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2022 ◽  
Vol 371 ◽  
pp. 131106
Author(s):  
Qixing Nie ◽  
Jielun Hu ◽  
Haihong Chen ◽  
Fang Geng ◽  
Shaoping Nie

2024 ◽  
Vol 84 ◽  
Author(s):  
A. Q. Alkhedaide ◽  
A. Mergani ◽  
A. A. Aldhahrani ◽  
A. Sabry ◽  
M. M. Soliman ◽  
...  

Abstract Several reasons may underlie the dramatic increase in type2 diabetes mellitus. One of these reasons is the genetic basis and variations. Vitamin D receptor polymorphisms are associated with different diseases such as rheumatoid arthritis and diabetes. The aim of this study is to investigate the possible association of two identified mutations ApaI (rs7975232) and TaqI (rs731236). Eighty-nine healthy individuals and Fifty-six Type 2 Diabetic (T2D) patients were investigated using RFLP technique for genotyping and haplotyping as well. The distribution of Apal genotypes was not statistically significant among the control (P=0.65) as well as for diabetic patients (P=0.58). For Taql allele frequencies of T allele was 0.61 where of G allele was 0.39. The frequency distribution of Taql genotypes was not statistically significant among the control (P=0.26) as well as diabetic patients (P=0.17). Relative risk of the allele T of Apa1 gene is 1.28 and the odds ratio of the same allele is 1.53, while both estimates were < 1.0 of the allele G. Similarly, with the Taq1 gene the relative risk and the odds ratio values for the allele T are 1.09 and 1.27 respectively and both estimates of the allele C were 0.86 for the relative risk and 0.79 for the odds ratio. The pairwise linkage disequilibrium between the two SNPs Taq1/apa1 was statistically significant in control group (D = 0.218, D' = 0.925 and P value < 0.001) and similar data in diabetic groups (D = 0.2, D' = 0.875 and P value < 0.001). These data suggest that the T allele of both genes Apa1 and Taq1 is associated with the increased risk of type 2 diabetes. We think that we need a larger number of volunteers to reach a more accurate conclusion.


2022 ◽  
Vol 65 (5) ◽  
pp. 101586
Author(s):  
Mariana Brondani de Mello ◽  
Natiele Camponogara Righi ◽  
Felipe Barreto Schuch ◽  
Luis Ulisses Signori ◽  
Antônio Marcos Vargas da Silva

2022 ◽  
Vol 12 (4) ◽  
pp. 756-762
Author(s):  
Changying Liu ◽  
Xuezhu Wei ◽  
Jun Li ◽  
Chao Liang ◽  
Wei Geng ◽  
...  

The patients with type 2 diabetes mellitus (T2DM) have high dental implant failure frequency. This study explores the function of glimepiride local delivery on dental implant osseointegration in diabetes animal. Glimepiride loaded PLGA microspheres were loaded on the surface of the dental implant, and transplanted into ten Goto-Kakizaki (GK) rats. Blood sugar level and Implant Stability Quotient (ISQ) were measured every week after surgery. Histological, osseointegration rate and bone-implant contact (BIC) rate analysis were performed to evaluate dental osseointegration. The results showed that Glimepiride loaded Poly-lactide-co-glycolide (PLGA) microspheres have sustained-release curve. The glimepiride group exhibited greater ISQ than the control group. The BIC rate of the control and glimepiride group was 44.60%±1.95% and 59.80%±1.79%, respectively. This study demonstrated that the glimepiride group has a significantly greater osseointegration rate than that of the control group. Thus, Glimepiride could provide an alternative drug release microspheres for enhance the dental implant osseointegration in diabetes patients.


2121 ◽  
Vol 7 (1) ◽  
pp. 55-64
Author(s):  
Elham Eghrari ◽  
◽  
Mohammad Hossein Bayazi ◽  
Ali Reza Rajayi ◽  
◽  
...  

