Polymeric nanoparticles with potential applications in sensing and biosensing

2022 ◽  
pp. 401-426
Author(s):  
Vinita Bharadwaj ◽  
Nimisha Singh ◽  
Suban K. Sahoo
Keyword(s):  
Polymeric Nanoparticles ◽  
Potential Applications

scholarly journals Investigation of Molecular Size Effect on the Formation of Lignin Nanoparticles by Nanoprecipitation

2020 ◽  
Vol 10 (14) ◽  
pp. 4910
Author(s):  
Jae Hoon Lee ◽  
Shin Young Park ◽  
In-Gyu Choi ◽  
Joon Weon Choi
Keyword(s):  
Polymeric Nanoparticles ◽  
Drug Carrier ◽  
Particle Surface ◽  
Molecular Size ◽  
Remarkable Change ◽  
Molecular Weights ◽  
Chemical Structures ◽  
Potential Applications ◽  
Soda Lignin ◽  
Average Size

In recent years, several studies focused on the synthesis of lignin-based nanoparticle in aqueous solution and its potential applications of the drug carrier were investigated. In this study, soda lignin (SL) nanoparticles (i.d. 128–560 nm) were synthesized by the nanoprecipitation process at three different concentrations (1, 2, and 4 mg/mL THF) with various molecular sizes of soda lignin (NP-F1, NP-F2, and NP-F3) obtained from sequential solvent extraction. The average molecular weights of SL, F1, F2, F3, F4, and F5 were 3130, 1190, 2550, 3680, 5310, and 14,650, respectively. The average size of the spherical lignin nanoparticle was a minimum of 128 nm for NP-C1 and the size increased up to 560 nm with increasing concentration. Particle surface charge increased with increasing concentration from −26 mV for NP-C1 to −38 mV for NP-C4. Contrary to expected general trends in polymeric nanoparticles, there was no remarkable change or trend with increasing lignin molecular weight since chemical structures of each lignin fraction are also remarkably different. Further studies to learn correlation between properties of lignin nanoparticle and its additional details regarding the chemical structures is needed.

Functional Nanomaterials and Their Potential Applications in Antibacterial Therapy

2019 ◽  
Vol 7 (2) ◽  
pp. 129-146 ◽  
Author(s):  
Le Hong ◽  
Shu-Han Luo ◽  
Chen-Hao Yu ◽  
Yu Xie ◽  
Meng-Ying Xia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Lower Side ◽  
Functional Nanomaterials ◽  
Graphene Oxides ◽  
The Past ◽  
Potential Applications ◽  
Carbon Based Nanomaterials ◽  
Direct Use

In the past decades, nanomaterials have shown great potential in biomedical fields, especially in drug delivery, imaging and targeted therapy. Recently, the development of novel functional nanomaterials for antibacterial application has attracted much attention. Compared to the traditional direct use of antibiotics, antibacterial nanomaterials either as drug delivery systems or active agents have a higher efficacy and lower side effects. Herein, we will focus on the antibacterial applications of four commonly used nanomaterials, including metal-based nanomaterials, polymeric nanoparticles, graphene oxides or carbon-based nanomaterials and nanogels.

scholarly journals α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

Materials ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 133 ◽  
Author(s):  
Adrian Domiński ◽  
Tomasz Konieczny ◽  
Piotr Kurcok
Keyword(s):  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Functional Materials ◽  
Building Blocks ◽  
Polymer Chains ◽  
Physical Interaction ◽  
Wide Range ◽  
Potential Applications ◽  
Noncovalent Bonds ◽  
Significant Attention

Supramolecular hydrogels that are based on inclusion complexes between α-cyclodextrin and (co)polymers have gained significant attention over the last decade. They are formed via dynamic noncovalent bonds, such as host–guest interactions and hydrogen bonds, between various building blocks. In contrast to typical chemical crosslinking (covalent linkages), supramolecular crosslinking is a type of physical interaction that is characterized by great flexibility and it can be used with ease to create a variety of “smart” hydrogels. Supramolecular hydrogels based on the self-assembly of polypseudorotaxanes formed by a polymer chain “guest” and α-cyclodextrin “host” are promising materials for a wide range of applications. α-cyclodextrin-based polypseudorotaxane hydrogels are an attractive platform for engineering novel functional materials due to their excellent biocompatibility, thixotropic nature, and reversible and stimuli-responsiveness properties. The aim of this review is to provide an overview of the current progress in the chemistry and methods of designing and creating α-cyclodextrin-based supramolecular polypseudorotaxane hydrogels. In the described systems, the guests are (co)polymer chains with various architectures or polymeric nanoparticles. The potential applications of such supramolecular hydrogels are also described.

