Electrophysiology-based assessment of the procedural success of radiofrequency renal denervation

Objective To assess whether electrode temperature and impedance change that are typically monitored during radiofrequency renal denervation (RDN) for safety reason may also be used as measures of the procedural success of the intervention. Methods We conducted a prospective clinical study of the radiofrequency RDN in patients meeting criteria of true resistant hypertension. The RDN treatment included the trunk and major branches of the renal artery. To obtain simple easy-to-use electrophysiology measures of the procedural success of RDN we averaged the maximal values of the temperature and change of impedance across all single treatments with a full duration. Then we assessed the relation of the average change in impedance and average maximal electrode temperature during RDN to blood pressure (BP) lowering 6 month post-procedure using a linear regression analysis. Also, we compared the groups with “successful” and “unsuccessful” procedures according to whether the impedance decreased, on average, ≥10% during RDN, and, alternatively, on whether the average maximal temperature of the electrode was ≥50 C. Results Of 65 treated patients 52 with quality recordings of the electrophysiology parameters during RDN completed 6-month follow-up. The mean 24-h systolic BP decreased significantly after RDN by −14.3 mmHg [95% CI: −8.7; −19.9]. The BP lowering was positively and significantly related to the decrease in impedance during RDN, r=0.35, p=0.013 and to less extent to the maximal electrode temperature, r=0.29, p=0.044. The 10% average drop in impedance predicted -9.9 mmHg decrease in 24-h mean systolic BP. According to group analysis the decrease of mean 24-h systolic BP was powerful in those with average decrease in impedance ≥10% during RDN (“successful” procedure), but almost zero otherwise: −19.9 [95% CI: −13.7; −24.5] vs −0.5 [95% CI: −11.9; 12.9] mmHg, respectively (raw estimates), p=0.003. The difference in BP lowering was less pronounced and non-significant when the procedural “success” was defined according to the average maximal electrode temperature. Conclusions The impedance decrease during radiofrequency RDN treatment may be an effective criterion of the procedural success of the intervention. Guiding radiofrequency RDN by the impedance drop 10% or greater may significantly improve the efficacy of the procedure. Funding Acknowledgement Type of funding source: None

Tripod Turnstile Machines Performance Analysis for the System Safety and Security without Considering Simultaneous Failures using Reliability Approach

As the crime is increasing day by day around the world. To stop the crime many security gadgets and machines have been developed by various security agencies. The tripod turnstile machine also helps in stopping the crime and restricting the entry of unauthorized person on the premises. In this paper, the aim is to analyze the reliability measures of the two tripod turnstile machines which work in a parallel configuration. In the case of non-functionality of the machine, unauthorized persons may enter into the premises. Due to security and safety reason, organizations install these machines. Hence these machines must be highly reliable in the operation to avoid any unwanted event. In this paper, for the considered system, the transition state diagram has been drawn with the help of the Markov model. The Chapman-Kolmogorov differential equations are developed from the transition state diagram and solved using Laplace transformation. The failure and repair rates are assumed to be constant and follow negative exponential distribution. The system upstate and downstate probabilities are determined. The explicit expression of the system Availability, Reliability and MTTF are also obtained. The sensitivity analysis is also performed to determine which machine affects the system reliability the most.

THE CONCEPTUAL DESIGN FOR LIQUID EFFLUENT TREATMENT OF UO2 KERNEL FABRICATION

THE CONCEPTUAL DESIGN FOR LIQUID EFFLUENT TREATMENT OF UO2 KERNEL FABRICATION. The pebble fuel for HTGR is prepared through fabrication of UO2 kernel, coated particle and spherical element fuel. In the fabrication of UO2 kernel by external gelation method, a multicomponent of liquid effluent is generated. Therefore, the liquid effluent is required to be treated for safety reason before disposed to waste storage. In this paper, the conceptual design for the liquid effluent treatment of UO2 kernel fabrication is performed with the simulation process using CHEMCAD software. CHEMCAD is a software that can be utilized for chemical process design. The results showed that the proposed conceptual design is able to separate valuable components: isopropyl alcohol (IPA) and tetrahydrofurfuryl alcohol (THFA). The flowrate of IPA product is 5.28 kg/h with purity of 0.99 in mass fraction and the flowrate of THFA product is 1.01 kg/h with purity of 0.99 in mass fraction.Keywords: liquid effluent, UO2 kernel, CHEMCAD, HTGR.

