HISTOLOGICAL ANALYSIS OF LUNGS AND PULMONARY LYMPH NODES IN CALVES WITH RESPIRATORY DISEASE

In order to identify pathomorphological changes, histological studies of the lungs of calves from two groups were performed. Calves of the first group had parainfluenza, and the second group included calves with an acute course of catarrhal purulent bronchopneumonia with clinical signs of chronic and acute pulmonary pathology. Clinical and histological methods of investigation were used in the work. Established pathomorphological changes in the lungs of calves of the first group in the form of chronic interstitial bronchopneumonia accompanied by compensatory chronic alveo-lar emphysema, formation of multinucleated symplast and multicellular syncytiae from the epitheli-um of alveoli, as well as mixed cytopathic forms of respiratory epithelium - symplasts-syncytiae are characteristic cytological signs of chronic parainfluenza infection. Detection of local thickening of bronchial walls due to proliferation of multilobular epithelium and infiltration of its submucosal base by lymphoid cells with narrowed lumen profiles also confirms parainfluenza etiology of the changes that occurred in the lungs. Marked manifestations of bronchopneumonia were manifested with maximum intensity in ventilated cardiac and diaphragmatic lungs of sick calves. Chronic inflammatory process in the lungs at parainfluenza was complicated by fibrinous pleurisy, as well as peri- and endocarditis, myocardiodystrophy with distorted structure of cardio-myocytes and atypical heart cells. In the pulmonary lymph nodes of parainfluenza-affected calves a moderately pronounced hyperplasia of lymphoid tissue cells with the presence of secondary lymph nodes, some of which had a pronounced structure of dark cellular periphery and a broad cell-rich germinative zone. In calves of the second group with an acute course of catarrhal purulent broncho-pneumonia we could not detect the above cytopathic changes in the airways and the respiratory part of the lungs. Pathological changes in the lungs were predominantly exudative, represented by se-rous alveolitis, catarrhal purulent bronchopneumonia with involvement of anterior and cardiac lobes of the organ. Short course of the disease was accompanied by weak proliferation of lymphoid tissue cells in pulmonary lymph nodes.

The ZIRP trap – The institutionalization of negative real interest rates

This paper analyzes the consequences of the monetary policies enact-ed by Western central banks from 2008 on and the possibilities to end these policies. Zero interest rate policies (ZIRP) actually impaired the recovery that was underway by subsidizing a distorted structure of production. The over­ indebtedness of Western economies was artificially propped up thus delaying recovery. We also show how ZIRP fosters moral hazard, the development of new bubbles and breeds unintended consequences that destabilize the finan­ cial system. ZIRP adversely influences entrepreneurship and culture by discour­ aging hard work and prudent investment. In today´s central bank world, ZIRP implies the institutionalization of negative real interest rates. It harms traditional entrepreneurial virtues, complicates long-term planning, politicizes society and erodes the foundations of capitalism. Exiting ZIRP is politically costly. We analyze the exit options that remain for policy makers, including financial repression, high inflation, default, capital levies, bail-ins and currency reforms, and evaluate them from a free-market perspective. Keywords: ZIRP, unconventional monetary policy, overindebtedness, exit op­ tions, negative real interest rates. JEL Classification: E14, E31, E32, E52 Resumen: Este artículo analiza las consecuencias de las políticas monetarias de los bancos centrales a partir de 2008 y la posibilidad de salir de estas políticas extraordinarias. ZIRP impidió la recuperación subvencionando una estructura productiva distorsionada. El sobreendeudamento de las economías occidentales se mantuvo y alargo artificialmente retrasando la recuperación. Mostramos también que ZIRP causa riesgo moral, el desarrollo de nuevas bur-bujas y consecuencias no intencionadas que desestabilizan el sistema financie-ro. ZIRP afecta negativamente a la función empresarial y a la cultura. Desincen-tiva el trabajo y la inversión prudente. En el mundo actual de bancos centrales, ZIRP implica la institucionalización de tipos de interés reales negativos. Daña las virtudes empresariales tradicionales, complica la planificación a largo pla-zo, politiza la sociedad y mina las bases del capitalismo. La salida de ZIRP es políticamente costosa. Analizamos las opciones de salida que les quedan a los políticos incluyendo la represión financiera, una inflación elevada, el incumplimiento en los pagos, los impuestos sobre el capital, bail-ins y reformas monetarias que son evaluadas desde una perspectiva liberal. Palabras clave: política de tipo de interés cero (ZIRP), política monetaria no convencional, sobreendeudamiento, opciones de salida, tipos de interés reales negativos. Clasificación JEL: E14, E31, E32, E52.

Site-preferential copper substitution for silicon leads to Cu-chains in the new ternary silicide Ir4−xCuSi2

The binary Ru4Si3 remained the only compound in its structure type for more than 60 years. Herein, we report the synthesis and crystal structure of the first ternary silicide (Ir4−xCuSi2) in the Ru4Si3-type structure, which can be derived from RuSi by unit cell twinning. According to single-crystal X-ray diffraction, Ir vacancies exist along the twin boundary. Ir4−xCuSi2 exhibits a distorted structure compared to Ru4Si3, as the larger Cu selectively replaces Si on only one of three possible sites, leading to zigzag chains with short Cu–Cu distances. Furthermore, DFT calculations show that the rigid band approximation does not apply to this structure type, but the similarities of electronic structures of the ideal binary and ternary compositions suggest that this structure type can accommodate a large variety of elemental substitutions without a significant change of its electronic structure if a similar valence electron count is maintained, hinting at a potentially rich substitutional chemistry.

