated by the cumulus parameterization. Frequencies above the moderate rate are well-reproduced, while frequencies above the other two rates present large deviations. No combination of physical schemes is found to perform best in reproducing the frequencies above all thresholds. Simulations using the NT and NS schemes show higher (lower) precipitation frequencies above the light drizzle rate (heavy rate) than those simulations using the KF and TK schemes. Precipitation frequency is higher reproduced by experiments using the RRTMG scheme than those using the CAM scheme, except for frequencies above the light rate over oceans. The overestimation of frequency is mainly caused by too-frequent convective rainfall. The results imply that the triggering based on the vertical velocity may increases the occurrence of rain event, while CAPE-based closure maybe increase the heavy precipitation frequency in the cumulus parameterizations.

Partial plantar fasciectomy for the treatment of plantar fibromatosis

Objective: We describe a series of patients treated with resection of the affected band. We assessed functional outcome, recurrence rate, and surgical wound complications, comparing these data with the available literature. Methods: This retrospective study (level of evidence IV) included 14 patients (17 feet) diagnosed with plantar fibromatosis in the medial portion of the fascia that was refractory to conservative treatment. All operations were performed between December 2016 and November 2018. All patients were assessed for symptom improvement and major and minor complications, in addition to recurrence during the study period.Results: Our sample included 9 men and 5 women, whose mean age was 40.6 years (15-63). All of the patients underwent partial fasciectomy of the medial fascial band with margins of at least 2 cm. There was recurrence in 5 of the 17 feet (29%), but only two required further intervention. Wound dehiscence occurred in 3 patients (17%), and one of the cases was severe, requiring plastic surgery. Two feet showed signs of injury to the digital branch of the medial plantar nerve. Conclusion: Partial plantar fasciectomy is an alternative treatment for plantar fibromatosis (Ledderhose’s disease). Our results agree with the literature in terms of recurrence and postoperative complications. The moderate rate of complications must be taken into account when indicating this procedure. Level of Evidence IV; Therapeutic Studies; Case Series.

Oral, Tongue-Coating Microbiota, and Metabolic Disorders: A Novel Area of Interactive Research

Interactions between colonizing microbiota and the host have been fully confirmed, among which the tongue-coating microbiota have a moderate rate of renewal and disease sensitivity and are easily obtained, making them an ideal research subject. Oral microbiota disorders are related to diabetes, obesity, cardiovascular disease, cancer, and other systemic diseases. As an important part of the oral cavity, tongue-coating microbiota can promote gastritis and digestive system tumors, affecting the occurrence and development of multiple chronic diseases. Common risk factors include diet, age, and immune status, among others. Metabolic regulatory mechanisms may be similar between the tongue and gut microbiota. Tongue-coating microbiota can be transferred to the respiratory or digestive tract and create a new balance with local microorganisms, together with the host epithelial cells forming a biological barrier. This barrier is involved in the production and circulation of nitric oxide (NO) and the function of taste receptors, forming the oral-gut-brain axis (similar to the gut-brain axis). At present, the disease model and mechanism of tongue-coating microbiota affecting metabolism have not been widely studied, but they have tremendous potential.

Production of Hydroxyl Radicals From Oxygenation of Simulated AMD In Presence of Extracellular Polymers Substances

While the reaction mechanisms Fe(II) abiotic oxidation produce ·OH by CaCO3-induced in AMD are well-documented, little is known about the influence of extracellular polymeric substances (EPS) secreted by microorganisms on Fe(II) oxidation in AMD. Given the recent finding, this study experimently measured the cumulative concentrations of ·OH produced from oxygenation of simulated AMD in the presence of EPS. Results of this study show that the cumulative ·OH increased from 56.75 to 158.70 μM within 24 h at pH 3 with the increase in EPS concentration from 0 to 12 mg/L. An appropriate pH (about 6) and EPS (6 mg/L) concentration were required for the moderate rate of Fe(II) oxidation, corresponding to the maximum production of ·OH. The presence of EPS enhanced the ·OH production from Fe(II) oxidation in simulated AMD under acid conditions. In the presence of EPS, ·OH production is attributed mainly the complexation of Fe(II) with EPS, of which is rich of carboxyl and hydroxyl groups. Besides, the yield of ·OH increased remarkably with the addition of Fe3+. It is most likely that EPS can contribute to reduce Fe(Ⅲ) to Fe(II), which is beneficial to the production of ·OH. The findings reveal from this study supplement the fundamental of ·OH production from Fe(II) oxidation by microorganisms in natural AMD.

1000 Versus 635 Days Approach for Prevention of Undernutrition in Children

Since the pre-independence era, India is dealing with a variety of health problems that have been eliminated in developed nations. As we prepare to enter post covid era, a problem which we are dealing since ages is child promotion and child survival. India is a nuclear weapon-affiliated country now but it still has a long way to go as far as child malnutrition is concerned. It is a surprising fact to know that the prevalence of malnutrition in India is double that of sub-Saharan country.[1] It has been 45 years since the launch of the Integrated Child Development Scheme (ICDS) and we still have 35.8% of undernourished children in our country makes one think about the drawbacks in our current approach. [2] There are a wide variety of reasons for decreased weight inchildren under the age of 5. Interestingly inadequate food security is considered as one of the primary reasons, however,it does not justify the 20.1% of underweight children belonging to high socioeconomic status.[2] Other reasons include infections i.e. diarrhea and acute respiratory infections in children and it could be attributed to a moderate rate (approximately 62%) of immunization in the under 5 age group.[2]