Psychosemantic Content of the Concept of Sexuality in the Language Consciousness of Adults

Introduction. The article presents the results of psycho-linguistic study of the representation in the linguistic consciousness, psychosemantic and psychological content of the relative neologism “sexuality” formed in the conditions of natural transcultural semiosis. Herein the author’s own definition of the phenomenon of sexuality was formulated. The aim of the study is to research the semantic content of the concept of “sexuality”, to analyze the existing definitions, to accentuate the concept of sexuality. On the basis of the results of psycho-linguistic and psychosemantic studies to formulate author’s own definition. Research Methods & Techniques. The psycho-linguistic methods were used: (a) extended word association experiment; (b) modified semantic differential method; (c) modified incomplete sentence method. Results. The extended word association experiment has shown that in the linguistic consciousness of the student’s youth (20–22 years), in the understanding of sexuality, most often there exist semantic associates to “sexy” (28,27%) calqued from the American English. In the associative field of persons the age of early adulthood, who have grown up in the conditions of natural linguistic semiosis, where there was no meaning of “sexy”, other verbal reactions prevail, namely trust, openness, safety, reason, a man. The modified unfinished sentence method revealed that the psychosemantic understanding of sexuality in men and women has both common and distinct features. Conclusions. The living word represents the cognitive-discursive activity of the individual and the society. Sexuality as a product of natural linguistic semiosis and as a psychological phenomenon is not reduced to sexual physicality. Being the part of a holistic self-concept and a meaningful identity, the concept of sexuality reaches the mental-spiritual level and is actively present in the linguistic consciousness of the adult. Therefore, sexuality functions on the physical, psycho-emotional and mental-spiritual levels and is considered in at least biological, psychological (psycholinguistic) and cultural aspects.

Estimation of various associated factors in multiparous females undergoing primary caesarean sections at a tertiary care health centre in rural Western Maharashtra, India

Background: Caesarean section is one of the commonly performed operation in women due to safety reason and modern techniques. Primary caesarean section in the multipara means first caesarean section done in the patients who had previously delivered vaginally once or more. Aims and objectives of this study were to know association of various parameters like Age, Parity, Haemoglobin, Blood Pressure, Baby weight, Perinatal and Maternal Mortality with primary caesarean section among multipara.Methods: This was a prospective study of primary caesarean section in multipara women admitted at tertiary care hospital in western rural Maharashtra during the period of 6 months from January 2018 to June 2018. Multipara with pregnancy of >28 weeks gestation (gravida 2 and above), each of whom has had a previous vaginal delivery of >20 weeks gestation were included. Women with previous abortions and previous section were excluded.Results: Total 1705 sections were performed during the same period out of total 4648 deliveries. Out of these sections 194 sections were performed in multipara for the first time. Maximum numbers of patients (58%) were in the age group of 15-24 years and Parity 2 (68%). Almost 70% women among multipara have Hb <11 Mgm/dl. Most of the patients (84.53%) have normal Blood pressure readings. Most of the babies’ i.e.70 (36.08%) have birth weight in the range of 2.5-3 kg. Out of 194 deliveries, there were only 3 neonatal deaths (1.54%) and 1 maternal death (0.51%).Conclusions: Proper antenatal and intrapartum care and early referral can reduce the maternal and perinatal morbidity and mortality in multipara.

The influence of the cargo weight and its position on the braking characteristics of light commercial vehicles

The influence of the cargo weight loaded on the vehicle and the total gross mass of the vehicle on the braking characteristics is often researched from the road safety reason. However, there is not enough knowledge about the influence of weight and load distribution on the loading area of small trucks or vans on their braking characteristics. This article presents the results of measurements of braking decelerations of the van of N1 category and the braking characteristics of a vehicle loaded with different cargo mass with different cargo locations on the loading area. The impact of the longitudinal cargo position on the loading area on the load of the individual axles and thus on the braking deceleration of the vehicle was investigated. The influence of the height of the center of gravity on the dynamic axle load during braking was also determined. Method of direct vehicle deceleration measurement was used by a decelerometer. There were calculated cargo weight and cargo position influences on the dynamic axle load during braking according to the vehicle deceleration.

Vefora, GETUG-AFU V06 study: Randomized multicenter phase II/III trial of fractionated cisplatin (CI)/gemcitabine (G) or carboplatin (CA)/g in patients (pts) with advanced urothelial cancer (UC) with impaired renal function (IRF)—Results of a planned interim analysis.