scholarly journals Technology Overview and Current Biomedical Application of Polymeric Nanoparticles

2018 ◽  
Vol 8 (6) ◽  
pp. 285-295
Author(s):  
Gurpreet Singh ◽  
Abdul Faruk ◽  
Preet Mohinder Singh Bedi
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Polymeric Nanoparticles ◽  
Preparation Methods ◽  
Polymeric Nanoparticle ◽  
Potential Applications ◽  
Dialysis Method ◽  
Novel Drug ◽  
Current Potential

Polymeric nanoparticle are of great importance in the treatment of various diseases, due to the flexibility in the  modification of their structures. Recent advances in the field of nanotechnology facilitate the engineering of multifunctional polymeric nanoparticles. All the scientific efforts of the pharmaceuticals companies are mainly focusing on two basic aspects, one is to discover new molecules of potential therapeutic interest and second is to develop of a new drug delivery system. In the last few decades,  research and development (R&D) scientists has directed their efforts toward formulating novel drug delivery systems that includes sustained and controlled release, modified release and targeted drug release dosage forms. Application of nanoscience and nanotechnology has opened several new possibilities in development of formulation This review compiles the different preparation methods of polymeric nanoparticles and then briefly explained their current potential applications. Keywords: Polymeric nanoparticles, PLGA, Biomedical applications, Biodegradable, Dialysis method

scholarly journals Compartmentalized Polymeric Nanoparticles Deliver Vancomycin in a pH-Responsive Manner

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1992
Author(s):  
Merve Seray Ural ◽  
Mario Menéndez-Miranda ◽  
Giuseppina Salzano ◽  
Jérémie Mathurin ◽  
Ece Neslihan Aybeke ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Electrostatic Interactions ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Resonance Spectroscopy ◽  
Acidic Ph ◽  
Ph Responsive ◽  
Force Microscopy ◽  
Electron Microscopies ◽  
Potential Applications

Vancomycin (VCM) is a last resort antibiotic in the treatment of severe Gram-positive infections. However, its administration is limited by several drawbacks such as: strong pH-dependent charge, tendency to aggregate, low bioavailability, and poor cellular uptake. These drawbacks were circumvented by engineering pH-responsive nanoparticles (NPs) capable to incorporate high VCM payload and deliver it specifically at slightly acidic pH corresponding to infection sites. Taking advantage of peculiar physicochemical properties of VCM, here we show how to incorporate VCM efficiently in biodegradable NPs made of poly(lactic-co-glycolic acid) and polylactic acid (co)polymers. The NPs were prepared by a simple and reproducible method, establishing strong electrostatic interactions between VCM and the (co)polymers’ end groups. VCM payloads reached up to 25 wt%. The drug loading mechanism was investigated by solid state nuclear magnetic resonance spectroscopy. The engineered NPs were characterized by a set of advanced physicochemical methods, which allowed examining their morphology, internal structures, and chemical composition on an individual NP basis. The compartmentalized structure of NPs was evidenced by cryogenic transmission electronic microscopy, whereas the chemical composition of the NPs’ top layers and core was obtained by electron microscopies associated with energy-dispersive X-ray spectroscopy. Noteworthy, atomic force microscopy coupled to infrared spectroscopy allowed mapping the drug location and gave semiquantitative information about the loadings of individual NPs. In addition, the NPs were stable upon storage and did not release the incorporated drug at neutral pH. Interestingly, a slight acidification of the medium induced a rapid VCM release. The compartmentalized NPs could find potential applications for controlled VCM release at an infected site with local acidic pH.

