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Life Sciences ◽  
2021 ◽  
Vol 286 ◽  
pp. 120011
Irina Zelinskaya ◽  
Oleg Kornushin ◽  
Elizaveta Savochkina ◽  
Vyacheslav Dyachuk ◽  
Marina Vasyutina ◽  

2021 ◽  
Vol 158 ◽  
pp. 38-46
Ananth Shankar ◽  
Tom Kurzawinski ◽  
Emma Ross ◽  
Sara Stoneham ◽  
Tim Beale ◽  

2022 ◽  
Vol 71 ◽  
pp. 103236
Ming–Xia Xiao ◽  
Chang–Hua Lu ◽  
Na Ta ◽  
Hai–Cheng Wei ◽  
Cheng–Chan Yang ◽  

2021 ◽  
Vol 9 (1) ◽  
pp. 007-012
Arar K ◽  
Ghouini A

Overcoming diabetes is a major health challenge of the 21st century. WHO predicts that by 2030 it will be the seventh leading cause of death in the world and calls for global action to stop its rise and improve care. Actually, Herbal and nutritional supplementation is required in the management of diabetic patients, a finding shared unanimously by scientists. Recently diabetologists have come to the evidence that a therapeutic supplement consisting of nutrients and herbal is necessary to optimize the treatment of diabetes. The treatment of Type 2 diabetes mellitus, which is very often associated with overweight, is based on hygiene and dietetic measures and, where appropriate, on taking oral antidiabetics .This review describes the therapeutic arsenal of conventional oral antidiabetic drugs and emphasizes on innovative therapeutic option introducing herbal medicine and nutrition to the management of diabetic patients. Recent studies showed interesting potential in the reduction of blood sugar for many herbal for example Cinnamon, also berberine has been linked to the reduction of blood glucose levels, insulin levels and showed to be as effective as metformin, the most commonly prescribed drug for diabetics, at controlling blood sugar levels in diabetics. Moreover, a medicinal plant or herbal mixture can provide multi-targeted therapeutic action due to its complex chemical composition with hundreds of active ingredients such as oligosaccharides, alkaloids, polyphenols, flavonoids, tannins and at the same time ensure safety for the patients. We conclude by the fact that herbal and nutritional supplementation can bring major and promising progress in order to improve the patient care, by slowing the progression of type 2 diabetes and limiting its complications.

2023 ◽  
María Arrieta-Leandro ◽  
Jessenia Hernández-Elizondo ◽  
Judith Jiménez-Díaz

Taqi Mohammed Jwad Taher ◽  
Jaffar Mohammed Majed ◽  
Yassamean Firas Ahmed ◽  
Firas Turki Rashed Sarray

2021 ◽  
Vol 8 (3) ◽  
pp. 198-201
Shantharam V ◽  
Raghavendra K

Diabetic nephropathy is a one of the microvascular complication in patients with type 2 diabetes mellitus due to increased production of free radicals and decreased levels of anti oxidants. The seviority of the disease totally depends on due to damage of foot process of podocytes. Hence, we need to evaluate the altered structural changes of podocytes, glomerular basement membrane in patients with type 2 diabetes mellitus. A total 60 type 2 diabetes mellitus patients were included in the present study and again sub classified into 2 types (Normoalbuminuria 30, Microalbuminuria 30) based on their urinary ACR. Basic laboratory investigations and radio graphical data were collected from the all subjects. A statistical was performed by using SPSS Version 21.0 and P value considers < 0.05 is statistically significant. The significantly elevated levels of plasma FBS, PPBS, Serum Urea, Creatinine, Uric Acid and HbA1c, Urinary albuminuria observed in type 2 diabetes mellitus with microalbuminuria when compared to normoalbuminuria. The radiographical data showed a significantly damaged foot process of podocytes and glomerular basement membrane are observed in patients with microalbuminuria when compared to normoalbuminuria. The increased levels blood sugar and HbA1c, Urinary Albuminuria directly indicates the damage of podocytes and glomerular basement membrane in the kidney. This study suggest continuous monitoring of these parameters may helpful for progression of type 2 diabetes mellitus complications.

2021 ◽  
Kai Wang ◽  
Zhiguo Lv ◽  
Peng Xu ◽  
Yabin Cui ◽  

Soumitra Mohanty ◽  
Witchuda Kamolvit ◽  
Silvia Zambrana ◽  
Eduardo Gonzales ◽  
Jonas Tovi ◽  

Abstract Infections are common in patients with diabetes, but increasing antibiotic resistance hampers successful bacterial clearance and calls for alternative treatment strategies. Hypoxia-inducible factor 1 (HIF-1) is known to influence the innate immune defense and could therefore serve as a possible target. However, the impact of high glucose on HIF-1 has received little attention and merits closer investigation. Here, we show that higher levels of proinflammatory cytokines and CAMP, encoding for the antimicrobial peptide cathelicidin, LL-37, correlate with HIF-1 in type 2 diabetic patients. Chemical activation of HIF-1 further enhanced LL-37, IL-1β, and IL-8 in human uroepithelial cells exposed to high glucose. Moreover, HIF-1 activation of transurethrally infected diabetic mice resulted in lower bacterial load. Drugs activating HIF-1 could therefore in the future potentially have a therapeutic role in clearing bacteria in diabetic patients with infections where antibiotic treatment failed. Key messages • Mohanty et al. “HIF-1 mediated activation of antimicrobial peptide LL-37 in type 2 diabetic patients.” • Our study highlights induction of the antimicrobial peptide, LL-37, and strengthening of the innate immunity through hypoxia-inducible factor 1 (HIF-1) in diabetes. • Our key observations are: 1. HIF-1 activation increased LL-37 expression in human urothelial cells treated with high glucose. In line with that, we demonstrated that patients with type 2 diabetes living at high altitude had increased levels of the LL-37. 2. HIF-1 activation increased IL-1β and IL-8 in human uroepithelial cells treated with high glucose concentration. 3. Pharmacological activation of HIF-1 decreased bacterial load in the urinary bladder of mice with hereditary diabetes. • We conclude that enhancing HIF-1 may along with antibiotics in the future contribute to the treatment in selected patient groups where traditional therapy is not possible.

2021 ◽  
Vol 7 (10) ◽  
pp. 214-224

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