461 Background: Standard treatment for advanced UC is chemotherapy (CT) combining CI and G. 70% of pts with UC are over 65 and 40% of them are unfit for CI because of IRF or comorbidities. CA replaces frequently CI, when creatinine clearance (Cr Cl) is < 60 ml/min according to Cockroft and Gault formula (CGF). However, CA tends to show a lower efficacy than CI, due to decreased dose intensity of CT. Methods: We performed a multicentre randomized phase II/III study in order to compare the activity and safety of a CT regimen with fractionated CI or CA for advanced UC in 1st line setting among pts unfit for standard CT because of IRF (40 ≤ Cr Cl ≤ 60ml/min) according to CGF. We report here the results of the interim analysis of phase II. Treatment: Arm A: CA AUC4,5 D1+ G 1000 mg/m² D1, [D1 = D21]; Arm B: fractionated CI 35 mg/m² D1D8 + G 1000 mg/m² D1D8, [D1 = D21] The co-primary objectives of the phase II were to evaluate activity (non-progression (RECIST V1.1) at (D21 C6)) and safety defined by the absence during treatment of: IRF: Cr Cl <35 mL/min or deterioration of Cr Cl >20%; delayed CT (≥ 2 weeks); decrease twice G dose on day 1 for: NCI CTC grade III or IV non-hematologic toxicity; hematologic toxicity; A two-stage Bryant and Day design was used. Results: A planned first step analysis was performed after randomization of 25 and 21 pts from April 2015 to January 2018. 23 and 19 of them were evaluable (resp. Arm A/B). 8 failures were reported for safety reason in experimental arm B, 7 for renal toxicity. Conclusions: According to our pre planned first step analysis, the trial met criteria for excessive toxicity in experimental arm (fractionated CI), predominantly renal toxicity. The study was therefore definitely stopped. Survival results will be available at the meeting. Clinical trial information: NCT02240017 . [Table: see text]

Iris Recognition at-a-Distance by Means of Chronological MBO-Based DBN

Now a days, Iris recognition is wieldy used for the identification of person. The superior bit of 1 countries exploits biometric system for safety reason with the conclusion goal that in runway boarding, custom freedom, gathering passage, etc. The Iris detection at-a-Distance (IAAD) framework is generally used to identify the person in most of the applications. In this system, different features of iris image are extracted in addition enhances the superiority of iris image. Over the span of the most recent ages there consume raised various structures to design and finish iris affirmation systems which works at longer separation going from one meter to sixty meter. Because of such long scope of iris detection schemes in addition iris attainment scheme provides for the best applications to the client. Therefore, It is necessary to design an effective algorithm for IAAD is necessary. In this article, an actual method for iris recognition is presents. A Chronological Monarch Butterfly Optimization -based Deep Belief Network (Chronological MBO-based DBN) technique is anticipated for iris detection.This technique algorithm is the combination of Chronological theory with the Monarch Butterfly Optimization. It is utilized to mastermind the sequential presumption of an iris picture. Additionally, the Hough Transform calculation is utilized for discovery of iris circle and edge. To enhance the accuracy of anticipated iris recognition system ScatT-Loop descriptor and the Local Gradient Pattern (LGP) are fed to the Chronological MBO-based DBN algorithm and these are castoff to abstract the dissimilar features of an iris picture. The dataset used for these tactices are UBIRIS.v1 For the normalization and segmentation of an iris image is done by by means of Dougman's rubber sheet model. This system is established on MATLAB for executing the Hough transform procedures also for reading the iris images. The simulation results shows that this system successfully recognize the iris at a distance 4 to 8 meter. Different performance parameters like as FAR accuracy, too FRR shows better results in this anticipated work.

Poli Propilen (Pp) Sebagai Alternatif Untuk Kemasan AMDK Isi Ulang ( 5 Galon)

Packed drinking water is a commodity which is widely needed by the customer. One kind of the packaging used is reusable packaging with 5 (five) gallon capacity which is made from Poly Carbonat (PC) or Glass. Based on the technical, and safety reason, Poly Propylene (PP) can be used as an alternative for the reusable packaging of the drinking water.

Automatic Identification System (AIS) dynamic data estimation based on discrete Kalman Filter (KF) algorithm

Due to the safety reason, the ship movement on the littoral area should be monitored, tracked, recorded and stored. Automatic Identification System (AIS) is the perfect tool to ensure this requirement. The limit probability for the AIS dynamic data availability can be limited by the lack of Global Position System (GPS) signal, heading (HDG) and rate of turn (ROT) data in position report. Availability of data link is an additional limitation. For this purpose, it is possible to attach the Discrete Kalman filter (KF) for the position, and course estimation. Coordinate estimation in the absence of a transmission link can improve the quality of AIS service at Vessel Traffic Service (VTS) stations. This article presents Kalman filtering algorithm to improve the possibilities of ship motion tracking and monitoring in the TSS (Traffic Separation Scheme) and fairways area. Only 39 iterations were presented to familiarize how the Kalman filter algorithm works. The archival data from 2006 were used deliberately. During that time, there were problems with the AIS availability service. With the use of measurements series from those years, it is easier to observe the effectiveness of Kalman filter in absence of AIS data.