Background: Diabetes mellitus is a widely diffused chronic condition that affects several aspects of patients’ lives. The patient’s life in this condition depends on diabetes management ability. Therefore, this study aimed to compare the effects of Acceptance and Commitment Therapy (ACT) and Emotion Regulation Training (ERT) on the diabetes empowerment of patients with type 2 diabetes. Methods: This was a quasi-experimental study with a pre-test, post-test-follow-up and a control group design. Of the statistical population of patients referring to the Diabetes Prevention and Control Center of Mashhad Province, Iran, 45 subjects were recruited by convenience sampling method; they were randomly assigned into three groups of ACT, ERT, and control (n=15/group). The study subjects were assessed using the Diabetes Empowerment Scale (F-DES-28) in the pre-test stage, after the intervention, and 3 months later. The obtained data were analyzed by repeated-measures Analysis of Variance (ANOVA) in SPSS V. 22. Results: Both provided interventions presented a significant effect on the empowerment of the research subjects, compared to the controls (P<0.001). The effectiveness of ACT on the diabetes empowerment of patients was significantly higher than that of the ERT group (P=0.04). Conclusion: It is recommended to use ACT and ERT to empower patients with type 2 diabetes.


2022 ◽  
Vol 28 ◽  
pp. 82-89
Author(s):  
Budi Hidayat ◽  
Royasia Viki Ramadani ◽  
Achmad Rudijanto ◽  
Pradana Soewondo ◽  
Ketut Suastika ◽  
...  

2023 ◽  
Vol 83 ◽  
Author(s):  
I. Liaqat ◽  
N. M. Ali ◽  
N. Arshad ◽  
S. Sajjad ◽  
F. Rashid ◽  
...  

Abstract The study was aimed to assess impact of high fat diet (HFD) and synthetic human gut microbiota (GM) combined with HFD and chow diet (CD) in inducing type-2 diabetes (T2D) using mice model. To our knowledge, this is the first study using selected human GM transplantation via culture based method coupled dietary modulation in mice for in vivo establishment of inflammation leading to T2D and gut dysbiosis. Twenty bacteria (T2D1-T2D20) from stool samples of confirmed T2D subjects were found to be morphologically different and subjected to purification on different media both aerobically and anerobically, which revealed seven bacteria more common among 20 isolates on the basis of biochemical characterization. On the basis of 16S rRNA gene sequencing, these seven isolates were identified as Bacteroides stercoris (MT152636), Lactobacillus acidophilus (MT152637), Lactobacillus salivarius (MT152638), Ruminococcus bromii (MT152639), Klebsiella aerogenes (MT152640), Bacteroides fragilis (MT152909), Clostridium botulinum (MT152910). The seven isolates were subsequently used as synthetic gut microbiome (GM) for their role in inducing T2D in mice. Inbred strains of albino mice were divided into four groups and were fed with CD, HFD, GM+HFD and GM+CD. Mice receiving HFD and GM+modified diet (CD/HFD) showed highly significant (P<0.05) increase in weight and blood glucose concentration as well as elevated level of inflammatory cytokines (TNF-α, IL-6, and MCP-1) compared to mice receiving CD only. The 16S rRNA gene sequencing of 11 fecal bacteria obtained from three randomly selected animals from each group revealed gut dysbiosis in animals receiving GM. Bacterial strains including Bacteroides gallinarum (MT152630), Ruminococcus bromii (MT152631), Lactobacillus acidophilus (MT152632), Parabacteroides gordonii (MT152633), Prevotella copri (MT152634) and Lactobacillus gasseri (MT152635) were isolated from mice treated with GM+modified diet (HFD/CD) compared to strains Akkermansia muciniphila (MT152625), Bacteriodes sp. (MT152626), Bacteroides faecis (MT152627), Bacteroides vulgatus (MT152628), Lactobacillus plantarum (MT152629) which were isolated from mice receiving CD/HFD. In conclusion, these findings suggest that constitution of GM and diet plays significant role in inflammation leading to onset or/and possibly progression of T2D. .


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