An in situ and ex situ TEM study of the formation of thin cobalt silicide films by molecular beam epitaxy on the silicon (100) surface

1988 ◽  
Vol 46 ◽  
pp. 884-885
Author(s):  
D. Loretto ◽  
J. M. Gibson ◽  
S. M. Yalisove ◽  
R. T. Tung
Keyword(s):  
Molecular Beam Epitaxy ◽  
Molecular Beam ◽  
Defect Density ◽  
High Vacuum ◽  
Ultra High Vacuum ◽  
Ex Situ ◽  
Metal Base ◽  
In Situ Experiments ◽  
Potential Applications

The cobalt disilicide/silicon system has potential applications as a metal-base and as a permeable-base transistor. Although thin, low defect density, films of CoSi2 on Si(111) have been successfully grown, there are reasons to believe that Si(100)/CoSi2 may be better suited to the transmission of electrons at the silicon/silicide interface than Si(111)/CoSi2. A TEM study of the formation of CoSi2 on Si(100) is therefore being conducted. We have previously reported TEM observations on Si(111)/CoSi2 grown both in situ, in an ultra high vacuum (UHV) TEM and ex situ, in a conventional Molecular Beam Epitaxy system.The procedures used for the MBE growth have been described elsewhere. In situ experiments were performed in a JEOL 200CX electron microscope, extensively modified to give a vacuum of better than 10-9 T in the specimen region and the capacity to do in situ sample heating and deposition. Cobalt was deposited onto clean Si(100) samples by thermal evaporation from cobalt-coated Ta filaments.

Microstructure of laser-irradiated, conducting Kapton polyimide

1995 ◽  
Vol 53 ◽  
pp. 502-503
Author(s):  
D. L. Callahan ◽  
Z. Ball ◽  
H. M. Phillips ◽  
R. Sauerbrey
Keyword(s):  
Electron Microscopy ◽  
Phase Transition ◽  
Transmission Electron Microscopy ◽  
Cross Section ◽  
Film Surface ◽  
Cross Sectional ◽  
General Utility ◽  
Transmission Electron ◽  
Considerable Debate ◽  
Potential Applications

Ultraviolet laser-irradiation can be used to induce an insulator-to-conductor phase transition on the surface of Kapton polyimide. Such structures have potential applications as resistors or conductors for VLSI applications as well as general utility electrodes. Although the percolative nature of the phase transformation has been well-established, there has been little definitive work on the mechanism or extent of transformation. In particular, there has been considerable debate about whether or not the transition is primarily photothermal in nature, as we propose, or photochemical. In this study, cross-sectional optical microscopy and transmission electron microscopy are utilized to characterize the nature of microstructural changes associated with the laser-induced pyrolysis of polyimide.Laser-modified polyimide samples initially 12 μm thick were prepared in cross-section by standard ultramicrotomy. Resulting contraction in parallel to the film surface has led to distortions in apparent magnification. The scale bars shown are calibrated for the direction normal to the film surface only.

Fabrication and characterization - by High Resolution Electron Microscopy and atom probe microanalysis - of Co-based metallic multilayer films

1990 ◽  
Vol 48 (4) ◽  
pp. 772-773
Author(s):  
Amanda K. Petford-Long ◽  
A. Cerezo ◽  
M.G. Hetherington
Keyword(s):  
Electron Microscopy ◽  
High Resolution ◽  
High Resolution Electron Microscopy ◽  
Atom Probe ◽  
Multilayer Films ◽  
Interface Roughness ◽  
Probe Field ◽  
Resolution Electron ◽  
Potential Applications ◽  
Field Ion Microscope

The fabrication of multilayer films (MLF) with layer thicknesses down to one monolayer has led to the development of materials with unique properties not found in bulk materials. The properties of interest depend critically on the structure and composition of the films, with the interfacial regions between the layers being of particular importance. There are a number of magnetic MLF systems based on Co, several of which have potential applications as perpendicular magnetic (e.g Co/Cr) or magneto-optic (e.g. Co/Pt) recording media. Of particular concern are the effects of parameters such as crystallographic texture and interface roughness, which are determined by the fabrication conditions, on magnetic properties and structure.In this study we have fabricated Co-based MLF by UHV thermal evaporation in the prechamber of an atom probe field-ion microscope (AP). The multilayers were deposited simultaneously onto cobalt field-ion specimens (for AP and position-sensitive atom probe (POSAP) microanalysis without exposure to atmosphere) and onto the flat (001) surface of oxidised silicon wafers (for subsequent study in cross-section using high-resolution electron microscopy (HREM) in a JEOL 4000EX. Deposi-tion was from W filaments loaded with material in the form of wire (Co, Fe, Ni, Pt and Au) or flakes (Cr). The base pressure in the chamber was around 8×10−8 torr during deposition with a typical deposition rate of 0.05 - 0.2nm/s.

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