Abstract P-24: Microscopic Analyses of Liquid-Liquid Phase Separation Induced by Linker Histone H1.0

Background: Liquid-liquid phase separation (LLPS) that leads to the formation of temporary functional domains in cells plays an important role in the processes of chromatin condensation and gene regulation. Earlier, it was demonstrated that histone H1.4 can form LLPS droplets with DNA. In the present work, LLPS was studied for histone H1.0, which is mainly expressed in differentiated and non-dividing cells. H1.0 is involved in cancer development: its amount decreases with the progression of tumor cells to malignancy. Methods: LSM710 confocal microscope (Zeiss) equipped with the 40x/1.2W objective was used to image mixtures of H1.0 with Cy3/Cy5 labeled DNA or nucleosomes in fluorescent and transmitted-light channels at the excitation of 514 nm. The formation of condensates as a result of LLPS was confirmed by salt-jump and FRAP/FLIP experiments. Results: Condensates were not observed when the ratio of negative to positive charges (N/P) in the samples was >1. At N/P~0.7, optically homogeneous droplet-like condensates were found. The appearance of condensates, their size and shape depended on concentrations of H1.0 and DNA. LLPS condensates but not aggregates disappeared by salt-jump to 650 mM NaCl. FRAP/FLIP experiments revealed a moderate rate of fluorescence recovery (τ½22s) indicating moderate DNA mobility of the H1.0-mediated condensates. The appearance of condensates was also observed in the mixtures of H1.0, DNA and Cy3/Cy5-labeled nucleosomes. Nucleosomes were involved in the condensate formation and found to be 2-fold more mobile (τ½10 s) than DNA. Conclusion: LLPS-related properties of H1.0 were studied for DNA and nucleosomes in vitro. Comparison with H1.4 shows that H1.0 forms liquid condensates of approximately the same size. Our result also may indicate that chromatin retains pronounced dynamic properties in H1.0-induced droplets despite the fact that H1.0 induces the formation of more compact chromatin.

Polymetallic Group 4 Complexes: Catalysts for the Ring Opening Polymerisation of rac-Lactide

Five novel air- and moisture-stable polymetallic Ti and Zr amino acid-derived amine bis(phenolate) (ABP) complexes were synthesised and fully characterised, including X-ray crystallographic studies. The reaction of the ABP proligands with Ti or Zr alkoxides has resulted in the formation of polymetallic aggregates of different nuclearity. The steric bulk on the pendant arm of the ligand was found to play a critical role in establishing the nuclearity of the aggregated complex. Sterically, less-demanding groups, such as H or Me, facilitated the formation of tetrametallic Ti clusters, bridged by carboxylate groups, while increased steric bulk (tBu) led to the formation of binuclear μ-oxo-bridged species. The isolated complexes were employed as catalysts for the ring opening polymerisation (ROP) of rac-lactide. Overall, the Ti catalysts were all active with the smaller, bimetallic Ti aggregates exhibiting relatively faster rates. A monometallic, bis(ABP) Zr complex was found to exert remarkable ROP activity, albeit with limited control over the tacticity and molecular weight distribution of the polymer. A further oxo-bridged Zr cluster was shown to display a previously unprecedented trimetallic structure and achieved a moderate rate in the ROP of rac-lactide.

Impact of Ozone Used-Alone and Coagulation Aid Treatment on The Reduction of Trihalomethanes Components

The whole research paper examines the impact of ozone as either a just use-alone and coagulation benefit, mainly upon the reduction of dissolved organic carbon from the water with a moderate rate of DOC 10.75 mg/land CaCO3 calcium hardness 300 mg/l. A raw water sample has been taken from the Tigris River (Baghdad, Iraq) was being adopted in research work. The performance of ozone therapy has been assessed by calculations of DOC, DOC quantities, UV254, as well as total trihalomethane (TTHM). Research findings have shown that with 0.9 mg O3/mg DOC ozone use-alone, approximately 60% UV254 reduction and approximately 28% DOC reduction will occur.DOC fractionation analysis indicates that within the water samples, ozone could alter the composition of DOC, transform the hydrophobic fractions toward hydrophilic fractions and reduce TTHM. Ozone was also responsible for a significant reduction in particle stability as well as the dissolved calcium content. Improved water flocculation and improved DOC removal were triggered by these simultaneous ozonation effects. This resulted in a decrease in the coagulant dosage while the dosage of ozone is considerably higher over 0.3 mg O3/mg DOC has added before ferric sulfate coagulation. The pre-ozonation coagulation method also accomplished favorable removal of TTHM with all tested ozone doses (0 to 0.9 mg O3/mg DOC), resulting in lower TTHM during pre-ozonated coagulated waters unlike those through related ozonated waters.

Word in Hmong

Hmong (Hmong-Mien; Laos and diaspora) possesses categories of both phonological word and grammatical word. Phonological words exhibit a prosodic prominence in certain pragmatic situations combined with a lack of pauses within the word, and a minimal consonant-vowel-tone structure of a syllable serves as a minor third criterion. Grammatical words exhibit grammatical cohesion of two types—isolability, where words can appear alone in their domain, and the absence of separability, where components of a word cannot be separated—and serve as the domain for reduplication and lexical tone melody alternations. Given a category of grammatical wordhood, affixes and compounds can be recognized in Hmong, and coordinate compounds and four-syllable elaborate expressions can be distinguished as set expressions and templatic constructions, respectively. Hmong attests mismatches between phonological and grammatical word, which include the presence of clitics and cliticization in casual speech at a moderate rate of speed, and varying arrangements of grammatical words in four-syllable elaborate expressions.