Melt crystallization mechanism analyzed with dimensional reduction of high-dimensional data representing distribution function geometries

Melt crystallization is essential to many industrial processes, including semiconductor, ice, and food manufacturing. Nevertheless, our understanding of the melt crystallization mechanism remains poor. This is because the molecular-scale structures of melts are difficult to clarify experimentally. Computer simulations, such as molecular dynamics (MD), are often used to investigate melt structures. However, the time evolution of the structural order in a melt during crystallization must be analyzed properly. In this study, dimensional reduction (DR), which is an unsupervised machine learning technique, is used to evaluate the time evolution of structural order. The DR is performed for high-dimensional data representing an atom–atom pair distribution function and the distribution function of the angle formed by three nearest neighboring atoms at each period during crystallization, which are obtained by an MD simulation of a supercooled Lennard–Jones melt. The results indicate that crystallization occurs via the following activation processes: nucleation of a crystal with a distorted structure and reconstruction of the crystal to a more stable structure. The time evolution of the local structures during crystallization is also evaluated with this method. The present method can be applied to studies of the mechanism of crystallization from a disordered system for real materials, even for complicated multicomponent materials.

The Design Strategy for an Aggregation- and Crystallization-Induced Emission-Active Molecule Based on the Introduction of Skeletal Distortion by Boron Complexation with a Tridentate Ligand

We describe here a new design strategy for obtaining boron complexes with aggregation- and crystallization-induced emission (AIE and CIE, respectively) properties based on the introduction of skeletal distortion. According to our recent results, despite the fact that an almost planar structure and robust conjugation were obtained, the boron azomethine complex provided a slight emission in solution and an enhanced emission in aggregation and crystal. Quantum calculation results propose that unexpected emission annihilation in solution could be caused through intramolecular bending in the excited state. Herein, to realize this unique molecular motion and obtain AIE and CIE molecules, the phenyl quinoline-based boron complexes BPhQ and BPhQm with distorted and planar structures were designed and synthesized, respectively. BPhQm showed emission in solution and aggregation-caused quenching (ACQ, BPhQm: ΦF,sol. = 0.21, ΦF,agg. = 0.072, ΦF,cryst. = 0.051), while BPhQ exhibited a typical AIE and CIE (BPhQ: ΦF,sol. = 0.008, ΦF,agg. = 0.014, ΦF,cryst. = 0.017). The optical data suggest that a large degree of molecular motion should occur in BPhQ after photo-excitation because of the intrinsic skeletal distortion. Furthermore, single-crystal X-ray diffraction data indicate that the distorted π-conjugated system plays a positive role in presenting solid-state emission by inhibiting consecutive π–π interactions. We demonstrate in this paper that the introduction of the distorted structure by boron complexation should be a new strategy for realizing AIE and CIE properties.

Synthesis and properties of 5-aza-15-thiaporphyrins

We have successfully prepared 5-aza-15-thiaporphyrin through nucleophilic sulfination of nitrogen-bridged dibromobisdipyrrin with sodium sulfide. X-ray diffraction analysis elucidated its structure in the solid state: two dipyrrin subunits were roughly coplanar around the sp2-hybridized meso-nitrogen. In contrast, they adopted a folded conformation around the meso-sulfur atom. Due to its relatively distorted structure, 5-aza-15-thiaporphyrin shows weak antiaromaticity in the magnetic criteria. The sulfur atom was oxidized with [Formula: see text]-chloroperbenzoic acid to provide 5-aza-15-thiaporphyrin [Formula: see text]-dioxide in good yield. While 5-aza-15-thiaporphyrin was non-emissive, its [Formula: see text]-dioxide exhibited fluorescence in solution.

The Effect of RF Sputtering Conditions on the Physical Characteristics of Deposited GeGaN Thin Film

Ge0.07GaN films were successfully made on Si (100), SiO2/Si (100) substrates by a radio frequency reactive sputtering technique at various deposition conditions listed as a range of 100–400 °C and 90–150 W with a single ceramic target containing 7 at % dopant Ge. The results showed that different RF sputtering power and heating temperature conditions affected the structural, electrical and optical properties of the sputtered Ge0.07GaN films. The as-deposited Ge0.07GaN films had an structural polycrystalline. The GeGaN films had a distorted structure under different growth conditions. The deposited-150 W Ge0.07GaN film exhibited the lowest photoenergy of 2.96 eV, the highest electron concentration of 5.50 × 1019 cm−3, a carrier conductivity of 35.2 S∙cm−1 and mobility of 4 cm2·V−1∙s−1.

Structural, Magnetic and Optical Properties of Gd and Co Co-Doped YFeO3 Nanopowders

YFeO3, YFe0.95Co0.05O3, Y0.95Gd0.05FeO3 and Y1−xGdxFe0.95Co0.05O3 (x = 0.0, 0.05, 0.10, 0.15 and 0.20) nanopowders were successfully fabricated via a low-temperature solid-state reaction technique. Results obtained using X-ray diffraction (XRD), scanning electron microscopy (SEM), and Raman spectra indicate that YFeO3 nanopowders with Gd3+ and Co3+ ions co-doping at Y and Fe-sites were fabricated at 800 °C in sizes below 50 nm, and a distorted structure was obtained. Magnetic hysteresis loop analyses illustrate that ferromagnetic behavior of YFeO3 nanopowders can be enhanced with the addition of Gd and Co. Whereas the maximum and remnant magnetization of the powders were found to be about 5.24 and 2.6 emu/g, respectively, the optical band gap was around 2.4 eV, proving that co-doped YFeO3 nanopowders have a strong capability to absorb visible light. Because both magnetic and optical properties of these materials are greatly improved with the addition of Gd and Co, one can expect the scope of their potential application in the magnetic and optical fields to increase.